{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:30:29Z","timestamp":1780414229149,"version":"3.54.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s00423-020-02068-7","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T21:03:44Z","timestamp":1609794224000},"page":"801-811","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcome of radical surgery for gallbladder carcinoma according to TNM stage: implications for adjuvant therapeutic strategies"],"prefix":"10.1007","volume":"406","author":[{"given":"Kizuki","family":"Yuza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-0133","authenticated-orcid":false,"given":"Jun","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Katada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyasu","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Nagahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Wakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"2068_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/00000658-199211000-00007","volume":"216","author":"Y Shirai","year":"1992","unstructured":"Shirai Y, Yoshida K, Tsukada K, Muto T, Watanabe H (1992) Radical surgery for gallbladder carcinoma. Long-term results. Ann Surg 216:565\u2013568","journal-title":"Ann Surg"},{"key":"2068_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/00000658-200010000-00011","volume":"232","author":"Y Fong","year":"2000","unstructured":"Fong Y, Jarnagin W, Blumgart LH (2000) Gallbladder cancer: comparison of patients presenting initially for definitive operation with those presenting after prior noncurative intervention. Ann Surg 232:557\u2013569","journal-title":"Ann Surg"},{"key":"2068_CR3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/01.sla.0000154118.07704.ef","volume":"241","author":"E Dixon","year":"2005","unstructured":"Dixon E, Vollmer CM Jr, Sahajpal A, Cattral M, Grant D, Doig C, Hemming A, Taylor B, Langer B, Greig P, Gallinger S (2005) An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American center. Ann Surg 241:385\u2013394","journal-title":"Ann Surg"},{"key":"2068_CR4","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.hpb.2019.02.019","volume":"21","author":"C Manterola","year":"2019","unstructured":"Manterola C, Duque G, Grande L, de Aretxabala X, Conejeros R, Otzen T, Garc\u00eda N (2019) A systematic review of the effectiveness of adjuvant therapy for patients with gallbladder cancer. HPB 21:1427\u20131435","journal-title":"HPB"},{"key":"2068_CR5","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/hpb.12444","volume":"17","author":"TA Aloia","year":"2015","unstructured":"Aloia TA, Jarufe N, Javle M et al (2015) Gallbladder cancer: expert consensus statement. HPB 17:681\u2013690","journal-title":"HPB"},{"key":"2068_CR6","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1245\/s10434-008-0189-3","volume":"16","author":"M D'Angelica","year":"2009","unstructured":"D'Angelica M, Dalal KM, DeMatteo RP, Fong Y, Blumgart LH, Jarnagin WR (2009) Analysis of the extent of resection for adenocarcinoma of the gallbladder. Ann Surg Oncol 16:806\u2013816","journal-title":"Ann Surg Oncol"},{"key":"2068_CR7","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/S0039-6060(96)80089-4","volume":"120","author":"K Tsukada","year":"1996","unstructured":"Tsukada K, Hatakeyama K, Kurosaki I, Uchida K, Shirai Y, Muto T, Yoshida K (1996) Outcome of radical surgery for carcinoma of the gallbladder according to the TNM stage. Surgery 120:816\u2013822","journal-title":"Surgery"},{"key":"2068_CR8","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1002\/(SICI)1097-0142(19971115)80:10<1904::AID-CNCR5>3.0.CO;2-N","volume":"80","author":"Y Shirai","year":"1997","unstructured":"Shirai Y, Ohtani T, Tsukada K, Hatakeyama K (1997) Combined pancreaticoduodenectomy and hepatectomy for patients with locally advanced gallbladder carcinoma: long term results. Cancer 80:1904\u20131909","journal-title":"Cancer"},{"key":"2068_CR9","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.surg.2015.09.009","volume":"159","author":"Y Yamamoto","year":"2016","unstructured":"Yamamoto Y, Sugiura T, Okamura Y, Ito T, Ashida R, Uemura S, Miyata T, Kato Y, Uesaka K (2016) Is combined pancreatoduodenectomy for advanced gallbladder cancer justified? Surgery 159:810\u2013820","journal-title":"Surgery"},{"key":"2068_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/PAS.0b013e3181c467d4","volume":"34","author":"T Wakai","year":"2010","unstructured":"Wakai T, Shirai Y, Sakata J, Nagahashi M, Ajioka Y, Hatakeyama K (2010) Mode of hepatic spread from gallbladder carcinoma: an immunohistochemical analysis of 42 hepatectomized specimens. Am J Surg Pathol 34:65\u201374","journal-title":"Am J Surg