{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:54:58Z","timestamp":1767830098583,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2003,6,25]],"date-time":"2003-06-25T00:00:00Z","timestamp":1056499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2003,8]]},"DOI":"10.1007\/s00424-003-1096-x","type":"journal-article","created":{"date-parts":[[2003,11,21]],"date-time":"2003-11-21T17:38:55Z","timestamp":1069436335000},"page":"529-540","source":"Crossref","is-referenced-by-count":10,"title":["A new view of K+-induced contraction in rat aorta: the role of Ca2+ binding"],"prefix":"10.1007","volume":"446","author":[{"given":"Gennadi M.","family":"Kravtsov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain C.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak Ming","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiu-Yin","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,6,25]]},"reference":[{"key":"1096_CR1","first-page":"245","volume":"4","author":"Altura","year":"1985","unstructured":"Altura BM, Altura BT (1985) New perspectives on the role of magnesium in pathophysiology in the cardiovascular system. II. Experimental aspects. Magnesium 4:245\u2013271","journal-title":"Magnesium"},{"key":"1096_CR2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1113\/expphysiol.1998.sp004117","volume":"83","author":"Bakhramov","year":"1998","unstructured":"Bakhramov A, Evans AM, Kozlowski RZ (1998) Differential effects of hypoxia on the intracellular Ca2+ concentration of myocytes isolated from different regions of the rat pulmonary arterial tree. Exp Physiol 83:337\u2013347","journal-title":"Exp Physiol"},{"key":"1096_CR3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/292777a0","volume":"292","author":"Bostr\u00f6m","year":"1981","unstructured":"Bostr\u00f6m S-L, Ljung B, Mardth S, Forsen S, Thulin E (1981) Interaction of antihypertensive drug felodipine with calmodulin. Nature 292:777\u2013778","journal-title":"Nature"},{"key":"1096_CR4","first-page":"H840","volume":"254","author":"Bruschi","year":"1988","unstructured":"Bruschi G, Bruschi ME, Regolisty G, Borghetti A (1988) Myoplasmic Ca2+-force relationship studied with fura-2 during stimulation of rat aortic smooth muscle. Am J Physiol 254:H840\u2013H854","journal-title":"Am J Physiol"},{"key":"1096_CR5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0014-2999(83)90219-4","volume":"90","author":"Daly","year":"1983","unstructured":"Daly MJ, Perry S, Mayer WG (1983) Calcium antagonists and calmodulin; Effect of verapamil, nifedipine and diltiazem. Eur J Pharmacol 90:103\u2013108","journal-title":"Eur J Pharmacol"},{"key":"1096_CR6","doi-asserted-by":"crossref","first-page":"16365","DOI":"10.1074\/jbc.M011634200","volume":"276","author":"Deng","year":"2001","unstructured":"Deng JT, Van Lierop JE, Sutherland C, Walsh MP (2001) Ca2+-independent smooth muscle contraction. J Biol Chem 276:16365\u201316373","journal-title":"J Biol Chem"},{"key":"1096_CR7","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/280506a0","volume":"280","author":"Fay","year":"1979","unstructured":"Fay FS, Shlevin HH, Granger WC, Taylor SP (1979) Aequorin luminescence during activation of single isolated smooth muscle cells. Nature 280:506\u2013508","journal-title":"Nature"},{"key":"1096_CR8","first-page":"8","volume":"240","author":"Gerthoffer","year":"1987","unstructured":"Gerthoffer WT (1987) Disssociation of myosin phosphorylation and active tension during muscarinic stimulation. J Pharmacol Exp Ther 240:8\u201315","journal-title":"J Pharmacol Exp Ther"},{"key":"1096_CR9","unstructured":"Godfraind T, Vanhoutte PM, Govoni S, Paoletti R (1985) Calcium entry blockers an tissue protection. Raven Press, New