{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T19:35:32Z","timestamp":1781033732453,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003252","name":"Lund University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>Surgery is recommended for most patients with gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NENs). Rates of complications and perioperative mortality have been reported in few mostly retrospective single-center series, but there has been no detailed analysis on risk factors for perioperative complications and mortality to date.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Data of patients with GEP-NENs operated between January 2015 and September 2018 were retrieved from EUROCRINE\u00a9, a European online endocrine surgical quality registry, and analyzed regarding rate and risk factors of surgical complications. Risk factors were assessed by logistic regression.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Some 376 patients (211 female, 167 male; age median 63, range 15\u201389\u00a0years) were included. Most NENs were located in the small intestine (SI) (<jats:italic>n<\/jats:italic>\u2009=\u2009132) or pancreas (<jats:italic>n<\/jats:italic>\u2009=\u2009111), the rest in the stomach (<jats:italic>n<\/jats:italic>\u2009=\u200934), duodenum (<jats:italic>n<\/jats:italic>\u2009=\u200930), appendix (<jats:italic>n<\/jats:italic>\u2009=\u200930), colon, and rectum (<jats:italic>n<\/jats:italic>\u2009=\u200922), or with unknown primary (<jats:italic>n<\/jats:italic>\u2009=\u200915). Of the tumors, 320 (85.1%) were well or moderately differentiated, and 147 (39.1%) of the patients had distant metastases at the time of operation. Severe complications (Dindo-Clavien \u2265\u20093) occurred in 56 (14.9%) patients, and 4 (1.1%) patients died perioperatively. Severe complications were more frequent in surgery for duodenopancreatic NENs (<jats:italic>n<\/jats:italic>\u2009=\u200931; 22.0%) compared with SI-NENs (<jats:italic>n<\/jats:italic>\u2009=\u200915; 11.4%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.014), in patients with lymph node metastases operated with curative aim of surgery (<jats:italic>n<\/jats:italic>\u2009=\u200924; 21.4%) versus non-metastasized tumors or palliative surgery (<jats:italic>n<\/jats:italic>\u2009=\u200932; 12.1%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.020), and in functioning tumors (<jats:italic>n<\/jats:italic>\u2009=\u200920; 23.0%) versus non-functioning tumors (<jats:italic>n<\/jats:italic>\u2009=\u200930; 13.5%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.042). Complication rates were not significantly associated with tumor stage or grade.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Severe complications are frequent in GEP-NEN surgery. Besides duodenopancreatic tumor location, curative resection of nodal metastases and functioning tumors are risk factors for complications.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00423-020-01869-0","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T02:02:47Z","timestamp":1586916167000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Complications of surgery for gastro-entero-pancreatic neuroendocrine neoplasias"],"prefix":"10.1007","volume":"405","author":[{"given":"Max B.","family":"Albers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Almquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bergenfelz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Nordenstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"1869_CR1","first-page":"426","volume":"1","author":"S Oberndorfer","year":"1907","unstructured":"Oberndorfer S (1907) Karzinoide Tumoren des D\u00fcnndarms. Frankfurter Zeitschrift f\u00fcr Pathologie 1:426\u2013429","journal-title":"Frankfurter Zeitschrift f\u00fcr Pathologie"},{"key":"1869_CR2","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"RV Lloyd","year":"2017","unstructured":"Lloyd RV, Osamura RY, Kl\u00f6ppel G, Rosai J (2017) WHO Classification of Tumours of Endocrine Organs, vol 10, 4th edn. IARC Press, Lyon","edition":"4"},{"issue":"10","key":"1869_CR3","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1001\/jamaoncol.2017.0589","volume":"3","author":"A