{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:03:34Z","timestamp":1784801014018,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172659"],"award-info":[{"award-number":["82172659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"DOI":"10.1007\/s00423-026-04085-4","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:54:51Z","timestamp":1780073691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A predictive model for metastatic colorectal cancer based on immune cells and tumor markers"],"prefix":"10.1007","volume":"411","author":[{"given":"Chentong","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"4085_CR1","first-page":"153","volume":"365","author":"J Weitz","year":"2005","unstructured":"Weitz J, Koch M, Debus J, H\u00f6hler T, Galle PR, B\u00fcchler MW (2005) Colorectal cancer The Lancet 365:153\u2013165","journal-title":"Colorectal cancer The Lancet"},{"key":"4085_CR2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/joim.13171","volume":"289","author":"R Hultcrantz","year":"2021","unstructured":"Hultcrantz R (2021) Aspects of colorectal cancer screening, methods, age and gender. J Intern Med 289:493\u2013507","journal-title":"J Intern Med"},{"key":"4085_CR3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M (2024) Sung Het al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin 74:229\u2013263","journal-title":"Cancer J Clin"},{"key":"4085_CR4","doi-asserted-by":"publisher","first-page":"729","DOI":"10.21147\/j.issn.1000-9604.2020.06.06","volume":"32","author":"Y Yang","year":"2020","unstructured":"Yang Y, Han Z, Li X, Huang A, Shi J, Gu J (2020) Epidemiology and risk factors of colorectal cancer in China. Chin J Cancer Res 32:729","journal-title":"Chin J Cancer Res"},{"key":"4085_CR5","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.tips.2023.01.003","volume":"44","author":"AE Shin","year":"2023","unstructured":"Shin AE, Giancotti FG, Rustgi AK (2023) Metastatic colorectal cancer: mechanisms and emerging therapeutics. Trends Pharmacol Sci 44:222\u2013236","journal-title":"Trends Pharmacol Sci"},{"key":"4085_CR6","doi-asserted-by":"crossref","unstructured":"Barton MK (2017) Primary tumor location found to impact prognosis and response to therapy in patients with metastatic colorectal cancer. CA Cancer J Clin 67(4):259\u2013260","DOI":"10.3322\/caac.21372"},{"key":"4085_CR7","doi-asserted-by":"crossref","unstructured":"Salem PA, Jabboury KW, McCallum WG, Stenoien RA, Wheeler TM (2022) Personalized multimodality therapy with immune checkpoint inhibitors, chemotherapy, and targeted treatment (ICTriplex) in advanced\/refractory cancer. J Clin Oncol 40:e14590","DOI":"10.1200\/JCO.2022.40.16_suppl.e14590"},{"key":"4085_CR8","doi-asserted-by":"publisher","first-page":"8722","DOI":"10.1038\/s41598-021-87929-x","volume":"11","author":"Q Li","year":"2021","unstructured":"Li Q, Wang G, Luo J, Li B, Chen W (2021) Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients. Sci Rep 11:8722","journal-title":"Sci Rep"},{"key":"4085_CR9","doi-asserted-by":"crossref","unstructured":"Cho T, Shiozawa E, Urushibara F et al (2017) The role of microvessel density, lymph node metastasis, and tumor size as prognostic factors of distant metastasis in colorectal cancer 13:4327\u20134333","DOI":"10.3892\/ol.2017.5959"},{"key":"4085_CR10","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/1751-2980.12936","volume":"21","author":"L Tang","year":"2020","unstructured":"Tang L, Lei YY, Liu YJ, Tang B, Yang SM (2020) The expression of seven key genes can predict distant metastasis of colorectal cancer to the liver or lung. J Dig Dis 21:639\u2013649","journal-title":"J Dig Dis"},{"key":"4085_CR11","doi-asserted-by":"crossref","unstructured":"Zhu Y, Meng M, Hou Z et al (2023) Impact of cytotoxic T lymphocytes immunotherapy on prognosis of colorectal cancer patients 13:1122669","DOI":"10.3389\/fonc.2023.1122669"},{"key":"4085_CR12","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1158\/0008-5472.CAN-23-2123","volume":"84","author":"X Liu","year":"2024","unstructured":"Liu X, Wang X, Yang Qet (2024) Th17 cells secrete TWEAK to trigger epithelial\u2013mesenchymal transition and promote colorectal cancer liver metastasis. Cancer Res 84:1352\u20131371","journal-title":"Cancer Res"},{"key":"4085_CR13","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.4251\/wjgo.v16.i5.1737","volume":"16","author":"C-M Zhou","year":"2024","unstructured":"Zhou C-M, Zhao S-H (2024) Evaluation of the value of combined detection of tumor markers CA724, carcinoembryonic antigen, CA242, and CA19-9 in gastric cancer. World J Gastrointest Oncol 16:1737","journal-title":"World J Gastrointest Oncol"},{"key":"4085_CR14","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41575-019-0189-8","volume":"16","author":"N Keum","year":"2019","unstructured":"Keum N, Giovannucci E (2019) Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat reviews Gastroenterol Hepatol 16:713\u2013732","journal-title":"Nat reviews Gastroenterol Hepatol"},{"key":"4085_CR15","doi-asserted-by":"publisher","first-page":"10542","DOI":"10.1200\/JCO.2021.39.15_suppl.10542","volume":"39","author":"Z Pan","year":"2021","unstructured":"Pan Z, Huang J, Huang M et al (2021) Risk factors for early-onset colorectal cancer in China. J Clin Oncol 39:10542","journal-title":"J Clin Oncol"},{"key":"4085_CR16","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3322\/caac.21550","volume":"69","author":"RC