{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:19:43Z","timestamp":1791861583979,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,10,27]],"date-time":"2007-10-27T00:00:00Z","timestamp":1193443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1007\/s00424-007-0364-6","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T09:57:55Z","timestamp":1193392675000},"page":"1041-1054","source":"Crossref","is-referenced-by-count":26,"title":["Missorting of the Aquaporin-2 mutant E258K to multivesicular bodies\/lysosomes in dominant NDI is associated with its monoubiquitination and increased phosphorylation by PKC but is due to the loss of E258"],"prefix":"10.1007","volume":"455","author":[{"given":"Erik-Jan","family":"Kamsteeg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J. M.","family":"Savelkoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giel","family":"Hendriks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene B. M.","family":"Konings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M. I.","family":"Nivillac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Karine","family":"Lagendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van der Sluijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M. T.","family":"Deen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,10,27]]},"reference":[{"key":"364_CR1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1523-1755.2003.00049.x","volume":"64","author":"T Asai","year":"2003","unstructured":"Asai T, Kuwahara M, Kurihara H, Sakai T, Terada Y, Marumo F, Sasaki S (2003) Pathogenesis of nephrogenic diabetes. insipidus by aquaporin-2 C-terminus mutations. Kidney Int 64:2\u201310","journal-title":"Kidney Int"},{"key":"364_CR2","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1093\/hmg\/ddh339","volume":"13","author":"F Mattia De","year":"2004","unstructured":"De Mattia F, Savelkoul PJ, Bichet DG, Kamsteeg EJ, Konings IB, Marr N, Arthus MF, Lonergan M, van Os CH, van der SP, Robertson G, Deen PM (2004) A novel mechanism in recessive nephrogenic diabetes insipidus: wild-type aquaporin-2 rescues the apical membrane expression of intracellularly retained AQP2-P262L. Hum Mol Genet 13:3045\u20133056","journal-title":"Hum Mol Genet"},{"key":"364_CR3","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1681\/ASN.2005010104","volume":"16","author":"F Mattia De","year":"2005","unstructured":"De Mattia F, Savelkoul PJ, Kamsteeg EJ, Konings IB, van der SP, Mallmann R, Oksche A, Deen PM (2005) Lack of arginine vasopressin-induced phosphorylation of Aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus. J Am Soc Nephrol 16:2872\u20132880","journal-title":"J Am Soc Nephrol"},{"key":"364_CR4","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1172\/JCI117920","volume":"95","author":"PMT Deen","year":"1995","unstructured":"Deen PMT, Croes H, van Aubel RA, Ginsel LA, van Os CH (1995) Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing. J Clin Invest 95:2291\u20132296","journal-title":"J Clin Invest"},{"key":"364_CR5","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1681\/ASN.V8101493","volume":"8","author":"PMT Deen","year":"1997","unstructured":"Deen PMT, Rijss JPL, Mulders SM, Errington RJ, van Baal J, van Os CH (1997) Aquaporin-2 transfection of Madin\u2013Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport. J Am Soc Nephrol 8:1493\u20131501","journal-title":"J Am Soc Nephrol"},{"key":"364_CR6","doi-asserted-by":"crossref","first-page":"F330","DOI":"10.1152\/ajpcell.00227.2001","volume":"282","author":"PMT Deen","year":"2002","unstructured":"Deen PMT, Van Balkom BWM, Savelkoul PJ, Kamsteeg EJ, Van Raak M, Jennings ML, Muth TR, Rajendran V, Caplan MJ (2002) Aquaporin-2: COOH terminus is necessary but not sufficient for routing to the apical membrane. Am J Physiol Renal Physiol 282:F330\u2013F340","journal-title":"Am J Physiol Renal