{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:58:57Z","timestamp":1784653137327,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Hemithyroidectomies are mainly performed for two indications, either therapeutically to relieve compression symptoms or diagnostically for suspicious nodule(s). In case of the latter, one could consider the approach to be rather extensive since the majority of patients have no symptoms and will have benign disease. The aim of this study is to investigate the complication rates of diagnostic hemithyroidectomy and to compare it with the complication rates of compressive symptoms hemithyroidectomy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data from patients who had undergone hemithyroidectomy either for compression symptoms or for excluding malignancy were extracted from a well-established Scandinavian quality register (SQRTPA). The following complications were analyzed: bleedings, wound infections, and paresis of the recurrent laryngeal nerve (RLN). Risk factors for these complications were examined by univariable and multivariable logistic regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 9677 patients were included, 3871 (40%) underwent surgery to exclude malignancy and 5806 (60%) due to compression symptoms. In the multivariable analysis, the totally excised thyroid weight was an independent risk factor for bleeding. Permanent (6\u201312\u00a0months after the operation) RLN paresis were less common in the excluding malignancy group (<jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A range of factors interfere and contribute to bleeding, wound infections, and RLN paresis after hemithyroidectomy. In this observational study based on a Scandinavian quality register, the indication \u201cexcluding malignancy\u201d for hemithyroidectomy is associated with less permanent RLN paresis than the indication \u201ccompression symptoms.\u201d Thus, patients undergoing diagnostic hemithyroidectomy can be reassured that this procedure is a safe surgical procedure and does not entail an unjustified risk.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00423-023-03168-w","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T20:01:55Z","timestamp":1701979315000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hemithyroidectomy, does the indication influence the outcome?"],"prefix":"10.1007","volume":"409","author":[{"given":"Ervin","family":"Beka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Olofsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Gimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"3168_CR1","unstructured":"Zamora EA, Khare S, Cassaro S (2023) Thyroid nodule. In: StatPearls. StatPearls Publishing LLC.: Treasure Island (FL)"},{"issue":"2","key":"3168_CR2","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00268-008-9837-9","volume":"33","author":"DY Greenblatt","year":"2009","unstructured":"Greenblatt DY et al (2009) Thyroid resection improves perception of swallowing function in patients with thyroid disease. World J Surg 33(2):255\u2013260","journal-title":"World J Surg"},{"issue":"6","key":"3168_CR3","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1177\/000348949310200607","volume":"102","author":"L Lacoste","year":"1993","unstructured":"Lacoste L et al (1993) Airway complications in thyroid surgery. Ann Otol Rhinol Laryngol 102(6):441\u2013446","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"2","key":"3168_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.23736\/S1824-4785.21.03330-6","volume":"65","author":"M Barczy\u0144ski","year":"2021","unstructured":"Barczy\u0144ski M (2021) Current approach to surgical management of hyperthyroidism. Q J Nucl Med Mol Imaging 65(2):124\u2013131","journal-title":"Q J Nucl Med Mol Imaging"},{"issue":"S2","key":"3168_CR5","doi-asserted-by":"publisher","first-page":"S150","DOI":"10.1017\/S0022215116000578","volume":"130","author":"AL Mitchell","year":"2016","unstructured":"Mitchell AL et al (2016) Management of thyroid cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 130(S2):S150-s160","journal-title":"J Laryngol Otol"},{"issue":"11","key":"3168_CR6","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1089\/thy.2017.0500","volume":"27","author":"ES Cibas","year":"2017","unstructured":"Cibas ES, Ali SZ (2017) The 