{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:39:31Z","timestamp":1792795171822,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universitat de Valencia"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                <jats:title>Purpose\n<\/jats:title>\n                <jats:p>To analyze short-term outcomes of curative-intent cancer surgery in all adult patients diagnosed with colorectal cancer undergoing surgery from January 2010 to December 2019 and determine risk factors for postoperative complications and mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Retrospective study conducted at a single tertiary university institution. Patients were stratified by age into two groups:\u2009&lt;\u200975\u00a0years and\u2009\u2265\u200975\u00a0years. Primary outcome was the influence of age on 30-day complications and mortality. Independent risk factors for postoperative adverse events or mortality were analyzed, and two novel nomograms were constructed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 1486 patients included, 580 were older (\u2265\u200975\u00a0years). Older subjects presented more comorbidities and tumors were located mainly in right colon (45.7%). After matching, no between-group differences in surgical postoperative complications were observed. The 30-day mortality rate was 5.3% for the older and 0.8% for the non-older group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In multivariable analysis, the independent risk factors for postoperative complications were peripheral vascular disease, chronic pulmonary disease, severe liver disease, postoperative transfusion, and surgical approach. Independent risk factors for 30-day mortality were age\u2009\u2265\u200980\u00a0years, cerebrovascular disease, severe liver disease, and postoperative transfusion. The model was internally and externally validated, showing high accuracy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients aged\u2009\u2265\u200975\u00a0years had similar postoperative complications but higher 30-day mortality than their younger counterparts. Patients with peripheral vascular disease, chronic pulmonary disease, or severe liver disease should be informed of higher postoperative complications. But patients aged\u2009\u2265\u200980 suffering cerebrovascular disease, severe liver disease, or needing postoperative transfusion should be warned of significantly increased risk of postoperative mortality.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00423-022-02688-1","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T06:06:20Z","timestamp":1663740380000},"page":"3587-3597","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Short-term outcomes of colorectal cancer surgery in older patients: a novel nomogram predicting postoperative morbi-mortality"],"prefix":"10.1007","volume":"407","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-8677","authenticated-orcid":false,"given":"David","family":"Moro-Valdezate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Mart\u00edn-Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Ferro-Echevarr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Pla-Mart\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Garc\u00eda-Botello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"P\u00e9rez-Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gadea-Mateo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Tarazona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desamparados","family":"Roda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Rosell\u00f3-Ker\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Esp\u00ed-Mac\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"2688_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","volume":"385","author":"GBD","year":"2013","unstructured":"GBD (2013) Mortality and Causes of Death Collaborators (2015) Global, regional, and national age\u2013sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. 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Informed consent was waived because of the retrospective nature of the study, and the analysis used anonymous clinical data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"<i>Payment or honoraria for lectures, presentations, speaker bureaus or educational events from Johnson & Johnson. Support for attending meetings and\/or travel from Takeda.<\/i><i>Payment or honoraria for lectures, presentations, speaker bureaus or educational events from Johnson & Johnson. Support for attending meetings and\/or travel from Takeda.<\/i><i>Declares no relationships, conditions or circumstances that present potential conflict of interest.<\/i><i>Payment or honoraria for lectures, presentations, speaker bureaus or educational events from Johnson & Johnson, Medtronic and Braun Medical. Support for attending meetings and\/or travel from Takeda.<\/i><i>Payment or honoraria for lectures, presentations, speaker bureaus or educational events from Johnson & Johnson.<\/i><i>Declares no relationships, conditions or circumstances that present potential conflict of interest.<\/i><i>Declares no relationships, conditions or circumstances that present potential conflict of interest.<\/i><i>Declares no relationships, conditions or circumstances that present potential conflict of interest.<\/i><i>Declares no relationships, conditions or circumstances that present potential conflict of interest.<\/i><i>Declares no relationships, conditions or circumstances that present potential conflict of interest.<\/i><i>Payment or honoraria for lectures, presentations, speaker bureaus or educational events from Johnson & Johnson, Medtronic and Braun Medical. Support for attending meetings and\/or travel from Takeda.<\/i>","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}