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Yet, there is a potential risk of surgical overtreatment. With this single center study, an analysis of potential overtreatment for suspected malignant thyroid disease in children and young adults was aimed for.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In a period from 2005 to 2018, 155 thyroid operations in children and young adults performed at the University Medical Center Mainz, Germany, were analyzed (patient age 3\u201320\u00a0years, 117 female). Cases were categorized for preoperative diagnosis: non-malignant (group I, <jats:italic>n<\/jats:italic>\u2009=\u200945) and malignant thyroid disease (group II, <jats:italic>n<\/jats:italic>\u2009=\u2009110). Postoperative parameters (histology, complication rates) were assessed and compared between groups.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>91.1% of group I were histologically benign. 44.5% of group II harbored malignancy. Permanent hypoparathyroidism was documented in group I (2.7%) and in group II (1.4%, <jats:italic>p<\/jats:italic>\u2009=\u20091.000). Wound infections were absent in group I but observed in group II (0.9%, p\u2009=\u20091.000). Transient vocal cord palsy was recorded only in group I (2.3%, 2\/85 vs. 0\/177 nerves at risk, <jats:italic>p<\/jats:italic>\u2009=\u20090.104). Permanent vocal cord palsies were absent.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Preoperative diagnoses were correct in over 90% of group I and in nearly 45% of group II. The high proportion of carcinomas in group II ruled out the issue of potential overtreatment. The risk of severe postoperative complications was equally low in both patient groups.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00423-020-01896-x","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T04:02:20Z","timestamp":1590552140000},"page":"451-460","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Thyroid surgery in children and young adults: potential overtreatment and complications"],"prefix":"10.1007","volume":"405","author":[{"given":"Julia I.","family":"Staubitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Poplawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Watzka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Pohlenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-7439","authenticated-orcid":false,"given":"Thomas J.","family":"Musholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"issue":"8","key":"1896_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27025","volume":"65","author":"M Massimino","year":"2018","unstructured":"Massimino M, Evans DB, Podda M, Spinelli C, Collini P, Pizzi N, Bleyer A (2018) Thyroid cancer in adolescents and young adults. 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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. The study was approved by the local ethical committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}