{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:20:28Z","timestamp":1772119228139,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100021092","name":"University of Yamanashi","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100021092","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This retrospective study investigated the validity of pancreatoduodenectomy (PD) with regard to recurrence in older patients with distal cholangiocarcinoma (DC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared 28 patients aged\u2009\u2265\u200975 years and 65 patients aged\u2009&lt;\u200975 years who underwent PD for DC, and evaluated the relationship between age, clinicopathological factors, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Postoperative mortality and morbidity rates did not differ between the groups. Although there were no significant differences in 5-year recurrence, disease-specific survival, and overall survival rates between the groups (45.4, 58.1, and 51.7% in patients\u2009\u2265\u200975 years and 50.3%, 62.7%, and 58.1% in patients\u2009&lt;\u200975 years;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.73, 0.44, and 0.24, respectively), the median time from recurrence to death (RTD) in older patients was significantly shorter than that in younger patients (0.5 years vs. 1.3 years,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.013). In multivariate analysis, age\u2009\u2265\u200975 years (hazard ratio [HR]: 3.0), controlling nutritional status (CONUT) score\u2009\u2265\u20094 (HR: 2.5), poorly-differentiated adenocarcinoma or adenosquamous carcinoma (HR: 3.2), and failure to implement treatment after recurrence (HR: 5.3) were independent risk factors for a short time from RTD. Furthermore, at the time of recurrence, older patients had significantly poorer serum albumin levels, prognostic nutrition index, Glasgow prognostic score, and CONUT score. Age\u2009\u2265\u200975 years (odds ratio: 0.19) was an independent risk factor for implementation of treatment after recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PD in older patients may be acceptable; however, the median time from RTD was shorter owing to lower nutritional status and rates of treatment implementation after recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-025-03694-9","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T13:23:46Z","timestamp":1743773026000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the validity of pancreatoduodenectomy in older patients with distal cholangiocarcinoma in terms of recurrence"],"prefix":"10.1007","volume":"410","author":[{"given":"Wataru","family":"Izumo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Kawaida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Nakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetake","family":"Amemiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudai","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Shoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"3694_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69\u201390","journal-title":"CA Cancer J Clin"},{"key":"3694_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2407-2-10","volume":"3","author":"T Patel","year":"2002","unstructured":"Patel T (2002) Worldwide trends in mortality from biliary tract malignancies. BMC Cancer 3:10","journal-title":"BMC Cancer"},{"key":"3694_CR3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrclinonc.2017.157","volume":"15","author":"S Rizvi","year":"2018","unstructured":"Rizvi S, Khan SA, Hallemeier CL, Kelley RK, Gores GJ (2018) Cholangiocarcinoma\u2013 evolving concepts and therapeutic strategies. Nat Rev Clin Oncol 15:95\u2013111","journal-title":"Nat Rev Clin Oncol"},{"key":"3694_CR4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/jhbp.870","volume":"28","author":"M Nagino","year":"2021","unstructured":"Nagino M, Hirano S, Yoshitomi H, Aoki T, Uesaka K, Unno M, Ebata T, Konishi M, Sano K, Shimada K, Shimizu H, Higuchi R, Wakai T, Isayama H, Okusaka T, Tsuyuguchi T, Hirooka Y, Furuse J, Maguchi H, Suzuki K, Yamazaki H, Kijima H, Yanagisawa A, Yoshida M, Yokoyama Y, Mizuno T, Endo I (2021) Clinical practice guidelines for the management of biliary tract cancers 2019: the 3rd english edition. J