2017 Bethesda system for reporting thyroid cytopathology. Thyroid 27(11):1341\u20131346","journal-title":"Thyroid"},{"issue":"4","key":"3168_CR7","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.surg.2013.12.002","volume":"155","author":"C Bures","year":"2014","unstructured":"Bures C et al (2014) A prospective study on surgical-site infections in thyroid operation. Surgery 155(4):675\u2013681","journal-title":"Surgery"},{"issue":"5","key":"3168_CR8","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00423-008-0366-7","volume":"393","author":"A Bergenfelz","year":"2008","unstructured":"Bergenfelz A et al (2008) Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients. Langenbecks Arch Surg 393(5):667\u2013673","journal-title":"Langenbecks Arch Surg"},{"issue":"5","key":"3168_CR9","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00423-008-0362-y","volume":"393","author":"P Leyre","year":"2008","unstructured":"Leyre P et al (2008) Does the risk of compressive hematoma after thyroidectomy authorize 1-day surgery? Langenbecks Arch Surg 393(5):733\u2013737","journal-title":"Langenbecks Arch Surg"},{"issue":"3","key":"3168_CR10","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/bjs.7824","volume":"99","author":"R Promberger","year":"2012","unstructured":"Promberger R et al (2012) Risk factors for postoperative bleeding after thyroid surgery. Br J Surg 99(3):373\u2013379","journal-title":"Br J Surg"},{"issue":"3","key":"3168_CR11","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/bjs.6417","volume":"96","author":"M Barczynski","year":"2009","unstructured":"Barczynski M, Konturek A, Cichon S (2009) Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy. Br J Surg 96(3):240\u2013246","journal-title":"Br J Surg"},{"issue":"13","key":"3168_CR12","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1002\/bjs.10276","volume":"103","author":"A Bergenfelz","year":"2016","unstructured":"Bergenfelz A et al (2016) Risk of recurrent laryngeal nerve palsy in patients undergoing thyroidectomy with and without intraoperative nerve monitoring. Br J Surg 103(13):1828\u20131838","journal-title":"Br J Surg"},{"issue":"8","key":"3168_CR13","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1007\/s00405-013-2767-7","volume":"271","author":"C Godballe","year":"2014","unstructured":"Godballe C et al (2014) Risk factors for recurrent nerve palsy after thyroid surgery: a national study of patients treated at Danish departments of ENT Head and Neck Surgery. Eur Arch Otorhinolaryngol 271(8):2267\u20132276","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"11","key":"3168_CR14","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1007\/s002680010221","volume":"24","author":"O Thomusch","year":"2000","unstructured":"Thomusch O et al (2000) Multivariate analysis of risk factors for postoperative complications in benign goiter surgery: prospective multicenter study in Germany. World J Surg 24(11):1335\u20131341","journal-title":"World J Surg"},{"issue":"1","key":"3168_CR15","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4103\/JOC.JOC_64_18","volume":"36","author":"P Upadhyaya","year":"2019","unstructured":"Upadhyaya P et al (2019) Histopathological review of diagnostic categories of the bethesda system for reporting thyroid cytopathology - an institutional experience of 5 years. J Cytol 36(1):48\u201352","journal-title":"J Cytol"},{"issue":"9596","key":"3168_CR16","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E et al (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370(9596):1453\u20131457","journal-title":"Lancet"},{"key":"3168_CR17","unstructured":"(2020) Scandinavian quality register for thyroid parathyroid and adrenal surgery. Annual Report.\u00a0https:\/\/sqrtpa.se\/arsrapporter"},{"key":"3168_CR18","unstructured":"(2013) Scandinavian quality register for thyroid parathyroid and adrenal surgery. Annual Report.