{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:31:12Z","timestamp":1746851472431,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006390","name":"University of Lausanne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006390","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>This prospective study aimed to analyze the functional, biological, and radiological aspects of the pancreatic anastomosis 1 year after pancreatoduodenectomy (PD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>From 2016 to 2019, patients with PD indication were screened. Questionnaires about pancreas insufficiency, fecal elastase tests, and magnetic resonance imaging (MRI) were performed before and 1 year after PD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty patients were prospectively\u00a0included. The only difference between pre- and postoperative questionnaires was constipation (less frequent 1 year after PD). Median pre- and postoperative fecal elastase levels were 96 \u03bcg\/g (IQR 15\u2013196, normal value &gt; 200) and 15 \u03bcg\/g (IQR 15\u201326, <jats:italic>p<\/jats:italic> = 0.042). There were no significant differences in terms of main pancreatic duct (MPD) size (4, IQR 3\u20135 <jats:italic>vs<\/jats:italic>. 4 mm, IQR 3\u20135, <jats:italic>p<\/jats:italic> = 0.892), border regularity, stenosis, visibility, image improvement, and secondary pancreatic duct dilation before and after secretin injection. All patients but one (2 refused and 2 were lost to follow-up, 15\/16, 94%) had a patent pancreaticojejunal anastomosis on 1-year MRI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Although median 1-year fecal elastase was significantly lower than preoperatively, suggesting that exocrine secretion was altered, the anatomical outcome as assessed by MRI was excellent showing high patency rate (15\/16, 94%) at 1 year. This emphasizes the difference between anatomy and function.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00423-023-03040-x","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:01:50Z","timestamp":1692684110000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional, biological, and radiological evaluation of the pancreaticojejunal anastomosis 1 year after pancreatoduodenectomy: a prospective study"],"prefix":"10.1007","volume":"408","author":[{"given":"Ga\u00ebtan-Romain","family":"Joliat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Allemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Labgaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Demartines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naik","family":"Vietti Violi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"issue":"9","key":"3040_CR1","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.hpb.2018.03.003","volume":"20","author":"LA Daamen","year":"2018","unstructured":"Daamen LA, Smits FJ, Besselink MG, Busch OR, Borel Rinkes IH, van Santvoort HC et al (2018) A web-based overview, systematic review and meta-analysis of pancreatic anastomosis techniques following pancreatoduodenectomy. HPB (Oxford) 20(9):777\u2013785","journal-title":"HPB (Oxford)"},{"issue":"3","key":"3040_CR2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/SLE.0000000000000530","volume":"28","author":"Y Lyu","year":"2018","unstructured":"Lyu Y, Li T, Cheng Y, Wang B, Chen L, Zhao S (2018) Pancreaticojejunostomy versus pancreaticogastrostomy after pancreaticoduodenectomy: an up-to-date meta-analysis of RCTs applying the ISGPS (2016) criteria. Surg Laparosc Endosc Percutan Tech 28(3):139\u2013146","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"issue":"9","key":"3040_CR3","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.gassur.2006.08.018","volume":"10","author":"JM Winter","year":"2006","unstructured":"Winter JM, Cameron JL, Campbell KA, Arnold MA, Chang DC, Coleman J et al (2006) 1423 pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg 10(9):1199\u20131210 discussion 1210-1211","journal-title":"J Gastrointest Surg"},{"issue":"1","key":"3040_CR4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/SLA.0000000000003451","volume":"271","author":"S van Roessel","year":"2020","unstructured":"van Roessel S, Mackay TM, van Dieren S, van der Schelling GP, Nieuwenhuijs VB, Bosscha K et al (2020) Textbook outcome: nationwide analysis of a novel quality measure in pancreatic surgery. Ann Surg 271(1):155\u2013162","journal-title":"Ann Surg"},{"issue":"5","key":"3040_CR5","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1097\/SLA.0b013e31823598fb","volume":"254","author":"M