Hepatobiliary Pancreat Sci 28:26\u201354","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"3694_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/bjs.9367","volume":"101","author":"AM Smith","year":"2014","unstructured":"Smith AM, Liaskos C, Verbeke CS (2014) Impact of intrapancreatic or extrapancreatic bile duct involvement on survival following pancreatoduodenectomy for common bile duct cancer. Br J Surg 101:89\u201399","journal-title":"Br J Surg"},{"key":"3694_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.annonc.2022.10.506","volume":"34","author":"A Vogel","year":"2023","unstructured":"Vogel A, Bridgewater J, Edeline J, Kelley RK, Kl\u00fcmpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M, ESMO Guidelines Committee (2023) Biliary tract cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol 34:127\u2013140","journal-title":"Ann Oncol"},{"key":"3694_CR7","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1016\/j.surg.2012.05.022","volume":"152","author":"C Fernandez-del Castillo","year":"2012","unstructured":"Fernandez-del Castillo C, Morales-Oyarvide V, McGrath D, Wargo JA, Ferrone CR, Thayer SP et al (2012) Evolution of the Whipple procedure at the Massachusetts general hospital. Surgery 152:S56\u2013S63","journal-title":"Surgery"},{"key":"3694_CR8","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/ags3.12324","volume":"4","author":"Y Kakeji","year":"2020","unstructured":"Kakeji Y, Takahashi A, Hasegawa H, Ueno H, Eguchi S, Endo I, Sasaki A, Takiguchi S, Takeuchi H, Hashimoto M, Horiguchi A, Masaki T, Marubashi S, Yoshida K, Gotoh M, Konno H, Yamamoto H, Miyata H, Seto Y, Kitagawa Y (2020) National clinical database. Surgical outcomes in gastroenterological surgery in Japan: report of the National clinical database.2011\u20132018. Ann Gastroenterol Surg 4:250\u2013274","journal-title":"Ann Gastroenterol Surg"},{"key":"3694_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.maturitas.2020.05.018","volume":"139","author":"E Rudnicka","year":"2020","unstructured":"Rudnicka E, Napoerala P, Podfigurna A, Meczekalski B, Smolarczyk R, Grymowicz M (2020) The world health organization (WHO) approach to healthy ageing. Maturitas 139:6\u201311","journal-title":"Maturitas"},{"key":"3694_CR10","unstructured":"Ministry of Health Labour and Welfare. chrome-extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/life\/tdfk20\/dl\/tdfk20-10.pdf"},{"key":"3694_CR11","unstructured":"https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/kenkou_iryou\/iryouhoken\/koukikourei\/index.html"},{"key":"3694_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0022-510X(88)90132-3","volume":"84","author":"J Lexell","year":"1988","unstructured":"Lexell J, Taylor CC, Sj\u00f6str\u00f6m M (1988) What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole Vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci 84:275\u2013294","journal-title":"J Neurol Sci"},{"key":"3694_CR13","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1086\/402632","volume":"34","author":"BL Strechler","year":"1959","unstructured":"Strechler BL (1959) Origin and comparison of the feects of time and high-energy radiations on living systems. Quart Rev Biol 34:117\u2013142","journal-title":"Quart Rev Biol"},{"key":"3694_CR14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00535-015-1103-y","volume":"51","author":"M Okuno","year":"2016","unstructured":"Okuno M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M (2016) Evaluation of inflammation-based prognostic scores in patients undergoing hepatobiliary resection for Perihilar cholangiocarcinoma. J Gastroenterol 51:153\u2013161","journal-title":"J Gastroenterol"},{"key":"3694_CR15","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1007\/s00268-017-3985-8","volume":"41","author":"K Takagi","year":"2017","unstructured":"Takagi K, Yagi T, Umeda Y, Shinoura S, Yoshida R, Nobuoka D, Kuise T, Araki H, Fujiwara T (2017) Preoperative controlling nutritional status (CONUT) score for assessment of prognosis following hepatectomy for hepatocellular carcinoma. World J Surg 41:2353\u20132360","journal-title":"World J Surg"},{"key":"3694_CR16","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s00423-021-02151-7","volume":"406","author":"M Shiihara","year":"2021","unstructured":"Shiihara