\u00a0https:\/\/sqrtpa.se\/arsrapporter"},{"issue":"10188","key":"3168_CR19","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1016\/S0140-6736(19)31205-X","volume":"393","author":"L The","year":"2019","unstructured":"The L (2019) ICD-11. Lancet 393(10188):2275","journal-title":"Lancet"},{"key":"3168_CR20","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.12659\/MSM.890988","volume":"20","author":"I Nawrot","year":"2014","unstructured":"Nawrot I et al (2014) Total thyroidectomy is associated with increased prevalence of permanent hypoparathyroidism. Med Sci Monit 20:1675\u20131681","journal-title":"Med Sci Monit"},{"key":"3168_CR21","doi-asserted-by":"publisher","unstructured":"Naushad A, Sattar S, Salik M, Wajid M, Khalid F, Hussain A, Siddiqui MIU, Masood MQ (2023) Frequency and risk factors of permanent hypoparathyroidism after total thyroidectomy: An experience at a tertiary care hospital in Pakistan. Ear Nose Throat J. https:\/\/doi.org\/10.1177\/01455613231173455","DOI":"10.1177\/01455613231173455"},{"issue":"1","key":"3168_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13044-021-00104-2","volume":"14","author":"IF Palop","year":"2021","unstructured":"Palop IF et al (2021) Determination of calcium and parathyroid hormone levels following hemithyroidectomy. Thyroid Res 14(1):13","journal-title":"Thyroid Res"},{"issue":"1","key":"3168_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/096228029900800102","volume":"8","author":"JL Schafer","year":"1999","unstructured":"Schafer JL (1999) Multiple imputation: a primer. Stat Methods Med Res 8(1):3\u201315","journal-title":"Stat Methods Med Res"},{"issue":"4","key":"3168_CR24","doi-asserted-by":"publisher","first-page":"318","DOI":"10.14310\/horm.2002.1283","volume":"9","author":"SN Karamanakos","year":"2010","unstructured":"Karamanakos SN et al (2010) Complications and risk factors related to the extent of surgery in thyroidectomy. Results from 2,043 procedures. Hormones (Athens) 9(4):318\u201325","journal-title":"Hormones (Athens)"},{"issue":"3","key":"3168_CR25","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.3390\/jcm12031212","volume":"12","author":"E Papadopoulou","year":"2023","unstructured":"Papadopoulou E et al (2023) The role of primary repair of the recurrent laryngeal nerve during thyroid\/parathyroid surgery in vocal outcomes-a systematic review. J Clin Med 12(3):1212","journal-title":"J Clin Med"},{"issue":"1\u20132","key":"3168_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1445-2197.2012.06247.x","volume":"83","author":"NJ Hayward","year":"2013","unstructured":"Hayward NJ et al (2013) Recurrent laryngeal nerve injury in thyroid surgery: a review. ANZ J Surg 83(1\u20132):15\u201321","journal-title":"ANZ J Surg"},{"issue":"1","key":"3168_CR27","first-page":"27","volume":"4","author":"P Mattsson","year":"2015","unstructured":"Mattsson P, Hydman J, Svensson M (2015) Recovery of laryngeal function after intraoperative injury to the recurrent laryngeal nerve. Gland Surg 4(1):27\u201335","journal-title":"Gland Surg"},{"issue":"7","key":"3168_CR28","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1177\/000348940911800709","volume":"118","author":"J Hydman","year":"2009","unstructured":"Hydman J et al (2009) Diagnosis and prognosis of iatrogenic injury of the recurrent laryngeal nerve. Ann Otol Rhinol Laryngol 118(7):506\u2013511","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"6","key":"3168_CR29","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.surg.2008.02.006","volume":"143","author":"FY Chiang","year":"2008","unstructured":"Chiang FY et al (2008) The mechanism of recurrent laryngeal nerve injury during thyroid surgery\u2013the application of intraoperative neuromonitoring. Surgery 143(6):743\u2013749","journal-title":"Surgery"},{"issue":"Suppl 1","key":"3168_CR30","first-page":"S1","volume":"121","author":"GW Randolph","year":"2011","unstructured":"Randolph GW et al (2011) Electrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery: international standards guideline statement. Laryngoscope 121(Suppl 1):S1-16","journal-title":"Laryngoscope"},{"issue":"1","key":"3168_CR31","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00423-023-02959-5","volume":"408","author":"J G\u00f3mez-Ram\u00edrez","year":"2023","unstructured":"G\u00f3mez-Ram\u00edrez J et al (2023) Large goiters and postoperative complications: does it really matter? Langenbecks Arch Surg 408(1):213","journal-title":"Langenbecks Arch Surg"},{"issue":"7","key":"3168_CR32","doi-asserted-by":"publisher","first-page":"e2762","DOI":"10.1210\/clinem\/dgac214","volume":"107","author":"I Mintziras","year":"2022","unstructured":"Mintziras I et al (2022) Heavier weight of resected thyroid specimen is associated with higher