{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:44:03Z","timestamp":1791945843185,"version":"4.3.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate the impact of autofluorescence technology on postoperative parathyroid function and short-term outcomes in patients undergoing thyroid surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 546 patients were included in the study, with 287 in the conventional treatment group and 259 in the autofluorescence group. Both groups underwent central lymph node dissection, which is known to affect parathyroid function. Short-term outcomes, including rates of postoperative hypocalcemia and parathyroid dysfunction, serum calcium and PTH levels on the first postoperative day, as well as the need for calcium supplementation, were analyzed. A multivariable analysis was also conducted to assess the impact of autofluorescence on postoperative parathyroid dysfunction, considering factors such as age, BMI, and preoperative calcium levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The autofluorescence group demonstrated significantly lower rates of postoperative hypocalcemia and parathyroid dysfunction compared to the conventional treatment group. The autofluorescence group also had better serum calcium and PTH levels on the first postoperative day, and a reduced need for calcium supplementation. Surprisingly, the use of autofluorescence technology did not prolong surgical time; instead, it led to a shorter hospitalization duration. The multivariable analysis showed that autofluorescence significantly reduced the risk of postoperative parathyroid dysfunction, while factors such as age, BMI, and preoperative calcium levels did not show a significant correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides evidence that autofluorescence technology can improve the preservation of parathyroid function during thyroid surgery, leading to better short-term outcomes and reduced postoperative complications. The findings highlight the potential of autofluorescence as a valuable tool in the management of parathyroid hypofunction. Further research and validation are needed to establish the routine use of autofluorescence technology in the thyroid.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-024-03256-5","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T04:45:39Z","timestamp":1710391539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The application of autofluorescence system contributes to the preservation of parathyroid function during thyroid surgery"],"prefix":"10.1007","volume":"409","author":[{"given":"XianBiao","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaBo","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JianFeng","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"issue":"2","key":"3256_CR1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/MOO.0000000000000346","volume":"25","author":"RA Dedivitis","year":"2017","unstructured":"Dedivitis RA, Aires FT, Cernea CR (2017) Hypoparathyroidism after thyroidectomy: prevention, assessment and management. Curr Opin Otolaryngol Head Neck Surg 25(2):142\u2013146","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"7","key":"3256_CR2","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1089\/thy.2017.0309","volume":"28","author":"LA Orloff","year":"2018","unstructured":"Orloff LA, Wiseman SM, Bernet VJ et al (2018) American Thyroid Association statement on postoperative hypoparathyroidism: diagnosis, prevention, and management in adults. Thyroid 28(7):830\u2013841","journal-title":"Thyroid"},{"issue":"6","key":"3256_CR3","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1002\/bjs.12028","volume":"108","author":"FA Salem","year":"2021","unstructured":"Salem FA, Bergenfelz A, Nordenstr\u00f6m E, Almquist M (2021) Central lymph node dissection and permanent hypoparathyroidism after total thyroidectomy for papillary thyroid cancer: population-based study. Br J Surg 108(6):684\u2013690","journal-title":"Br J Surg"},{"issue":"5","key":"3256_CR4","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/jbmr.3368","volume":"33","author":"L Underbjerg","year":"2018","unstructured":"Underbjerg L, Sikjaer T, Rejnmark L (2018) Long-term complications in patients with hypoparathyroidism evaluated by biochemical findings: a case-control study. J Bone Miner Res 33(5):822\u2013831","journal-title":"J Bone Miner Res"},{"issue":"1","key":"3256_CR5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1080\/15622970600995146","volume":"8","author":"T Bohrer","year":"2007","unstructured":"Bohrer T, Krannich JH (2007) Depression as a manifestation of latent chronic hypoparathyroidism. World J Biol Psychiatr 8(1):56\u201359","journal-title":"World J Biol Psychiatr"},{"key":"3256_CR6","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fendo.2016.00172","volume":"7","author":"EG Abate","year":"2017","unstructured":"Abate EG, Clarke BL (2017) Review of hypoparathyroidism. Front Endocrinol (Lausanne) 7:172","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"19","key":"3256_CR7","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1111\/j.1742-4658.2011.08300.x","volume":"278","author":"GA Datsis","year":"2011","unstructured":"Datsis GA, Berdiaki A, Nikitovic