{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:36:59Z","timestamp":1773268619079,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K10202"],"award-info":[{"award-number":["15K10202"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08703"],"award-info":[{"award-number":["18K08703"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s00423-020-01955-3","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T22:53:05Z","timestamp":1597791185000},"page":"989-998","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Invasion category-oriented lymph node metastases of cholangiocarcinoma and the prognostic impact"],"prefix":"10.1007","volume":"405","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-1067","authenticated-orcid":false,"given":"Shogo","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tomokuni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihito","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Sakon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"issue":"1","key":"1955_CR1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1097\/SLA.0b013e318176c4d3","volume":"248","author":"I Endo","year":"2008","unstructured":"Endo I, Gonen M, Yopp AC, Dalal KM, Zhou Q, Klimstra D, D'Angelica M, DeMatteo RP, Fong Y, Schwartz L, Kemeny N, O'Reilly E, Abou-Alfa GK, Shimada H, Blumgart LH, Jarnagin WR (2008) Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg 248(1):84\u201396","journal-title":"Ann Surg"},{"issue":"5","key":"1955_CR2","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1634\/theoncologist.2015-0446","volume":"21","author":"SK Saha","year":"2016","unstructured":"Saha SK, Zhu AX, Fuchs CS, Brooks GA (2016) Forty-year trends in cholangiocarcinoma incidence in the U.S.: intrahepatic disease on the rise. Oncologist 21(5):594\u2013599","journal-title":"Oncologist"},{"key":"1955_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ags3.12008","volume":"1","author":"H Colvin","year":"2017","unstructured":"Colvin H, Mizushima T, Eguchi H, Takiguchi S, Doki Y, Mori M (2017) Gastroenterological surgery in Japan: the past, the present and the future. Ann Gastorenterol Surg 1:5\u201310","journal-title":"Ann Gastorenterol Surg"},{"issue":"3","key":"1955_CR4","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00534-010-0349-2","volume":"18","author":"K Uchiyama","year":"2011","unstructured":"Uchiyama K, Yamamoto M, Yamaue H, Ariizumi S, Aoki T, Kokudo N, Ebata T, Nagino M, Ohtsuka M, Miyazaki M, Tanaka E, Kondo S, Uenishi T, Kubo S, Yoshida H, Unno M, Imura S, Shimada M, Ueno M, Takada T (2011) Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 18(3):443\u2013452","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"2","key":"1955_CR5","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/SLA.0000000000002865","volume":"270","author":"S Kobayashi","year":"2019","unstructured":"Kobayashi S, Nagano H, Tomokuni A, Gotoh K, Sakai D, Hatano E, Seo S, Terajima H, Uchida Y, Ajiki T, Satake H, Kamei K, Tohyama T, Hirose T, Ikai I, Morita S, Ioka T (2019) A prospective, randomized phase II study of adjuvant gemcitabine versus s-1 after major hepatectomy for biliary tract cancer (KHBO 1208). Ann Surg 270(2):230\u2013237","journal-title":"Ann Surg"},{"issue":"4","key":"1955_CR6","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.ejso.2016.12.008","volume":"43","author":"S Kobayashi","year":"2017","unstructured":"Kobayashi S, Tomokuni A, Gotoh K, Takahashi H, Akita H, Marubashi S, Yamada T, Teshima T, Fukui K, Fujiwara Y, Sakon M (2017) A retrospective analysis of the clinical effects of neoadjuvant combination therapy with full-dose gemcitabine and radiation therapy in patients with biliary tract cancer. Eur J Surg Oncol 43(4):763\u2013771","journal-title":"Eur J Surg Oncol"},{"issue":"1","key":"1955_CR7","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/1097-0142(197701)39:1<232::AID-CNCR2820390137>3.0.CO;2-Y","volume":"29","author":"K Okuda","year":"1977","unstructured":"Okuda K, Kubo Y, Okazaki N, Arishima T, Hashimoto M (1977) Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma: a study of 57 autopsy-proven cases. Cancer 29(1):232\u2013246","journal-title":"Cancer"},{"key":"1955_CR8","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.5833\/jjgs.28.1049","volume":"28","author":"H Makino","year":"1995","unstructured":"Makino H, Sonoyama T, Yamagishi H, Oka T, Naito