{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:08:12Z","timestamp":1777540092219,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T00:00:00Z","timestamp":1332201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1007\/s00423-012-0948-2","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T05:01:23Z","timestamp":1332133283000},"page":"1093-1098","source":"Crossref","is-referenced-by-count":44,"title":["Botulinum toxin injection versus lateral internal sphincterotomy for the treatment of chronic anal fissure: randomized prospective controlled trial"],"prefix":"10.1007","volume":"397","author":[{"given":"Neda","family":"Valizadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloufar Yahyapour","family":"Jalaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Hassanzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereshteh","family":"Kamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Dadvar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shapour","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Salehimarzijarani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,3,20]]},"reference":[{"key":"948_CR1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02054225","volume":"38","author":"C Oh","year":"1995","unstructured":"Oh C, Divino CM, Steinhagen RM (1995) Anal fissure. 20-year experience. Dis Colon Rectum 38:378\u2013382","journal-title":"Dis Colon Rectum"},{"key":"948_CR2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00384-002-0438-z","volume":"18","author":"H Rohde","year":"2003","unstructured":"Rohde H (2003) The pathogenetic mechanism causing anal fissure. Int J Colorectal Dis 18:95","journal-title":"Int J Colorectal Dis"},{"key":"948_CR3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10151-007-0355-9","volume":"11","author":"EE Collins","year":"2007","unstructured":"Collins EE, Lund JN (2007) A review of chronic anal fissure management. Tech Coloproctol 11:209\u2013223","journal-title":"Tech Coloproctol"},{"key":"948_CR4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1463-1318.2004.00576.x","volume":"6","author":"N Griffin","year":"2004","unstructured":"Griffin N, Acheson AG, Tung P, Sheard C, Glazebrook C, Scholefield JH (2004) Quality of life in patients with chronic anal fissure. Colorectal Dis 6:39\u201344","journal-title":"Colorectal Dis"},{"key":"948_CR5","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1046\/j.1365-2168.1998.00958.x","volume":"85","author":"M Sailer","year":"1998","unstructured":"Sailer M, Bussen D, Debus ES, Fuchs KH, Thiede A (1998) Quality of life in patients with benign anorectal disorders. Br J Surg 85:1716\u20131719","journal-title":"Br J Surg"},{"key":"948_CR6","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/BF02556488","volume":"30","author":"RM Weaver","year":"1987","unstructured":"Weaver RM, Ambrose NS, Alexander-Williams J et al (1987) Manual dilatation of the anus vs. lateral subcutaneous sphincterotomy in the treatment of chronic fissure-in-ano. Results of a prospective, randomized, clinical trial. Dis Colon Rectum 30:420\u2013423","journal-title":"Dis Colon Rectum"},{"key":"948_CR7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF02587197","volume":"23","author":"H Abcarian","year":"1980","unstructured":"Abcarian H (1980) Surgical correction of chronic anal fissure: results of lateral internal sphincterotomy vs. fissurectomy-midline sphincterotomy. Dis Colon Rectum 23:31\u201336","journal-title":"Dis Colon Rectum"},{"key":"948_CR8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF02053862","volume":"38","author":"AF Leong","year":"1995","unstructured":"Leong AF, Seow-Choen F (1995) Lateral sphincterotomy compared with anal advancement flap for chronic anal fissure. Dis Colon Rectum 38:69\u201371","journal-title":"Dis Colon Rectum"},{"key":"948_CR9","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1007\/BF02234220","volume":"42","author":"DC Nyam","year":"1999","unstructured":"Nyam DC, Pemberton JH (1999) Long-term results of lateral internal sphincterotomy for chronic anal fissure with particular reference to incidence of fecal incontinence. Dis Colon Rectum 42:1306\u20131310","journal-title":"Dis Colon Rectum"},{"key":"948_CR10","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1007\/BF02236694","volume":"42","author":"M M\u00ednguez","year":"1999","unstructured":"M\u00ednguez M, Melo F, Esp\u00ed A et al (1999) Therapeutics effects of different doses of botulinum toxin in chronic anal fissure. Dis Colon Rectum 42:1016\u20131021","journal-title":"Dis Colon Rectum"},{"key":"948_CR11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00384-002-0408-5","volume":"17","author":"W Jost","year":"2002","unstructured":"Jost W (2002) Ten years experience with botulin toxin in anal fissure. Int J Colorectal Dis 17:287\u2013297","journal-title":"Int J Colorectal Dis"},{"key":"948_CR12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM199907083410201","volume":"341","author":"G Brisinda","year":"1999","unstructured":"Brisinda G, Maria G, Bentivoglio AR