D et al (2011) Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration. FEBS J 278(19):3782\u20133792","journal-title":"FEBS J"},{"issue":"7347","key":"3256_CR8","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1136\/bmj.324.7347.1218","volume":"324","author":"G Kuijpers","year":"2002","unstructured":"Kuijpers G, Schneider B, Stadel B, Colman E (2002) Recombinant human parathyroid hormone. Preclinical data on rat osteosarcoma were not dismissed. BMJ 324(7347):1218","journal-title":"BMJ"},{"issue":"2","key":"3256_CR9","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1272\/jnms.81.84","volume":"81","author":"S Takeuchi","year":"2014","unstructured":"Takeuchi S, Shimizu K, Shimizu K Jr, Akasu H, Okamura R (2014) Identification of pathological and normal parathyroid tissue by fluorescent labeling with 5-aminolevulinic acid during endocrine neck surgery. J Nippon Med Sch 81(2):84\u201393","journal-title":"J Nippon Med Sch"},{"issue":"9","key":"3256_CR10","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1089\/pho.2010.2916","volume":"29","author":"WW Liu","year":"2011","unstructured":"Liu WW, Li CQ, Guo ZM, Li H, Zhang Q, Yang AK (2011) Fluorescence identification of parathyroid glands by aminolevulinic acid hydrochloride in rats. Photomed Laser Surg 29(9):635\u2013638","journal-title":"Photomed Laser Surg"},{"issue":"6","key":"3256_CR11","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1097\/MLG.0b013e3181671b61","volume":"118","author":"SA Asher","year":"2008","unstructured":"Asher SA, Peters GE, Pehler SF, Zinn K, Newman JR, Rosenthal EL (2008) Fluorescent detection of rat parathyroid glands via 5-aminolevulinic acid. Laryngoscope 118(6):1014\u20131018","journal-title":"Laryngoscope"},{"key":"3256_CR12","doi-asserted-by":"publisher","first-page":"1035840","DOI":"10.3389\/fsurg.2022.1035840","volume":"9","author":"Z Ye","year":"2022","unstructured":"Ye Z, Wu K, Hu Z, Jin F (2022) Nanocarbon or indocyanine green: which is superior for gasless transaxillary endoscopic thyroidectomy to protect the parathyroid gland? Front Surg 9:1035840","journal-title":"Front Surg"},{"issue":"6","key":"3256_CR13","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.12669\/pjms.336.13940","volume":"33","author":"F Liu","year":"2017","unstructured":"Liu F, Zhu Y, Qian Y, Zhang J, Zhang Y, Zhang Y (2017) Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue. Pak J Med Sci 33(6):1485\u20131489","journal-title":"Pak J Med Sci"},{"issue":"4","key":"3256_CR14","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1177\/1553350620980263","volume":"28","author":"S Van Slycke","year":"2021","unstructured":"Van Slycke S, Van Den Heede K, Brusselaers N, Vermeersch H (2021) Feasibility of autofluorescence for parathyroid glands during thyroid surgery and the risk of hypocalcemia: first results in belgium and review of the literature. Surg Innov 28(4):409\u2013418","journal-title":"Surg Innov"},{"issue":"Suppl 2","key":"3256_CR15","doi-asserted-by":"publisher","first-page":"S136","DOI":"10.21037\/gs.2020.01.04","volume":"9","author":"AN Di Marco","year":"2020","unstructured":"Di Marco AN, Palazzo FF (2020) Near-infrared autofluorescence in thyroid and parathyroid surgery. Gland Surg 9(Suppl 2):S136\u2013S146","journal-title":"Gland Surg"},{"issue":"2","key":"3256_CR16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1001\/jamasurg.2019.4613","volume":"155","author":"F Benmiloud","year":"2020","unstructured":"Benmiloud F, Godiris-Petit G, Gras R et al (2020) Association of autofluorescence-based detection of the parathyroid glands during total thyroidectomy with postoperative hypocalcemia risk: results of the PARAFLUO multicenter randomized clinical trial. JAMA Surg 155(2):106\u2013112","journal-title":"JAMA Surg"},{"issue":"1","key":"3256_CR17","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.surg.2019.04.072","volume":"167","author":"E Kose","year":"2020","unstructured":"Kose E, Rudin AV, Kahramangil B et al (2020) Autofluorescence imaging of parathyroid glands: an assessment of potential indications. Surgery 167(1):173\u2013179","journal-title":"Surgery"},{"issue":"6","key":"3256_CR18","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1097\/SLA.0000000000003700","volume":"272","author":"CC Sol\u00f3rzano","year":"2020","unstructured":"Sol\u00f3rzano CC, Thomas G, Baregamian N, Mahadevan-Jansen A (2020) Detecting the near infrared autofluorescence of the human parathyroid: hype or opportunity? Ann Surg 272(6):973\u2013985","journal-title":"Ann Surg"},{"issue":"9","key":"3256_CR19","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1111\/ans.17117","volume":"91","author":"R Tjahjono","year":"2021","unstructured":"Tjahjono R, Nguyen K, Phung D, Riffat F, Palme CE (2021) Methods of identification of parathyroid glands in thyroid surgery: a literature review. ANZ J Surg 91(9):1711\u20131716","journal-title":"ANZ J Surg"},{"issue":"4","key":"3256_CR20","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.path.2019.08.006","volume":"12","author":"J Guilmette","year":"2019","unstructured":"Guilmette J, Sadow PM (2019) Parathyroid pathology. Surg Pathol Clin 12(4):1007\u20131019","journal-title":"Surg Pathol