Pathol"},{"key":"2068_CR11","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1097\/SLA.0b013e318216f5f3","volume":"253","author":"H Nishio","year":"2011","unstructured":"Nishio H, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M (2011) Gallbladder cancer involving the extrahepatic bile duct is worthy of resection. Ann Surg 253:953\u2013960","journal-title":"Ann Surg"},{"key":"2068_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/bjs.7262","volume":"98","author":"K Shimada","year":"2011","unstructured":"Shimada K, Nara S, Esaki M, Sakamoto Y, Kosuge T, Hiraoka N (2011) Extended right hemihepatectomy for gallbladder carcinoma involving the hepatic hilum. Br J Surg 98:117\u2013123","journal-title":"Br J Surg"},{"key":"2068_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/bjs.10401","volume":"104","author":"Y Yamamoto","year":"2017","unstructured":"Yamamoto Y, Sugiura T, Ashida R, Okamura Y, Ito T, Uesaka K (2017) Indications for major hepatectomy and combined procedures for advanced gallbladder cancer. Br J Surg 104:257\u2013266","journal-title":"Br J Surg"},{"key":"2068_CR14","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1002\/cncr.10831","volume":"95","author":"T Takada","year":"2002","unstructured":"Takada T, Amano H, Yasuda H, Nimura Y, Matsushiro T, Kato H, Nagakawa T, Nakayama T, Study Group of Surgical Adjuvant Therapy for Carcinomas of the Pancreas and Biliary Tract (2002) Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer 95:1685\u20131695","journal-title":"Cancer"},{"key":"2068_CR15","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s11605-011-1479-9","volume":"15","author":"Y Murakami","year":"2011","unstructured":"Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima A, Kondo N, Sakabe R, Kobayashi H, Sueda T (2011) Prognostic factors of patients with advanced gallbladder carcinoma following aggressive surgical resection. J Gastrointest Surg 15:1007\u20131016","journal-title":"J Gastrointest Surg"},{"key":"2068_CR16","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1056\/NEJMoa072252","volume":"357","author":"S Sakuramoto","year":"2007","unstructured":"Sakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A, Furukawa H, Nakajima T, Ohashi Y, Imamura H, Higashino M, Yamamura Y, Kurita A, Arai K (2007) Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 357:1810\u20131820","journal-title":"N Engl J Med"},{"key":"2068_CR17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0140-6736(16)30583-9","volume":"388","author":"K Uesaka","year":"2016","unstructured":"Uesaka K, Boku N, Fukutomi A, Okamura Y, Konishi M, Matsumoto I, Kaneoka Y, Shimizu Y, Nakamori S, Sakamoto H, Morinaga S, Kainuma O, Imai K, Sata N, Hishinuma S, Ojima H, Yamaguchi R, Hirano S, Sudo T, Ohashi Y (2016) Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet 388:248\u2013257","journal-title":"Lancet"},{"key":"2068_CR18","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S1470-2045(18)30915-X","volume":"20","author":"JN Primrose","year":"2019","unstructured":"Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J, Primrose JN, Fox RP, Morement H, Chan O, Rees C, Ma YT, Hickish T, Falk S, Finch-Jones M, Pope I, Corrie P, Crosby T, Sothi S, Sharkland K, Adamson D, Wall L, Evans J, Dent J, Hombaiah U, Iwuji C, Anthoney A, Bridgewater J, Cunningham D, Gillmore R, Ross P, Slater S, Wasan H, Waters J, Valle JW, Palmer D, Malik H, Neoptolemos J, Faluyi O, Sumpter K, Dernedde U, Maduhusudan S, Cogill G, Archer C, Iveson T, Wadsley J, Darby S, Peterson M, Mukhtar AA, Thorpe JG, Bateman A, Tsang D, Cummins S, Nolan L, Beaumont E, Prasad R, Mirza D, Stocken D, Praseedom R, Davidson B, Raftery J, Zhu S, Garden J, Stubbs C, Coxon F (2019) Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study. Lancet Oncol 20:663\u2013673","journal-title":"Lancet Oncol"},{"key":"2068_CR19","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/SLA.0000000000002865","volume":"270","author":"S Kobayashi","year":"2019","unstructured":"Kobayashi S, Nagano H, Tomokuni A, Gotoh K, Sakai D, Hatano E, Seo S, Terajima H, Uchida Y, Ajiki T, Satake H, Kamei K, Tohyama T, Hirose T, Ikai I, Morita S, Ioka T, Kansai Hepato-Biliary Oncology (KHBO) Group (2019) Prospective, randomized phase II study of adjuvant gemcitabine versus S-1 after major hepatectomy for biliary tract cancer (KHBO 1208). Ann Surg 270:230\u2013237","journal-title":"Ann Surg"},{"key":"2068_CR20","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1245\/s10434-016-5262-8","volume":"23","author":"Y Kim","year":"2016","unstructured":"Kim Y, Amini N, Wilson A, Margonis GA, Ethun CG, Poultsides G, Tran T, Idrees K, Isom CA, Fields RC, Krasnick B, Weber SM, Salem A, Martin RCG, Scoggins C, Shen P, Mogal HD, Schmidt C, Beal E, Hatzaras I, Shenoy R, Cardona K, Maithel SK, Pawlik TM (2016) Impact of