M, Higuchi R, Izumo W, Yazawa T, Uemura S, Furukawa T, Yamamoto M (2021) Impact of the controlling nutritional status score on severe postoperative complications of pancreaticoduodenectomy for pancreatic cancer. Langenbecks Arch Surg 406:1491\u20131498","journal-title":"Langenbecks Arch Surg"},{"key":"3694_CR17","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1007\/s00423-021-02170-4","volume":"406","author":"W Izumo","year":"2021","unstructured":"Izumo W, Higuchi R, Furukawa T, Yazawa T, Uemura S, Matsunaga Y, Shiihara M, Yamamoto M (2021) Evaluation of the validity of pancreatectomy for very elderly patients with pancreatic ductal adenocarcinoma. Langenbecks Arch Surg 406:1081\u20131092","journal-title":"Langenbecks Arch Surg"},{"key":"3694_CR18","doi-asserted-by":"publisher","first-page":"6347","DOI":"10.21873\/anticanres.13846","volume":"39","author":"K Sugimachi","year":"2019","unstructured":"Sugimachi K, Iguchi T, Mano Y, Nishijima T, Nakanoko T, Uehara H et al (2019) The impact of immunonutritional and physical status on surgical outcome after pancreaticoduodenectomy in elderly patients. Anticancer Res 39:6347\u20136353","journal-title":"Anticancer Res"},{"key":"3694_CR19","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/ags3.12395","volume":"5","author":"T Okabayashi","year":"2021","unstructured":"Okabayashi T, Sui K, Murokawa T, Kimura J, Iwata J, Morita S et al (2021) Indications for pancreaticoduodenectomy affected postoperative outcomes in octogenarians. Ann Gastroenterol Surg 5:102\u2013110","journal-title":"Ann Gastroenterol Surg"},{"key":"3694_CR20","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s00423-023-02843-2","volume":"408","author":"N Ikenaga","year":"2023","unstructured":"Ikenaga N, Nakata K, Abe T, Ideno N, Fujimori N, Oono T et al (2023) Risks and benefits of pancreaticoduodenectomy in patients aged 80 years and over. Langenbecks Arch Surg 408:108","journal-title":"Langenbecks Arch Surg"},{"key":"3694_CR21","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/jhbp.1396","volume":"31","author":"Y Mori","year":"2024","unstructured":"Mori Y, Okawara M, Shibao K, Kohi S, Tamura T, Sato N, Fujino Y, Fushimi K, Matsuda S, Hirata K (2024) Short-term outcomes of pancreatoduodenectomy in older individuals over a 9-year period using real-world data: A multilevel analysis based on a nationwide administrative database in Japan. J Hepatobiliary Pancreat Sci 31:262\u2013272","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"3694_CR22","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.jgo.2021.02.004","volume":"12","author":"W Zhang","year":"2021","unstructured":"Zhang W, Huang Z, Zhang J, Che X (2021) Safety and effectiveness of open pancreaticoduodenectomy in adults aged 70 or older: a meta-analysis. J Geriatr Oncol 12:1136\u20131145","journal-title":"J Geriatr Oncol"},{"key":"3694_CR23","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.jgo.2019.10.012","volume":"11","author":"WL Shaib","year":"2020","unstructured":"Shaib WL, Zakka K, Hoodbhoy FN, Belalcazar A, Kim S, Cardona K et al (2020) In-hospital 30-day mortality for older patients with pancreatic cancer undergoing pancreaticoduodenectomy. J Geriatr Oncol 11:660\u2013667","journal-title":"J Geriatr Oncol"},{"key":"3694_CR24","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ijsu.2018.11.016","volume":"60","author":"F Yuan","year":"2018","unstructured":"Yuan F, Essaji Y, Belley-Cote EP, Gafni A, Latchupatula L, Ruo L et al (2018) Postoperative complications in elderly patients following pancreaticoduodenectomy lead to increased postoperative mortality and costs. A retrospective cohort study. Int J Surg 60:204\u2013209","journal-title":"Int J Surg"},{"key":"3694_CR25","unstructured":"Cancer Statistics Cancer information service, National cancer center, Japan (National cancer registry, ministry of health, labour and Welfare). https:\/\/ganjoho.jp\/reg_stat\/statistics\/data\/dl\/excel\/cancer_incidenceNCR(2016-2020).xls"},{"key":"3694_CR26","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1097\/ALN.0000000000001541","volume":"126","author":"EE Hurwitz","year":"2017","unstructured":"Hurwitz EE, Simon M, Vinta SR, Zehm CF, Shabot SM, Minhajuddin A, Abouleish AE (2017) Adding examples