{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:51:12Z","timestamp":1778277072134,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,1,3]],"date-time":"2008-01-03T00:00:00Z","timestamp":1199318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1007\/s00424-007-0401-5","type":"journal-article","created":{"date-parts":[[2008,1,2]],"date-time":"2008-01-02T12:29:31Z","timestamp":1199276971000},"page":"425-436","source":"Crossref","is-referenced-by-count":25,"title":["Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPAR\u03b3 agonist pioglitazone"],"prefix":"10.1007","volume":"456","author":[{"given":"Ferruh","family":"Artunc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Sandulache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omaima","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna M.","family":"Boini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Beier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Dicks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"P\u00f6tzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Amann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie L.","family":"Blazer-Yost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teut","family":"Risler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Kuhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,1,3]]},"reference":[{"key":"401_CR1","doi-asserted-by":"crossref","first-page":"37834","DOI":"10.1074\/jbc.274.53.37834","volume":"274","author":"D Alvarez de la Rosa","year":"1999","unstructured":"Alvarez de la Rosa D, Zhang P, Naray-Fejes-Toth A, Fejes-Toth G, Canessa CM (1999) The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes. J Biol Chem 274:37834\u201337839","journal-title":"J Biol Chem"},{"key":"401_CR2","doi-asserted-by":"crossref","first-page":"F90","DOI":"10.1152\/ajprenal.00390.2004","volume":"289","author":"MF Arteaga","year":"2005","unstructured":"Arteaga MF, Canessa CM (2005) Functional specificity of Sgk1 and Akt1 on ENaC activity. Am J Physiol Renal Physiol 289:F90\u2013F96","journal-title":"Am J Physiol Renal Physiol"},{"key":"401_CR3","doi-asserted-by":"crossref","first-page":"C605","DOI":"10.1152\/ajpcell.1996.271.2.C605","volume":"271","author":"C Asher","year":"1996","unstructured":"Asher C, Wald H, Rossier BC, Garty H (1996) Aldosterone-induced increase in the abundance of Na+ channel subunits. Am J Physiol 271:C605\u2013C611","journal-title":"Am J Physiol"},{"key":"401_CR4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.med.57.121304.131428","volume":"57","author":"SW Beaven","year":"2006","unstructured":"Beaven SW, Tontonoz P (2006) Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med 57:313\u2013329","journal-title":"Annu Rev Med"},{"key":"401_CR5","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1681\/ASN.2005090983","volume":"17","author":"A Benigni","year":"2006","unstructured":"Benigni A, Zoja C, Tomasoni S, Campana M, Corna D, Zanchi C, Gagliardini E, Garofano E, Rottoli D, Ito T, Remuzzi G (2006) Transcriptional regulation of nephrin gene by peroxisome proliferator-activated receptor-gamma agonist: molecular mechanism of the antiproteinuric effect of pioglitazone. J Am Soc Nephrol 17:1624\u20131632","journal-title":"J Am Soc Nephrol"},{"key":"401_CR6","doi-asserted-by":"crossref","first-page":"C1373","DOI":"10.1152\/ajpcell.1998.274.5.C1373","volume":"274","author":"BL Blazer-Yost","year":"1998","unstructured":"Blazer-Yost BL, Liu X, Helman SI (1998) Hormonal regulation of ENaCs: insulin and aldosterone. Am J Physiol 274:C1373\u2013C1379","journal-title":"Am J Physiol"},{"key":"401_CR7","doi-asserted-by":"crossref","first-page":"C531","DOI":"10.1152\/ajpcell.1999.277.3.C531","volume":"277","author":"BL Blazer-Yost","year":"1999","unstructured":"Blazer-Yost BL, Paunescu TG, Helman SI, Lee KD, Vlahos CJ (1999) Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption. Am J Physiol 277:C531\u2013C536","journal-title":"Am J Physiol"},{"key":"401_CR8","doi-asserted-by":"crossref","first-page":"C1569","DOI":"10.1152\/ajpcell.00226.2004","volume":"287","author":"BL Blazer-Yost","year":"2004","unstructured":"Blazer-Yost BL, Vahle JC, Byars JM, Bacallao RL (2004) Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na(+) channels. Am J Physiol Cell Physiol 287:C1569\u2013C1576","journal-title":"Am J Physiol Cell Physiol"},{"key":"401_CR9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/01.HYP.0000030153.19366.26","volume":"40","author":"A Busjahn","year":"2002","unstructured":"Busjahn A, Aydin A, Uhlmann R, Krasko C, Bahring S, Szelestei T, Feng Y, Dahm S, Sharma AM, Luft FC, Lang F (2002) Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Hypertension 40:256\u2013260","journal-title":"Hypertension"},{"key":"401_CR10","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1073\/pnas.96.5.2514","volume":"96","author":"SY Chen","year":"1999","unstructured":"Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D (1999) Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci USA 96:2514\u20132519","journal-title":"Proc Natl Acad Sci USA"},{"key":"401_CR11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.coph.2004.11.004","volume":"5","author":"G Chinetti-Gbaguidi","year":"2005","unstructured":"Chinetti-Gbaguidi G, Fruchart JC, Staels B (2005) Role of the PPAR family of nuclear receptors in the regulation of metabolic and cardiovascular homeostasis: new approaches to therapy. Curr Opin Pharmacol 5:177\u2013183","journal-title":"Curr Opin Pharmacol"},{"key":"401_CR12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00041552-200403000-00010","volume":"13","author":"ML Correia","year":"2004","unstructured":"Correia ML, Haynes WG (2004) Leptin, obesity and cardiovascular disease. Curr Opin Nephrol Hypertens 13:215\u2013223","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"401_CR13","doi-asserted-by":"crossref","first-page":"38134","DOI":"10.1074\/jbc.M403260200","volume":"279","author":"A Diakov","year":"2004","unstructured":"Diakov A, Korbmacher C (2004) A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel\u2019s alpha-subunit. J Biol Chem 279:38134\u201338142","journal-title":"J Biol Chem"},{"key":"401_CR14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/01.HYP.0000063885.48344.EA","volume":"41","author":"M Farjah","year":"2003","unstructured":"Farjah M, Roxas BP, Geenen DL, Danziger RS (2003) Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat. Hypertension 41:874\u2013878","journal-title":"Hypertension"},{"key":"401_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000070244","volume":"13","author":"GL Firestone","year":"2003","unstructured":"Firestone GL, Giampaolo JR, O\u2019Keeffe BA (2003) Stimulus-dependent regulation of the serum and glucocorticoid inducible protein kinase (Sgk) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 13:1\u201312","journal-title":"Cell Physiol Biochem"},{"key":"401_CR16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0010-4825(91)90033-6","volume":"21","author":"N Foldager","year":"1991","unstructured":"Foldager N, Blomqvist CG (1991) Repeated plasma volume determination with the Evans Blue dye dilution technique: the method and a computer program. Comput Biol Med 21:35\u201341","journal-title":"Comput Biol Med"},{"key":"401_CR17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/sj.ki.5002018","volume":"71","author":"E Gonzalez-Rodriguez","year":"2007","unstructured":"Gonzalez-Rodriguez E, Gaeggeler HP, Rossier BC (2007) IGF-1 vs insulin: respective roles in modulating sodium transport via the PI-3 kinase\/Sgk1 pathway in a cortical collecting duct cell line. Kidney Int 71:116\u2013125","journal-title":"Kidney Int"},{"key":"401_CR18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1001\/archinte.159.1.99","volume":"159","author":"DM Gorson","year":"1999","unstructured":"Gorson DM (1999) Significant weight gain with rezulin therapy. Arch Intern Med 159:99","journal-title":"Arch Intern Med"},{"key":"401_CR19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nm1278","volume":"11","author":"Y Guan","year":"2005","unstructured":"Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD (2005) Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med 11:861\u2013866","journal-title":"Nat Med"},{"key":"401_CR20","first-page":"F1013","volume":"273","author":"Y Guan","year":"1997","unstructured":"Guan Y, Zhang Y, Davis L, Breyer MD (1997) Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans. Am J Physiol 273:F1013\u2013F1022","journal-title":"Am J Physiol"},{"key":"401_CR21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.2042-7158.1976.tb02793.x","volume":"28","author":"TW Hill","year":"1976","unstructured":"Hill TW, Randall PJ (1976) A method for screening diuretic agents in the mouse: an investigation of sexual differences. J Pharm Pharmacol 28:552\u2013554","journal-title":"J Pharm Pharmacol"},{"key":"401_CR22","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1096\/fj.03-0181fje","volume":"17","author":"G Hong","year":"2003","unstructured":"Hong G, Lockhart A, Davis B, Rahmoune H, Baker S, Ye L, Thompson P, Shou Y, O\u2019Shaughnessy K, Ronco P, Brown J (2003) PPARgamma activation enhances cell surface ENaCalpha via up-regulation of SGK1 in human collecting duct cells. FASEB J 17:1966\u20131968","journal-title":"FASEB J"},{"key":"401_CR23","doi-asserted-by":"crossref","first-page":"R935","DOI":"10.1152\/ajpregu.00382.2005","volume":"290","author":"DY Huang","year":"2006","unstructured":"Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, Wulff P, Kuhl D, Vallon V, Lang F (2006) Blunted hypertensive effect of combined fructose and high salt diet in gene targeted mice lacking functional serum and glucocorticoid inducible kinase SGK1. Am J Physiol Regul Integr Comp Physiol 290:R935\u2013R944","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"401_CR24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/01.ASN.0000120368.59693.A8","volume":"15","author":"DY Huang","year":"2004","unstructured":"Huang DY, Wulff P, Volkl H, Loffing J, Richter K, Kuhl D, Lang F, Vallon V (2004) Impaired regulation of renal K+ elimination in the sgk1-knockout mouse. J Am Soc Nephrol 15:885\u2013891","journal-title":"J Am Soc Nephrol"},{"key":"401_CR25","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/dvdy.1155","volume":"221","author":"SM Huber","year":"2001","unstructured":"Huber SM, Friedrich B, Klingel K, Lenka N, Hescheler J, Lang F (2001) Protein and mRNA expression of serum and glucocorticoid-dependent kinase 1 in metanephrogenesis. Dev Dyn 221:464\u2013469","journal-title":"Dev Dyn"},{"key":"401_CR26","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1681\/ASN.2006060606","volume":"17","author":"J Karalliedde","year":"2006","unstructured":"Karalliedde J, Buckingham R, Starkie M, Lorand D, Stewart M, Viberti G (2006) Effect of various diuretic treatments on rosiglitazone-induced fluid retention. J Am Soc Nephrol 17:3482\u20133490","journal-title":"J Am Soc Nephrol"},{"key":"401_CR27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1073\/pnas.89.1.314","volume":"89","author":"K Klingel","year":"1992","unstructured":"Klingel K, Hohenadl C, Canu A, Albrecht M, Seemann M, Mall G, Kandolf R (1992) Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation. Proc Natl Acad Sci USA 89:314\u2013318","journal-title":"Proc Natl Acad Sci USA"},{"key":"401_CR28","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1152\/physrev.00050.2005","volume":"86","author":"F Lang","year":"2006","unstructured":"Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V (2006) (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 86:1151\u20131178","journal-title":"Physiol Rev"},{"key":"401_CR29","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1073\/pnas.97.14.8157","volume":"97","author":"F Lang","year":"2000","unstructured":"Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, Friedrich B, Lanzendorfer M, Melzig J, Moschen I, Steuer S, Waldegger S, Sauter M, Paulmichl M, Gerke V, Risler T, Gamba G, Capasso G, Kandolf R, Hebert SC, Massry SG, Broer S (2000) Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. Proc Natl Acad Sci USA 97:8157\u20138162","journal-title":"Proc Natl Acad Sci USA"},{"key":"401_CR30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1681\/ASN.2005030257","volume":"17","author":"Y Li","year":"2006","unstructured":"Li Y, Wen X, Spataro BC, Hu K, Dai C, Liu Y (2006) hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists. J Am Soc Nephrol 17:54\u201365","journal-title":"J Am Soc