{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:22:44Z","timestamp":1786980164359,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018936","name":"Universit\u00e4tsklinikum Heidelberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018936","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Sufficient liver function is crucial in extracellular matrix growth, hemostasis, and wound healing. Repeated abdominal surgery is a known risk factor for the development of wound complications. This study aimed to evaluate this high-risk constellation in patients undergoing associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) and repeated liver resections (RLR) in comparison to single liver resection (SLR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Forty patients who underwent ALPPS between 2011 and 2020 were evenly matched with patients undergoing RLR or SLR (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940 per group) using propensity scores. Postoperative outcomes were compared and factors associated with wound complications were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Postoperative wound complications were significantly more frequent in ALPPS group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The reoperation rate was not significantly different between the three groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.143). However, surgical reintervention due to wound complications occurred more frequently in the ALPPS group in relation to RLR and SLR (17.5% vs. 7.5% and 5% respectively). Length of stay was significantly longer in the ALPPS group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). ALPPS was an independent risk factor for postoperative wound complication (OR\u2009=\u20098.55, 95% CI:1.07\u201368.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043). Risk factor analysis identified age\u2009\u2265\u200960 years (OR\u2009=\u200927.64, 95% CI:3.09-246.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), BMI\u2009\u2265\u200930\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (OR\u2009=\u200930.21, 95% CI:3.35-271.83,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and low postoperative albumin levels (OR\u2009=\u2009168.41, 95% CI:7.76-3651.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) as independent predictors of postoperative wound complications after major liver resection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients undergoing ALPPS and RLR are faced with a high risk of developing wound complications. Older age, obesity, a history of previous abdominal surgery, and a decreased postoperative albumin level were independent risk factors for wound complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-024-03540-4","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T01:01:39Z","timestamp":1731459699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk factors for wound complications after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) compared to repeated liver resection - a propensity score matching analysis"],"prefix":"10.1007","volume":"409","author":[{"given":"Elias","family":"Khajeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Sabetkish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ramouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Werba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Klotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph W.","family":"Michalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianeb","family":"Mehrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Pianka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"issue":"3","key":"3540_CR1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.5582\/bst.2022.01245","volume":"16","author":"H Maki","year":"2022","unstructured":"Maki H, Hasegawa K (2022) Advances in the surgical treatment of liver cancer. 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