{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:50:26Z","timestamp":1773978626015,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,7,10]],"date-time":"2004-07-10T00:00:00Z","timestamp":1089417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1007\/s00424-004-1310-5","type":"journal-article","created":{"date-parts":[[2004,7,9]],"date-time":"2004-07-09T14:23:21Z","timestamp":1089383001000},"page":"106-114","source":"Crossref","is-referenced-by-count":19,"title":["Bronchiolar expression of aquaporin-3 (AQP3) in rat lung and its dynamics in pulmonary oedema"],"prefix":"10.1007","volume":"449","author":[{"given":"Kimiya","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Aida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,7,10]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","unstructured":"Agre P, King LS, Yasui M, Guggino WB, Ottersen OP, Fujiyoshi Y, Engel A, Nielsen S (2002) Aquaporin water channels?from atomic structure to clinical medicine. J Physiol (Lond) 542:3?16","DOI":"10.1113\/jphysiol.2002.020818"},{"key":"CR2","first-page":"L193","volume":"267","author":"Al-Bazzaz","year":"1994","unstructured":"Al-Bazzaz FJ (1994) Regulation of Na and Cl transport in sheep distal airways. Am J Physiol 267:L193?L198","journal-title":"Am J Physiol"},{"key":"CR3","first-page":"H1711","volume":"256","author":"Allison","year":"1989","unstructured":"Allison RC, Rippe B, Prasad VR, Parker JC, Taylor AE (1989) Pulmonary vascular permeability and resistance measurements in control and ANTU-injured dog lungs. Am J Physiol 256:H1711?H1718","journal-title":"Am J Physiol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1172\/JCI4138","volume":"103","author":"Bai","year":"1999","unstructured":"Bai C, Fukuda N, Song YL, Ma T, Matthay MA, Verkman AS (1999) Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest 103:555?561","journal-title":"J Clin Invest"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1152\/jappl.1992.73.5.2021","volume":"73","author":"Ballard","year":"1992","unstructured":"Ballard ST, Schepens SM, Falcone JC, Meininger GA, Taylor AE (1992) Regional bioelectric properties of porcine airway epithelium. J Appl Physiol 73:2021?2027","journal-title":"J Appl Physiol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1681\/ASN.V991553","volume":"9","author":"Baumgarten","year":"1998","unstructured":"Baumgarten R, Van De Pol MH, Wetzels JF, Van Os CH, Deen PM (1998) Glycosylation is not essential for vasopressin-dependent routing of aquaporin-2 in transfected Madin-Darby canine kidney cells. J Am Soc Nephrol 9:1553?1559","journal-title":"J Am Soc Nephrol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.4869","volume":"27","author":"Blouquit","year":"2002","unstructured":"Blouquit S, Morel H, Hinnrasky J, Naline E, Puchelle E, Chinet T (2002) Characterization of ion and fluid transport in human bronchioles. Am J Respir Cell Mol Biol 27:503?510","journal-title":"Am J Respir Cell Mol Biol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.68.1.425","volume":"68","author":"Borgnia","year":"1999","unstructured":"Borgnia M, Nielsen S, Engel A, Agre P (1999) Cellular and molecular biology of the aquaporin water channels. Annu Rev Biochem 68:425?458","journal-title":"Annu Rev Biochem"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1152\/japplphysiol.01171.2001","volume":"93","author":"Borok","year":"2002","unstructured":"Borok Z, Verkman AS (2002) Role of aquaporin water channels in fluid transport in lung and airways. J Appl Physiol 93:2199?2206","journal-title":"J Appl Physiol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1164\/ajrccm.150.1.8025763","volume":"150","author":"Boucher","year":"1994","unstructured":"Boucher RC (1994) Human airway ion transport. Part one. Am J Respir Crit Care Med 150:271?281","journal-title":"Am J Respir Crit Care Med"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1164\/ajrccm.150.2.8049852","volume":"150","author":"Boucher","year":"1994","unstructured":"Boucher RC (1994) Human airway ion transport. Part two. Am J Respir Crit Care Med 150:581?593","journal-title":"Am J Respir Crit Care Med"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1164\/ajrccm.163.4.2006116","volume":"163","author":"Crandall","year":"2001","unstructured":"Crandall