{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:33:18Z","timestamp":1783578798239,"version":"3.55.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the impact of extended versus nonextended perioperative antibiotic prophylaxis (PAP) on reducing postoperative complications and hospital stays in patients undergoing radical cystectomy and urinary diversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted this systematic review and meta-analysis in accordance with the PRISMA guidelines. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and the Cochrane Library for studies comparing short-term (\u2264\u200924\u00a0h) and extended (\u2265\u200924\u00a0h) PAP in patients undergoing radical cystectomy and urinary diversion. The primary outcomes were surgical site infections (SSIs), urinary tract infections (UTIs), and length of hospital stay. The statistical analysis was performed via RevMan version 5.3. The results are presented as risk ratios (RRs) and mean differences (MDs). Results are presented as risk ratios (RRs) and mean differences (MDs). The quality of evidence was assessed using the GRADE methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 214 studies were screened. Four studies involving 680 patients were included. No significant differences were detected between short-term and extended PAP in terms of SSIs (RR\u2009=\u20090.71 [95% CI 0.43\u20131.17];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.18]), febrile UTIs (RR\u2009=\u20091.19 [95% CI 0.91\u20131.56];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.20]), or length of hospital stay (MD\u2009=\u20090.76 days [95% CI [-2.72, 4.25];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.67]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No significant difference was observed between 24-h and extended PAP for reducing postoperative complications after radical cystectomy and urinary diversion. Short-term PAP is a reliable and effective strategy and is recommended as the standard practice for reducing antimicrobial resistance and improving postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-025-03943-x","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:13:53Z","timestamp":1768464833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimal duration of perioperative antibiotics in radical cystectomy and urinary diversion: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"411","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8580-2266","authenticated-orcid":false,"given":"Tarek","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha\u2019 Aldeen","family":"Bani Irshid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8122-1786","authenticated-orcid":false,"given":"Hamza","family":"Elhashamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6197-3273","authenticated-orcid":false,"given":"Mohammad Ghassab","family":"Deameh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Hassab El-Naby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3408-9953","authenticated-orcid":false,"given":"Mohamed","family":"Ramez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"3943_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.euo.2018.07.006","volume":"2","author":"SB Williams","year":"2019","unstructured":"Williams SB, Hudgins HK, Ray-Zack MD et al (2019) Systematic review of factors associated with the utilization of radical cystectomy for bladder cancer. Eur Urol Oncol 2:119\u2013125. https:\/\/doi.org\/10.1016\/j.euo.2018.07.006","journal-title":"Eur Urol Oncol"},{"key":"3943_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/MOU.0000000000000738","volume":"30","author":"N Almassi","year":"2020","unstructured":"Almassi N, Bochner BH (2020) Ileal conduit or orthotopic neobladder: selection and contemporary patterns of use. Curr Opin Urol 30:415\u2013420. https:\/\/doi.org\/10.1097\/MOU.0000000000000738","journal-title":"Curr Opin Urol"},{"key":"3943_CR3","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.juro.2007.05.028","volume":"178","author":"E Kouba","year":"2007","unstructured":"Kouba E, Sands M, Lentz A et al (2007) Incidence and risk factors for stomal complications in patients undergoing cystectomy with ileal conduit urinary diversion for bladder