K, Ohmori Y, Hironaka T (1995) Clinicopathological studies of central type of cholangiocarcinoma compared with hilar bile duct cancer. Jpn J Gastroenterol Surg 28:1049\u20131054","journal-title":"Jpn J Gastroenterol Surg"},{"key":"1955_CR9","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/(SICI)1097-0029(19970915)38:6<552::AID-JEMT2>3.0.CO;2-H","volume":"38","author":"Y Nakanuma","year":"1997","unstructured":"Nakanuma Y, Hoso M, Sanzen T, Sasaki M (1997) Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply. Microsc Res Tech 38:552\u2013570","journal-title":"Microsc Res Tech"},{"issue":"12","key":"1955_CR10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.4254\/wjh.v2.i12.419","volume":"2","author":"Y Nakanuma","year":"2010","unstructured":"Nakanuma Y, Sato Y, Harada K, Sasaki M, Xu J, Ikeda H (2010) Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J Hepatol 2(12):419\u2013427","journal-title":"World J Hepatol"},{"issue":"3","key":"1955_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/jhbp.211","volume":"22","author":"M Miyazaki","year":"2015","unstructured":"Miyazaki M, Ohtsuka M, Miyakawa S, Nagino M, Yamamoto M, Kokudo N, Sano K, Endo I, Unno M, Chijiiwa K, Horiguchi A, Kinoshita H, Oka M, Kubota K, Sugiyama M, Uemoto S, Shimada M, Suzuki Y, Inui K, Tazuma S, Furuse J, Yanagisawa A, Nakanuma Y, Kijima H, Takada T (2015) Classification of biliary tract cancers established by the Japanese Society of Hepato-Biliary-Pancreatic Surgery: 3(rd) English edition. J Hepatobiliary Pancreat Sci 22(3):181\u2013196","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"11","key":"1955_CR12","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1007\/s00535-018-1469-8","volume":"53","author":"T Orimo","year":"2018","unstructured":"Orimo T, Kamiyama T, Mitsuhashi T, Kamachi H, Yokoo H, Wakayama K, Shimada S, Nagatsu A, Taketomi A (2018) Impact of tumor localization on the outcomes of surgery for an intrahepatic cholangiocarcinoma. J Gastroenterol 53(11):1206\u20131215","journal-title":"J Gastroenterol"},{"issue":"3","key":"1955_CR13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/jjco\/29.3.147","volume":"29","author":"M Yamamoto","year":"1999","unstructured":"Yamamoto M, Takasaki K, Yoshikawa T (1999) Lymph node metastasis in intrahepatic cholangiocarcinoma. Jpn J Clin Oncol 29(3):147\u2013150","journal-title":"Jpn J Clin Oncol"},{"issue":"7","key":"1955_CR14","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.hpb.2018.12.011","volume":"21","author":"R Zhou","year":"2019","unstructured":"Zhou R, Lu D, Li W, Tan W, Zhu S, Chen X, Min J, Shang C, Chen Y (2019) Is lymph node dissection necessary for resectable intrahepatic cholangiocarcinoma? A systematic review and meta-analysis. HPB (Oxford) 21(7):784\u2013792","journal-title":"HPB (Oxford)"},{"issue":"7","key":"1955_CR15","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1007\/s11605-003-0029-5","volume":"7","author":"J Okami","year":"2003","unstructured":"Okami J, Dono K, Sakon M, Tsujie M, Hayashi N, Fujiwara Y, Nagano H, Umeshita K, Nakamori S, Monden M (2003) Patterns of regional lymph node involvement in intrahepatic cholangiocarcinoma of the left lobe. J Gastrointest Surg 7(7):850\u2013856","journal-title":"J Gastrointest Surg"},{"issue":"1","key":"1955_CR16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10620-013-2894-4","volume":"59","author":"S Marubashi","year":"2014","unstructured":"Marubashi S, Gotoh K, Takahashi H, Ohigashi H, Yano M, Ishikawa O, Sakon M (2014) Prediction of the postoperative prognosis of intrahepatic cholangiocarcinoma (ICC): importance of preoperatively- determined anatomic invasion level and number of tumors. Dig Dis Sci 59(1):201\u2013213","journal-title":"Dig Dis Sci"},{"key":"1955_CR17","doi-asserted-by":"crossref","unstructured":"Sobin L, Gospodarowicz M, Wittekind C (2009). TNM classification of maligngnt tumours, 7th edn. UICC International Union Against Cancer. Wiley-blackwell","DOI":"10.1002\/9780471420194.tnmc26.pub2"},{"issue":"2","key":"1955_CR18","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ijsu.2012.12.006","volume":"11","author":"S Kobayashi","year":"2013","unstructured":"Kobayashi S, Nagano H, Marubashi S, Kawamoto K, Wada H, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M (2013) Clinicopathological features of long-term survivors for advanced biliary tract cancer and impact of the