Physiol"},{"key":"364_CR7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.8140421","volume":"264","author":"PMT Deen","year":"1994","unstructured":"Deen PMT, Verdijk MAJ, Knoers NVAM, Wieringa B, Monnens LAH, van Os CH, van Oost BA (1994) Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science 264:92\u201395","journal-title":"Science"},{"key":"364_CR8","first-page":"F663","volume":"38","author":"CA Ecelbarger","year":"1995","unstructured":"Ecelbarger CA, Terris J, Frindt G, Echevarria M, Marples D, Nielsen S, Knepper MA (1995) Aquaporin-3 water channel localization and regulation in rat kidney. Am J Physiol 38:F663\u2013F672","journal-title":"Am J Physiol"},{"key":"364_CR9","doi-asserted-by":"crossref","first-page":"14800","DOI":"10.1074\/jbc.272.23.14800","volume":"272","author":"K Fushimi","year":"1997","unstructured":"Fushimi K, Sasaki S, Marumo F (1997) Phosphorylation of serine 256 is required for cAMP- dependent regulatory exocytosis of the aquaporin-2 water channel. J Biol Chem 272:14800\u201314804","journal-title":"J Biol Chem"},{"key":"364_CR10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00027.2001","volume":"82","author":"MH Glickman","year":"2002","unstructured":"Glickman MH, Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82:373\u2013428","journal-title":"Physiol Rev"},{"key":"364_CR11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature02503","volume":"429","author":"T Gonen","year":"2004","unstructured":"Gonen T, Sliz P, Kistler J, Cheng Y, Walz T (2004) Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature 429:193\u2013197","journal-title":"Nature"},{"key":"364_CR12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ncb983","volume":"5","author":"K Haglund","year":"2003","unstructured":"Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore PP, Dikic I (2003) Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol 5:461\u2013466","journal-title":"Nat Cell Biol"},{"key":"364_CR13","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1074\/jbc.M310767200","volume":"279","author":"G Hendriks","year":"2004","unstructured":"Hendriks G, Koudijs M, van Balkom BW, Oorschot V, Klumperman J, Deen PMT, van der SP (2004) Glycosylation is important for cell surface expression of the water channel aquaporin-2 but is not essential for tetramerization in the endoplasmic reticulum. J Biol Chem 279:2975\u20132983","journal-title":"J Biol Chem"},{"key":"364_CR14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0002-9440(10)63635-8","volume":"163","author":"K Hirano","year":"2003","unstructured":"Hirano K, Zuber C, Roth J, Ziak M (2003) The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus. Am J Pathol 163:111\u2013120","journal-title":"Am J Pathol"},{"key":"364_CR15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.molcel.2006.02.018","volume":"21","author":"F Huang","year":"2006","unstructured":"Huang F, Kirkpatrick D, Jiang X, Gygi S, Sorkin A (2006) Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell 21:737\u2013748","journal-title":"Mol Cell"},{"key":"364_CR16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0092-8674(95)90078-0","volume":"81","author":"E Ikonen","year":"1995","unstructured":"Ikonen E, Tagaya M, Ullrich O, Montecucco C, Simons K (1995) Different requirements for NSF, SNAP, and Rab proteins in apical and basolateral transport in MDCK cells. Cell 81:571\u2013580","journal-title":"Cell"},{"key":"364_CR17","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200309017","volume":"163","author":"EJ Kamsteeg","year":"2003","unstructured":"Kamsteeg EJ, Bichet DG, Konings IB, Nivet H, Lonergan M, Arthus MF, van Os CH, Deen PMT (2003) Reversed polarized delivery of an aquaporin-2 mutant causes dominant nephrogenic diabetes insipidus. J Cell Biol 163:1099\u20131109","journal-title":"J Cell Biol"},{"key":"364_CR18","doi-asserted-by":"crossref","first-page":"F778","DOI":"10.1152\/ajprenal.2000.279.4.F778","volume":"279","author":"EJ Kamsteeg","year":"2000","unstructured":"Kamsteeg