Dasari","year":"2017","unstructured":"Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC (2017) Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol 3(10):1335\u20131342. https:\/\/doi.org\/10.1001\/jamaoncol.2017.0589","journal-title":"JAMA Oncol"},{"issue":"3","key":"1869_CR4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s12020-018-1592-6","volume":"60","author":"I Kruljac","year":"2018","unstructured":"Kruljac I, Vurnek I, Maasberg S, Kust D, Blaslov K, Ladika Davidovic B, Stefanovic M, Demirovic A, Biscanin A, Filipovic-Cugura J, Maric Brozic J, Pape UF, Vrkljan M (2018) A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms. Endocrine 60(3):395\u2013406. https:\/\/doi.org\/10.1007\/s12020-018-1592-6","journal-title":"Endocrine"},{"issue":"6","key":"1869_CR5","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/MPA.0b013e3181eb7451","volume":"39","author":"LK Kvols","year":"2010","unstructured":"Kvols LK, Brendtro KL, North American Neuroendocrine Tumor S (2010) The North American Neuroendocrine Tumor Society (NANETS) guidelines: mission, goals, and process. Pancreas 39(6):705\u2013706. https:\/\/doi.org\/10.1097\/MPA.0b013e3181eb7451","journal-title":"Pancreas"},{"issue":"6","key":"1869_CR6","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1097\/MPA.0b013e3181ebb56f","volume":"39","author":"JR Strosberg","year":"2010","unstructured":"Strosberg JR, Coppola D, Klimstra DS, Phan AT, Kulke MH, Wiseman GA, Kvols LK, North American Neuroendocrine Tumor S (2010) The NANETS consensus guidelines for the diagnosis and management of poorly differentiated (high-grade) extrapulmonary neuroendocrine carcinomas. Pancreas 39(6):799\u2013800. https:\/\/doi.org\/10.1097\/MPA.0b013e3181ebb56f","journal-title":"Pancreas"},{"issue":"2","key":"1869_CR7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1159\/000443170","volume":"103","author":"B Niederle","year":"2016","unstructured":"Niederle B, Pape UF, Costa F, Gross D, Kelestimur F, Knigge U, Oberg K, Pavel M, Perren A, Toumpanakis C, O\u2019Connor J, O\u2019Toole D, Krenning E, Reed N, Kianmanesh R, Vienna Consensus Conference p (2016) ENETS consensus guidelines update for neuroendocrine neoplasms of the jejunum and ileum. Neuroendocrinology 103(2):125\u2013138. https:\/\/doi.org\/10.1159\/000443170","journal-title":"Neuroendocrinology"},{"issue":"2","key":"1869_CR8","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1159\/000443171","volume":"103","author":"M Falconi","year":"2016","unstructured":"Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M, Kos-Kudla B, Kwekkeboom D, Rindi G, Kloppel G, Reed N, Kianmanesh R, Jensen RT, Vienna Consensus Conference p (2016) ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors. Neuroendocrinology 103(2):153\u2013171. https:\/\/doi.org\/10.1159\/000443171","journal-title":"Neuroendocrinology"},{"issue":"2","key":"1869_CR9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000443169","volume":"103","author":"D O\u2019Toole","year":"2016","unstructured":"O\u2019Toole D, Kianmanesh R, Caplin M (2016) ENETS 2016 consensus guidelines for the management of patients with digestive neuroendocrine tumors: an update. Neuroendocrinology 103(2):117\u2013118. https:\/\/doi.org\/10.1159\/000443169","journal-title":"Neuroendocrinology"},{"issue":"2","key":"1869_CR10","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1159\/000443167","volume":"103","author":"M. Pavel","year":"2016","unstructured":"Pavel M, O\u2019Toole D, Costa F, Capdevila J, Gross D, Kianmanesh R, Krenning E, Knigge U, Salazar R, Pape UF, Oberg K, Vienna Consensus Conference p (2016) ENETS consensus guidelines update for the management of distant metastatic disease of intestinal, pancreatic, bronchial neuroendocrine neoplasms (NEN) and NEN of unknown primary site. Neuroendocrinology 103 (2):172\u2013185. doi:https:\/\/doi.org\/10.1159\/000443167","journal-title":"Neuroendocrinology"},{"issue":"2","key":"1869_CR11","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1159\/000443165","volume":"103","author":"U.