{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:28:26Z","timestamp":1761154106374,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The efficacy of the novel SphinKeeper\u00ae procedure for the treatment of fecal incontinence (FI) is not yet well defined. This study aimed to assess long-term functional outcomes after SphinKeeper\u00ae surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 32 patients with FI (28 female), who were operated at a tertiary referral center between August 2018 and September 2021. Functional outcome and quality of life were evaluated prospectively using validated questionnaires before and after surgery. Additionally, endoanal ultrasound and anal manometry were conducted prior and after SphinKeeper\u00ae implantation. Predictive parameters for treatment success were defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow-up time was 22.62\u2009\u00b1\u20098.82\u00a0months. The St. Mark\u2019s incontinence score decreased significantly after surgery (median preoperative\u2009=\u200919 (IQR 17\u201322) versus median last follow-up\u2009=\u200912 (IQR 8\u201316),<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Similarly, physical short-form health survey showed a significant improvement after SphinKeeper\u00ae implantation (<jats:italic>p<\/jats:italic>\u2009=\u20090.011).<\/jats:p><jats:p>Patients with a higher degree of internal sphincter defect showed an improved objective therapy success (<jats:italic>r<\/jats:italic>\u2009=\u20090.633,<jats:italic>p<\/jats:italic>\u2009=\u20090.015) after SphinKeeper\u00ae operation, whereas the type and severity of FI had no impact on the functional outcome. Notably, a higher number of dislocated prostheses (<jats:italic>r<\/jats:italic>\u2009=\u20090.772,<jats:italic>p<\/jats:italic>\u2009=\u20090.015) showed a significant correlation with reduced improvement of incontinence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The SphinKeeper\u00ae procedure showed a significant long-term functional improvement in over half of the patients. Patients with a higher internal sphincter defect benefited most, whereas dislocation of the prostheses was associated with less favorable results.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00423-023-03188-6","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T03:01:58Z","timestamp":1701831718000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long-term outcome after SphinKeeper\u00ae surgery for treating fecal incontinence\u2014who are good candidates?"],"prefix":"10.1007","volume":"408","author":[{"given":"Christopher","family":"Dawoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin Melanie","family":"Widmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pereyra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Harpain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Riss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"issue":"12","key":"3188_CR1","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1097\/DCR.0000000000000514","volume":"58","author":"KS Ng","year":"2015","unstructured":"Ng KS, Sivakumaran Y, Nassar N, Gladman MA (2015) Fecal incontinence: community prevalence and associated factors\u2013a systematic review. 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The ethics committee of the Medical University of Vienna approved this study (no. 1814\/2020). This study was registered at ClinicalTrials.gov (NCT04992429) June 18, 2021.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Patients signed informed consent regarding publishing their data and photographs.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"456"}}