postoperative morbidity in benign goiter. J Clin Endocrinol Metab 107(7):e2762\u2013e2769","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"3168_CR33","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1080\/00015458.2021.1979185","volume":"123","author":"M Pisarska-Adamczyk","year":"2023","unstructured":"Pisarska-Adamczyk M et al (2023) Thyroidectomy: is it safe to be performed by general surgery residents? - single centre experience. Acta Chir Belg 123(3):266\u2013271","journal-title":"Acta Chir Belg"},{"issue":"4","key":"3168_CR34","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1213\/ANE.0000000000005276","volume":"132","author":"MB Brodsky","year":"2021","unstructured":"Brodsky MB et al (2021) Laryngeal injury and upper airway symptoms after endotracheal intubation during surgery: a systematic review and meta-analysis. Anesth Analg 132(4):1023\u20131032","journal-title":"Anesth Analg"},{"issue":"Suppl 1","key":"3168_CR35","doi-asserted-by":"publisher","first-page":"24","DOI":"10.4274\/2017.26.suppl.04","volume":"26","author":"AY Kargi","year":"2017","unstructured":"Kargi AY, Bustamante MP, Gulec S (2017) Genomic profiling of thyroid nodules: current role for ThyroSeq next-generation sequencing on clinical decision-making. Mol Imaging Radionucl Ther 26(Suppl 1):24\u201335","journal-title":"Mol Imaging Radionucl Ther"},{"issue":"5","key":"3168_CR36","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/bjs5.50310","volume":"4","author":"JI Staubitz","year":"2020","unstructured":"Staubitz JI et al (2020) Effect of intraoperative nerve monitoring on postoperative vocal cord palsy rates after thyroidectomy: European multicentre registry-based study. BJS Open 4(5):821\u2013829","journal-title":"BJS Open"},{"issue":"6","key":"3168_CR37","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.otohns.2008.12.047","volume":"140","author":"O Cavicchi","year":"2009","unstructured":"Cavicchi O et al (2009) The value of neurostimulation and intraoperative nerve monitoring of inferior laryngeal nerve in thyroid surgery. Otolaryngol Head Neck Surg 140(6):866\u2013870","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"6","key":"3168_CR38","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1002\/lary.24550","volume":"124","author":"E Phelan","year":"2014","unstructured":"Phelan E et al (2014) Continuous vagal IONM prevents recurrent laryngeal nerve paralysis by revealing initial EMG changes of impending neuropraxic injury: a prospective, multicenter study. Laryngoscope 124(6):1498\u20131505","journal-title":"Laryngoscope"},{"issue":"6","key":"3168_CR39","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1002\/hed.23676","volume":"37","author":"Y Pavier","year":"2015","unstructured":"Pavier Y et al (2015) Acute prediction of laryngeal outcome during thyroid surgery by electromyographic laryngeal monitoring. Head Neck 37(6):835\u2013839","journal-title":"Head Neck"},{"issue":"6","key":"3168_CR40","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s00423-016-1441-0","volume":"402","author":"M Stopa","year":"2017","unstructured":"Stopa M, Barczy\u0144ski M (2017) Prognostic value of intraoperative neural monitoring of the recurrent laryngeal nerve in thyroid surgery. Langenbecks Arch Surg 402(6):957\u2013964","journal-title":"Langenbecks Arch Surg"},{"issue":"3","key":"3168_CR41","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1007\/s12020-018-1739-5","volume":"62","author":"O Cavicchi","year":"2018","unstructured":"Cavicchi O et al (2018) Intraoperative intermittent neuromonitoring of inferior laryngeal nerve and staged thyroidectomy: our experience. Endocrine 62(3):560\u2013565","journal-title":"Endocrine"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-023-03168-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-023-03168-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-023-03168-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T08:08:26Z","timestamp":1710144506000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-023-03168-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3168"],"URL":"https:\/\/doi.org\/10.1007\/s00423-023-03168-w","relation":{},"ISSN":["1435-2451"],"issn-type":[{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,7]]},"assertion":[{"value":"13 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}