-F. Pape","year":"2016","unstructured":"Pape UF, Niederle B, Costa F, Gross D, Kelestimur F, Kianmanesh R, Knigge U, Oberg K, Pavel M, Perren A, Toumpanakis C, O\u2019Connor J, Krenning E, Reed N, O\u2019Toole D, Vienna Consensus Conference p (2016) ENETS consensus guidelines for neuroendocrine neoplasms of the appendix (excluding goblet cell carcinomas). Neuroendocrinology 103 (2):144\u2013152. doi:https:\/\/doi.org\/10.1159\/000443165","journal-title":"Neuroendocrinology"},{"key":"1869_CR12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s12094-018-1980-7","volume":"21","author":"E Gonzalez-Flores","year":"2018","unstructured":"Gonzalez-Flores E, Serrano R, Sevilla I, Viudez A, Barriuso J, Benavent M, Capdevila J, Jimenez-Fonseca P, Lopez C, Garcia-Carbonero R (2018) SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic and bronchial neuroendocrine neoplasms (NENs) (2018). Clin Transl Oncol 21:55\u201363. https:\/\/doi.org\/10.1007\/s12094-018-1980-7","journal-title":"Clin Transl Oncol"},{"issue":"10","key":"1869_CR13","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.1007\/s00464-016-5411-y","volume":"31","author":"JA Cienfuegos","year":"2017","unstructured":"Cienfuegos JA, Salguero J, Nunez-Cordoba JM, Ruiz-Canela M, Benito A, Ocana S, Zozaya G, Marti-Cruchaga P, Pardo F, Hernandez-Lizoain JL, Rotellar F (2017) Short- and long-term outcomes of laparoscopic organ-sparing resection in pancreatic neuroendocrine tumors: a single-center experience. Surg Endosc 31(10):3847\u20133857. https:\/\/doi.org\/10.1007\/s00464-016-5411-y","journal-title":"Surg Endosc"},{"issue":"7","key":"1869_CR14","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s00268-012-1598-9","volume":"36","author":"SM Inchauste","year":"2012","unstructured":"Inchauste SM, Lanier BJ, Libutti SK, Phan GQ, Nilubol N, Steinberg SM, Kebebew E, Hughes MS (2012) Rate of clinically significant postoperative pancreatic fistula in pancreatic neuroendocrine tumors. World J Surg 36(7):1517\u20131526. https:\/\/doi.org\/10.1007\/s00268-012-1598-9","journal-title":"World J Surg"},{"issue":"13","key":"1869_CR15","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1245\/s10434-012-2462-8","volume":"19","author":"S Gaujoux","year":"2012","unstructured":"Gaujoux S, Gonen M, Tang L, Klimstra D, Brennan MF, D\u2019Angelica M, Dematteo R, Allen PJ, Jarnagin W, Fong Y (2012) Synchronous resection of primary and liver metastases for neuroendocrine tumors. Ann Surg Oncol 19(13):4270\u20134277. https:\/\/doi.org\/10.1245\/s10434-012-2462-8","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"1869_CR16","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3748\/wjg.v16.i12.1527","volume":"16","author":"SL Han","year":"2010","unstructured":"Han SL, Cheng J, Zhou HZ, Guo SC, Jia ZR, Wang PF (2010) Surgically treated primary malignant tumor of small bowel: a clinical analysis. World J Gastroenterol 16(12):1527\u20131532","journal-title":"World J Gastroenterol"},{"issue":"6","key":"1869_CR17","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s00268-011-1296-z","volume":"36","author":"O Norlen","year":"2012","unstructured":"Norlen O, Stalberg P, Oberg K, Eriksson J, Hedberg J, Hessman O, Janson ET, Hellman P, Akerstrom G (2012) Long-term results of surgery for small intestinal neuroendocrine tumors at a tertiary referral center. World J Surg 36(6):1419\u20131431. https:\/\/doi.org\/10.1007\/s00268-011-1296-z","journal-title":"World J Surg"},{"issue":"3","key":"1869_CR18","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00268-015-3328-6","volume":"40","author":"AP Jilesen","year":"2016","unstructured":"Jilesen AP, van Eijck CH, in\u2019t Hof KH, van Dieren S, Gouma DJ, van Dijkum EJ (2016) Postoperative complications, in-hospital mortality and 5-year survival after surgical resection for patients with a pancreatic neuroendocrine tumor: a systematic review. World J Surg 40(3):729\u2013748. https:\/\/doi.org\/10.1007\/s00268-015-3328-6","journal-title":"World J Surg"},{"issue":"6","key":"1869_CR19","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1097\/01.sla.0000246856.03918.9a","volume":"244","author":"ML DeOliveira","year":"2006","unstructured":"DeOliveira ML, Winter JM, Schafer M, Cunningham SC, Cameron JL, Yeo CJ, Clavien PA (2006) Assessment of complications after pancreatic surgery: a novel grading system applied to 