York"},{"key":"1096_CR10","first-page":"415","volume":"177","author":"Goodman","year":"1971","unstructured":"Goodman FR, Weiss GB (1971) Effect of lanthanum on45Ca movements on contractions induced by norepinephrine, histamine and potassium in vascular smooth muscle. J Pharmacol Exp Ther 177:415\u2013425","journal-title":"J Pharmacol Exp Ther"},{"key":"1096_CR11","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"Grynkiewicz","year":"1985","unstructured":"Grynkiewicz G, Poenie M, Tsien R (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440\u20133450","journal-title":"J Biol Chem"},{"key":"1096_CR12","first-page":"H195","volume":"268","author":"Hatem","year":"1995","unstructured":"Hatem SN, Sweeten T, Vetter V, Morad M (1995) Evidence for the presence of Ca2+ channel-gated Ca2+ stores in neonatal human atrial myocytes. Am J Physiol 268:H195\u2013H201","journal-title":"Am J Physiol"},{"key":"1096_CR13","doi-asserted-by":"crossref","unstructured":"Himpens B, Matthijs G, Somlyo P (1989) Desensitization to cytoplasmic Ca2+ and Ca2+ sensitivities of guinea-pig ileum and rabbit pulmonary artery smooth muscle. J Physiol (Lond) 413: 489\u2013503","DOI":"10.1113\/jphysiol.1989.sp017665"},{"key":"1096_CR14","first-page":"C491","volume":"26","author":"Ito","year":"2002","unstructured":"Ito S, Kume H, Yamaki K, Katoh H, Honjo H, Kodama I, Hayashi H (2002) Regulation of capacitative and noncapacitative receptor-operated Ca2+ entry by rho-kinase in tracheal smooth muscle. Am J Respir 26:C491\u2013C498","journal-title":"Am J Respir"},{"key":"1096_CR15","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2170\/jjphysiol.31.831","volume":"31","author":"Itoh","year":"1981","unstructured":"Itoh T, Suzuki H, Kuriyama H (1981) Effects of sodium depletion on contractions evoked in intact and skinned muscles of guinea-pig mesenteric artery. Jpn J Physiol 31:831\u2013847","journal-title":"Jpn J Physiol"},{"key":"1096_CR16","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1074\/jbc.R000028200","volume":"276","author":"Kam","year":"2001","unstructured":"Kam KE, Stull J (2001) Dedicated myosin light chain kinases with diverse cellular functions. J Biol Chem 276:4527\u20134530","journal-title":"J Biol Chem"},{"key":"1096_CR17","first-page":"28","volume":"18","author":"Karaki","year":"1981","unstructured":"Karaki H, Weis GB (1981) Inhibitors of mitochondrial Ca2+ uptake dissociate potassium-induced tension responses from increased 45Ca retention in rabbit aortic smooth muscle. Blood Vessels 18:28\u201335","journal-title":"Blood Vessels"},{"key":"1096_CR18","first-page":"157","volume":"49","author":"Karaki","year":"1997","unstructured":"Karaki H, Ozaki H, Hori M, Misui-Saito M, Amano K-I, Harada K-I, Miayamoto S, Nakazawa H, Won K-J, Sato K (1997) Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev 49:157\u2013230","journal-title":"Pharmacol Rev"},{"key":"1096_CR19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1085\/jgp.90.1.49","volume":"90","author":"Kargacin","year":"1987","unstructured":"Kargacin G, Fay FS (1987) Physiological and structural properties of saponin-skinned single smooth muscle cells. J Gen Physiol 90:49\u201373","journal-title":"J Gen Physiol"},{"key":"1096_CR20","doi-asserted-by":"crossref","first-page":"C1468","DOI":"10.1152\/ajpcell.1996.270.5.C1468","volume":"270","author":"Khoyi","year":"1996","unstructured":"Khoyi MA, Ishikawa T, Keef KD, Westfall DP (1996) Ca2+ induced inhibition of 45Ca2+ influx and Ca2+ current in smooth muscle of the rat vas deferens. Am J Physiol 270:C1468\u2013C1477","journal-title":"Am J Physiol"},{"key":"1096_CR21","first-page":"403","volume":"282","author":"Kojima","year":"1997","unstructured":"Kojima Y, Tsunoda Y, Owyang C (1997) Adenosine 3\u2032, 5\u2032-cyclic