{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:05:21Z","timestamp":1789013121005,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background\n<\/jats:title>\n                <jats:p>Although preoperative splenic artery embolism (SAE) has been widely used for splenomegaly, the efficiency and safety of preoperative SAE in patients with sinistral portal hypertension (SPH) is unknown.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We designed a retrospective cohort of SPH patients who received preoperative SAE in our hospital (February 2018 to September 2020) and compared to those who received splenectomy only, in terms of intraoperative and postoperative outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In all, 59 patients (18 patients received preoperative SAE) were analyzed. The median age was 44.7\u00a0years. Preoperative SAE reduced the intraoperative blood loss (637.0 vs. 420.3\u00a0ml, <jats:italic>P<\/jats:italic>\u2009=\u20090.041) and operation time (174.0 vs. 141.5\u00a0min, <jats:italic>P<\/jats:italic>\u2009=\u20090.012). The incidence of complications including postoperative pancreatic fistula (POPF), bleeding, and thromboembolism was comparable. Multivariate analysis showed that SAE was a protective factor for intraoperative blood loss and operation time, while prior pancreatic pseudocyst\/abscess was a risk factor.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Preoperative SAE could reduce intraoperative blood loss and operation time in SPH patients without increasing the incidence of complications compared to splenectomy only.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00423-021-02329-z","type":"journal-article","created":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T02:02:39Z","timestamp":1632016959000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Preoperative splenic artery embolism followed by splenectomy is safe and effective in patients with sinistral portal hypertension"],"prefix":"10.1007","volume":"407","author":[{"given":"Zihe","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2577-5131","authenticated-orcid":false,"given":"Bole","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,19]]},"reference":[{"issue":"5","key":"2329_CR1","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s10620-006-9307-x","volume":"52","author":"S K\u00f6kl\u00fc","year":"2007","unstructured":"K\u00f6kl\u00fc S, Coban S, Y\u00fcksel O, Arhan M (2007) Left-sided portal hypertension. Dig Dis Sci 52(5):1141\u20131149","journal-title":"Dig Dis Sci"},{"key":"2329_CR2","first-page":"3825186","volume":"2020","author":"K Zheng","year":"2020","unstructured":"Zheng K, Guo X, Feng J, Bai Z, Shao X, Yi F et al (2020) Gastrointestinal bleeding due to pancreatitis-induced splenic vein thrombosis: treatment with percutaneous splenic vein recanalization. Gastroenterol Res Pract 2020:3825186","journal-title":"Gastroenterol Res Pract"},{"issue":"6","key":"2329_CR3","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jpge.2015.09.006","volume":"22","author":"A Fernandes","year":"2015","unstructured":"Fernandes A, Almeida N, Ferreira AM, Casela A, Gomes D, Portela F et al (2015) Left-sided portal hypertension: a sinister entity. GE Port J Gastroenterol 22(6):234\u2013239","journal-title":"GE Port J Gastroenterol"},{"issue":"8","key":"2329_CR4","first-page":"1070","volume":"86","author":"SM Sheen-Chen","year":"1991","unstructured":"Sheen-Chen SM, Eng HL, Wan YL, Chou FF (1991) Acinar cell carcinoma of the pancreas: a rare cause of left-sided portal hypertension. Am J Gastroenterol 86(8):1070\u20131072","journal-title":"Am J Gastroenterol"},{"key":"2329_CR5","doi-asserted-by":"crossref","unstructured":"Li H, Yang Z, Tian F (2019) Clinical characteristics and risk factors for sinistral portal hypertension associated with moderate and severe acute pancreatitis: a seven-year single-center retrospective study.\u00a0Med Sci Monit\u202f25:5969\u20135976","DOI":"10.12659\/MSM.916192"},{"issue":"124","key":"2329_CR6","first-page":"890","volume":"60","author":"K Yalin","year":"2013","unstructured":"Yalin K, Hongyi Z, Xiaojun H, Chengli L, Mei X, Di W et al (2013) Left-sided portal hypertension secondary to pancreatic cancer: clinical features, surgical treatment and outcome of 48 cases. Hepatogastroenterology 60(124):890\u2013895","journal-title":"Hepatogastroenterology"},{"issue":"3","key":"2329_CR7","first-page":"175","volume":"75","author":"RJ Thompson","year":"2006","unstructured":"Thompson RJ, Taylor MA, McKie LD, Diamond T (2006) Sinistral portal hypertension. Ulst Med J 75(3):175\u2013177","journal-title":"Ulst Med J"},{"issue":"9","key":"2329_CR8","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1002\/lt.20543","volume":"11","author":"HY Ou","year":"2005","unstructured":"Ou HY, Huang TL, Chen TY, Tsang LL, Concejero AM, Chen CL et al (2005) Emergency splenic arterial embolization for massive variceal bleeding in liver recipient with left-sided portal hypertension. Liver Transpl 11(9):1136\u20131139","journal-title":"Liver Transpl"},{"issue":"6","key":"2329_CR9","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.diii.2016.01.005","volume":"97","author":"J Ghelfi","year":"2016","unstructured":"Ghelfi J, Thony F, Frandon J, Rodiere M, Leroy V, Vendrell A (2016) Gastrointestinal bleeding due to pancreatitis-induced splenic vein thrombosis: treatment with percutaneous splenic vein recanalization. Diagn Interv Imaging 97(6):677\u2013679","journal-title":"Diagn Interv Imaging"},{"issue":"6","key":"2329_CR10","first-page":"445","volume":"3","author":"E