{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:13:07Z","timestamp":1788509587371,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"DOI":"10.1007\/s00423-026-04166-4","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:14:28Z","timestamp":1788498868000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of living donor liver transplantation in elderly Egyptian patients: a retrospective study"],"prefix":"10.1007","volume":"411","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-357X","authenticated-orcid":false,"given":"Ahmed","family":"Abdelrafee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelwahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Sanad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Eldesoky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Elmorshedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel Ali","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed M. R.","family":"Elsarraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"4166_CR1","doi-asserted-by":"publisher","first-page":"10108","DOI":"10.3389\/ti.2022.10108","volume":"35","author":"MS Schulz","year":"2022","unstructured":"Schulz MS, Gu W, Schnitzbauer AA, Trebicka J (2022) Liver Transplantation as a Cornerstone Treatment for Acute-On-Chronic Liver Failure. Transpl Int 35:10108. https:\/\/doi.org\/10.3389\/ti.2022.10108","journal-title":"Transpl Int"},{"issue":"7","key":"4166_CR2","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1111\/ajt.16440","volume":"21","author":"A Barbetta","year":"2021","unstructured":"Barbetta A, Aljehani M, Kim M, Tien C, Ahearn A, Schilperoort H, Sher L, Emamaullee J (2021) Meta-analysis and meta-regression of outcomes for adult living donor liver transplantation versus deceased donor liver transplantation. Am J Transpl 21(7):2399\u20132412. https:\/\/doi.org\/10.1111\/ajt.16440","journal-title":"Am J Transpl"},{"issue":"1","key":"4166_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41392-024-02072-z","volume":"10","author":"C Gan","year":"2025","unstructured":"Gan C, Yuan Y, Shen H, Gao J, Kong X, Che Z, Guo Y, Wang H, Dong E, Xiao J (2025) Liver diseases: epidemiology, causes, trends and predictions. Signal Transduct Target Ther 10(1):33. https:\/\/doi.org\/10.1038\/s41392-024-02072-z","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"4166_CR4","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.jhep.2024.07.032","volume":"81","author":"European Association for the Study of the Liver","year":"2024","unstructured":"European Association for the Study of the Liver (2024) EASL Clinical Practice Guidelines on liver transplantation. ) J Hepatol 81(6):1040\u20131086. https:\/\/doi.org\/10.1016\/j.jhep.2024.07.032","journal-title":") J Hepatol"},{"issue":"2","key":"4166_CR5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.4240\/wjgs.v16.i2.331","volume":"16","author":"M Bezjak","year":"2024","unstructured":"Bezjak M, Stresec I, Kocman B, Jadrijevi\u0107 S, Filipec Kanizaj T, Antonijevi\u0107 M, Dalbelo Ba\u0161i\u0107 B, Mikuli\u0107 D (2024) Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study. World J Gastrointest Surg 16(2):331\u2013344. https:\/\/doi.org\/10.4240\/wjgs.v16.i2.331","journal-title":"World J Gastrointest Surg"},{"issue":"6","key":"4166_CR6","doi-asserted-by":"publisher","first-page":"100741","DOI":"10.1016\/j.aohep.2022.100741","volume":"27","author":"BP Mohan","year":"2022","unstructured":"Mohan BP, Iriana S, Khan SR, Yarra P, Ponnada S, Gallegos-Orozco JF (2022) Outcomes of liver transplantation in patients 70 years or older: a systematic review and meta-analysis. Ann Hepatol 27(6):100741. https:\/\/doi.org\/10.1016\/j.aohep.2022.100741","journal-title":"Ann Hepatol"},{"issue":"5","key":"4166_CR7","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1097\/LVT.0000000000000518","volume":"31","author":"FH Saner","year":"2025","unstructured":"Saner FH, Raptis DA, Alchibi