cancer. J Urol 178:950\u2013954. https:\/\/doi.org\/10.1016\/j.juro.2007.05.028","journal-title":"J Urol"},{"key":"3943_CR4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.eururo.2014.12.007","volume":"67","author":"G Novara","year":"2015","unstructured":"Novara G, Catto JWF, Wilson T et al (2015) Systematic review and cumulative analysis of perioperative outcomes and complications after robot-assisted radical cystectomy. Eur Urol 67:376\u2013401. https:\/\/doi.org\/10.1016\/j.eururo.2014.12.007","journal-title":"Eur Urol"},{"key":"3943_CR5","doi-asserted-by":"publisher","first-page":"320","DOI":"10.5455\/medarh.2017.71.320-324","volume":"71","author":"A Prcic","year":"2017","unstructured":"Prcic A, Begic E (2017) Complications after ileal urinary derivations. Med Arch 71:320\u2013324. https:\/\/doi.org\/10.5455\/medarh.2017.71.320-324","journal-title":"Med Arch"},{"key":"3943_CR6","doi-asserted-by":"publisher","first-page":"e2439382","DOI":"10.1001\/jamanetworkopen.2024.39382","volume":"7","author":"MC Thurnheer","year":"2024","unstructured":"Thurnheer MC, Sch\u00fcrmann A, Huber M et al (2024) Perioperative antibiotic prophylaxis duration in patients undergoing cystectomy with urinary diversion: A randomized clinical trial. JAMA Netw Open 7:e2439382. https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.39382","journal-title":"JAMA Netw Open"},{"key":"3943_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.juro.2017.02.3340","volume":"198","author":"RE Krasnow","year":"2017","unstructured":"Krasnow RE, Mossanen M, Koo S et al (2017) Prophylactic antibiotics and postoperative complications of radical cystectomy: A population based analysis in the united States. J Urol 198:297\u2013304. https:\/\/doi.org\/10.1016\/j.juro.2017.02.3340","journal-title":"J Urol"},{"key":"3943_CR8","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","volume":"339","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700. https:\/\/doi.org\/10.1136\/bmj.b2700","journal-title":"BMJ"},{"key":"3943_CR9","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomized trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"3943_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.13105\/wjma.v5.i4.80","volume":"5","author":"C Luchini","year":"2017","unstructured":"Luchini C, Stubbs B, Solmi M, Veronese N (2017) Assessing the quality of studies in meta-analyses: advantages and limitations of the Newcastle Ottawa scale. WJG 5:80. https:\/\/doi.org\/10.13105\/wjma.v5.i4.80","journal-title":"WJG"},{"key":"3943_CR11","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1159\/000509881","volume":"104","author":"N Numao","year":"2020","unstructured":"Numao N, Fujiwara R, Uehara S et al (2020) Intraoperative only versus extended duration use of antimicrobial prophylaxis for infectious complications in radical cystectomy with intestinal urinary diversion. Urol Int 104:954\u2013959. https:\/\/doi.org\/10.1159\/000509881","journal-title":"Urol Int"},{"key":"3943_CR12","doi-asserted-by":"publisher","first-page":"e13196","DOI":"10.1097\/MD.0000000000013196","volume":"97","author":"C-J Kim","year":"2018","unstructured":"Kim C-J, Kim KH, Song W et al (2018) Impact of a change in duration of prophylactic antibiotics on infectious complications after radical cystectomy with a neobladder. Med (Baltim) 97:e13196. https:\/\/doi.org\/10.1097\/MD.0000000000013196","journal-title":"Med (Baltim)"},{"key":"3943_CR13","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/j.1442-2042.2008.02050.x","volume":"15","author":"N Hara","year":"2008","unstructured":"Hara N, Kitamura Y, Saito T et al (2008) Perioperative antibiotics in radical cystectomy with ileal conduit urinary diversion: efficacy and risk of antimicrobial prophylaxis on the operation day alone. Int J Urol 15:511\u2013515. https:\/\/doi.org\/10.1111\/j.1442-2042.2008.02050.x","journal-title":"Int J Urol"},{"key":"3943_CR14","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1200\/JCO.2001.19.3.666","volume":"19","author":"JP Stein","year":"2001","unstructured":"Stein JP, Lieskovsky G, Cote R et al (2001) Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 19:666\u2013675. https:\/\/doi.org\/10.1200\/JCO.2001.19.3.666","journal-title":"J Clin