ED, Matthay MA (2001) Alveolar epithelial transport. Basic science to clinical medicine. Am J Respir Crit Care Med 163:1021?1029","journal-title":"Am J Respir Crit Care Med"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.1711060103","volume":"106","author":"Cunningham","year":"1972","unstructured":"Cunningham AL, Hurley JV (1972) Alpha-naphthyl-thiourea-induced pulmonary oedema in the rat: a topographical and electron-microscope study. J Pathol 106:25?35","journal-title":"J Pathol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1085\/jgp.119.2.199","volume":"119","author":"Fang","year":"2002","unstructured":"Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA (2002) Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol 119:199?207","journal-title":"J Gen Physiol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1073\/pnas.92.10.4328","volume":"92","author":"Frigeri","year":"1995","unstructured":"Frigeri A, Gropper MA, Turck CW, Verkman AS (1995) Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc Natl Acad Sci USA 92:4328?4331","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0034-5687(00)00193-6","volume":"124","author":"Hales","year":"2001","unstructured":"Hales CA, Du HK, Volokhov A, Mourfarrej R, Quinn DA (2001) Aquaporin channels may modulate ventilator-induced lung injury. Respir Physiol 124:159?166","journal-title":"Respir Physiol"},{"key":"CR17","first-page":"441","volume":"127","author":"Havill","year":"1987","unstructured":"Havill AM, Gee MH (1987) Resolution of increased permeability pulmonary edema in rats. Am J Pathol 127:441?446","journal-title":"Am J Pathol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1126\/science.291.5512.2364","volume":"291","author":"Helenius","year":"2001","unstructured":"Helenius A, Aebi M (2001) Intracellular functions of N-linked glycans. Science 291:2364?2369","journal-title":"Science"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1074\/jbc.M310767200","volume":"279","author":"Hendriks","year":"2004","unstructured":"Hendriks G, Koudijs M, van Balkom BWM, Oorschot V, Klumperman J, Deen PMT, van der Sluijs P (2004) Glycosylation is important for cell surface expression of the water channel aquaporin-2 but is not essential for tetramerization in the endoplasmic reticulum. J Biol Chem 279:2975?2983","journal-title":"J Biol Chem"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"17913","DOI":"10.1074\/jbc.270.30.17913","volume":"270","author":"Inase","year":"1995","unstructured":"Inase N, Fushimi K, Ishibashi K, Uchida S, Ichioka M, Sasaki S, Marumo F (1995) Isolation of human aquaporin 3 gene. J Biol Chem 270:17913?17916","journal-title":"J Biol Chem"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1172\/JCI118659","volume":"97","author":"King","year":"1996","unstructured":"King LS, Nielsen S, Agre P (1996) Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. J Clin Invest 97:2183?2191","journal-title":"J Clin Invest"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1073\/pnas.022626499","volume":"99","author":"King","year":"2002","unstructured":"King LS, Nielsen S, Agre P, Brown RH (2002) Decreased pulmonary vascular permeability in aquaporin-1-null humans. Proc Natl Acad Sci USA 99:1059?1063","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"C621","DOI":"10.1152\/ajpcell.1999.276.3.C621","volume":"276","author":"Koyama","year":"1999","unstructured":"Koyama Y, Yamamoto T, Tani T, Nihei K, Kondo D, Funaki H, Yaoita E, Kawasaki K, Sato N, Hatakeyama K, Kihara I (1999) Expression and localization of aquaporins in rat gastrointestinal tract. Am J Physiol 276:C621?C627","journal-title":"Am J Physiol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/j.1523-1755.2002.kid564.x","volume":"62","author":"Lai","year":"2002","unstructured":"Lai KN, Leung JCK, Chan LYY, Tang S, Li FK, Lui SL, Chan TM (2002) Expression of aquaporin-3 in human peritoneal mesothelial cells and its up-regulation by glucose in vitro. Kidney Int 62:1431?1439","journal-title":"Kidney Int"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI8258","volume":"105","author":"Ma","year":"2000","unstructured":"Ma T, Fukuda N, Song YL, Matthay MA, Verkman AS (2000) Lung fluid transport in