{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:31:46Z","timestamp":1792668706317,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00423-021-02323-5","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T05:03:28Z","timestamp":1631077408000},"page":"2807-2815","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pelvic exenteration, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancy: experience and outcomes from an exenterative and peritonectomy unit"],"prefix":"10.1007","volume":"406","author":[{"given":"Michael P.","family":"Flood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peadar S.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Soucisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob J.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Warrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Heriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"issue":"2","key":"2323_CR1","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O","volume":"88","author":"B Sadeghi","year":"2000","unstructured":"Sadeghi B, Arvieux C, Glehen O, Beaujard AC, Rivoire M, Baulieux J et al (2000) Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer 88(2):358\u2013363","journal-title":"Cancer"},{"issue":"5","key":"2323_CR2","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1056\/NEJMra040958","volume":"352","author":"JA Meyerhardt","year":"2005","unstructured":"Meyerhardt JA, Mayer RJ (2005) Systemic therapy for colorectal cancer. N Engl J Med 352(5):476\u2013487","journal-title":"N Engl J Med"},{"issue":"1","key":"2323_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00000658-199501000-00004","volume":"221","author":"PH Sugarbaker","year":"1995","unstructured":"Sugarbaker PH (1995) Peritonectomy procedures. Ann Surg 221(1):29\u201342","journal-title":"Ann Surg"},{"issue":"2","key":"2323_CR4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/jso.24813","volume":"117","author":"WF Morano","year":"2018","unstructured":"Morano WF, Khalili M, Chi DS, Bowne WB, Esquivel J (2018) Clinical studies in CRS and HIPEC: trials, tribulations, and future directions-a systematic review. J Surg Oncol 117(2):245\u2013259","journal-title":"J Surg Oncol"},{"key":"2323_CR5","doi-asserted-by":"crossref","unstructured":"Chicago Consensus Working G. The Chicago Consensus on peritoneal surface malignancies: management of colorectal metastases. Ann Surg Oncol. 2020;27(6):1761\u20137.","DOI":"10.1245\/s10434-020-08315-x"},{"issue":"20","key":"2323_CR6","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1200\/JCO.2011.39.7166","volume":"30","author":"TC Chua","year":"2012","unstructured":"Chua TC, Moran BJ, Sugarbaker PH, Levine EA, Glehen O, Gilly FN et al (2012) Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol 30(20):2449\u20132456","journal-title":"J Clin Oncol"},{"key":"2323_CR7","doi-asserted-by":"crossref","unstructured":"Hentzen J, Rovers KP, Kuipers H et al (2019) Impact of synchronous versus metachronous onset of colorectal peritoneal metastases on survival outcomes after cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC): a multicenter, retrospective, observational study. Ann Surg Oncol 26(7):2210\u20132221","DOI":"10.1245\/s10434-019-07294-y"},{"key":"2323_CR8","doi-asserted-by":"crossref","unstructured":"van Driel WJ, Koole SN, Sikorska K, Schagen van Leeuwen JH, Schreuder HWR, Hermans RHM, et al. Hyperthermic intraperitoneal chemotherapy in ovarian cancer. N Engl J Med. 2018;378(3):230\u201340.","DOI":"10.1056\/NEJMoa1708618"},{"issue":"1","key":"2323_CR9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/00000658-199201000-00009","volume":"215","author":"GH Hafner","year":"1992","unstructured":"Hafner GH, Herrera L, Petrelli NJ (1992) Morbidity and mortality after pelvic exenteration for colorectal adenocarcinoma. Ann Surg 215(1):63\u201367","journal-title":"Ann Surg"},{"issue":"7","key":"2323_CR10","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/DCR.0000000000000839","volume":"60","author":"KGM Brown","year":"2017","unstructured":"Brown KGM, Solomon MJ, Koh CE (2017) Pelvic exenteration surgery: the evolution of radical surgical techniques for advanced and recurrent pelvic malignancy. Dis Colon Rectum 60(7):745\u2013754","journal-title":"Dis Colon Rectum"},{"issue":"6","key":"2323_CR11","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.ejso.2016.02.016","volume":"42","author":"AJ Quyn","year":"2016","unstructured":"Quyn AJ, Austin KK, Young JM, Badgery-Parker T, Masya LM, Roberts R et al (2016) Outcomes of pelvic exenteration for locally advanced primary rectal cancer: overall survival and quality of life. Eur J Surg Oncol 42(6):823\u2013828","journal-title":"Eur J Surg Oncol"},{"key":"2323_CR12","doi-asserted-by":"crossref","unstructured":"PelvExCollaborative. Pelvic exenteration for advanced nonrectal pelvic malignancy. Ann Surg. 