monophosphate-stimulated Ca2+ efflux and acetylcoline release in ileal myenteric plexus are mediated by N-type Ca2+ channels: inhibition by the kappa opioid receptor agonist. J Pharmacol Exp Ther 282:403\u2013409","journal-title":"J Pharmacol Exp Ther"},{"key":"1096_CR22","doi-asserted-by":"crossref","unstructured":"Kravtsov GM, Kwan CY (1995) Regulation of vascular contraction by ionic matrix surfaces of smooth muscle cells: changes in SHR? Clin Exp Pharmacol Physiol [Suppl] 1:S237\u2013S239","DOI":"10.1111\/j.1440-1681.1995.tb02898.x"},{"key":"1096_CR23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000109436","volume":"4","author":"Kravtsov","year":"1995","unstructured":"Kravtsov GM, Kwan CY (1995) A revisitation of the mechanism of action of KCl-induced vascular smooth muscle contraction: a key role of cation binding to the plasma membrane. Biol Signals 4:160\u2013167","journal-title":"Biol Signals"},{"key":"1096_CR24","first-page":"197","volume":"17","author":"Kravtsov","year":"1996","unstructured":"Kravtsov GM, Kwan CY (1996) Protein kinase plays no role in KCl-induced vascular contraction in Ca2+-free medium. Acta Pharmacol Sin 17:197\u2013201","journal-title":"Acta Pharmacol Sin"},{"key":"1096_CR25","doi-asserted-by":"crossref","unstructured":"Kuo C-C, Hess P (1993) Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaechromocytoma cells. J Physiol (Lond) 466:683\u2013706","DOI":"10.1113\/jphysiol.1993.sp019740"},{"key":"1096_CR26","unstructured":"Martell AE, Smith RM (1974) Critical stability constants, vol 1. Plenum Press, New York"},{"key":"1096_CR27","unstructured":"Martell AE, Smith RM (1977) Critical stability constants, vol 3. Plenum Press, New York"},{"key":"1096_CR28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1042\/bj20020191","volume":"364","author":"Mita","year":"2002","unstructured":"Mita M, Yanagihara H, Hishiinuma S, Saito M and Walsh MP (2002) Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J 364:431\u2013440","journal-title":"Biochem J"},{"key":"1096_CR29","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1139\/y00-050","volume":"78","author":"Mori","year":"2000","unstructured":"Mori M, Tsushima H (2000) Activation of Rho signaling contributes to lysophosphatic acid-induced contraction of intact ileal smooth muscle of guinea-pig. Can J Physiol Pharmacol 78:729\u2013736","journal-title":"Can J Physiol Pharmacol"},{"key":"1096_CR30","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1016\/0006-2952(84)90037-6","volume":"35","author":"Movsesian","year":"1984","unstructured":"Movsesian MA, Swain AL, Adelstein RS (1984) Inhibition of turkey gizzard myosin light chain kinase activity by dihydropyridine calcium antagonists. Biochem Pharmacol 35:3759\u20133764","journal-title":"Biochem Pharmacol"},{"key":"1096_CR31","doi-asserted-by":"crossref","first-page":"C57","DOI":"10.1152\/ajpcell.2000.278.1.C57","volume":"278","author":"Nagumo","year":"2000","unstructured":"Nagumo H, Sasaki Y, Ono Y, Okamoto H, Seto M, Takuwa Y (2000) Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. Am J Physiol 278:C57\u2013C65","journal-title":"Am J Physiol"},{"key":"1096_CR32","doi-asserted-by":"crossref","first-page":"C480","DOI":"10.1152\/ajpcell.2000.279.2.C480","volume":"279","author":"Nakamura","year":"2000","unstructured":"Nakamura M, Sunagawa M, Kosugi T, Serekalis N (2000) Actin filaments disruption inhibits L-type Ca2+ channels current in cultured vascular muscle cells. Am J Physiol 279:C480\u2013C487","journal-title":"Am J Physiol"},{"key":"1096_CR33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1254\/jjp.60.403","volume":"60","author":"Okada","year":"1992","unstructured":"Okada Y, Yanagisawa T, Taira N (1992) KCl-depolarization potentiates the