Wender","year":"2019","unstructured":"Wender RC, Brawley OW, Fedewa SA, Gansler T, Smith RA (2019) A blueprint for cancer screening and early detection: Advancing screening\u2019s contribution to cancer control. Cancer J Clin 69:50\u201379","journal-title":"Cancer J Clin"},{"key":"4085_CR17","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2019.37.15_suppl.3567","author":"IY Ronit","year":"2019","unstructured":"Ronit IY, Kim N (2019) Young-onset colorectal cancer patients disproportionately diagnosed with advanced disease: patient self-reported journey of symptom duration and misdiagnosis. J Clin Oncol 37:3567. https:\/\/doi.org\/10.1200\/jco.2019.37.15_suppl.3567","journal-title":"J Clin Oncol"},{"key":"4085_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-022-04238-z","author":"C Weibin","year":"2022","unstructured":"Weibin C, Qianqian S, Ze-mao L, Zhong-yao L, Liqing K (2022) Diagnostic value of spiral CT energy spectrum imaging in lymph node metastasis of colorectal cancer. Int J Colorectal Dis 37(9):2021\u20132029. https:\/\/doi.org\/10.1007\/s00384-022-04238-z","journal-title":"Int J Colorectal Dis"},{"key":"4085_CR19","doi-asserted-by":"publisher","unstructured":"Diederik JH, Stook JL Yannick M et al (2022) Primary Colorectal Cancer Histopathology Predicts the Histopathological Growth Pattern of Corresponding Liver Metastasis Hpb. https:\/\/doi.org\/10.1016\/j.hpb.2022.05.046","DOI":"10.1016\/j.hpb.2022.05.046"},{"key":"4085_CR20","doi-asserted-by":"crossref","unstructured":"Filip S, Vymetalkova V, Petera J et al (2020) Distant metastasis in colorectal cancer patients\u2014do we have new predicting clinicopathological and molecular biomarkers? A comprehensive review 21:5255","DOI":"10.3390\/ijms21155255"},{"key":"4085_CR21","doi-asserted-by":"publisher","first-page":"5528","DOI":"10.1158\/1538-7445.AM2024-5528","volume":"84","author":"A Trailin","year":"2024","unstructured":"Trailin A, Ye W, Ali E et al (2024) Adaptive immune cells in colorectal cancer between normal mucosa, primary tumor and liver metastasis. Cancer Res 84:5528\u20135528","journal-title":"Cancer Res"},{"key":"4085_CR22","doi-asserted-by":"crossref","unstructured":"Tosolini M, Kirilovsky A, Mlecnik B et al (2011) Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer 71:1263\u20131271","DOI":"10.1158\/0008-5472.CAN-10-2907"},{"key":"4085_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2017.08.109","volume":"493","author":"Y Song","year":"2017","unstructured":"Song Y, Yang JM (2017) Role of interleukin (IL)-17 and T-helper (Th) 17 cells in cancer. Biochem Biophys Res Commun 493:1\u20138","journal-title":"Biochem Biophys Res Commun"},{"key":"4085_CR24","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.7150\/ijbs.74985","volume":"19","author":"Y Lv","year":"2023","unstructured":"Lv Y, Tang W, Xu Y (2023) Apolipoprotein L3 enhances CD8\u2009+\u2009T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis. Int J Biol Sci 19:1284","journal-title":"Int J Biol Sci"},{"key":"4085_CR25","doi-asserted-by":"crossref","unstructured":"Thomsen M, Skovlund E, Sorbye H et al (2018) Prognostic role of carcinoembryonic antigen and carbohydrate antigen 19\u2009\u2013\u20099 in metastatic colorectal cancer: a BRAF-mutant subset with high CA 19\u2009\u2013\u20099 level and poor outcome 118:1609\u20131616","DOI":"10.1038\/s41416-018-0115-9"},{"key":"4085_CR26","first-page":"100907","volume":"43","author":"MH Gramkow","year":"2025","unstructured":"Gramkow MH, Mosgaard CS, Schou, JVet (2025) The prognostic role of circulating CA19\u20139 and CEA in patients with colorectal cancer. Cancer Treat Res Commun 43:100907","journal-title":"Cancer Treat Res Commun"},{"key":"4085_CR27","doi-asserted-by":"publisher","first-page":"2929233","DOI":"10.1155\/2021\/2929233","volume":"2021","author":"J Ding","year":"2021","unstructured":"Ding J, Zhang H, Wu Z (2021) Study on the Differential Value of Tumor marker CA724 on primary gastric Cancer. J Oncol 2021:2929233","journal-title":"J Oncol"},{"key":"4085_CR28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10151-023-02873-4","volume":"28","author":"I Kildusiene","year":"2024","unstructured":"Kildusiene I, Dulskas A, Smailyte G (2024) Value of combined serum CEA, CA72-4, and CA19-9 marker detection in diagnosis of colorectal cancer. Tech Coloproctol 28:33","journal-title":"Tech Coloproctol"},{"key":"4085_CR29","doi-asserted-by":"publisher","first-page":"463","DOI":"10.4240\/wjgs.v16.i2.463","volume":"16","author":"L Xiong","year":"2024","unstructured":"Xiong L, Liu F-C (2024) Immune function status of postoperative patients with colon cancer for predicting liver metastasis. World J Gastrointest Surg 16:463","journal-title":"World J Gastrointest Surg"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-026-04085-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-026-04085-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-026-04085-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:29:30Z","timestamp":1784798970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-026-04085-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4085"],"URL":"https:\/\/doi.org\/10.1007\/s00423-026-04085-4","relation":{},"ISSN":["1435-2451"],"issn-type":[{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"24 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"198"}}