EJ, Deen PMT (2000) Importance of aquaporin-2 expression levels in genotype -phenotype studies in nephrogenic diabetes insipidus. Am J Physiol Renal Physiol 279:F778\u2013F784","journal-title":"Am J Physiol Renal Physiol"},{"key":"364_CR19","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1083\/jcb.151.4.919","volume":"151","author":"EJ Kamsteeg","year":"2000","unstructured":"Kamsteeg EJ, Heijnen I, van Os CH, Deen PMT (2000) The subcellular localization of an Aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers. J Cell Biol 151:919\u2013930","journal-title":"J Cell Biol"},{"key":"364_CR20","doi-asserted-by":"crossref","first-page":"18344","DOI":"10.1073\/pnas.0604073103","volume":"103","author":"EJ Kamsteeg","year":"2006","unstructured":"Kamsteeg EJ, Hendriks G, Boone M, Konings IB, Oorschot V, van der SP, Klumperman J, Deen PM (2006) Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel. Proc Natl Acad Sci USA 103:18344\u201318349","journal-title":"Proc Natl Acad Sci USA"},{"key":"364_CR21","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1093\/emboj\/18.9.2394","volume":"18","author":"EJ Kamsteeg","year":"1999","unstructured":"Kamsteeg EJ, Wormhoudt TA, Rijss JPL, van Os CH, Deen PMT (1999) An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus. EMBO J 18:2394\u20132400","journal-title":"EMBO J"},{"key":"364_CR22","first-page":"F816","volume":"41","author":"T Katsura","year":"1997","unstructured":"Katsura T, Gustafson CE, Ausiello DA, Brown D (1997) Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells. Am J Physiol 41:F816\u2013F822","journal-title":"Am J Physiol"},{"key":"364_CR23","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1086\/323643","volume":"69","author":"M Kuwahara","year":"2001","unstructured":"Kuwahara M, Iwai K, Ooeda T, Igarashi T, Ogawa E, Katsushima Y, Shinbo I, Uchida S, Terada Y, Arthus MF, Lonergan M, Fujiwara TM, Bichet DG, Marumo F, Sasaki S (2001) Three families with autosomal dominant nephrogenic diabetes insipidus caused by aquaporin-2 mutations in the C-terminus. Am J Hum Genet 69:738\u2013748","journal-title":"Am J Hum Genet"},{"key":"364_CR24","doi-asserted-by":"crossref","first-page":"45509","DOI":"10.1074\/jbc.C100527200","volume":"276","author":"A Marchese","year":"2001","unstructured":"Marchese A, Benovic JL (2001) Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem 276:45509\u201345512","journal-title":"J Biol Chem"},{"key":"364_CR25","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1097\/01.ASN.0000027355.41663.14","volume":"13","author":"N Marr","year":"2002","unstructured":"Marr N, Bichet DG, Hoefs S, Savelkoul PJ, Konings IB, De Mattia F, Graat MP, Arthus MF, Lonergan M, Fujiwara TM, Knoers NVAM, Landau D, Balfe WJ, Oksche A, Rosenthal W, Muller D, van Os CH, Deen PMT (2002) Cell-biologic and functional analyses of five new aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus. J Am Soc Nephrol 13:2267\u20132277","journal-title":"J Am Soc Nephrol"},{"key":"364_CR26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/hmg\/11.7.779","volume":"11","author":"N Marr","year":"2002","unstructured":"Marr N, Bichet DG, Lonergan M, Arthus MF, Jeck N, Seyberth HW, Rosenthal W, van Os CH, Oksche A, Deen PMT (2002) Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin- 2 and their misrouting to late endosomes\/lysosomes explains dominant nephrogenic diabetes insipidus. Hum Mol Genet 11:779\u2013789","journal-title":"Hum Mol Genet"},{"key":"364_CR27","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1073\/pnas.0602087103","volume":"103","author":"BW McDill","year":"2006","unstructured":"McDill BW, Li SZ, Kovach PA, Ding L, Chen F (2006) Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. Proc Natl Acad Sci USA 103:6952\u20136957","journal-title":"Proc Natl Acad Sci USA"},{"key":"364_CR28","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1083\/jcb.142.6.1399","volume":"142","author":"SS