Ca2+ sensitization by endothelin-1 in canine coronary artery. Jpn J Pharmacol 60:403\u2013405","journal-title":"Jpn J Pharmacol"},{"key":"1096_CR34","doi-asserted-by":"crossref","first-page":"18201","DOI":"10.1074\/jbc.270.31.18201","volume":"270","author":"Peterson","year":"1995","unstructured":"Peterson BZ, Catterall WA (1995) Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding. J Biol Chem 270:18201\u201318204","journal-title":"J Biol Chem"},{"key":"1096_CR35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF00586517","volume":"410","author":"Pritchard","year":"1987","unstructured":"Pritchard K, Ashley CC (1987) Evidence for Na+\/Ca2+ exchange in isolated smooth muscle cells: a fura-2 study. Pflugers Arch 410:401\u2013407","journal-title":"Pflugers Arch"},{"key":"1096_CR36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00969089","volume":"18","author":"Reig","year":"1993","unstructured":"Reig JA, Viniegra S, Ballesta JJ, Palmero M, Guitierrez LM (1993) Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells. Neurochem Res 18:317\u2013323","journal-title":"Neurochem Res"},{"key":"1096_CR37","first-page":"497","volume":"261","author":"Sato","year":"1992","unstructured":"Sato K, Hori M, Ozaki H, Takano-Ohmuro H, Tsuchiya T, Sugi H, Karaki H (1992) Myosin phosphorylation-independent contraction induced by phorbol ester in vascular smooth muscle. J Pharmacol Exp Ther 261:497\u2013505","journal-title":"J Pharmacol Exp Ther"},{"key":"1096_CR38","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1016\/S0021-9258(18)47638-7","volume":"262","author":"Satoh","year":"1987","unstructured":"Satoh M, Ishikawa T, Matsushima S, Naka, M, Hidaka H (1987) Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J Biol Chem 262:7796\u20137801","journal-title":"J Biol Chem"},{"key":"1096_CR39","doi-asserted-by":"crossref","unstructured":"Somlyo AP, Somlyo AV (2000) Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol (Lond) 522:177\u2013185","DOI":"10.1111\/j.1469-7793.2000.t01-2-00177.x"},{"key":"1096_CR40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1126\/science.2451291","volume":"240","author":"Tang","year":"1989","unstructured":"Tang C-M, Presser F, Morad M (1989) Amiloride selectively blocks the low threshold (T) calcium channel. Science 240:213\u2013215","journal-title":"Science"},{"key":"1096_CR41","doi-asserted-by":"crossref","unstructured":"Triggle CR, Triggle DJ (1975) An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle. J Physiol (Lond) 254:39\u201354","DOI":"10.1113\/jphysiol.1976.sp011219"},{"key":"1096_CR42","doi-asserted-by":"crossref","unstructured":"Ueno H (1985) Calcium mobilization in enzymically isolated single intact and skinned muscle cells of the porcine coronary artery. J Physiol (Lond) 363:103\u2013117","DOI":"10.1113\/jphysiol.1985.sp015698"},{"key":"1096_CR43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00587378","volume":"359","author":"Van","year":"1975","unstructured":"Van Bremeen C, Wuytack F, Casteels R (1975) Stimulation of45Ca efflux from smooth muscle cells by metabolic inhibition and high K depolarization. Pflugers Arch 359:183\u2013196","journal-title":"Pflugers Arch"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-003-1096-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-003-1096-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-003-1096-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T13:34:32Z","timestamp":1704980072000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-003-1096-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,25]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["1096"],"URL":"https:\/\/doi.org\/10.1007\/s00424-003-1096-x","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,25]]}}}