633 patients undergoing pancreaticoduodenectomy. Ann Surg 244(6):931\u2013937; discussion 937-939. https:\/\/doi.org\/10.1097\/01.sla.0000246856.03918.9a","journal-title":"Ann Surg"},{"issue":"4","key":"1869_CR20","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00428-007-0452-1","volume":"451","author":"G Rindi","year":"2007","unstructured":"Rindi G, Kloppel G, Couvelard A, Komminoth P, Korner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A, Scoazec JY, Wiedenmann B (2007) TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch 451(4):757\u2013762. https:\/\/doi.org\/10.1007\/s00428-007-0452-1","journal-title":"Virchows Arch"},{"issue":"2","key":"1869_CR21","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205\u2013213","journal-title":"Ann Surg"},{"issue":"2","key":"1869_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000443168","volume":"103","author":"G Delle Fave","year":"2016","unstructured":"Delle Fave G, O\u2019Toole D, Sundin A, Taal B, Ferolla P, Ramage JK, Ferone D, Ito T, Weber W, Zheng-Pei Z, De Herder WW, Pascher A, Ruszniewski P, Vienna Consensus Conference p (2016) ENETS consensus guidelines update for gastroduodenal neuroendocrine neoplasms. Neuroendocrinology 103(2):119\u2013124. https:\/\/doi.org\/10.1159\/000443168","journal-title":"Neuroendocrinology"},{"issue":"2","key":"1869_CR23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1159\/000443166","volume":"103","author":"J.K. Ramage","year":"2016","unstructured":"Ramage JK, De Herder WW, Delle Fave G, Ferolla P, Ferone D, Ito T, Ruszniewski P, Sundin A, Weber W, Zheng-Pei Z, Taal B, Pascher A, Vienna Consensus Conference p (2016) ENETS consensus guidelines update for colorectal neuroendocrine neoplasms. Neuroendocrinology 103 (2):139\u2013143. doi:https:\/\/doi.org\/10.1159\/000443166","journal-title":"Neuroendocrinology"},{"issue":"11","key":"1869_CR24","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1016\/j.ejso.2017.07.012","volume":"43","author":"R Valente","year":"2017","unstructured":"Valente R, Lykoudis P, Tamburrino D, Inama M, Passas I, Toumpanakis C, Luong TV, Davidson B, Imber C, Malago M, Rahman SH, Shankar A, Sharma D, Caplin M, Fusai G (2017) Major postoperative complications after pancreatic resection for P-NETS are not associated to earlier recurrence. Eur J Surg Oncol 43(11):2119\u20132128. https:\/\/doi.org\/10.1016\/j.ejso.2017.07.012","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"1869_CR25","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s00268-015-3341-9","volume":"40","author":"AP Jilesen","year":"2016","unstructured":"Jilesen AP, van Eijck CH, Busch OR, van Gulik TM, Gouma DJ, van Dijkum EJ (2016) Postoperative outcomes of enucleation and standard resections in patients with a pancreatic neuroendocrine tumor. World J Surg 40(3):715\u2013728. https:\/\/doi.org\/10.1007\/s00268-015-3341-9","journal-title":"World J Surg"},{"issue":"5","key":"1869_CR26","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00423-018-1695-9","volume":"403","author":"AC Milanetto","year":"2018","unstructured":"Milanetto AC, Pasquali C, Da Broi M, Brambilla T, Capretti G, Zerbi A (2018) Ampullary neuroendocrine neoplasms: surgical experience of a rare and challenging entity. Langenbeck's Arch Surg 403(5):581\u2013589. https:\/\/doi.org\/10.1007\/s00423-018-1695-9","journal-title":"Langenbeck's Arch Surg"},{"issue":"4","key":"1869_CR27","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00423-019-01786-x","volume":"404","author":"S Alfieri","year":"2019","unstructured":"Alfieri S, Butturini G, Boggi U, Pietrabissa A, Morelli L, Vistoli F, Damoli I, Peri A, Fiorillo C, Pugliese L, Ramera M, De Lio N, Di Franco G, Esposito A, Landoni L, Rosa F, Menghi R, Doglietto GB, Quero G, Italian Robotic p NETG (2019) Short-term and long-term outcomes after robot-assisted versus laparoscopic distal pancreatectomy for pancreatic neuroendocrine tumors (pNETs): a multicenter comparative study. Langenbeck's Arch Surg 404(4):459\u2013468. https:\/\/doi.org\/10.1007\/s00423-019-01786-x","journal-title":"Langenbeck's Arch Surg"},{"key":"1869_CR28","doi-asserted-by":"publisher","unstructured":"Najafi N, Mintziras I, Wiese D, Albers MB, Maurer