Oncol"},{"key":"3943_CR15","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.eursup.2010.09.001","volume":"9","author":"R Colombo","year":"2010","unstructured":"Colombo R, Naspro R (2010) Ileal conduit as the standard for urinary diversion after radical cystectomy for bladder cancer. Eur Urol Supplements 9:736\u2013744. https:\/\/doi.org\/10.1016\/j.eursup.2010.09.001","journal-title":"Eur Urol Supplements"},{"key":"3943_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s11255-020-02653-1","volume":"53","author":"Y Wang","year":"2021","unstructured":"Wang Y, Shen W, Yuan X et al (2021) A perioperative management to reduce rate of urinary tract infection for patient underwent radical cystectomy with ileal conduit diversion. Int Urol Nephrol 53:401\u2013407. https:\/\/doi.org\/10.1007\/s11255-020-02653-1","journal-title":"Int Urol Nephrol"},{"key":"3943_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12879-019-3932-4","volume":"19","author":"E Kolwijck","year":"2019","unstructured":"Kolwijck E, Seegers AEM, Tops SCM et al (2019) Incidence and microbiology of postoperative infections after radical cystectomy and ureteral stent removal; a retrospective cohort study. BMC Infect Dis 19:303. https:\/\/doi.org\/10.1186\/s12879-019-3932-4","journal-title":"BMC Infect Dis"},{"key":"3943_CR18","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s00345-018-2482-5","volume":"37","author":"H Goldberg","year":"2019","unstructured":"Goldberg H, Shenhar C, Tamir H et al (2019) Predictors of surgical site infection after radical cystectomy: should we enhance surgical antibiotic prophylaxis? World J Urol 37:1137\u20131143. https:\/\/doi.org\/10.1007\/s00345-018-2482-5","journal-title":"World J Urol"},{"key":"3943_CR19","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1086\/676022","volume":"35","author":"DJ Anderson","year":"2014","unstructured":"Anderson DJ, Podgorny K, Berr\u00edos-Torres SI et al (2014) Strategies to prevent surgical site infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol 35:605\u2013627. https:\/\/doi.org\/10.1086\/676022","journal-title":"Infect Control Hosp Epidemiol"},{"key":"3943_CR20","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2146\/ajhp120568","volume":"70","author":"DW Bratzler","year":"2013","unstructured":"Bratzler DW, Dellinger EP, Olsen KM et al (2013) Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm 70:195\u2013283. https:\/\/doi.org\/10.2146\/ajhp120568","journal-title":"Am J Health Syst Pharm"},{"key":"3943_CR21","doi-asserted-by":"publisher","first-page":"a1924","DOI":"10.1136\/bmj.a1924","volume":"337","author":"D Leaper","year":"2008","unstructured":"Leaper D, Burman-Roy S, Palanca A et al (2008) Prevention and treatment of surgical site infection: summary of NICE guidance. BMJ 337:a1924. https:\/\/doi.org\/10.1136\/bmj.a1924","journal-title":"BMJ"},{"key":"3943_CR22","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1445-2197.2005.03397.x","volume":"75","author":"LM Mui","year":"2005","unstructured":"Mui LM, Ng CSH, Wong SKH et al (2005) Optimum duration of prophylactic antibiotics in acute nonperforated appendicitis. ANZ J Surg 75:425\u2013428. https:\/\/doi.org\/10.1111\/j.1445-2197.2005.03397.x","journal-title":"ANZ J Surg"},{"key":"3943_CR23","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1161\/01.cir.101.25.2916","volume":"101","author":"S Harbarth","year":"2000","unstructured":"Harbarth S, Samore MH, Lichtenberg D, Carmeli Y (2000) Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation 101:2916\u20132921. https:\/\/doi.org\/10.1161\/01.cir.101.25.2916","journal-title":"Circulation"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-025-03943-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-025-03943-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-025-03943-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:15:07Z","timestamp":1768976107000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-025-03943-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3943"],"URL":"https:\/\/doi.org\/10.1007\/s00423-025-03943-x","relation":{},"ISSN":["1435-2451"],"issn-type":[{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"19 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"58"}}