number of lymph nodes involved. Int J Surg 11(2):145\u2013151","journal-title":"Int J Surg"},{"issue":"8","key":"1955_CR19","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/bjs.6654","volume":"96","author":"D Tamandl","year":"2009","unstructured":"Tamandl D, Kaczirek K, Gruenberger B, Koelblinger C, Maresch J, Jakesz R, Gruenberger T (2009) Lymph node ratio after curative surgery for intrahepatic cholangiocarcinoma. Br J Surg 96(8):919\u2013925","journal-title":"Br J Surg"},{"issue":"6","key":"1955_CR20","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1007\/s11605-019-04108-0","volume":"23","author":"A Ruzzenente","year":"2019","unstructured":"Ruzzenente A, Conci S, Vigan\u00f2 L, Ercolani G, Manfreda S, Bagante F, Ciangherotti A, Pedrazzani C, Pinna AD, Iacono C, Torzilli G, Guglielmi A (2019) Role of lymph node dissection in small (\u22643\u00a0cm) intrahepatic cholangiocarcinoma. J Gastrointest Surg 23(6):1122\u20131129","journal-title":"J Gastrointest Surg"},{"issue":"3","key":"1955_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/jso.21811","volume":"103","author":"S Kobayashi","year":"2011","unstructured":"Kobayashi S, Nagano H, Hoshino H, Wada H, Marubashi S, Eguchi H, Takeda Y, Tanemura M, Kim T, Shimosegawa E, Hatazawa J, Doki Y, Mori M (2011) Diagnostic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer. J Surg Oncol 103(3):223\u2013229","journal-title":"J Surg Oncol"},{"issue":"2","key":"1955_CR22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/SLE.0000000000000510","volume":"28","author":"S Kobayashi","year":"2018","unstructured":"Kobayashi S, Tomokuni A, Takahashi H, Akita H, Marubashi S, Gotoh K, Yanagimoto Y, Takahashi Y, Sugimura K, Miyoshi N, Moon JH, Yasui M, Omori T, Miyata H, Ohue M, Fujiwara Y, Yano M, Sakon M (2018) Laparoscopic hilar lymph node sampling in patients with biliary tract cancers that are rarely associated with nodal metastasis. Surg Laparosc Endosc Percutan Tech 28(2):90\u201395","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"issue":"4","key":"1955_CR23","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s00280-014-2543-4","volume":"74","author":"S Kobayashi","year":"2014","unstructured":"Kobayashi S, Nagano H, Sakai D, Eguchi H, Hatano E, Kanai M, Seo S, Taura K, Fujiwara Y, Ajiki T, Takemura S, Kubo S, Yanagimoto H, Toyokawa H, Tsuji A, Terajima H, Morita S, Ioka T (2014) Phase I study of adjuvant gemcitabine or S-1 in patients with biliary tract cancers undergoing major hepatectomy: KHBO1003 study. Cancer Chemother Pharmacol 74(4):699\u2013709","journal-title":"Cancer Chemother Pharmacol"},{"issue":"6","key":"1955_CR24","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1007\/s00280-014-2431-y","volume":"73","author":"M Toyoda","year":"2014","unstructured":"Toyoda M, Ajiki T, Fujiwara Y, Nagano H, Kobayashi S, Sakai D, Hatano E, Kanai M, Nakamori S, Miyamoto A, Tsuji A, Kaihara S, Ikoma H, Takemura S, Toyokawa H, Terajima H, Morita S, Ioka T (2014) Phase I study of adjuvant chemotherapy with gemcitabine plus cisplatin in patients with biliary tract cancer undergoing curative resection without major hepatectomy (KHBO1004). Cancer Chemother Pharmacol 73(6):1295\u20131301","journal-title":"Cancer Chemother Pharmacol"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-020-01955-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-020-01955-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-020-01955-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T23:47:33Z","timestamp":1629244053000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-020-01955-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["1955"],"URL":"https:\/\/doi.org\/10.1007\/s00423-020-01955-3","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"value":"1435-2443","type":"print"},{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,18]]},"assertion":[{"value":"19 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the institutional review board (approve number: 1511209163).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients signed an informed consent form in accordance with the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All patients signed an informed consent form.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The statistical software program used was StatView J-5.0 (SAS, Cary, NC, USA).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}