2019;270(5):899\u2013905.","DOI":"10.1097\/SLA.0000000000003533"},{"issue":"1","key":"2323_CR13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ejca.2012.06.025","volume":"49","author":"PA Georgiou","year":"2013","unstructured":"Georgiou PA, Tekkis PP, Constantinides VA, Patel U, Goldin RD, Darzi AW et al (2013) Diagnostic accuracy and value of magnetic resonance imaging (MRI) in planning exenterative pelvic surgery for advanced colorectal cancer. Eur J Cancer 49(1):72\u201381","journal-title":"Eur J Cancer"},{"issue":"2","key":"2323_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205\u2013213","journal-title":"Ann Surg"},{"issue":"13","key":"2323_CR15","doi-asserted-by":"publisher","first-page":"4224","DOI":"10.1245\/s10434-013-3145-9","volume":"20","author":"AM Kuijpers","year":"2013","unstructured":"Kuijpers AM, Mirck B, Aalbers AG, Nienhuijs SW, de Hingh IH, Wiezer MJ et al (2013) Cytoreduction and HIPEC in the Netherlands: nationwide long-term outcome following the Dutch protocol. Ann Surg Oncol 20(13):4224\u20134230","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"2323_CR16","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.surg.2009.10.012","volume":"147","author":"NN Rahbari","year":"2010","unstructured":"Rahbari NN, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A et al (2010) Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery 147(3):339\u2013351","journal-title":"Surgery"},{"issue":"2","key":"2323_CR17","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10151-019-02141-4","volume":"24","author":"O Peacock","year":"2020","unstructured":"Peacock O, Waters PS, Kong JC, Warrier SK, Wakeman C, Eglinton T et al (2020) Complications and 5-year survival after radical resections which include urological organs for locally advanced and recurrent pelvic malignancies: analysis of 646 consecutive cases. Tech Coloproctol 24(2):181\u2013190","journal-title":"Tech Coloproctol"},{"issue":"12","key":"2323_CR18","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1016\/j.ejso.2019.07.015","volume":"45","author":"PS Waters","year":"2019","unstructured":"Waters PS, Peacock O, Warrier SK, Wakeman C, Eglinton T, Lynch AC et al (2019) Evolution of pelvic exenteration surgery-resectional trends and survival outcomes over three decades. Eur J Surg Oncol 45(12):2325\u20132333","journal-title":"Eur J Surg Oncol"},{"key":"2323_CR19","doi-asserted-by":"publisher","first-page":"101553","DOI":"10.1016\/j.suronc.2021.101553","volume":"37","author":"MP Flood","year":"2021","unstructured":"Flood MP, Waters PS, Kelly ME, Shields C, Conneely J, Ramsay R et al (2021) Outcomes following synchronous liver resection, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal liver and peritoneal metastases: a bi-institutional study. Surg Oncol. 37:101553","journal-title":"Surg Oncol."},{"key":"2323_CR20","doi-asserted-by":"crossref","unstructured":"Tuech JJ, Pinson J, Nouhaud FX, Wood G, Clavier T, Sabourin JC, et al. Total Pelvic exenteration, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy for rectal cancer with associate peritoneal metastases: surgical strategies to optimize safety. Cancers (Basel). 2020;12(11).","DOI":"10.3390\/cancers12113478"},{"issue":"Suppl 1","key":"2323_CR21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s13193-019-00882-0","volume":"10","author":"RS Shinde","year":"2019","unstructured":"Shinde RS, Acharya R, Kumar NA, Solanki S, Desouza A, Saklani A (2019) Pelvic exenteration with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) for rectal cancer-case series with review of literature. Indian J Surg Oncol 10(Suppl 1):80\u201383","journal-title":"Indian J Surg Oncol"},{"key":"2323_CR22","doi-asserted-by":"crossref","unstructured":"Sugarbaker PH. Total pelvic exenterative surgery in patients with peritoneal metastases from appendiceal neoplasms. A case series of 2 patients. Int J Surg Case Rep. 2019;65:279\u201383.","DOI":"10.1016\/j.ijscr.2019.10.064"},{"issue":"5","key":"2323_CR23","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00423-019-01805-x","volume":"404","author":"V Narasimhan","year":"2019","unstructured":"Narasimhan V, Das A, Warrier S, Lynch C, McCormick J, Tie J et al (2019) Evaluation of cytoreductive surgery and HIPEC for peritoneal surface malignancies: analysis of 384 consecutive cases. Langenbecks Arch Surg 404(5):527\u2013539","journal-title":"Langenbecks Arch Surg"},{"issue":"13","key":"2323_CR24","doi-asserted-by":"publisher","first-page":"3950","DOI":"10.1245\/s10434-018-6823-9","volume":"25","author":"MHA Choudry","year":"2018","unstructured":"Choudry MHA, Shuai Y, Jones HL, Pai RK, Pingpank JF, Ahrendt SS et al (2018) Postoperative complications independently predict cancer-related survival in peritoneal malignancies. Ann Surg Oncol 25(13):3950\u20133959","journal-title":"Ann Surg