L, Kareem SA, Marquez KAH, Elsheikh Y, Alnemary Y, Alabbad S, Boehnert MU, Malago M, Broering DC (2025) Comparative outcomes of living donor liver transplantation in elderly recipients: A study on morbidity and survival in 1018 recipients. Liver Transpl 31(5):630\u2013636","journal-title":"Liver Transpl"},{"issue":"2","key":"4166_CR8","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3978\/j.issn.2304-3881.2015.10.03","volume":"5","author":"KE Amer","year":"2016","unstructured":"Amer KE, Marwan I (2016) Living donor liver transplantation in Egypt. Hepatobiliary Surg Nutr 5(2):98\u2013106. https:\/\/doi.org\/10.3978\/j.issn.2304-3881.2015.10.03","journal-title":"Hepatobiliary Surg Nutr"},{"key":"4166_CR9","doi-asserted-by":"publisher","first-page":"1566466","DOI":"10.3389\/frtra.2025.1566466","volume":"4","author":"L Knoedler","year":"2025","unstructured":"Knoedler L, Boroumand S, Hinze CA, Knoedler S, Lellouch AG, Maheta BJ, Iske J, Panayi AC (2025) The perioperative management of geriatric patients in transplantation surgery-clinical, immunological, and translational considerations. Front Transpl 4:1566466. https:\/\/doi.org\/10.3389\/frtra.2025.1566466","journal-title":"Front Transpl"},{"issue":"9","key":"4166_CR10","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1002\/lt.26061","volume":"27","author":"AR Hakeem","year":"2021","unstructured":"Hakeem AR, Fathima R, Padmanaban H, Haribabu K, Rajalingam R, Palaniappan K, Jothimani D, Kanagavelu R, Rajakumar A, Kaliamoorthy I, Reddy MS, Rela M (2021) Propensity Score-Matched Analysis of Posttransplant Outcomes in Living Donor Liver Transplantation for Older Adult Recipients. Liver Transpl 27(9):1273\u20131282. https:\/\/doi.org\/10.1002\/lt.26061","journal-title":"Liver Transpl"},{"issue":"12","key":"4166_CR11","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1111\/hpb.12312","volume":"16","author":"GC Wilson 3rd","year":"2014","unstructured":"Wilson GC, Quillin RC 3rd, Wima K, Sutton JM, Hoehn RS, Hanseman DJ, Paquette IM, Paterno F, Woodle ES, Abbott DE, Shah SA (2014) Is liver transplantation safe and effective in elderly (\u2265\u200970 years) recipients? a case-controlled analysis. HPB (Oxford) 16(12):1088\u20131094. https:\/\/doi.org\/10.1111\/hpb.12312","journal-title":"HPB (Oxford)"},{"issue":"6","key":"4166_CR12","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.hpb.2021.11.007","volume":"24","author":"C G\u00f3mez-Gavara","year":"2022","unstructured":"G\u00f3mez-Gavara C, Lim C, Adam R, Zieniewicz K, Karam V, Mirza D, Heneghan M et al (2022) all the ELTR centers (www.eltr.org) for the European Liver and Intestine Transplant Association (ELITA). The impact of advanced patient age in liver transplantation: a European Liver Transplant Registry propensity-score matching study. HPB (Oxford) 24(6):974\u2013985. https:\/\/doi.org\/10.1016\/j.hpb.2021.11.007","journal-title":"HPB (Oxford)"},{"issue":"6","key":"4166_CR13","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00595-020-01996-7","volume":"50","author":"S Dolnikov","year":"2020","unstructured":"Dolnikov S, Adam R, Cherqui D, Allard MA (2020) Liver transplantation in elderly patients: what do we know at the beginning of 2020? Surg Today 50(6):533\u2013539. https:\/\/doi.org\/10.1007\/s00595-020-01996-7","journal-title":"Surg Today"},{"key":"4166_CR14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.21037\/tgh-19-282","volume":"6","author":"M Finotti","year":"2021","unstructured":"Finotti M, Auricchio P, Vitale A, Gringeri E, Cillo U (2021) Liver transplantation for rare liver diseases and rare indications for liver transplant. Transl Gastroenterol Hepatol 6:27. https:\/\/doi.org\/10.21037\/tgh-19-282","journal-title":"Transl Gastroenterol Hepatol"},{"key":"4166_CR15","unstructured":"World Health Organization Global Health Observatory Data, Egypt: country