et al (1999) A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl J Med 341:65\u201369","journal-title":"N Engl J Med"},{"key":"948_CR13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0002-9610(99)00255-X","volume":"179","author":"G Maria","year":"2000","unstructured":"Maria G, Brisinda G, Bentivoglio AR et al (2000) Influence of botulinum toxin site of injections on healing rate in patients with chronic anal fissure. Am J Surg 179:46\u201350","journal-title":"Am J Surg"},{"key":"948_CR14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1067\/msy.2002.119314","volume":"131","author":"G Brisinda","year":"2002","unstructured":"Brisinda G, Maria G, Sganga G et al (2002) Effectiveness of higher doses of botulinum toxin to induce healing in patients with chronic anal fissures. Surgery 131:179\u2013184","journal-title":"Surgery"},{"key":"948_CR15","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/BF02236548","volume":"43","author":"CS Richard","year":"2000","unstructured":"Richard CS, Gregoire R, Plewes EA et al (2000) Internal sphincterotomy is superior to topical nitroglycerin in the treatment of chronic anal fissure: results of a randomized, controlled trial by the Canadian Colorectal Surgical Trials Group. Dis Colon Rectum 43:1048\u20131057","journal-title":"Dis Colon Rectum"},{"key":"948_CR16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF02234828","volume":"44","author":"JE Evans","year":"2001","unstructured":"Evans JE, Luck A, Hewett P (2001) Glyceryl trinitate vs lateral sphincterotomy for chronic anal fissure. Prospective, randomized trial. Dis Colon Rectum 44:93\u201397","journal-title":"Dis Colon Rectum"},{"key":"948_CR17","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1046\/j.1365-2168.2002.02121.x","volume":"89","author":"G Maria","year":"2002","unstructured":"Maria G, Sganga G, Civello IM et al (2002) Botulinum neurotoxin and other treatments for fissure-in-ano and pelvic floor disorders. Br J Surg 89:950\u2013961","journal-title":"Br J Surg"},{"key":"948_CR18","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00384-009-0683-5","volume":"24","author":"WJ Shao","year":"2009","unstructured":"Shao WJ, Li GC, Zhang ZK (2009) Systemic review and meta-analysis of randomized controlled trails comparing botulinum toxin injection with lateral internal sphincterotomy for chronic anal fissure. Int J Colorectal Dis 24:995\u20131000","journal-title":"Int J Colorectal Dis"},{"key":"948_CR19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1053\/sder.2001.25964","volume":"20","author":"AW Klein","year":"2001","unstructured":"Klein AW (2001) Complications and adverse reactions with the use of botulinum toxin. Semin Cutan Med Surg 20:109\u2013120","journal-title":"Semin Cutan Med Surg"},{"key":"948_CR20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJM199801223380402","volume":"338","author":"G Maria","year":"1998","unstructured":"Maria G, Cassetta E, Gui D, Brisinda G, Bentivoglio AR, Albanese A (1998) A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 338:217\u2013220","journal-title":"N Engl J Med"},{"key":"948_CR21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/BF02050924","volume":"40","author":"WH Jost","year":"1997","unstructured":"Jost WH (1997) One hundred cases of anal fissure treated with botulinum toxin. Early and long term results. Dis Colon Rectum 40:1029\u20131032","journal-title":"Dis Colon Rectum"},{"key":"948_CR22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0140-6736(94)90633-5","volume":"344","author":"D Gui","year":"1994","unstructured":"Gui D, Cassetta E, Asastasio G, Bentivoglio AR, Maria G, Albanese A (1994) A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. Lancet 344:1127\u20131128","journal-title":"Lancet"},{"key":"948_CR23","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/BF02236199","volume":"42","author":"JM Church","year":"1999","unstructured":"Church JM, Fleshman JW, Kane RL et al (1999) Patient and surgeon ranking of the severity of symptoms associated with fecal incontinence: the fecal incontinence severity index. Dis Colon Rectum 42:1525\u20131532","journal-title":"Dis Colon Rectum"},{"key":"948_CR24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02050307","volume":"36","author":"JMN Jorge","year":"1993","unstructured":"Jorge JMN, Wexner SD (1993) Etiology and management of fecal incontinence. Dis Colon Rectum 36:77\u201397","journal-title":"Dis Colon Rectum"},{"key":"948_CR25","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1007\/BF02050639","volume":"36","author":"WH Jost","year":"1993","unstructured":"Jost WH, Schimrigk K (1993) Use of botulinum toxin in anal fissure. Dis Colon Rectum 36:974","journal-title":"Dis Colon Rectum"},{"key":"948_CR26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s10350-004-6528-y","volume":"46","author":"BB Mentes","year":"2003","unstructured":"Mentes BB, Irkorucu O, Akin M, Leventoglu S, Tatlicioglu E (2003) Comparison of botulinum toxin injection and lateral Internal sphincterotomy for the treatment of chronic anal fissure. Dis