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Extensive surgical debridement of necrotic tissues until healthy tissue is the cornerstone of management. Despite this, in-hospital mortality remains high for these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the experience of an Emergency Surgery center over a 15-year period. We evaluated factors related to in-hospital mortality. Secondary outcomes were assessment of morbidity, need for intensive care admission, risk of amputation, and outcomes related to the timing of surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and eight patients were included in this retrospective cohort study. All patients, except one (99.1%), underwent surgical debridement. Of these, 64 patients (59.3%) required multiple revisions (2.0\u2009\u00b1\u20092.7). Negative pressure wound therapy was applied to 52 patients (48.1%), for a mean duration of 21.7\u2009\u00b1\u200923.3 days. The mortality rate was 25.9% (28 patients). Ninety patients (83.3%) developed a complication during hospitalization, most of which were severe (20 patients grade III and 64 grade IV). Patients operated on within 10\u00a0h experienced a reduction in the rate of major complications (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). Fourteen patients (13%) underwent limb amputation and 37 patients (34.3%) presented motor deficits at discharge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Necrotizing soft tissue infections are a challenge for the emergency surgeon. An accurate diagnosis is not always possible and rapid intervention improves the results. Currently, there are no elements that allow a definitive diagnosis and a determining factor for a correct and accurate diagnostic framework is the competence of the surgeon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-026-04038-x","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:16:53Z","timestamp":1774948613000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Results of surgical treatment of necrotizing soft tissue infections. A 15-years retrospective cohort study of a single center of emergency surgery"],"prefix":"10.1007","volume":"411","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-4725","authenticated-orcid":false,"given":"Silvia","family":"Tedesco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-7545","authenticated-orcid":false,"given":"Marta","family":"Di Grezia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-2430","authenticated-orcid":false,"given":"Gaia","family":"Altieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-5233","authenticated-orcid":false,"given":"Caterina","family":"Cina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1619-4164","authenticated-orcid":false,"given":"Valeria","family":"Fico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3080-0883","authenticated-orcid":false,"given":"Filomena","family":"Misuriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4596-2644","authenticated-orcid":false,"given":"Giada","family":"Bracalente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0967-1719","authenticated-orcid":false,"given":"Edoardo","family":"Piras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8820-9471","authenticated-orcid":false,"given":"Giuseppe","family":"Brisinda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"issue":"11","key":"4038_CR1","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1001\/jamasurg.2024.3365","volume":"159","author":"J McDermott","year":"2024","unstructured":"McDermott J, Kao LS, Keeley JA et al (2024) Necrotizing Soft Tissue Infections: A Review. 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