{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:10:13Z","timestamp":1770819013683,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:00:00Z","timestamp":1337644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s00424-012-1114-y","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T04:31:23Z","timestamp":1337574683000},"page":"167-174","source":"Crossref","is-referenced-by-count":22,"title":["Tetrodotoxin blocks L-type Ca2+ channels in canine ventricular cardiomyocytes"],"prefix":"10.1007","volume":"464","author":[{"given":"Bence","family":"Hegyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"B\u00e1r\u00e1ndi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Kom\u00e1romi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Papp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Magyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"B\u00e1ny\u00e1sz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Krasznai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Szentandr\u00e1ssy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter P.","family":"N\u00e1n\u00e1si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,22]]},"reference":[{"key":"1114_CR1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1469-7793.1997.353bb.x","volume":"505","author":"R Aggarwal","year":"1997","unstructured":"Aggarwal R, Shorofsky SR, Goldman L, Balke CW (1997) Tetrodotoxin-blockable calcium currents in rat ventricular myocytes; a third type of cardiac cell sodium current. J Physiol (Lond) 505:353\u2013369","journal-title":"J Physiol (Lond)"},{"key":"1114_CR2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cardiores.2004.05.010","volume":"63","author":"JL Alvarez","year":"2004","unstructured":"Alvarez JL, Salinas-Stefanon E, Orta G, Ferrer T, Talavera K, Gal\u00e1n L, Vassort G (2004) Occurrence of a tetrodotoxin-sensitive calcium current in rat ventricular myocytes after long-term myocardial infarction. Cardiovasc Res 63:653\u2013661","journal-title":"Cardiovasc Res"},{"key":"1114_CR3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/263344a0","volume":"263","author":"M Baer","year":"1976","unstructured":"Baer M, Best PM, Reuter H (1976) Voltage-dependent action of tetrodotoxin in mammalian cardiac muscle. Nature 263:344\u2013345","journal-title":"Nature"},{"key":"1114_CR4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0008-6363(02)00853-2","volume":"58","author":"T B\u00e1ny\u00e1sz","year":"2003","unstructured":"B\u00e1ny\u00e1sz T, F\u00fcl\u00f6p L, Magyar J, Szentandr\u00e1ssy N, Varr\u00f3 A, N\u00e1n\u00e1si PP (2003) Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp. Cardiovasc Res 58:66\u201375","journal-title":"Cardiovasc Res"},{"key":"1114_CR5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1113\/jphysiol.1981.sp013879","volume":"318","author":"AM Brown","year":"1981","unstructured":"Brown AM, Lee KS, Powell T (1981) Sodium current in single rat heart muscle cells. J Physiol (Lond) 318:479\u2013500","journal-title":"J Physiol (Lond)"},{"key":"1114_CR6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/B:MCBI.0000028759.22274.cf","volume":"261","author":"A Chorvatova","year":"2004","unstructured":"Chorvatova A, Snowdon R, Hart G, Hussain M (2004) Effects of pressure overload-induced hypertrophy on TTX-sensitive inward currents in guinea pig left ventricle. Mol Cell Biochem 261:217\u2013226","journal-title":"Mol Cell Biochem"},{"key":"1114_CR7","first-page":"H128","volume":"273","author":"WC Cole","year":"1997","unstructured":"Cole WC, Chartier D, Martin M, Leblanc N (1997) Ca2+ permeation through Na+ channels in guinea pig ventricular myocytes. Am J Physiol 273:H128\u2013H137","journal-title":"Am J Physiol"},{"key":"1114_CR8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF00581808","volume":"413","author":"T Doerr","year":"1989","unstructured":"Doerr T, Denger R, Trautwein W (1989) Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp. Pflugers Arch 413:599\u2013603","journal-title":"Pflugers Arch"},{"key":"1114_CR9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/BF00392058","volume":"416","author":"T Doerr","year":"1990","unstructured":"Doerr T, Denger R, Doerr A, Trautwein W (1990) Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp. Pflugers Arch 416:230\u2013237","journal-title":"Pflugers Arch"},{"key":"1114_CR10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","volume":"391","author":"OP Hamill","year":"1981","unstructured":"Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85\u2013100","journal-title":"Pflugers