aquaporin-5 knockout mice. J Clin Invest 105:93?100","journal-title":"J Clin Invest"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"C55","DOI":"10.1152\/ajpcell.2001.281.1.C55","volume":"281","author":"Matsuzaki","year":"2001","unstructured":"Matsuzaki T, Suzuki T, Takata K (2001) Hypertonicity-induced expression of aquaporin 3 in MDCK cells. Am J Physiol 281:C55?C63","journal-title":"Am J Physiol"},{"key":"CR27","first-page":"L487","volume":"270","author":"Matthay","year":"1996","unstructured":"Matthay MA, Folkesson HG, and Verkman AS (1996) Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol 270:L487?L503","journal-title":"Am J Physiol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1152\/physrev.00003.2002","volume":"82","author":"Matthay","year":"2002","unstructured":"Matthay MA, Folkesson HG, Clerici C (2002) Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev 82:569?600","journal-title":"Physiol Rev"},{"key":"CR29","first-page":"474","volume":"119","author":"Michel","year":"1985","unstructured":"Michel RP (1985) Lung microvascular permeability to dextran in ?-naphthylthiourea-induced edema. Sites of filtration, patterns of accumulation, and effects of fixation. Am J Pathol 119:474?484","journal-title":"Am J Pathol"},{"key":"CR30","first-page":"679","volume":"79","author":"Nakanishi","year":"1999","unstructured":"Nakanishi K, Tajima F, Osada H, Kato T, Miyazaki H, Kawai T, Torikata C, Suga T, Takishima K, Aurues T, Ikeda T (1999) Thrombopoietin expression in normal and hypobaric hypoxia-induced thrombocytopenic rats. Lab Invest 79:679?688","journal-title":"Lab Invest"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"C1549","DOI":"10.1152\/ajpcell.1997.273.5.C1549","volume":"273","author":"Nielsen","year":"1997","unstructured":"Nielsen S, King LS, Christensen BM, Agre P (1997) Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. Am J Physiol 273:C1549?C1561","journal-title":"Am J Physiol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.med.45.1.421","volume":"45","author":"Noone","year":"1994","unstructured":"Noone PG, Olivier KN, Knowles MR (1994) Modulation of the ionic milieu of the airway in health and disease. Annu Rev Med 45:421?34","journal-title":"Annu Rev Med"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1620\/tjem.138.299","volume":"138","author":"Ohkuda","year":"1982","unstructured":"Ohkuda K, Ohnuki T, Koike K, Nitta S, Nakada T (1982) Quantitative assessment of water content of human lung: a study on open lung biopsy specimen. Tohoku J Exp Med 138:299?307","journal-title":"Tohoku J Exp Med"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.RES.16.5.482","volume":"16","author":"Pearce","year":"1965","unstructured":"Pearce ML, Yamashita J, Beazell J (1965) Measurement of pulmonary edema. Circ Res 16:482?488","journal-title":"Circ Res"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1046\/j.1523-1755.2003.00753.x","volume":"63","author":"Rabb","year":"2003","unstructured":"Rabb H, Wang Z, Nemoto T, Hotchkiss J, Yokota N, Soleimani M (2003) Acute renal failure leads to dysregulation of lung salt and water channels. Kidney Int 63:600?606","journal-title":"Kidney Int"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1152\/jappl.1982.52.5.1316","volume":"52","author":"Rutili","year":"1982","unstructured":"Rutili G, Kvietys P, Martin D, Parker JC, Taylor AE (1982) Increased pulmonary microvascular permeability induced by ?-naphthylthiourea. J Appl Physiol 52:1316?1323","journal-title":"J Appl Physiol"},{"key":"CR37","doi-asserted-by":"crossref","unstructured":"Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS (2000) Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol (Lond) 525:771?779","DOI":"10.1111\/j.1469-7793.2000.00771.x"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"C1744","DOI":"10.1152\/ajpcell.2000.279.6.C1744","volume":"279","author":"Song","year":"2000","unstructured":"Song Y, Yang B, Matthay MA, Ma T, Verkman AS (2000) Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol 279:C1744?C1750","journal-title":"Am J Physiol"},{"key":"CR39","first-page":"F1034","volume":"282","author":"Spector","year":"2002","unstructured":"Spector DA, Wade JB, Dillow R, Steplock DA, Weinman EJ (2002) Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Am J Physiol 282:F1034?F1042","journal-title":"Am J Physiol"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0167-4781(01)00320-7","volume":"1522","author":"Sugiyama","year":"2001","unstructured":"Sugiyama Y, Ota Y, Hara M, Inoue S (2001) Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes. Biochim Biophys Acta 1522:82?88","journal-title":"Biochim Biophys Acta"},{"key":"CR41","first-page":"L1090","volume":"273","author":"Tanaka","year":"1997","unstructured":"Tanaka M, Inase N, Fushimi K, Ishibashi K, Ichioka M, Sasaki S, Marumo F (1997) Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line. Am J Physiol 273:L1090?L1095","journal-title":"Am J Physiol"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1053\/ajkd.2001.26097","volume":"38","author":"Tang","year":"2001","unstructured":"Tang S, Leung JCK, Lam CWK, Lai FM, Chan TM, Lai KN (2001) In vitro studies of aquaporins 1 and 3 expression in cultured human proximal tubular cells: upregulation by transferrin but not albumin. Am J Kidney Dis 38:317?330","journal-title":"Am J Kidney Dis"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1165\/ajrcmb.22.1.3818","volume":"22","author":"Towne","year":"2000","unstructured":"Towne JE, Harrod KS, Krane CM, Menon AG (2000) Decreased expression of aquaporin (AQP) 1 and AQP5 in mouse lung after acute viral infection. Am J Respir Cell Mol Biol 22:34?44","journal-title":"Am J Respir Cell Mol Biol"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1006\/geno.1998.5337","volume":"50","author":"Umenishi","year":"1998","unstructured":"Umenishi F, Verkman AS (1998) Isolation and functional analysis of alternative promoters in the human aquaporin-4 water channel gene. Genomics 50:373?377","journal-title":"Genomics"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1165\/ajrcmb.15.5.8918374","volume":"15","author":"Umenishi","year":"1996","unstructured":"Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS (1996) Sharp increase in rat lung water channel expression in the perinatal period. Am J Respir Cell Mol Biol 15:673?679","journal-title":"Am J Respir Cell Mol Biol"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1021\/bi00007a015","volume":"34","author":"Van","year":"1995","unstructured":"Van Hoek AN, Wiener MC, Verbavatz JM, Brown D, Lipniunas PH, Townsend RR, Verkman AS (1995) Purification and structure-function analysis of native, PNGase F-treated, and endo-?-galactosidase-treated CHIP28 water channels. Biochemistry 34:2212?2219","journal-title":"Biochemistry"},{"key":"CR47","first-page":"L867","volume":"278","author":"Verkman","year":"2000","unstructured":"Verkman AS, Matthay MA, Song Y (2000) Aquaporin water channel and lung physiology. Am J Physiol 278:L867?L879","journal-title":"Am J Physiol"},{"key":"CR48","doi-asserted-by":"crossref","unstructured":"Yasui M, Serlachius E, Lofgren M, Belusa R, Nielsen S, Aperia A (1997) Perinatal change in expression of aquaporin-4 and other water and ion transporters in rat lung. J Physiol (Lond) 505:2?11","DOI":"10.1111\/j.1469-7793.1997.003bc.x"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0014-5793(00)02437-6","volume":"489","author":"Zheng","year":"2001","unstructured":"Zheng X, Chen X (2001) Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. FEBS Lett 489:4?7","journal-title":"FEBS Lett"},{"key":"CR50","first-page":"L896","volume":"271","author":"Zuege","year":"1996","unstructured":"Zuege D, Suzuki S, Berthiaume Y (1996) Increase of lung sodium-potassium-ATPase activity during recovery from high-permeability pulmonary edema. Am J Physiol 271:L896?L909","journal-title":"Am J Physiol"}],"container-title":["Pfl\ufffdgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-004-1310-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-004-1310-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-004-1310-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T04:21:26Z","timestamp":1624508486000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-004-1310-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,10]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["1310"],"URL":"https:\/\/doi.org\/10.1007\/s00424-004-1310-5","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,10]]}}}