E, Bartsch DK (2020) A retrospective comparison of robotic versus laparoscopic distal resection and enucleation for potentially benign pancreatic neoplasms. Surg Today:1\u20139. https:\/\/doi.org\/10.1007\/s00595-020-01966-z","DOI":"10.1007\/s00595-020-01966-z"},{"issue":"11","key":"1869_CR29","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1007\/s002680010236","volume":"24","author":"JA Soreide","year":"2000","unstructured":"Soreide JA, van Heerden JA, Thompson GB, Schleck C, Ilstrup DM, Churchward M (2000) Gastrointestinal carcinoid tumors: long-term prognosis for surgically treated patients. World J Surg 24(11):1431\u20131436","journal-title":"World J Surg"},{"issue":"4","key":"1869_CR30","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.jamcollsurg.2016.12.032","volume":"224","author":"EA Woltering","year":"2017","unstructured":"Woltering EA, Voros BA, Beyer DT, Wang YZ, Thiagarajan R, Ryan P, Wright A, Ramirez RA, Ricks MJ, Boudreaux JP (2017) Aggressive surgical approach to the management of neuroendocrine tumors: a report of 1,000 surgical cytoreductions by a single institution. J Am Coll Surg 224(4):434\u2013447. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2016.12.032","journal-title":"J Am Coll Surg"},{"issue":"6","key":"1869_CR31","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1111\/codi.13244","volume":"18","author":"E Bosma","year":"2016","unstructured":"Bosma E, Pullens MJ, de Vries J, Roukema JA (2016) The impact of complications on quality of life following colorectal surgery: a prospective cohort study to evaluate the Clavien-Dindo classification system. Color Dis 18(6):594\u2013602. https:\/\/doi.org\/10.1111\/codi.13244","journal-title":"Color Dis"},{"issue":"1","key":"1869_CR32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/BF02237249","volume":"43","author":"WE Longo","year":"2000","unstructured":"Longo WE, Virgo KS, Johnson FE, Oprian CA, Vernava AM, Wade TP, Phelan MA, Henderson WG, Daley J, Khuri SF (2000) Risk factors for morbidity and mortality after colectomy for colon cancer. Dis Colon Rectum 43(1):83\u201391","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"1869_CR33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1754-9493-4-5","volume":"4","author":"P Kirchhoff","year":"2010","unstructured":"Kirchhoff P, Clavien PA, Hahnloser D (2010) Complications in colorectal surgery: risk factors and preventive strategies. Patient Saf Surg 4(1):5. https:\/\/doi.org\/10.1186\/1754-9493-4-5","journal-title":"Patient Saf Surg"},{"issue":"8","key":"1869_CR34","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s00423-019-01828-4","volume":"404","author":"O Gimm","year":"2019","unstructured":"Gimm O, Barczynski M, Mihai R, Raffaelli M (2019) Training in endocrine surgery. Langenbeck's Arch Surg 404(8):929\u2013944. https:\/\/doi.org\/10.1007\/s00423-019-01828-4","journal-title":"Langenbeck's Arch Surg"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-020-01869-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-020-01869-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-020-01869-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T08:16:34Z","timestamp":1618474594000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-020-01869-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["1869"],"URL":"https:\/\/doi.org\/10.1007\/s00423-020-01869-0","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"value":"1435-2443","type":"print"},{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"26 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The first author (MBA) received the Sten Tibblin research fellowship grant from the Department of Surgery, University of Lund, supported by an unrestricted grant from Novartis AG, Basel, Switzerland. The sponsor had no role in the design, execution, analysis, and reporting of the study. The other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study were in accordance with the ethical standards of the regional ethical committee and with the 1964 Helsinki declaration and its later amendments. Ethical approval was given by the Regional Ethical Review Board of Lund University (2018\/488).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}