{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:56:04Z","timestamp":1774677364826,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To assess the association of postoperative C-reactive protein (CRP), leucocytes and vital signs in the first three postoperative days (PODs) with major complications after oncological colorectal resections in a tertiary referral centre for colorectal cancer in The Netherlands.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective cohort study, including 594 consecutive patients who underwent an oncological colorectal resection at Maastricht University Medical Centre between January 2016 and December 2020. Descriptive analyses of patient characteristics were performed. Logistic regression models were used to assess associations of leucocytes, CRP and Modified Early Warning Score (MEWS) at PODs 1\u20133 with major complications. Receiver operating characteristic curve analyses were used to establish cut-off values for CRP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 364 (61.3%) patients have recovered without any postoperative complications, 134 (22.6%) patients have encountered minor complications and 96 (16.2%) developed major complications. CRP levels reached their peak on POD 2, with a mean value of 155\u00a0mg\/L. This peak was significantly higher in patients with more advanced stages of disease and patients undergoing open procedures, regardless of complications<jats:italic>.<\/jats:italic> A cut-off value of 170\u00a0mg\/L was established for CRP on POD 2 and 152\u00a0mg\/L on POD 3. Leucocytes and MEWS also demonstrated a peak on POD 2 for patients with major complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Statistically significant associations were found for CRP, \u0394 CRP, \u0394 leucocytes and MEWS with major complications on POD 2. Patients with CRP levels\u2009\u2265\u2009170\u00a0mg\/L on POD 2 should be carefully evaluated, as this may indicate an increased risk of developing major complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00423-024-03266-3","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T04:40:12Z","timestamp":1709008812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The value of C-reactive protein, leucocytes and vital signs in detecting major complications after oncological colorectal surgery"],"prefix":"10.1007","volume":"409","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-9349","authenticated-orcid":false,"given":"Anke H. 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