Molloy","year":"1998","unstructured":"Molloy SS, Thomas L, Kamibayashi C, Mumby MC, Thomas G (1998) Regulation of endosome sorting by a specific PP2A isoform. J Cell Biol 142:1399\u20131411","journal-title":"J Cell Biol"},{"key":"364_CR29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1172\/JCI2605","volume":"102","author":"SM Mulders","year":"1998","unstructured":"Mulders SM, Bichet DG, Rijss JPL, Kamsteeg EJ, Arthus MF, Lonergan M, Fujiwara M, Morgan K, Leijendekker R, van der Sluijs P, van Os CH, Deen PMT (1998) An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex. J Clin Invest 102:57\u201366","journal-title":"J Clin Invest"},{"key":"364_CR30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35036519","volume":"407","author":"K Murata","year":"2000","unstructured":"Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y (2000) Structural determinants of water permeation through aquaporin-1. Nature 407:599\u2013605","journal-title":"Nature"},{"key":"364_CR31","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1083\/jcb.115.6.1573","volume":"115","author":"IR Nabi","year":"1991","unstructured":"Nabi IR, Le Bivic A, Fambrough D, Rodriguez-Boulan E (1991) An endogenous MDCK lysosomal membrane glycoprotein is targeted basolaterally before delivery to lysosomes. J Cell Biol 115:1573\u20131584","journal-title":"J Cell Biol"},{"key":"364_CR32","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1093\/nar\/gkg509","volume":"31","author":"PC Ng","year":"2003","unstructured":"Ng PC, Henikoff S (2003) SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 31:3812\u20133814","journal-title":"Nucleic Acids Res"},{"key":"364_CR33","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1096\/fj.02-0870fje","volume":"17","author":"G Procino","year":"2003","unstructured":"Procino G, Carmosino M, Marin O, Brunati AM, Contri A, Pinna LA, Mannucci R, Nielsen S, Kwon TH, Svelto M, Valenti G (2003) Ser-256 phosphorylation dynamics of Aquaporin 2 during maturation from the ER to the vesicular compartment in renal cells. FASEB J 17:1886\u20131888","journal-title":"FASEB J"},{"key":"364_CR34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0889-8529(18)30031-8","volume":"24","author":"GL Robertson","year":"1995","unstructured":"Robertson GL (1995) Diabetes insipidus. Endocrinol Metab Clin North Am 24:549\u2013572","journal-title":"Endocrinol Metab Clin North Am"},{"key":"364_CR35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/359233a0","volume":"359","author":"W Rosenthal","year":"1992","unstructured":"Rosenthal W, Seibold A, Antaramian A, Lonergan M, Arthus M-F, Hendy GN, Birnbaumer M, Bichet DG (1992) Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus. Nature 359:233\u2013235","journal-title":"Nature"},{"key":"364_CR36","first-page":"287","volume":"20","author":"DD Sabatini","year":"1996","unstructured":"Sabatini DD, Adesnik M, Ivanov IE, Simon JP (1996) Mechanism of formation of post Golgi vesicles from TGN membranes: Arf-dependent coat assembly and PKC-regulated vesicle scission. Biocell 20:287\u2013300","journal-title":"Biocell"},{"key":"364_CR37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jmb.2005.04.030","volume":"350","author":"AD Schenk","year":"2005","unstructured":"Schenk AD, Werten PJ, Scheuring S, de Groot BL, Muller SA, Stahlberg H, Philippsen A, Engel A (2005) The 4.5A Structure of Human AQP2. J Mol Biol 350:278\u2013289","journal-title":"J Mol Biol"},{"key":"364_CR38","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1126\/science.1063866","volume":"294","author":"SK Shenoy","year":"2001","unstructured":"Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294:1307\u20131313","journal-title":"Science"},{"key":"364_CR39","doi-asserted-by":"crossref","first-page":"14217","DOI":"10.1073\/pnas.0602331103","volume":"103","author":"E Sohara","year":"2006","unstructured":"Sohara E, Rai T, Yang SS, Uchida K, Nitta K, Horita S, Ohno M, Harada A, Sasaki S, Uchida