Clin"},{"issue":"14","key":"3256_CR21","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.3390\/molecules24142560","volume":"24","author":"R Ladurner","year":"2019","unstructured":"Ladurner R, Lerchenberger M, Al Arabi N, Gallwas JKS, Stepp H, Hallfeldt KKJ (2019) Parathyroid autofluorescence-how does it affect parathyroid and thyroid surgery? A 5 year experience. Molecules 24(14):2560","journal-title":"Molecules"},{"key":"3256_CR22","doi-asserted-by":"publisher","first-page":"1190282","DOI":"10.3389\/fendo.2023.1190282","volume":"14","author":"KM Ali","year":"2023","unstructured":"Ali KM, Wolfe SA, Nagururu NV et al (2023) Parathyroid gland detection using an intraoperative autofluorescence handheld imager - early feasibility study. Front Endocrinol (Lausanne) 14:1190282","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"3256_CR23","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00423-021-02269-8","volume":"407","author":"DH Kim","year":"2022","unstructured":"Kim DH, Lee S, Jung J, Kim S, Kim SW, Hwang SH (2022) Near-infrared autofluorescence-based parathyroid glands identification in the thyroidectomy or parathyroidectomy: a systematic review and meta-analysis. Langenbecks Arch Surg 407(2):491\u2013499","journal-title":"Langenbecks Arch Surg"},{"issue":"8","key":"3256_CR24","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1007\/s00464-016-5338-3","volume":"31","author":"R Ladurner","year":"2017","unstructured":"Ladurner R, Sommerey S, Arabi NA, Hallfeldt KKJ, Stepp H, Gallwas JKS (2017) Intraoperative near-infrared autofluorescence imaging of parathyroid glands. Surg Endosc 31(8):3140\u20133145","journal-title":"Surg Endosc"},{"issue":"6","key":"3256_CR25","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00268-009-0363-1","volume":"34","author":"Z El Khatib","year":"2010","unstructured":"El Khatib Z, Lamblin J, Aubert S et al (2010) Is thymectomy worthwhile in central lymph node dissection for differentiated thyroid cancer? World J Surg. 34(6):1181\u20131186","journal-title":"World J Surg."},{"issue":"2","key":"3256_CR26","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.jamcollsurg.2016.04.049","volume":"223","author":"J Falco","year":"2016","unstructured":"Falco J, Dip F, Quadri P, de la Fuente M, Rosenthal R (2016) Cutting edge in thyroid surgery: autofluorescence of parathyroid glands. J Am Coll Surg 223(2):374\u2013380","journal-title":"J Am Coll Surg"},{"issue":"7","key":"3256_CR27","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1002\/jso.26603","volume":"124","author":"E Berber","year":"2021","unstructured":"Berber E, Akbulut S (2021) Can near-infrared autofluorescence imaging be used for intraoperative confirmation of parathyroid tissue? J Surg Oncol 124(7):1008\u20131013","journal-title":"J Surg Oncol"},{"issue":"6","key":"3256_CR28","doi-asserted-by":"publisher","first-page":"067012","DOI":"10.1117\/1.3583571","volume":"16","author":"C Paras","year":"2011","unstructured":"Paras C, Keller M, White L, Phay J, Mahadevan-Jansen A (2011) Near-infrared autofluorescence for the detection of parathyroid glands. J Biomed Opt 16(6):067012","journal-title":"J Biomed Opt"},{"issue":"1","key":"3256_CR29","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/ohn.272","volume":"169","author":"BM Su-Velez","year":"2023","unstructured":"Su-Velez BM, Hartman GE, Seeley H, Orloff LA, Noel JE, Meister KD (2023) Parathyroid autofluorescence in pediatric thyroid surgery: experience with false positive and false negative results. Otolaryngol Head Neck Surg 169(1):185\u2013189","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"3256_CR30","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.surg.2015.06.047","volume":"159","author":"MA McWade","year":"2016","unstructured":"McWade MA, Sanders ME, Broome JT, Sol\u00f3rzano CC, Mahadevan-Jansen A (2016) Establishing the clinical utility of autofluorescence spectroscopy for parathyroid detection. Surgery 159(1):193\u2013202","journal-title":"Surgery"}],"updated-by":[{"DOI":"10.1007\/s00423-024-03580-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000}}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-024-03256-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-024-03256-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-024-03256-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:02:09Z","timestamp":1735257729000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-024-03256-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3256"],"URL":"https:\/\/doi.org\/10.1007\/s00423-024-03256-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3602841\/v1","asserted-by":"object"}]},"ISSN":["1435-2451"],"issn-type":[{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]},"assertion":[{"value":"13 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: In this article, Guan Lv was affiliated with \u2018Nanjing Medical University, Nanjing, China\u2019 and JianFeng Sang was affiliated with \u2018Nanjing Drum Tower Hospital, Nanjing, China\u2019. The correct affiliation of both authors should be \u2018Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China\u2019","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00423-024-03580-w","URL":"https:\/\/doi.org\/10.1007\/s00423-024-03580-w","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"96"}}