to the ASA-Physical status classification improves correct assignment to patients. Anesthesiology 126:614\u2013622","journal-title":"Anesthesiology"},{"key":"3694_CR27","volume-title":"AJCC cancer staging manual","author":"MB Amin","year":"2017","unstructured":"Amin MB, American Joint Committee on Cancer (2017) AJCC cancer staging manual, 8th edn. Springer, New York, NY","edition":"8"},{"key":"3694_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205\u2013213","journal-title":"Ann Surg"},{"key":"3694_CR29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.surg.2005.05.001","volume":"138","author":"C Bassi","year":"2005","unstructured":"Bassi C, Dervenis C, Butturini G, the International Study Group on Pancreatic Fistula Definition (2005) Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 138:8\u201313","journal-title":"Surgery"},{"key":"3694_CR30","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","volume":"142","author":"MN Wente","year":"2007","unstructured":"Wente MN, Bassi C, Dervenis C et al (2007) Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the international study group of pancreatic surgery (ISGPS). Surgery 142:761\u2013768","journal-title":"Surgery"},{"key":"3694_CR31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.surg.2007.02.001","volume":"142","author":"MN Wente","year":"2007","unstructured":"Wente MN, Veit JA, Bassi C et al (2007) Postpancreatectomy hemorrhage (PPH): an international study group of pancreatic surgery (ISGPS) definition. Surgery 142:20\u201325","journal-title":"Surgery"},{"key":"3694_CR32","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1200\/JCO.21.02568","volume":"40","author":"J Bridgewater","year":"2022","unstructured":"Bridgewater J, Fletcher P, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans TR, Stocken D, Stubbs C, Praseedom R, Ma YT, Davidson B, Neoptolemos J, Iveson T, Cunningham D, Garden OJ, Valle JW, Primrose J, BILCAP study group (2022) Long-Term outcomes and exploratory analyses of the randomized phase III BILCAP study. J Clin Oncol 40:2048\u20132057","journal-title":"J Clin Oncol"},{"key":"3694_CR33","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0140-6736(22)02038-4","volume":"401","author":"K Nakachi","year":"2023","unstructured":"Nakachi K, Ikeda M, Konishi M, Nomura S, Katayama H, Kataoka T, Todaka A, Yanagimoto H, Morinaga S, Kobayashi S, Shimada K, Takahashi Y, Nakagohri T, Gotoh K, Kamata K, Shimizu Y, Ueno M, Ishii H, Okusaka T, Furuse J, Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG) (2023) Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial. Lancet 401:195\u2013203","journal-title":"Lancet"},{"key":"3694_CR34","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/jhbp.1219","volume":"30","author":"T Ioka","year":"2023","unstructured":"Ioka T, Kanai M, Kobayashi S, Sakai D, Eguchi H, Baba H, Seo S, Taketomi A, Takayama T, Yamaue H, Takahashi M, Sho M, Kamei K, Fujimoto J, Toyoda M, Shimizu J, Goto T, Shindo Y, Yoshimura K, Hatano E, Nagano H (2023) Kansai hepatobiliary oncology group (KHBO). Randomized phase III study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401- MITSUBA). J Hepatobiliary Pancreat Sci 30:102\u2013110","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"3694_CR35","doi-asserted-by":"publisher","first-page":"EVIDoa2200015","DOI":"10.1056\/EVIDoa2200015","volume":"1","author":"D Oh","year":"2022","unstructured":"Oh D, Ruth HA, Qin S, Chen LT, Okusaka T, Vogel A et al (2022) Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer. NEJM Evid 1:EVIDoa2200015","journal-title":"NEJM Evid"},{"key":"3694_CR36","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1186\/s12885-021-08247-z","volume":"21","author":"C Tawarungruang","year":"2021","unstructured":"Tawarungruang C, Khuntikeo N, Chamadol N, Laopaiboon V, Thuanman J, Thinkhamrop K et al (2021) Survival after surgery among patients with cholangiocarcinoma in Northeast Thailand according to anatomical and morphological classification. BMC Cancer 21:497. chromeextension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/ganjoho.jp\/public\/qa_links\/report\/statistics\/pdf\/cancer_statistics_2024_fig_J.pdf","journal-title":"BMC Cancer"},{"key":"3694_CR37","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1200\/JCO.2012.42.9894","volume":"31","author":"T