S (2006) Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci USA 103:14217\u201314222","journal-title":"Proc Natl Acad Sci USA"},{"key":"364_CR40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1152\/physrev.00020.2005","volume":"86","author":"O Staub","year":"2006","unstructured":"Staub O, Rotin D (2006) Role of ubiquitylation in cellular membrane transport. Physiol Rev 86:669\u2013707","journal-title":"Physiol Rev"},{"key":"364_CR41","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1242\/jcs.108.6.2405","volume":"108","author":"VN Subramaniam","year":"1995","unstructured":"Subramaniam VN, Krijnse-Locker J, Tang BL, Ericsson M, Yusoff AR, Griffiths G, Hong W (1995) Monoclonal antibody HFD9 identifies a novel 28\u00a0kDa integral membrane protein on the cis-Golgi. J Cell Sci 108:2405\u20132414","journal-title":"J Cell Sci"},{"key":"364_CR42","first-page":"F775","volume":"38","author":"J Terris","year":"1995","unstructured":"Terris J, Ecelbarger CA, Marples D, Knepper MA, Nielsen S (1995) Distribution of aquaporin-4 water channel expression within rat kidney. Am J Physiol 38:F775\u2013F785","journal-title":"Am J Physiol"},{"key":"364_CR43","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1038\/sj.onc.1204010","volume":"19","author":"P Thomsen","year":"2000","unstructured":"Thomsen P, van Deurs B, Norrild B, Kayser L (2000) The HPV16 E5 oncogene inhibits endocytic trafficking. Oncogene 19:6023\u20136032","journal-title":"Oncogene"},{"key":"364_CR44","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature04316","volume":"439","author":"S Tornroth-Horsefield","year":"2006","unstructured":"Tornroth-Horsefield S, Wang Y, Hedfalk K, Johanson U, Karlsson M, Tajkhorshid E, Neutze R, Kjellbom P (2006) Structural mechanism of plant aquaporin gating. Nature 439:688\u2013694","journal-title":"Nature"},{"key":"364_CR45","doi-asserted-by":"crossref","first-page":"41473","DOI":"10.1074\/jbc.M207525200","volume":"277","author":"BWM Balkom Van","year":"2002","unstructured":"Van Balkom BWM, Savelkoul PJ, markovich D, Hofman E, Nielsen S, van der Sluijs P, Deen PMT (2002) The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel. J Biol Chem 277:41473\u201341479","journal-title":"J Biol Chem"},{"key":"364_CR46","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.bbamem.2006.03.007","volume":"1758","author":"M Beest van","year":"2006","unstructured":"van Beest M, Robben JH, Savelkoul PJ, Hendriks G, Devonald MA, Konings IB, Lagendijk AK, Karet F, Deen PM (2006) Polarisation, key to good localisation. Biochim Biophys Acta 1758:1126\u20131133","journal-title":"Biochim Biophys Acta"},{"key":"364_CR47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/ng1092-99","volume":"2","author":"AM Ouweland van den","year":"1992","unstructured":"van den Ouweland AM, Dreesen JC, Verdijk MAJ, Knoers NVAM (1992) Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with Nephrogenic Diabetes Insipidus. Nat Genet 2:99\u2013102","journal-title":"Nat Genet"},{"key":"364_CR48","first-page":"648","volume":"55","author":"AF Lieburg van","year":"1994","unstructured":"van Lieburg AF, Verdijk MAJ, Knoers NVAM, van Essen AJ, Proesmans W, Mallmann R, Monnens LAH, van Oost BA, van Os CH, Deen PMT (1994) Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water-channel gene. Am J Hum Genet 55:648\u2013652","journal-title":"Am J Hum Genet"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-007-0364-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-007-0364-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-007-0364-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T07:35:31Z","timestamp":1629963331000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-007-0364-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,27]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["364"],"URL":"https:\/\/doi.org\/10.1007\/s00424-007-0364-6","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,27]]}}}