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While their clinical use is well established in neonatal care, their potential in thoracic surgery remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review the current and emerging applications of surfactants in thoracic surgical practice, and to assess their role in perioperative lung protection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed recent literature on surfactant biology, perioperative administration strategies, and novel formulations, including bio-derived and responsive surfactants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Exogenous surfactants may improve lung compliance, preventing atelectasis, and mitigating postoperative respiratory complications. In thoracic surgery, surfactants may also serve as drug delivery vehicles or anti-inflammatory agents. However, clinical use remains limited, and further studies are needed to define optimal dosing, timing, and patient selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surfactants represent a versatile and evolving tool in thoracic surgery. With continued innovation and clinical validation, they may become an effective adjunct for enhancing perioperative respiratory outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00423-026-04265-2","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:44:54Z","timestamp":1790653494000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biophysical rationale and emerging clinical perspectives of surfactants in thoracic surgery: a translational review"],"prefix":"10.1007","volume":"411","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1544-6985","authenticated-orcid":false,"given":"Xiayimaierdan","family":"Yibulayin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Arkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangmin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kalverkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan W.","family":"Spillner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Greven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"3","key":"4265_CR1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/s0095-5108(05)70111-1","volume":"28","author":"AH Jobe","year":"2001","unstructured":"Jobe AH, Ikegami M (2001) Biology of surfactant. 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