Aparicio","year":"2013","unstructured":"Aparicio T, Jouve JL, Teillet L, Gargot D, Subtil F, Le Brun-Ly V et al (2013) Geriatric factors predict chemotherapy feasibility: ancillary results of FFCD 2001-02 phase Iii study in first-line chemotherapy for metastatic colorectal cancer in elderly patients. J Clin Oncol 31:1464\u20131470","journal-title":"J Clin Oncol"},{"key":"3694_CR38","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1002\/cncr.26646","volume":"118","author":"M Extermann","year":"2012","unstructured":"Extermann M, Boler I, Reich RR, Lyman GH, Brown RH, DeFelice J, Levine RM, Lubiner ET, Reyes P, Schreiber FJ III, Balducci L (2012) Predicting the risk of chemotherapy toxicity in older patients: the chemotherapy risk assessment scale for high-age patients (CRASH) score. Cancer 118:3377\u20133386","journal-title":"Cancer"},{"key":"3694_CR39","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.ejso.2019.12.008","volume":"46","author":"H Jansson","year":"2020","unstructured":"Jansson H, Cornillet M, Bj\u00f6rkstr\u00f6m NK, Sturesson C, Sparrelid E (2020) Prognostic value of preoperative inflammatory markers in resectable biliary tract cancer - Validation and comparison of the Glasgow prognostic score and modified Glasgow prognostic score in a Western cohort. Eur J Surg Oncol 46:804\u2013810","journal-title":"Eur J Surg Oncol"},{"key":"3694_CR40","first-page":"1","volume":"66","author":"X Lv","year":"2020","unstructured":"Lv X, Zhang Z, Yuan W (2020) Pretreatment prognostic nutritional index (PNI) as a prognostic factor in patients with biliary tract cancer: a meta-analysis. Nutr Cancer 66:1\u201310","journal-title":"Nutr Cancer"},{"key":"3694_CR41","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1245\/s10434-020-08728-8","volume":"28","author":"J Wang","year":"2021","unstructured":"Wang J, Bo X, Li M, Nan L, Wang C, Gao Z, Suo T, Ni X, Liu H, Han J, Lu P, Liu H, Wang Y (2021) Prediction efficacy for clinical outcome of prognostic nutritional index in patients with resectable biliary tract cancer depends on sex and obstructive jaundice status. Ann Surg Oncol 28:430\u2013438","journal-title":"Ann Surg Oncol"},{"key":"3694_CR42","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1007\/s12029-024-01034-6","volume":"55","author":"M Utsumi","year":"2024","unstructured":"Utsumi M, Inagaki M, Kitada K, Tokunaga N, Yonoki K, Sakurai Y, Okabayashi H, Hamano R, Miyasou H, Tsunemitsu Y, Otsuka S (2024) Prognostic significance of sarcopenia and systemic inflammatory markers in biliary tract cancer: A retrospective cohort study. J Gastrointest Cancer 55:888\u2013899","journal-title":"J Gastrointest Cancer"},{"key":"3694_CR43","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1002\/jso.23900","volume":"111","author":"G Spolverato","year":"2015","unstructured":"Spolverato G, Maqsood H, Kim Y, Margonis G, Luo T, Ejaz A, Pawlik TM (2015) Neutrophil-lymphocyte and platelet\u2013lymphocyte ratio in patients after resection for hepato-pancreatico-biliary malignancies. J Surg Oncol 111:868\u2013874","journal-title":"J Surg Oncol"},{"key":"3694_CR44","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1007\/s11605-020-04725-0","volume":"25","author":"AI Al Abbas","year":"2021","unstructured":"Al Abbas AI, Borrebach JD, Pitt HA, Bellon J, Hogg ME, Zeh HJ 3rd, Zureikat AH (2021) Development of a novel Pancreatoduodenectomy-Specific risk calculator: an analysis of 10,000 patients. J Gastrointest Surg 25:1503\u20131511","journal-title":"J Gastrointest Surg"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-025-03694-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-025-03694-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-025-03694-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T14:53:48Z","timestamp":1743864828000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-025-03694-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3694"],"URL":"https:\/\/doi.org\/10.1007\/s00423-025-03694-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4688865\/v1","asserted-by":"object"}]},"ISSN":["1435-2451"],"issn-type":[{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]},"assertion":[{"value":"5 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"119"}}