Colon Rectum 46:232\u2013237","journal-title":"Dis Colon Rectum"},{"key":"948_CR27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.amjsurg.2004.06.045","volume":"189","author":"A Arroyo","year":"2005","unstructured":"Arroyo A, Perez F, Serrano P, Candela F, Lacueva J, Calpena R (2005) Surgical versus chemical (botulinum toxin) sphincterotomy For chronic anal fissure: long-term results of a prospective randomized clinical and manometric study. Am J Surg 189:429\u2013434","journal-title":"Am J Surg"},{"key":"948_CR28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.5144\/0256-4947.2005.140","volume":"25","author":"BW Massoud","year":"2005","unstructured":"Massoud BW, Mehrdad V, Baharak T, Alireza Z (2005) Botulinum toxin injection versus internal anal sphincterotomy For the treatment of chronic anal fissure. Ann Saudi Med 25:140\u2013142","journal-title":"Ann Saudi Med"},{"key":"948_CR29","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1445-2197.2005.03427.x","volume":"75","author":"H Iswariah","year":"2005","unstructured":"Iswariah H, Stephens J, Rieger N, Rodda D, Hewett P (2005) Randomized prospective controlled trial of lateral internal sphincterotomy versus injection of botulinum toxin for the treatment of idiopathic fissure in ano. ANZ J Surg 75:553\u2013555","journal-title":"ANZ J Surg"},{"key":"948_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00423-003-0430-2","volume":"390","author":"AG Acheson","year":"2005","unstructured":"Acheson AG, Scholefield JH (2005) Anal fissure: the changing management of a surgical condition. Langenbecks Arch Surg 390:1\u20137","journal-title":"Langenbecks Arch Surg"},{"key":"948_CR31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s10350-003-0079-5","volume":"47","author":"R Nelson","year":"2004","unstructured":"Nelson R (2004) A systemic review of medical therapy for anal fissure. Dis Colon Rectum 47:422\u2013431","journal-title":"Dis Colon Rectum"},{"key":"948_CR32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-230X-4-7","volume":"4","author":"A Giral","year":"2004","unstructured":"Giral A, Memisoglu K, Gultekin Y et al (2004) Botulinum toxin injection versus lateral internal sphincterotomy in the treatment chronic anal fissure: a non-randomized controlled trial. BMC Gastroenterol 4:7","journal-title":"BMC Gastroenterol"},{"key":"948_CR33","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/00000658-199811000-00005","volume":"228","author":"G Maria","year":"1998","unstructured":"Maria G, Brisinda G, Bentivoglio AR et al (1998) Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure. Long-term results after two different dosage regimens. Ann Surg 228:664\u2013669","journal-title":"Ann Surg"},{"key":"948_CR34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1053\/gast.2002.34219","volume":"123","author":"M Minguez","year":"2002","unstructured":"Minguez M, Herreros B, Espi A et al (2002) Long-term follow-up (42 months) of chronic anal fissure alter healing with botulinum Toxin. Gastroenterology 123:112\u2013117","journal-title":"Gastroenterology"},{"key":"948_CR35","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1056\/NEJM199907083410209","volume":"341","author":"M Hallett","year":"1999","unstructured":"Hallett M (1999) One man\u2019s poison\u2014clinical applications of botulinum toxin. N Engl J Med 341:118\u2013120","journal-title":"N Engl J Med"},{"key":"948_CR36","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/BF02234710","volume":"44","author":"J Pitt","year":"2001","unstructured":"Pitt J, Willilams S, Dawson PM (2001) Reason for failure of glyceryl trinitrate treatment of chronic fissure-in-ano. A multivariate analysis. Dis Colon Rectum 44:864\u2013867","journal-title":"Dis Colon Rectum"},{"key":"948_CR37","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1177\/000313480907501013","volume":"75","author":"O Aivaz","year":"2009","unstructured":"Aivaz O, Rayhanabad J, Nguyen V et al (2009) Botulinum toxin A with fissurectomy is a viable alternative to lateral internal sphincterotomy for chronic anal fissure. Am Surg 75:925\u2013928","journal-title":"Am Surg"},{"key":"948_CR38","first-page":"138","volume":"22","author":"D Huppe","year":"1992","unstructured":"Huppe D, Enck P, Kruskemper G et al (1992) Psychosocial aspects of fecal incontinence. Leber Megan Darm 22:138\u2013142","journal-title":"Leber Megan Darm"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-012-0948-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00423-012-0948-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-012-0948-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T16:29:13Z","timestamp":1641313753000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00423-012-0948-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,20]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["948"],"URL":"https:\/\/doi.org\/10.1007\/s00423-012-0948-2","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"value":"1435-2443","type":"print"},{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,20]]}}}