profiles. http:\/\/www.who.int\/countries\/egy\/en"},{"issue":"37","key":"4166_CR16","doi-asserted-by":"publisher","first-page":"13607","DOI":"10.3748\/wjg.v20.i37.13607","volume":"20","author":"MA Wahab","year":"2014","unstructured":"Wahab MA, Hamed H, Salah T, Elsarraf W, Elshobary M, Sultan AM, Shehta A, Fathy O et al (2014) Problem of living liver donation in the absence of deceased liver transplantation program: Mansoura experience. World J Gastroenterol 20(37):13607\u201313614","journal-title":"World J Gastroenterol"},{"issue":"5","key":"4166_CR17","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1016\/j.transproceed.2018.02.085","volume":"50","author":"MA Wahab","year":"2018","unstructured":"Wahab MA, Shehta A, Elshoubary M, Yassen AM, Elmorshedi M, Salah T et al (2018) Living-donor liver transplantation in hepatitis C virus era: a report of 500 consecutive cases in a single center. Transpl Proc 50(5):1396\u20131406","journal-title":"Transpl Proc"},{"issue":"12","key":"4166_CR18","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1007\/s11605-018-3876-9","volume":"22","author":"MA Wahab","year":"2018","unstructured":"Wahab MA, Shehta A, Elshoubary M, Salah T, Fathy O, Sultan A et al (2018) Outcomes of living donor liver transplantation for patients with preoperative portal vein problems. J Gastrointest Surg 22(12):2055\u20132063","journal-title":"J Gastrointest Surg"},{"issue":"2","key":"4166_CR19","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.transproceed.2021.01.033","volume":"53","author":"MA Wahab","year":"2021","unstructured":"Wahab MA, Abdel-Khalek EE, Elshoubary M, Yassen AM, Salah T, Sultan AM et al (2021) Predictive factors of DE Novo malignancies after living-donor liver transplantation: a single-center experience. Transplantation Proceedings 53(2):636\u2013644","journal-title":"Transplantation Proceedings"},{"key":"4166_CR20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12893-025-02780-5","volume":"25","author":"MS Habl","year":"2025","unstructured":"Habl MS, Emara MM, Zayed RA et al (2025) Allograft tolerance after adult living donor liver transplantation: a case-control study. BMC Surg 25:52. https:\/\/doi.org\/10.1186\/s12893-025-02780-5","journal-title":"BMC Surg"},{"issue":"2","key":"4166_CR21","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205\u2013213. https:\/\/doi.org\/10.1097\/01.sla.0000133083.54934.ae","journal-title":"Ann Surg"},{"key":"4166_CR22","unstructured":"https:\/\/www.theglobaleconomy.com\/Egypt\/life_expectancy"},{"issue":"6","key":"4166_CR23","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.jhep.2023.03.025","volume":"78","author":"P Tandon","year":"2023","unstructured":"Tandon P, Zanetto A, Piano S, Heimbach JK, Dasarathy S (2023) Liver transplantation in the patient with physical frailty. J Hepatol 78(6):1105\u20131117. https:\/\/doi.org\/10.1016\/j.jhep.2023.03.025","journal-title":"J Hepatol"},{"issue":"6","key":"4166_CR24","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1002\/jcsm.13337","volume":"14","author":"K Guo","year":"2023","unstructured":"Guo K, Wang X, Lu X, Yang Y, Lu W, Wang S, Tang X, Wu Y, Xu Y, Chen Q, Liu S (2023) Effects of sarcopenia and frailty on postoperative recovery in elderly patients: A prospective cohort study. J Cachexia Sarcopenia Muscle 14(6):2642\u20132652. https:\/\/doi.org\/10.1002\/jcsm.13337","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"4166_CR25","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s00423-023-03115-9","volume":"408","author":"A Shehta","year":"2023","unstructured":"Shehta A, Elshobari M, Salah T et al (2023) Feasibility and outcomes of living-donor liver transplantation utilizing the right hemi-liver graft with portal vein anatomical variations. Langenbecks Arch Surg 408:387. https:\/\/doi.org\/10.1007\/s00423-023-03115-9","journal-title":"Langenbecks Arch Surg"},{"issue":"4","key":"4166_CR26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/lt.24682","volume":"23","author":"SA