{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:22:31Z","timestamp":1789658551320,"version":"4.0.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:00:00Z","timestamp":1211241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1007\/s00424-008-0522-5","type":"journal-article","created":{"date-parts":[[2008,5,19]],"date-time":"2008-05-19T10:21:15Z","timestamp":1211192475000},"page":"453-461","source":"Crossref","is-referenced-by-count":33,"title":["ATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance"],"prefix":"10.1007","volume":"457","author":[{"given":"Ning","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,20]]},"reference":[{"key":"522_CR1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/000348947808700207","volume":"87","author":"RP Bobbin","year":"1978","unstructured":"Bobbin RP, Thompson MH (1978) Effects of putative transmitters on afferent cochlear transmission. Ann Otol Rhinol Larygnol 87:185\u2013190","journal-title":"Ann Otol Rhinol Larygnol"},{"key":"522_CR2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0378-5955(94)90091-4","volume":"76","author":"SG Kujawa","year":"1994","unstructured":"Kujawa SG, Erostegui C, Fallon M, Crist J, Bobbin RP (1994) Effects of adenosine 5\u2032-triphosphate and related agonists on cochlear function. Hear Res 76:87\u2013100","journal-title":"Hear Res"},{"key":"522_CR3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0378-5955(95)00152-3","volume":"90","author":"DJ Munoz","year":"1995","unstructured":"Munoz DJ, Thorne PR, Housley GD, Billett TE, Battersby JM (1995) Extracellular adenosine 5\u2032-triphosphate (ATP) in the endolymphatic compartment influences cochlear function. Hear Res 90:106\u2013118","journal-title":"Hear Res"},{"key":"522_CR4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0378-5955(99)00151-3","volume":"138","author":"DJ Munoz","year":"1999","unstructured":"Munoz DJ, Thorne PR, Housley GD (1999) P2X receptor-mediated changes in cochlear potentials arising from exogenous adenosine 5\u2032-triphosphate in endolymph. Hear Res 138:56\u201364","journal-title":"Hear Res"},{"key":"522_CR5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-5955(03)00221-1","volume":"183","author":"T Sueta","year":"2003","unstructured":"Sueta T, Paki B, Everett AW, Robertson D (2003) Purinergic receptors in auditory neurotransmission. Hear Res 183:97\u2013108","journal-title":"Hear Res"},{"key":"522_CR6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/jphysiol.1990.sp018203","volume":"428","author":"JF Ashmore","year":"1990","unstructured":"Ashmore JF, Ohmori H (1990) Control of intracellular calcium by ATP in isolated outer hair cells of the guinea-pig cochlea. J Physiol 428:109\u2013131","journal-title":"J Physiol"},{"key":"522_CR7","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1152\/jn.1990.63.5.1068","volume":"63","author":"T Nakagawa","year":"1990","unstructured":"Nakagawa T, Akaike N, Kimitsuki T, Komune S, Arima T (1990) ATP-induced current in isolated outer hair cells of guinea pig cochlea. J Neurophysiol 63:1068\u20131074","journal-title":"J Neurophysiol"},{"key":"522_CR8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00001756-199102000-00001","volume":"2","author":"D Dulon","year":"1991","unstructured":"Dulon D, Mollard P, Aran JM (1991) Extracellular ATP elevates cytosolic Ca2+ in cochlear inner hair cells. NeuroReport 2:69\u201372","journal-title":"NeuroReport"},{"key":"522_CR9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1098\/rspb.1992.0113","volume":"249","author":"GD Housley","year":"1992","unstructured":"Housley GD, Greenwood D, Ashmore JF (1992) Localization of cholinergic and purinergic receptors on outer hair cells isolated from the guinea-pig cochlea. Proc R Soc Lond B 249:265\u2013273","journal-title":"Proc R Soc Lond B"},{"key":"522_CR10","doi-asserted-by":"crossref","first-page":"8377","DOI":"10.1523\/JNEUROSCI.19-19-08377.1999","volume":"19","author":"GD Housley","year":"1999","unstructured":"Housley GD, Kanjhan R, Raybould NP, Greenwood D, Salih SG, Jarlebark L, Burton LD, Setz VC, Cannell MB, Soeller C, Christie DL, Usami S, Matsubara A, Yoshie H, Ryan AF, Thorne PR (1999) Expression of the P2X2 receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission. J Neurosci 19:8377\u20138388","journal-title":"J Neurosci"},{"key":"522_CR11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1113\/jphysiol.1996.sp021251","volume":"491","author":"M Sugasawa","year":"1996","unstructured":"Sugasawa M, Erostegui C, Blanchet C, Dulon D (1996) ATP activates non-selective cation channels and calcium release in inner hair cells of the guinea-pig cochlea. J Physiol 491:707\u2013718","journal-title":"J Physiol"},{"key":"522_CR12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0378-5955(97)00093-2","volume":"111","author":"RA Skellett","year":"1997","unstructured":"Skellett RA, Chen C, Fallon M, Nenov AP, Bobbin RP (1997) Pharmacological evidence that endogenous ATP modulates cochlear mechanics. Hear Res 111:42\u201354","journal-title":"Hear