{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:42:40Z","timestamp":1789616560824,"version":"build-2803163510"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"DOI":"10.1007\/s00423-022-02500-0","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T02:02:40Z","timestamp":1649124160000},"page":"2027-2034","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early-onset non-metastatic colon cancers do not portend worse prognosis \u2014 implications for adjuvant chemotherapy"],"prefix":"10.1007","volume":"407","author":[{"given":"Mufaddal","family":"Kazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayesh","family":"Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Srivishnu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Desouza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-7612","authenticated-orcid":false,"given":"Avanish","family":"Saklani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"2500_CR1","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1158\/1055-9965.EPI-18-1111","volume":"28","author":"RN Lui","year":"2019","unstructured":"Lui RN, Tsoi KKF, Ho JMW, Lo CM, Chan FCH, Kyaw MH et al (2019) Global increasing incidence of young-onset colorectal cancer across 5 continents: a joinpoint regression analysis of 1,922,167 cases. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 28:1275\u20131282","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol"},{"key":"2500_CR2","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1136\/gutjnl-2018-317592","volume":"68","author":"FE Vuik","year":"2019","unstructured":"Vuik FE, Nieuwenburg SA, Bardou M, Lansdorp-Vogelaar I, Dinis-Ribeiro M, Bento MJ et al (2019) Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years. Gut 68:1820\u20131826","journal-title":"Gut"},{"issue":"125","key":"2500_CR3","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1002\/cncr.31994","volume":"15","author":"AN Willauer","year":"2019","unstructured":"Willauer AN, Liu Y, Pereira AAL, Lam M, Morris JS, Raghav KPS et al (2019) Clinical and molecular characterization of early-onset colorectal cancer. Cancer 15(125):2002\u20132010","journal-title":"Cancer"},{"key":"2500_CR4","unstructured":"Foppa C, Tamburello S, Maroli A, Carvello M, Poliani L, Laghi L, et al. Early age of onset is an independent predictor for worse disease-free survival in sporadic rectal cancer patients. A comparative analysis of 980 consecutive patients. Eur J Surg Oncol [Internet]. Elsevier; 2021 Oct 27 [cited 2021 Nov 6]; 0. Available from: https:\/\/www.ejso.com\/article\/S0748-7983(21)00771-X\/fulltext"},{"issue":"27","key":"2500_CR5","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1200\/JCO.2008.20.6771","volume":"1","author":"T Andr\u00e9","year":"2009","unstructured":"Andr\u00e9 T, Boni C, Navarro M, Tabernero J, Hickish T, Topham C et al (2009) Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol Off J Am Soc Clin Oncol 1(27):3109\u20133116","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"29","key":"2500_CR6","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1200\/JCO.2011.36.4539","volume":"1","author":"G Yothers","year":"2011","unstructured":"Yothers G, O\u2019Connell MJ, Allegra CJ, Kuebler JP, Colangelo LH, Petrelli NJ et al (2011) Oxaliplatin as adjuvant therapy for colon cancer: updated results of NSABP C-07 trial, including survival and subset analyses. J Clin Oncol Off J Am Soc Clin Oncol 1(29):3768\u20133774","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"2500_CR7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD et al (2009) The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 250:187\u2013196","journal-title":"Ann Surg"},{"key":"2500_CR8","doi-asserted-by":"publisher","first-page":"329","DOI":"10.6004\/jnccn.2021.0012","volume":"19","author":"AB Benson","year":"2021","unstructured":"Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen Y-J, Ciombor KK et al (2021) Colon Cancer, Version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 19:329\u2013359","journal-title":"J Natl Compr Cancer Netw."},{"issue":"4","key":"2500_CR9","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s13193-017-0655-0","volume":"8","author":"PS Patil","year":"2017","unstructured":"Patil PS, Saklani A, Gambhire P et al (2017) Colorectal cancer in India: an audit from a tertiary center in a low prevalence area. Indian J Surg Oncol 8(4):484\u2013490","journal-title":"Indian J Surg Oncol"},{"key":"2500_CR10","unstructured":"Colorectal Cancer Guideline | How often to have screening tests [Internet]. [cited 2021 Dec 18]. Available from: https:\/\/www.cancer.org\/cancer\/colon-rectal-cancer\/detection-diagnosis-staging\/acs-recommendations.html"},{"key":"2500_CR11","unstructured":"US Preventive Services Task Force. Colorectal cancer: screening.