Nephrol"},{"key":"401_CR31","doi-asserted-by":"crossref","first-page":"F675","DOI":"10.1152\/ajprenal.2001.280.4.F675","volume":"280","author":"J Loffing","year":"2001","unstructured":"Loffing J, Zecevic M, Feraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, Verrey F (2001) Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol 280:F675\u2013F682","journal-title":"Am J Physiol Renal Physiol"},{"key":"401_CR32","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.2337\/diabetes.53.11.2844","volume":"53","author":"J Matsui","year":"2004","unstructured":"Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T (2004) Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet. Diabetes 53:2844\u20132854","journal-title":"Diabetes"},{"key":"401_CR33","doi-asserted-by":"crossref","first-page":"F339","DOI":"10.1152\/ajprenal.2000.278.3.F339","volume":"278","author":"P Meneton","year":"2000","unstructured":"Meneton P, Ichikawa I, Inagami T, Schnermann J (2000) Renal physiology of the mouse. Am J Physiol Renal Physiol 278:F339\u2013F351","journal-title":"Am J Physiol Renal Physiol"},{"key":"401_CR34","doi-asserted-by":"crossref","first-page":"16973","DOI":"10.1074\/jbc.274.24.16973","volume":"274","author":"A Naray-Fejes-Toth","year":"1999","unstructured":"Naray-Fejes-Toth A, Canessa C, Cleaveland ES, Aldrich G, Fejes-Toth G (1999) Sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial Na+ channels. J Biol Chem 274:16973\u201316978","journal-title":"J Biol Chem"},{"key":"401_CR35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/01.crd.0000102419.52594.90","volume":"12","author":"LA Nikolaidis","year":"2004","unstructured":"Nikolaidis LA, Levine TB (2004) Peroxisome proliferator activator receptors (PPAR), insulin resistance, and cardiomyopathy: friends or foes for the diabetic patient with heart failure. Cardiol Rev 12:158\u2013170","journal-title":"Cardiol Rev"},{"key":"401_CR36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00424-005-1477-4","volume":"451","author":"C Nofziger","year":"2005","unstructured":"Nofziger C, Chen L, Shane MA, Smith CD, Brown KK, Blazer-Yost BL (2005) PPARgamma agonists do not directly enhance basal or insulin-stimulated Na(+) transport via the epithelial Na(+) channel. Pflugers Arch 451:445\u2013453","journal-title":"Pflugers Arch"},{"key":"401_CR37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1517\/14728214.11.3.379","volume":"11","author":"B Pourcet","year":"2006","unstructured":"Pourcet B, Fruchart JC, Staels B, Glineur C (2006) Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis. Expert Opin Emerg Drugs 11:379\u2013401","journal-title":"Expert Opin Emerg Drugs"},{"key":"401_CR38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1524-6175.2005.04784.x","volume":"8","author":"R Qayyum","year":"2006","unstructured":"Qayyum R, Adomaityte J (2006) A meta-analysis of the effect of thiazolidinediones on blood pressure. J Clin Hypertens (Greenwich) 8:19\u201328","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"401_CR39","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1517\/13543784.15.7.763","volume":"15","author":"RS Savkur","year":"2006","unstructured":"Savkur RS, Miller AR (2006) Investigational PPAR-gamma agonists for the treatment of Type 2 diabetes. Expert Opin Investig Drugs 15:763\u2013778","journal-title":"Expert Opin Investig Drugs"},{"key":"401_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000071068","volume":"94","author":"V Vallon","year":"2003","unstructured":"Vallon V (2003) In vivo studies of the genetically modified mouse kidney. Nephron Physiol 94:1\u20135","journal-title":"Nephron Physiol"},{"key":"401_CR41","doi-asserted-by":"crossref","first-page":"R395","DOI":"10.1152\/ajpregu.00731.2004","volume":"289","author":"V Vallon","year":"2005","unstructured":"Vallon V, Huang DY, Grahammer F, Wyatt AW, Osswald H, Wulff P, Kuhl D, Lang F (2005) SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess. Am J Physiol Regul Integr Comp Physiol 289:R395\u2013R401","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"401_CR42","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1161\/01.CIR.0000147614.85888.7A","volume":"110","author":"W Verreth","year":"2004","unstructured":"Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki JK, Mertens A, Quarck R, Benhabiles N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, Holvoet P (2004) Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice. Circulation 110:3259\u20133269","journal-title":"Circulation"},{"key":"401_CR43","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1111\/j.1523-1755.2005.00672.x","volume":"68","author":"F von Wowern","year":"2005","unstructured":"von Wowern F, Berglund G, Carlson J, Mansson H, Hedblad B, Melander O (2005) Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. Kidney Int 68:2164\u20132172","journal-title":"Kidney Int"},{"key":"401_CR44","first-page":"618","volume":"54","author":"H Wong","year":"2004","unstructured":"Wong H, Ozalp Y, Lainesse A, Alpan RS (2004) In vivo bioequivalence of oral antidiabetic agents: pioglitazone tablets. Arzneimittelforschung 54:618\u2013624","journal-title":"Arzneimittelforschung"},{"key":"401_CR45","first-page":"219","volume":"166","author":"E Wooltorton","year":"2002","unstructured":"Wooltorton E (2002) Rosiglitazone (Avandia) and pioglitazone (Actos) and heart failure. CMAJ 166:219","journal-title":"CMAJ"},{"key":"401_CR46","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI0215696","volume":"110","author":"P Wulff","year":"2002","unstructured":"Wulff P, Vallon V, Huang DY, Volkl H, Yu F, Richter K, Jansen M, Schlunz M, Klingel K, Loffing J, Kauselmann G, Bosl MR, Lang F, Kuhl D (2002) Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest 110:1263\u20131268","journal-title":"J Clin Invest"},{"key":"401_CR47","doi-asserted-by":"crossref","first-page":"E966","DOI":"10.1152\/ajpendo.00149.2002","volume":"284","author":"K Yajima","year":"2003","unstructured":"Yajima K, Hirose H, Fujita H, Seto Y, Fujita H, Ukeda K, Miyashita K, Kawai T, Yamamoto Y, Ogawa T, Yamada T, Saruta T (2003) Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db\/db mice. Am J Physiol Endocrinol Metab 284:E966\u2013E971","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"401_CR48","doi-asserted-by":"crossref","first-page":"F966","DOI":"10.1152\/ajpcell.1999.277.5.C994","volume":"277","author":"T Yang","year":"1999","unstructured":"Yang T, Michele DE, Park J, Smart AM, Lin Z, Brosius FC III, Schnermann JB, Briggs JP (1999) Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney. Am J Physiol 277:F966\u2013F973","journal-title":"Am J Physiol"},{"key":"401_CR49","doi-asserted-by":"crossref","first-page":"E989","DOI":"10.1152\/ajpcell.1997.272.3.C989","volume":"272","author":"T Yoshimoto","year":"1997","unstructured":"Yoshimoto T, Naruse M, Nishikawa M, Naruse K, Tanabe A, Seki T, Imaki T, Demura R, Aikawa E, Demura H (1997) Antihypertensive and vasculo- and renoprotective effects of pioglitazone in genetically obese diabetic rats. Am J Physiol 272:E989\u2013E996","journal-title":"Am J Physiol"},{"key":"401_CR50","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1681\/ASN.2004040278","volume":"16","author":"S Zafiriou","year":"2005","unstructured":"Zafiriou S, Stanners SR, Saad S, Polhill TS, Poronnik P, Pollock CA (2005) Pioglitazone inhibits cell growth and reduces matrix production in human kidney fibroblasts. J Am Soc Nephrol 16:638\u2013645","journal-title":"J Am Soc Nephrol"},{"key":"401_CR51","doi-asserted-by":"crossref","first-page":"9406","DOI":"10.1073\/pnas.0501744102","volume":"102","author":"H Zhang","year":"2005","unstructured":"Zhang H, Zhang A, Kohan DE, Nelson RD, Gonzalez FJ, Yang T (2005) Collecting duct-specific deletion of peroxisome proliferator-activated receptor {gamma} blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci USA 102:9406\u20139411","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-007-0401-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-007-0401-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-007-0401-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T20:52:27Z","timestamp":1559076747000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-007-0401-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,3]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["401"],"URL":"https:\/\/doi.org\/10.1007\/s00424-007-0401-5","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,3]]}}}