Res"},{"key":"522_CR13","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1126\/science.3966153","volume":"227","author":"WE Brownell","year":"1985","unstructured":"Brownell WE, Bader CR, Bertrand D, Ribaupierre Y (1985) Evoked mechanical responses of isolated cochlear outer hair cells. Science 227:194\u2013196","journal-title":"Science"},{"key":"522_CR14","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1523\/JNEUROSCI.12-12-04575.1992","volume":"12","author":"P Dallos","year":"1992","unstructured":"Dallos P (1992) The active cochlea. J Neurosci 12:4575\u20134585","journal-title":"J Neurosci"},{"key":"522_CR15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/20686","volume":"399","author":"HB Zhao","year":"1999","unstructured":"Zhao HB, Santos-Sacchi J (1999) Auditory collusion and a coupled couple of outer hair cells. Nature 399:359\u2013362","journal-title":"Nature"},{"key":"522_CR16","doi-asserted-by":"crossref","first-page":"18724","DOI":"10.1073\/pnas.0506481102","volume":"102","author":"HB Zhao","year":"2005","unstructured":"Zhao HB, Yu N, Fleming CR (2005) Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear. Proc Natl Acad Sci U S A 102:18724\u201318729","journal-title":"Proc Natl Acad Sci U S A"},{"key":"522_CR17","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1021\/jm020046y","volume":"45","author":"KA Jacobson","year":"2002","unstructured":"Jacobson KA, Jarvis MF, Williams M (2002) Purine and pyrimidine (P2) receptors as drug targets. J Med Chem 45:4057\u20134093","journal-title":"J Med Chem"},{"key":"522_CR18","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","volume":"82","author":"RA North","year":"2002","unstructured":"North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013\u20131067","journal-title":"Physiol Rev"},{"key":"522_CR19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1113\/jphysiol.1997.sp021896","volume":"498","author":"NP Raybould","year":"1997","unstructured":"Raybould NP, Housley GD (1997) Variation in expression of the outer hair cell P2X receptor conductance along the guinea-pig cochlea. J Physiol 498:717\u2013727","journal-title":"J Physiol"},{"key":"522_CR20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(99)00648-5","volume":"273","author":"U Brandle","year":"1999","unstructured":"Brandle U, Zenner HP, Ruppersberg JP (1999) Gene expression of P2x7-receptors in the developing inner ear of the rat. Neurosci Lett 273:105\u2013108","journal-title":"Neurosci Lett"},{"key":"522_CR21","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1097\/00001756-200210280-00030","volume":"13","author":"L Jarlebark","year":"2002","unstructured":"Jarlebark L, Housley GD, Raybould NP, Vlajkovic S, Thorne PR (2002) ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea. NeuroReport 13:1979\u20131984","journal-title":"NeuroReport"},{"key":"522_CR22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1096-9861(20000605)421:3<289::AID-CNE1>3.0.CO;2-0","volume":"421","author":"LE Jarlebark","year":"2000","unstructured":"Jarlebark LE, Housley GD, Thorne PR (2000) Immunohistochemical localization of adenosine 5\u2032-triphosphate-gated ion channel P2X2 receptor subunits in adult and developing rat cochlea. J Comp Neurol 421:289\u2013301","journal-title":"J Comp Neurol"},{"key":"522_CR23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.heares.2004.04.008","volume":"196","author":"A Szucs","year":"2004","unstructured":"Szucs A, Szappanos H, Toth A, Farkas Z, Panyi G, Csernoch L, Sziklai I (2004) Differential expression of purinergic receptor subtypes in the outer hair cells of the guinea pig. Hear Res 196:2\u20137","journal-title":"Hear Res"},{"key":"522_CR24","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1055\/s-0040-1715744","volume":"14","author":"MS Parker","year":"2003","unstructured":"Parker MS, Nkeiruka NO, Bobbin RP (2003) Localization of the P2Y4 receptor in the guinea pig organ of Corti. J Am Acad Audiol 14:286\u2013295","journal-title":"J Am Acad Audiol"},{"key":"522_CR25","unstructured":"Yu N, Zhao HB (2005) Extracellular ATP mediates outer hair cell electromotility. Proceedings of the 28th Association for Research in Otolaryngology Annual Meeting, New Orleans, LA, 19\u201324 February. Available at http:\/\/www.aro.org"},{"key":"522_CR26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.brainres.2006.04.017","volume":"1095","author":"N Yu","year":"2006","unstructured":"Yu N, Zhu ML, Zhao HB (2006) Prestin is expressed on the whole outer hair cell basolateral surface. Brain Res 1095:51\u201358","journal-title":"Brain Res"},{"key":"522_CR27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00424-003-1053-8","volume":"446","author":"J Santos-Sacchi","year":"2003","unstructured":"Santos-Sacchi J, Zhao HB (2003) Excitation of fluorescent dyes inactivates the outer hair cell integral membrane motor protein prestin and betrays its lateral mobility. Pflugers Arch 446:617\u2013622","journal-title":"Pflugers Arch"},{"key":"522_CR28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1469-7793.1998.225bz.x","volume":"510","author":"J Santos-Sacchi","year":"1998","unstructured":"Santos-Sacchi