{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:22:42Z","timestamp":1786980162476,"version":"build-2736575974"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universitat de Valencia"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The most common cause (&gt;\u200980% of cases) of primary hyperparathyroidism (PHPT) is parathyroid adenoma. Its diagnosis is conventionally made by cervical ultrasound and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI scintigraphy. However [\n                      <jats:sup>18<\/jats:sup>\n                      F-Choline PET-CT ( [\n                      <jats:sup>18<\/jats:sup>\n                      F-FCh PET-CT) offers greater sensitivity and specificity, although at a high cost, which prevents it from being a first-line diagnostic method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Observational retrospective cohort study of 100 consecutive patients operated on for PHPT by parathyroidectomy in a tertiary hospital. Patients were divided into two groups: Group 1, patients with successful diagnosis using conventional tests (42 patients) and Group 2, patients with an initial failed diagnosis who required\n                      <jats:sup>18<\/jats:sup>\n                      F-FCh PET-CT (52 patients). A group with an ideal diagnostic strategy using only\n                      <jats:sup>18<\/jats:sup>\n                      F-FCh PET-CT was simulated and the costs were compared with the groups in the sample.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sample finally analyzed 94 patients, 78.7% female, mean age 61.73 years. 55,3 % of the patients required a\n                      <jats:sup>18<\/jats:sup>\n                      F-FCh PET-CT for the location diagnosis. The group 2 required more consultations, more complementary tests and a longer interval between the first consultation and the intervention. The ideal diagnostic strategy (\u20ac1,399.77\/patient) represents a lower cost than the other strategy (\u20ac1,730.61\/patient).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The diagnosis of location of a parathyroid adenoma with\n                      <jats:sup>18<\/jats:sup>\n                      F-FCh PET-CT required fewer complementary tests and consultations, reducing the interval until surgical intervention, with no difference in surgical results. The costs if\n                      <jats:sup>18<\/jats:sup>\n                      F-Ch PET-CT is performed as the only location diagnostic test are lower when a group of patients is studied, so its use is recommended as a first line diagnostic tool.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical trial number<\/jats:bold>\n                      : Not applicable.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-025-03824-3","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T08:25:30Z","timestamp":1753950330000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is the\u00a018F-choline PET-CT more cost-effective than standard protocol for locating a parathyroid adenoma?"],"prefix":"10.1007","volume":"410","author":[{"given":"Joaqu\u00edn","family":"Ortega-Serrano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Serrano-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Alfonso-Ballester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Mart\u00ed-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Lape\u00f1a-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael D\u00edaz","family":"Exp\u00f3sito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Cassinello-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"3824_CR1","doi-asserted-by":"publisher","unstructured":"Palermo A, Tabacco G, Makras P, Zavatta G, Trimboli P, Castellano E et al (2024) Primary hyperparathyroidism: from guidelines to outpatient clinic. 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