chemotherapy and external-beam radiation therapy on outcomes among patients with resected gallbladder cancer: a multi-institutional analysis. Ann Surg Oncol 23:2998\u20133008","journal-title":"Ann Surg Oncol"},{"key":"2068_CR21","volume-title":"AJCC cancer staging manual","year":"2017","unstructured":"Amin MB, Edge SB, Greene FL et al (eds) (2017) AJCC cancer staging manual, 8th edn. Springer, New York","edition":"8"},{"key":"2068_CR22","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1245\/s10434-009-0899-1","volume":"17","author":"J Sakata","year":"2010","unstructured":"Sakata J, Shirai Y, Wakai T, Ajioka Y, Hatakeyama K (2010) Number of positive lymph nodes independently determines the prognosis after resection in patients with gallbladder carcinoma. Ann Surg Oncol 17:1831\u20131840","journal-title":"Ann Surg Oncol"},{"key":"2068_CR23","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1245\/s10434-017-5939-7","volume":"24","author":"J Sakata","year":"2017","unstructured":"Sakata J, Kobayashi T, Tajima Y, Ohashi T, Hirose Y, Takano K, Takizawa K, Miura K, Wakai T (2017) Relevance of dissection of the posterior superior pancreaticoduodenal lymph nodes in gallbladder carcinoma. Ann Surg Oncol 24:2474\u20132481","journal-title":"Ann Surg Oncol"},{"key":"2068_CR24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ijsu.2018.02.052","volume":"52","author":"JR Bergquist","year":"2018","unstructured":"Bergquist JR, Shah HN, Habermann EB, Hernandez MC, Ivanics T, Kendrick ML, Smoot RL, Nagorney DM, Borad MJ, McWilliams RR, Truty MJ (2018) Adjuvant systemic therapy after resection of node positive gallbladder cancer: time for a well-designed trial? (results of a US-national retrospective cohort study). Int J Surg 52:171\u2013179","journal-title":"Int J Surg"},{"key":"2068_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s00268-005-0181-z","volume":"30","author":"R Sasaki","year":"2006","unstructured":"Sasaki R, Itabashi H, Fujita T, Takeda Y, Hoshikawa K, Takahashi M, Funato O, Nitta H, Kanno S, Saito K (2006) Significance of extensive surgery including resection of the pancreas head for the treatment of gallbladder cancer--from the perspective of mode of lymph node involvement and surgical outcome. World J Surg 30:36\u201342","journal-title":"World J Surg"},{"key":"2068_CR26","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.jamcollsurg.2016.12.058","volume":"224","author":"JM Creasy","year":"2017","unstructured":"Creasy JM, Goldman DA, Dudeja V, Lowery MA, Cercek A, Balachandran VP, Allen PJ, DeMatteo RP, Kingham TP, D'Angelica MI, Jarnagin WR (2017) Systemic chemotherapy combined with resection for locally advanced gallbladder carcinoma: surgical and survival outcomes. J Am Coll Surg 224:906\u2013916","journal-title":"J Am Coll Surg"},{"key":"2068_CR27","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.hpb.2018.03.008","volume":"20","author":"VA Chaudhari","year":"2018","unstructured":"Chaudhari VA, Ostwal V, Patkar S, Sahu A, Toshniwal A, Ramaswamy A, Shetty NS, Shrikhande SV, Goel M (2018) Outcome of neoadjuvant chemotherapy in \u201clocally advanced\/borderline resectable\u201d gallbladder cancer: the need to define indications. HPB 20:841\u2013847","journal-title":"HPB"},{"key":"2068_CR28","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1245\/s10434-016-5197-0","volume":"23","author":"R Engineer","year":"2016","unstructured":"Engineer R, Goel M, Chopra S, Patil P, Purandare N, Rangarajan V, Ph R, Bal M, Shrikhande S, Shrivastava SK, Mehta S (2016) Neoadjuvant chemoradiation followed by surgery for locally advanced gallbladder cancers: a new paradigm. Ann Surg Oncol 23:3009\u20133015","journal-title":"Ann Surg Oncol"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-020-02068-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-020-02068-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-020-02068-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T10:07:42Z","timestamp":1620468462000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-020-02068-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,4]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["2068"],"URL":"https:\/\/doi.org\/10.1007\/s00423-020-02068-7","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"value":"1435-2443","type":"print"},{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,4]]},"assertion":[{"value":"22 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the institutional review board of Niigata University. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with 1964 Helsinki declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The need for informed consent was waived due to the retrospective observational nature of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}