Poulin","year":"1993","unstructured":"Poulin E, Thibault C, Mamazza J, Girotti M, C\u00f4t\u00e9 G, Renaud A (1993) Laparoscopic splenectomy: clinical experience and the role of preoperative splenic artery embolization. Surg Laparosc Endosc 3(6):445\u2013450","journal-title":"Surg Laparosc Endosc"},{"issue":"10","key":"2329_CR11","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1007\/s00464-012-2270-z","volume":"26","author":"Z Wu","year":"2012","unstructured":"Wu Z, Zhou J, Pankaj P, Peng B (2012) Comparative treatment and literature review for laparoscopic splenectomy alone versus preoperative splenic artery embolization splenectomy. Surg Endosc 26(10):2758\u20132766","journal-title":"Surg Endosc"},{"issue":"8","key":"2329_CR12","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1185\/03007999609115227","volume":"13","author":"F Mercuriali","year":"1996","unstructured":"Mercuriali F, Inghilleri G (1996) Proposal of an algorithm to help the choice of the best transfusion strategy. Curr Med Res Opin 13(8):465\u2013478","journal-title":"Curr Med Res Opin"},{"issue":"3","key":"2329_CR13","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.surg.2016.11.014","volume":"161","author":"C Bassi","year":"2017","unstructured":"Bassi C, Marchegiani G, Dervenis C, Sarr M, Abu Hilal M, Adham M et al (2017) The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery 161(3):584\u2013591","journal-title":"Surgery"},{"issue":"1","key":"2329_CR14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","volume":"80","author":"D Firth","year":"1993","unstructured":"Firth D (1993) Bias reduction of maximum likelihood estimates. Biometrika 80(1):27\u201338","journal-title":"Biometrika"},{"issue":"3","key":"2329_CR15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00270-015-1199-8","volume":"39","author":"Q Wang","year":"2016","unstructured":"Wang Q, Xiong B, Zheng C, Liang M, Han P (2016) Splenic arterial embolization in the treatment of severe portal hypertension due to pancreatic diseases: the primary experience in 14 patients. Cardiovasc Intervent Radiol 39(3):353\u2013358","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2329_CR16","doi-asserted-by":"crossref","unstructured":"Wei B, Zhang L, Tong H, Wang Z, Wu H (2020) Retrospective comparison of clinical outcomes following splenic vein stenting and splenic arterial embolization in sinistral portal hypertension-related gastrointestinal bleeding.\u00a0AJR Am J Roentgenl 216(6):1579\u20131587","DOI":"10.2214\/AJR.20.23859"},{"issue":"6","key":"2329_CR17","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.amjsurg.2006.09.043","volume":"193","author":"JJ Naoum","year":"2007","unstructured":"Naoum JJ, Silberfein EJ, Zhou W, Sweeney JF, Albo D, Brunicardi FC et al (2007) Concomitant intraoperative splenic artery embolization and laparoscopic splenectomy versus laparoscopic splenectomy: comparison of treatment outcome. Am J Surg 193(6):713\u2013718","journal-title":"Am J Surg"},{"issue":"8","key":"2329_CR18","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1007\/s00464-010-0896-2","volume":"24","author":"A Reso","year":"2010","unstructured":"Reso A, Brar MS, Church N, Mitchell P, Dixon E, Debru E (2010) Outcome of laparoscopic splenectomy with preoperative splenic artery embolization for massive splenomegaly. Surg Endosc 24(8):2008\u20132012","journal-title":"Surg Endosc"},{"issue":"1","key":"2329_CR19","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s00270-013-0625-z","volume":"37","author":"X Luo","year":"2014","unstructured":"Luo X, Nie L, Wang Z, Tsauo J, Tang C, Li X (2014) Transjugular endovascular recanalization of splenic vein in patients with regional portal hypertension complicated by gastrointestinal bleeding. Cardiovasc Intervent Radiol 37(1):108\u2013113","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"5","key":"2329_CR20","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1007\/s10620-005-2674-x","volume":"50","author":"S K\u00f6kl\u00fc","year":"2005","unstructured":"K\u00f6kl\u00fc S, Y\u00fcksel O, Arhan M, Coban S, Ba\u015far O, Yolcu OF et al (2005) Report of 24 left-sided portal hypertension cases: a single-center prospective cohort study. Dig Dis Sci 50(5):976\u2013982","journal-title":"Dig Dis Sci"},{"issue":"8","key":"2329_CR21","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/1751-2980.12916","volume":"21","author":"N Ru","year":"2020","unstructured":"Ru N, He CH, Ren XL, Chen JY, Yu FF, Yan ZJ et al (2020) Risk factors for sinistral portal hypertension and related variceal bleeding in patients with chronic pancreatitis. J Dig Dis 21(8):468\u2013474","journal-title":"J Dig Dis"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-021-02329-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-021-02329-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-021-02329-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T04:41:24Z","timestamp":1644986484000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-021-02329-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,19]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["2329"],"URL":"https:\/\/doi.org\/10.1007\/s00423-021-02329-z","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"value":"1435-2443","type":"print"},{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,19]]},"assertion":[{"value":"13 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed according to the Declaration of Helsinki and approved by the local ethics committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}