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Additionally, 60 (24.5%) were diagnosed with non-specific abdominal pain (NSAP), and 18 (7.3%) with gallstones without cholecystitis. Median PCT levels were significantly higher in patients with calculous cholecystitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and pancreatitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) compared to those with NSAP. The proportion of patients with a PCT cut-off \u2265\u20090.04\u00a0\u00b5g\/L was significantly higher across all IAI subgroups compared to the NSAP group. However, 18 (10.8%) of IAI patients exhibited PCT levels\u2009\u2265\u20090.5\u00a0\u00b5g\/L, indicating systemic infection. Spearman\u2019s rho analysis revealed a significant correlation between PCT and LC, NC, and CRP in patients with IAI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Moreover, median PCT levels were significantly higher in perforation\/abscess vs. gangrenous appendicitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), complicated vs. uncomplicated diverticulitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048), and severe vs. mild cholecystitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PCT correlates strongly with conventional inflammatory biomarkers in patients with IAI. However, PCT appears to offer limited additional clinical value for guiding therapeutic decisions concerning the initial diagnosis and\/or severity grading of IAI in patients admitted with acute abdomen. Further research is warranted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-025-03636-5","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T03:34:14Z","timestamp":1741664054000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of procalcitonin versus conventional inflammatory biomarkers for clinical severity grading in patients with intra-abdominal infection"],"prefix":"10.1007","volume":"410","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-792X","authenticated-orcid":false,"given":"Cihan","family":"Ozen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Karasoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5427-8118","authenticated-orcid":false,"given":"Ali","family":"Yalcinkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sine Huus","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-0155","authenticated-orcid":false,"given":"Steen Kaare","family":"Fagerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-8758","authenticated-orcid":false,"given":"Peter","family":"Hindersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Derek Christian","family":"Leutscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4680-8344","authenticated-orcid":false,"given":"Kathrine","family":"Holte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"issue":"9","key":"3636_CR1","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1111\/ans.15255","volume":"89","author":"A Teo","year":"2019","unstructured":"Teo A, Wang C, Wilson RB (2019) Time is of the essence: evaluation of emergency department triage and time performance in the preoperative management of acute abdomen. 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