Braga","year":"2011","unstructured":"Braga M, Capretti G, Pecorelli N, Balzano G, Doglioni C, Ariotti R et al (2011) A prognostic score to predict major complications after pancreaticoduodenectomy. Ann Surg 254(5):702\u2013707 discussion 707-708","journal-title":"Ann Surg"},{"issue":"3","key":"3040_CR6","doi-asserted-by":"publisher","first-page":"e597","DOI":"10.1097\/SLA.0000000000004855","volume":"277","author":"F Schuh","year":"2023","unstructured":"Schuh F, Mihaljevic AL, Probst P, Trudeau MT, M\u00fcller PC, Marchegiani G et al (2023) A simple classification of pancreatic duct size and texture predicts postoperative pancreatic fistula: a classification of the International Study Group of Pancreatic Surgery. Ann Surg 277(3):e597\u2013e608","journal-title":"Ann Surg"},{"issue":"11","key":"3040_CR7","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.hpb.2018.04.003","volume":"20","author":"D Eshmuminov","year":"2018","unstructured":"Eshmuminov D, Schneider MA, Tschuor C, Raptis DA, Kambakamba P, Muller X et al (2018) Systematic review and meta-analysis of postoperative pancreatic fistula rates using the updated 2016 International Study Group Pancreatic Fistula definition in patients undergoing pancreatic resection with soft and hard pancreatic texture. HPB (Oxford) 20(11):992\u20131003","journal-title":"HPB (Oxford)"},{"issue":"5","key":"3040_CR8","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.2214\/ajr.183.5.1831267","volume":"183","author":"J Monill","year":"2004","unstructured":"Monill J, Pernas J, Clavero J, Farr\u00e9 A, Morales A, Gonz\u00e1lez M et al (2004) Pancreatic duct after pancreatoduodenectomy: morphologic and functional evaluation with secretin-stimulated MR pancreatography. AJR Am J Roentgenol 183(5):1267\u20131274","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"3040_CR9","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00261-002-0065-8","volume":"28","author":"C Aub\u00e9","year":"2003","unstructured":"Aub\u00e9 C, Lebigot J, Pessaux P, Tuech JJ, Kapel N, Burtin P et al (2003) Evaluation of the permeability of pancreaticogastric anastomoses (PGA) with dynamic magnetic resonance pancreatography after secretin stimulation (secretin MRCP). Abdom Imaging 28(4):563\u2013570","journal-title":"Abdom Imaging"},{"issue":"1","key":"3040_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s00534-003-0868-1","volume":"11","author":"H Shinchi","year":"2004","unstructured":"Shinchi H, Takao S, Maemura K, Fukukura Y, Noma H, Matsuo Y et al (2004) Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy. J Hepato-Biliary-Pancreat Surg 11(1):50\u201355","journal-title":"J Hepato-Biliary-Pancreat Surg"},{"issue":"2","key":"3040_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien P-A (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205\u2013213","journal-title":"Ann Surg"},{"issue":"1","key":"3040_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/SLA.0b013e318296c732","volume":"258","author":"K Slankamenac","year":"2013","unstructured":"Slankamenac K, Graf R, Barkun J, Puhan MA, Clavien P-A (2013) The comprehensive complication index: a novel continuous scale to measure surgical morbidity. Ann Surg 258(1):1\u20137","journal-title":"Ann Surg"},{"issue":"5","key":"3040_CR13","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","volume":"142","author":"MN Wente","year":"2007","unstructured":"Wente MN, Bassi C, Dervenis C, Fingerhut A, Gouma DJ, Izbicki JR et al (2007) Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 142(5):761\u2013768","journal-title":"Surgery"},{"issue":"1","key":"3040_CR14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.surg.2005.05.001","volume":"138","author":"C Bassi","year":"2005","unstructured":"Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J et al (2005) Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 138(1):8\u201313","journal-title":"Surgery"},{"issue":"1","key":"3040_CR15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.surg.2007.02.001","volume":"142","author":"MN Wente","year":"2007","unstructured":"Wente MN, Veit JA, Bassi C, Dervenis C, Fingerhut A, Gouma DJ et al (2007) Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery 142(1):20\u201325","journal-title":"Surgery"},{"issue":"10","key":"3040_CR16","doi-asserted-by":"publisher","first-page":"606","DOI":"10.2307\/30148464","volume":"13","author":"TC Horan","year":"1992","unstructured":"Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG (1992) CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol 13(10):606\u2013608","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"1","key":"3040_CR17","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.pan.2021.11.005","volume":"22","author":"A Khan","year":"2022","unstructured":"Khan A, Vege SS, Dudeja V, Chari ST (2022) Staging exocrine pancreatic dysfunction. Pancreatology 22(1):168\u2013172","journal-title":"Pancreatology"},{"issue":"2","key":"3040_CR18","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1148\/radiology.203.2.9114101","volume":"203","author":"C Matos","year":"1997","unstructured":"Matos C, Metens T, Devi\u00e8re J, Nicaise N, Braud\u00e9 P, Van Yperen G et al (1997) Pancreatic duct: morphologic and functional evaluation with dynamic MR pancreatography after secretin stimulation. Radiology 203(2):435\u2013441","journal-title":"Radiology"},{"issue":"41","key":"3040_CR19","doi-asserted-by":"publisher","first-page":"7177","DOI":"10.3748\/wjg.v19.i41.7177","volume":"19","author":"Y Bian","year":"2013","unstructured":"Bian Y, Wang L, Chen C, Lu J-P, Fan J-B, Chen S-Y et al (2013) Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP. World J Gastroenterol 19(41):7177\u20137182","journal-title":"World J Gastroenterol"},{"issue":"3","key":"3040_CR20","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/00006676-200110000-00015","volume":"23","author":"L Czak\u00f3","year":"2001","unstructured":"Czak\u00f3 L, Endes J, Tak\u00e1cs T, Boda K, Lonovics J (2001) Evaluation of pancreatic exocrine function by secretin-enhanced magnetic resonance cholangiopancreatography. Pancreas 23(3):323\u2013328","journal-title":"Pancreas"},{"issue":"33","key":"3040_CR21","first-page":"866","volume":"47","author":"N Hashimoto","year":"2000","unstructured":"Hashimoto N, Fujiwara H, Nomura H, Ohyanagi H (2000) In vivo evaluation of long-term patency of pancreaticoenterostomy after Whipple operation. Hepatogastroenterology 47(33):866\u2013868","journal-title":"Hepatogastroenterology"},{"issue":"4","key":"3040_CR22","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1046\/j.1365-2168.2000.01388.x","volume":"87","author":"E Lemaire","year":"2000","unstructured":"Lemaire E, O\u2019Toole D, Sauvanet A, Hammel P, Belghiti J, Ruszniewski P (2000) Functional and morphological changes in the pancreatic remnant following pancreaticoduodenectomy with pancreaticogastric anastomosis. Br J Surg 87(4):434\u2013438","journal-title":"Br J Surg"},{"issue":"2","key":"3040_CR23","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jamcollsurg.2005.03.026","volume":"201","author":"A Rault","year":"2005","unstructured":"Rault A, SaCunha A, Klopfenstein D, Larroud\u00e9 D, Epoy FND, Collet D et al (2005) Pancreaticojejunal anastomosis is preferable to pancreaticogastrostomy after pancreaticoduodenectomy for longterm outcomes of pancreatic exocrine function. J Am Coll Surg 201(2):239\u2013244","journal-title":"J Am Coll Surg"},{"key":"3040_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/2156-7514.107909","volume":"3","author":"M Anis","year":"2013","unstructured":"Anis M, Mortele K (2013) Role of secretin-enhanced magnetic resonance cholangiopancreatography in the evaluation of patients following pancreatojejunostomy. J Clin Imaging Sci 3:7","journal-title":"J Clin Imaging Sci"},{"issue":"24","key":"3040_CR25","first-page":"2382","volume":"45","author":"H Amano","year":"1998","unstructured":"Amano H, Takada T, Ammori BJ, Yasuda H, Yoshida M, Uchida T et al (1998) Pancreatic duct patency after pancreaticogastrostomy: long-term follow-up study. Hepatogastroenterology 45(24):2382\u20132387","journal-title":"Hepatogastroenterology"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-023-03040-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-023-03040-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-023-03040-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:10:30Z","timestamp":1705623030000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-023-03040-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,22]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3040"],"URL":"https:\/\/doi.org\/10.1007\/s00423-023-03040-x","relation":{},"ISSN":["1435-2451"],"issn-type":[{"type":"electronic","value":"1435-2451"}],"subject":[],"published":{"date-parts":[[2023,8,22]]},"assertion":[{"value":"24 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study protocol was reviewed and approved by the local Ethics Committee (#2016-0018) and was recorded in ClinicalTrials.gov (NCT03714542).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from participants to participate in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"326"}}