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The aim of this study was to investigate the association between secondary generalized peritonitis and short-term mortality and postoperative complications in patients undergoing major abdominal emergency surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included patients with the age\u2009\u2265\u200918\u00a0years undergoing major emergency abdominal surgery in a University Hospital from 2017 to 2019 after the introduction of a perioperative bundle care program. The primary outcome measures were short-term mortality, defined as death within 30 and 90\u00a0days after surgery and postoperative complications within 30\u00a0days after surgery. Uni- and multivariable logistic regression analyses were performed to evaluate risk factors for 30- and 90-days mortality and 30-days postoperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 591 patients were included, of whom 21% (124\/591) had generalized peritonitis. The overall 30\u00a0day-mortality rate was 12.5% (74\/591). Patients with generalized peritonitis had a significantly higher 30-day mortality rate than patients with non-generalized peritonitis 18.5% (23\/124) vs. 10.9% (51\/467),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033. Generalized peritonitis was an independent risk factor for 30- and 90- days mortality. There was a significantly higher rate of admission to ICU for patients with generalized peritonitis 39.5% (49\/124) vs. 12.6% (59\/467),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001. Patients with generalized peritonitis had significantly higher rates of surgical and non-surgical complication compared to patients with non-generalized peritonitis 87.1% (108\/124) vs. 65.7% (307\/467),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001. Generalized peritonitis was an independent risk factor of 30\u00a0days postoperative complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a population undergoing major emergency abdominal surgery treated in a perioperative optimization protocol, generalized peritonitis was an independent risk factor for both 30- and 90-days mortality and postoperative complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-025-03637-4","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T11:34:48Z","timestamp":1739273688000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["High risk of short-term mortality and postoperative complications in patients with generalized peritonitis undergoing major emergency abdominal surgery\u2014a cohort study"],"prefix":"10.1007","volume":"410","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-8381","authenticated-orcid":false,"given":"Maria","family":"Olausson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette A.","family":"Tolver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"G\u00f6genur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"3637_CR1","doi-asserted-by":"crossref","unstructured":"Murray CJL, Vos T, Lozano R et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in: a systematic analysis for the Global Burden of Disease Study 2010. 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