Rather","year":"2017","unstructured":"Rather SA, Nayeem MA, Agarwal S, Goyal N, Gupta S (2017) Vascular complications in living donor liver transplantation at a high-volume center: Evolving protocols and trends observed over 10 years. Liver Transpl 23(4):457\u2013464. https:\/\/doi.org\/10.1002\/lt.24682","journal-title":"Liver Transpl"},{"issue":"1","key":"4166_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00595-019-01881-y","volume":"50","author":"T Yoshizumi","year":"2020","unstructured":"Yoshizumi T, Mori M (2020) Portal flow modulation in living donor liver transplantation: review with a focus on splenectomy. Surg Today 50(1):21\u201329","journal-title":"Surg Today"},{"key":"4166_CR28","doi-asserted-by":"publisher","first-page":"952434","DOI":"10.3389\/fphys.2022.952434","volume":"13","author":"J Lu","year":"2022","unstructured":"Lu J, Liu J, Zhu L, Zhang Y, Li A (2022) The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis. Front Physiol 13:952434. https:\/\/doi.org\/10.3389\/fphys.2022.952434. Published 2022 Sep 27","journal-title":"Front Physiol"},{"key":"4166_CR29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fmed.2017.00020","volume":"4","author":"S Mart\u00edn","year":"2017","unstructured":"Mart\u00edn S, P\u00e9rez A, Aldecoa C (2017) Sepsis and immunosenescence in the elderly patient: a Review. Front Med (Lausanne) 4:20. https:\/\/doi.org\/10.3389\/fmed.2017.00020","journal-title":"Front Med (Lausanne)"},{"issue":"10","key":"4166_CR30","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1111\/j.1600-6143.2012.04245.x","volume":"12","author":"M Abecassis","year":"2012","unstructured":"Abecassis M, Bridges ND, Clancy CJ, Dew MA, Eldadah B, Englesbe MJ, Flessner MF, Frank JC et al (2012) Solid-organ transplantation in older adults: current status and future research. Am J Transpl 12(10):2608\u20132622. https:\/\/doi.org\/10.1111\/j.1600-6143.2012.04245.x","journal-title":"Am J Transpl"},{"issue":"4","key":"4166_CR31","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.bjane.2021.02.040","volume":"71","author":"JY Park","year":"2021","unstructured":"Park JY, Choi YJ, Ri HS, Lee JM, Son HJ, Lee YS, Ryu JH, Yang KH (2021) Impact of age on the incidence of complications after liver transplantation: A single-center retrospective study. Braz J Anesthesiol 71(4):387\u2013394. https:\/\/doi.org\/10.1016\/j.bjane.2021.02.040","journal-title":"Braz J Anesthesiol"},{"issue":"10","key":"4166_CR32","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1001\/jamasurg.2022.3327","volume":"157","author":"WE Jackson","year":"2022","unstructured":"Jackson WE, Malamon JS, Kaplan B, Saben JL, Schold JD, Pomposelli JJ, Pomfret EA (2022) Survival Benefit of Living-Donor Liver Transplant. JAMA Surg 157(10):926\u2013932. https:\/\/doi.org\/10.1001\/jamasurg.2022.3327","journal-title":"JAMA Surg"},{"issue":"2","key":"4166_CR33","doi-asserted-by":"publisher","first-page":"171","DOI":"10.17998\/jlc.2024.08.30","volume":"24","author":"SY Hwang","year":"2024","unstructured":"Hwang SY, Choi H, Jeon W, Kim RG (2024) Multidisciplinary approaches to downstaging hepatocellular carcinoma: present and future. J Liver Cancer 24(2):171\u2013177. https:\/\/doi.org\/10.17998\/jlc.2024.08.30","journal-title":"J Liver Cancer"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00423-026-04166-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-026-04166-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-026-04166-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:24:35Z","timestamp":1788506675000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00423-026-04166-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4166"],"URL":"https:\/\/doi.org\/10.1007\/s00423-026-04166-4","relation":{},"ISSN":["1435-2451"],"issn-type":[{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"assertion":[{"value":"22 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"224"}}