Oncol"},{"issue":"10","key":"2323_CR25","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1097\/DCR.0000000000001456","volume":"62","author":"V Narasimhan","year":"2019","unstructured":"Narasimhan V, Britto M, Pham T, Warrier S, Naik A, Lynch AC et al (2019) Evolution of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: 8-year single-institutional experience. Dis Colon Rectum 62(10):1195\u20131203","journal-title":"Dis Colon Rectum"},{"issue":"2","key":"2323_CR26","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/jso.24290","volume":"114","author":"IS Froysnes","year":"2016","unstructured":"Froysnes IS, Larsen SG, Spasojevic M, Dueland S, Flatmark K (2016) Complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastasis in Norway: prognostic factors and oncologic outcome in a national patient cohort. J Surg Oncol 114(2):222\u2013227","journal-title":"J Surg Oncol"},{"issue":"4","key":"2323_CR27","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/jso.24911","volume":"117","author":"MA Kozman","year":"2018","unstructured":"Kozman MA, Fisher OM, Rebolledo BJ, Parikh R, Valle SJ, Arrowaili A et al (2018) CEA to peritoneal carcinomatosis index (PCI) ratio is prognostic in patients with colorectal cancer peritoneal carcinomatosis undergoing cytoreduction surgery and intraperitoneal chemotherapy: a retrospective cohort study. J Surg Oncol 117(4):725\u2013736","journal-title":"J Surg Oncol"},{"issue":"7","key":"2323_CR28","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/jso.24248","volume":"113","author":"G Passot","year":"2016","unstructured":"Passot G, Vaudoyer D, Villeneuve L, Kepenekian V, Beaujard AC, Bakrin N et al (2016) What made hyperthermic intraperitoneal chemotherapy an effective curative treatment for peritoneal surface malignancy: a 25-year experience with 1,125 procedures. J Surg Oncol 113(7):796\u2013803","journal-title":"J Surg Oncol"},{"issue":"1","key":"2323_CR29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12957-020-1784-4","volume":"18","author":"JSM Wong","year":"2020","unstructured":"Wong JSM, Tan GHC, Chia CS, Ong J, Ng WY, Teo MCC (2020) The importance of synchronicity in the management of colorectal peritoneal metastases with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. World J Surg Oncol 18(1):10","journal-title":"World J Surg Oncol"},{"key":"2323_CR30","doi-asserted-by":"crossref","unstructured":"Brown KGM, Ansari N, Solomon MJ, Austin KKS, Hamilton AER, Young CJ. Pelvic exenteration combined with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for advanced primary or recurrent colorectal cancer with peritoneal metastases. Colorectal Dis. 2020.","DOI":"10.1111\/codi.15378"},{"issue":"1","key":"2323_CR31","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s12885-019-5545-0","volume":"19","author":"KP Rovers","year":"2019","unstructured":"Rovers KP, Bakkers C, Simkens G, Burger JWA, Nienhuijs SW, Creemers GM et al (2019) Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6). BMC Cancer 19(1):390","journal-title":"BMC Cancer"},{"issue":"4","key":"2323_CR32","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00423-020-01895-y","volume":"405","author":"JC Kong","year":"2020","unstructured":"Kong JC, Peacock O, Waters PS, Eglinton T, Warrier SK, Wakeman C et al (2020) Predictors of overall survival following extended radical resections for locally advanced and recurrent pelvic malignancies. Langenbecks Arch Surg 405(4):491\u2013502","journal-title":"Langenbecks Arch Surg"},{"issue":"7","key":"2323_CR33","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1111\/codi.14969","volume":"22","author":"O Peacock","year":"2020","unstructured":"Peacock O, Smith N, Waters PS, Cheung F, McCormick JJ, Warrier SK et al (2020) Outcomes of extended radical resections for locally advanced and recurrent pelvic malignancy involving the aortoiliac axis. Colorectal Dis 22(7):818\u2013823","journal-title":"Colorectal Dis"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-021-02323-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-021-02323-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-021-02323-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T05:13:04Z","timestamp":1643692384000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-021-02323-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2323"],"URL":"https:\/\/doi.org\/10.1007\/s00423-021-02323-5","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"value":"1435-2443","type":"print"},{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,8]]},"assertion":[{"value":"4 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors have completed the Conflict of Interest Disclosure Form. This project satisfied Peter MacCallum Cancer Centre Ethics Committee and governance requirements and was granted ethical approval. Ethics approval number was 20\/81R.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}