J, Kakehata S, Takahashi S (1998) Effects of membrane potential on the voltage dependence of motility-related charge in outer hair cells of the guinea-pig. J Physiol 510:225\u2013235","journal-title":"J Physiol"},{"key":"522_CR29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-5955(95)00153-5","volume":"90","author":"DJ Munoz","year":"1995","unstructured":"Munoz DJ, Thorne PR, Housley GD, Billett TE (1995) Adenosine 5\u2032-triphosphate (ATP) concentrations in the endolymph and perilymph of the guinea-pig cochlea. Hear Res 90:119\u2013125","journal-title":"Hear Res"},{"key":"522_CR30","unstructured":"Ji N, Zhao HB (2005) Expressions of ATP-gated purinergic (P2) receptors in the cochlear outer hair cells. Proceedings of the 28th Association for Research in Otolaryngology Annual Meeting, New Orleans, LA, 19\u201324 February. Available at http:\/\/www.aro.org"},{"key":"522_CR31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.heares.2005.02.009","volume":"205","author":"RP Bobbin","year":"2005","unstructured":"Bobbin RP, Salt AN (2005) ATP-gamma-S shifts the operating point of outer hair cell transduction towards scala tympani. Hear Res 205:35\u201343","journal-title":"Hear Res"},{"key":"522_CR32","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1523\/JNEUROSCI.17-06-02212.1997","volume":"17","author":"P Dallos","year":"1997","unstructured":"Dallos P, He DZZ, Sziklai I, Metha S, Evans BN (1997) Acetylcholine, outer hair cell electromotility, and the cochlear amplifier. J Neurosci 17:2212\u20132226","journal-title":"J Neurosci"},{"key":"522_CR33","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1523\/JNEUROSCI.20-16-05940.2000","volume":"20","author":"GI Frolenkov","year":"2000","unstructured":"Frolenkov GI, Mammano F, Belyantseva IA, Coling D, Kachar B (2000) Two distinct Ca2+-dependent signaling pathways regulate the motor output of cochlear outer hair cells. J Neurosci 20:5940\u20135948","journal-title":"J Neurosci"},{"key":"522_CR34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00232-005-0835-7","volume":"209","author":"GD Housley","year":"2006","unstructured":"Housley GD, Marcotti W, Navaratnam D, Yamoah EN (2006) Hair cells\u2014beyond the transducer. J Membr Biol 209:89\u2013118","journal-title":"J Membr Biol"},{"key":"522_CR35","doi-asserted-by":"crossref","first-page":"6918","DOI":"10.1523\/JNEUROSCI.19-16-06918.1999","volume":"19","author":"F Mammano","year":"1999","unstructured":"Mammano F, Frolenkov GI, Lagostena L, Belyantseva IA, Kurc M, Dodane V, Colavita A, Kachar B (1999) ATP-induced Ca2+ release in cochlear outer hair cells: localization of an inositol triphosphate-gated Ca2+ store to the base of the sensory hair bundle. J Neurosci 19:6918\u20136929","journal-title":"J Neurosci"},{"key":"522_CR36","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1523\/JNEUROSCI.16-08-02574.1996","volume":"16","author":"C Blanchet","year":"1996","unstructured":"Blanchet C, Erostegui C, Sugasawa M, Dulon D (1996) Acetylcholine-induced potassium current of guinea pig outer hair cells: its dependence on a calcium influx through nicotinic-like receptors. J Neurosci 16:2574\u20132584","journal-title":"J Neurosci"},{"key":"522_CR37","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1113\/jphysiol.1996.sp021240","volume":"491","author":"MG Evans","year":"1996","unstructured":"Evans MG (1996) Acetylcholine activates two currents in guinea-pig outer hair cells. J Physiol 491:563\u2013578","journal-title":"J Physiol"},{"key":"522_CR38","unstructured":"Yu N, Zhao HB (2008) Cytoskeleton mediates outer hair cell electromotility and memory function. Proceedings of the 31st Association for Research in Otolaryngology Annual Meeting, Phoenix, AZ, 16\u201321 February. Available at http:\/\/www.aro.org"},{"key":"522_CR39","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/j.1460-9568.2005.04031.x","volume":"21","author":"HB Zhao","year":"2005","unstructured":"Zhao HB (2005) Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signaling and metabolic communications. Eur J Neurosci 21:1859\u20131868","journal-title":"Eur J Neurosci"},{"key":"522_CR40","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1073\/pnas.95.12.7127","volume":"95","author":"A Fridberger","year":"1998","unstructured":"Fridberger A, Flock A, Ulfendahl M, Flock B (1998) Acoustic overstimulation increases outer hair cell Ca2+ concentrations and causes dynamic contractions of the hearing organ. Proc Natl Acad Sci U S A 95:7127\u20137132","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-008-0522-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-008-0522-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-008-0522-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T22:09:43Z","timestamp":1631311783000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-008-0522-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,20]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["522"],"URL":"https:\/\/doi.org\/10.1007\/s00424-008-0522-5","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,20]]}}}