\u00a0https:\/\/uspreventiveservicestaskforce.org\/uspstf\/draft-recommendation\/colorectal-cancer-screening. Accessed 18 Nov\u00a02020"},{"key":"2500_CR12","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.1200\/JCO.21.02008","volume":"39","author":"E Fontana","year":"2021","unstructured":"Fontana E, Meyers J, Sobrero A, Iveson T, Shields AF, Taieb J et al (2021) Early-onset colorectal adenocarcinoma in the IDEA database: treatment adherence, toxicities, and outcomes with 3 and 6 months of adjuvant fluoropyrimidine and oxaliplatin. J Clin Oncol. 39:4009\u20134019","journal-title":"J Clin Oncol."},{"key":"2500_CR13","doi-asserted-by":"publisher","first-page":"e1920407","DOI":"10.1001\/jamanetworkopen.2019.20407","volume":"3","author":"WH Abualkhair","year":"2020","unstructured":"Abualkhair WH, Zhou M, Ahnen D, Yu Q, Wu X-C, Karlitz JJ (2020) Trends in incidence of early-onset colorectal cancer in the United States among those approaching screening age. JAMA Netw Open 3:e1920407","journal-title":"JAMA Netw Open"},{"key":"2500_CR14","doi-asserted-by":"publisher","first-page":"e2112539","DOI":"10.1001\/jamanetworkopen.2021.12539","volume":"4","author":"E Cheng","year":"2021","unstructured":"Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X et al (2021) Analysis of survival among adults with early-onset colorectal cancer in the national cancer database. JAMA Netw Open 4:e2112539","journal-title":"JAMA Netw Open"},{"issue":"113","key":"2500_CR15","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1093\/jnci\/djab123","volume":"1","author":"Z Jin","year":"2021","unstructured":"Jin Z, Dixon JG, Fiskum JM, Parekh HD, Sinicrope FA, Yothers G et al (2021) Clinicopathological and molecular characteristics of early-onset stage III colon adenocarcinoma: an analysis of the ACCENT database. JNCI J Natl Cancer Inst 1(113):1693\u20131704","journal-title":"JNCI J Natl Cancer Inst"},{"key":"2500_CR16","doi-asserted-by":"crossref","unstructured":"R T. Birkett, E Chamely, SJ. Concors, JI. Bleier, et al. Overuse and limited benefit of chemotherapy for stage II colon cancer in young patients. Clinical Colorectal Cancer 2019; 18(4):292\u2013300.","DOI":"10.1016\/j.clcc.2019.04.002"},{"issue":"5","key":"2500_CR17","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1001\/jamasurg.2014.3572","volume":"150","author":"PJ Kneuertz","year":"2015","unstructured":"Kneuertz PJ, Chang GJ, Hu CY et al (2015) Overtreatment of young adults with colon cancer: more intense treatments with unmatched survival gains. JAMA Surg 150(5):402\u2013409","journal-title":"JAMA Surg"},{"key":"2500_CR18","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1002\/jso.26637","volume":"124","author":"M Kazi","year":"2021","unstructured":"Kazi M, Jain D, Padhy AS, Menon M, Desouza A, Sukumar V et al (2021) Optimal neoadjuvant strategy for signet ring cell carcinoma of the rectum-Is TNT the solution? J Surg Oncol 124:1417\u20131430","journal-title":"J Surg Oncol"},{"key":"2500_CR19","doi-asserted-by":"crossref","unstructured":"REACCT Collaborative; Alexandra M Zaborowski, Ahmed Abdile, Michel Adamina. et al Characteristics of early-onset vs late-onset colorectal cancer. a review. JAMA Surg. 2021; 156 (9):865\u2013874.","DOI":"10.1001\/jamasurg.2021.2380"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-022-02500-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-022-02500-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-022-02500-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T02:09:15Z","timestamp":1661306955000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-022-02500-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["2500"],"URL":"https:\/\/doi.org\/10.1007\/s00423-022-02500-0","relation":{},"ISSN":["1435-2451"],"issn-type":[{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]},"assertion":[{"value":"18 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No pre-registration exists for the study reported in this article due to its retrospective nature.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Pre-registration statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}