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Historically, primary surgery has been the preferred treatment modality. This was called into question during the last decade, with the successful application of non-operative therapy in selected patients. The aim of this systematic review is to identify cases of perforated duodenal diverticula published over the past decade and to assess any subsequent evolution in treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A systematic review of English and non-English articles reporting on perforated duodenal diverticula using MEDLINE (2008\u20132020) was performed. Only cases of perforated duodenal diverticula in adults (&gt;\u200918\u00a0years) that reported on diagnosis and treatment were included.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Some 328 studies were identified, of which 31 articles met the inclusion criteria. These studies included a total of 47 patients with perforated duodenal diverticula. This series suggests a trend towards conservative management with 34% (16\/47) of patients managed non-operatively. In 31% (5\/16) patients initially managed conservatively, a step-up approach to surgical intervention was required.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Conservative treatment of perforated duodenal diverticula appears to be an acceptable and safe treatment strategy in stable patients without signs of peritonitis under careful observation. For patients who fail to respond to conservative treatment, a step-up approach to percutaneous drainage or surgery can be applied. If surgery is required, competence in techniques ranging from simple diverticulectomy to Roux-en-Y gastric diversion or even Whipple\u2019s procedure may be required depending on tissue friability and diverticular collar size.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00423-021-02238-1","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T18:03:53Z","timestamp":1624471433000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A systematic review of the perforated duodenal diverticula: lessons learned from the last decade"],"prefix":"10.1007","volume":"407","author":[{"given":"Joshua R.","family":"Kapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-3449","authenticated-orcid":false,"given":"Philip C.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gertsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Gubler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Alain","family":"Clavien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuno","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"2238_CR1","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/00004728-198905000-00036","volume":"13","author":"B Van Beers","year":"1989","unstructured":"Van Beers B, Trigaux JP, De Ronde T, Melange M (1989) CT findings of perforated duodenal diverticulitis. 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The study was approved by the institutional review board of the University of Zurich.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable due to the nature of the study design.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}