Arch"},{"key":"1114_CR11","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s004240050713","volume":"436","author":"JC Hancox","year":"1998","unstructured":"Hancox JC, Levi AJ, Witchel HJ (1998) Time course and voltage dependence of expressed HERG current compared with the native \u201crapid\u201d delayed rectifier K current during the cardiac ventricular action potential. Pflugers Arch 436:843\u2013853","journal-title":"Pflugers Arch"},{"key":"1114_CR12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1748-1716.2007.01734.x","volume":"191","author":"J Haverinen","year":"2007","unstructured":"Haverinen J, Hassinen M, Vornanen M (2007) Fish cardiac sodium channels are tetrodotoxin sensitive. Acta Physiol (Oxf) 191:197\u2013204","journal-title":"Acta Physiol (Oxf)"},{"key":"1114_CR13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/356441a0","volume":"356","author":"SH Heinemann","year":"1992","unstructured":"Heinemann SH, Terlau H, St\u00fchmer W, Imoto K, Numa S (1992) Calcium channel characteristics conferred on the sodium channel by single mutations. Nature 356:441\u2013443","journal-title":"Nature"},{"key":"1114_CR14","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/01.RES.86.6.628","volume":"86","author":"JF Heubach","year":"2000","unstructured":"Heubach JF, K\u00f6hler A, Wettwer E, Ravens U (2000) T-type and tetrodotoxin-sensitive Ca2+ currents coexist in guinea pig ventricular myocytes and are both blocked by mibefradil. Circ Res 86:628\u2013635","journal-title":"Circ Res"},{"key":"1114_CR15","volume-title":"Ion channels in excitable membranes","author":"B Hille","year":"2001","unstructured":"Hille B (2001) Ion channels in excitable membranes. Sinauer Associates Inc, Sunderland"},{"key":"1114_CR16","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s00424-006-0077-2","volume":"452","author":"B Horv\u00e1th","year":"2006","unstructured":"Horv\u00e1th B, Magyar J, Szentandr\u00e1ssy N, Birinyi P, N\u00e1n\u00e1si PP, B\u00e1ny\u00e1sz T (2006) Contribution of I Ks to ventricular repolarization in canine myocytes. Pflugers Arch 452:698\u2013706","journal-title":"Pflugers Arch"},{"key":"1114_CR17","first-page":"71","volume":"3","author":"S Lemaire","year":"1995","unstructured":"Lemaire S, Piot C, Seguin J, Nargeot J, Richard S (1995) Tetrodotoxin-sensitive Ca2+ and Ba2+ currents in human atrial cells. Receptors Channels 3:71\u201381","journal-title":"Receptors Channels"},{"key":"1114_CR18","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s004240050982","volume":"439","author":"KW Linz","year":"2000","unstructured":"Linz KW, Meyer R (2000) Profile and kinetics of L-type calcium current during the cardiac ventricular action potential compared in guinea-pigs, rats and rabbits. Pflugers Arch 439:588\u2013599","journal-title":"Pflugers Arch"},{"key":"1114_CR19","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/0306-3623(94)90369-7","volume":"25","author":"PP N\u00e1n\u00e1si","year":"1994","unstructured":"N\u00e1n\u00e1si PP, Varr\u00f3 A, Lathrop DA, Bryant SH (1994) Effects of veratridine on Na and Ca currents in frog skeletal muscle. Gen Pharmacol 25:1661\u20131666","journal-title":"Gen Pharmacol"},{"key":"1114_CR20","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera\u2014a visualization system for exploratory research and analysis. J Comput Chem 25:1605\u20131612","journal-title":"J Comput Chem"},{"key":"1114_CR21","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1074\/jbc.M110.175406","volume":"286","author":"DB Tikhonov","year":"2011","unstructured":"Tikhonov DB, Zhorov BS (2011) Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channels. J Biol Chem 286:2998\u20133006","journal-title":"J Biol Chem"},{"key":"1114_CR22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1529\/biophysj.104.048173","volume":"88","author":"DB Tikhonov","year":"2005","unstructured":"Tikhonov DB, Zhorov BS (2005) Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands. Biophys J 88:184\u2013197","journal-title":"Biophys J"},{"key":"1114_CR23","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1126\/science.279.5353.1027","volume":"279","author":"LF Santana","year":"1998","unstructured":"Santana LF, G\u00f3mez AM, Lederer WJ (1998) Ca2+ flux through promiscuous cardiac Na+ channels: slip-mode conductance. Science 279:1027\u20131033","journal-title":"Science"},{"key":"1114_CR24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1124\/jpet.103.056564","volume":"308","author":"Z Su","year":"2004","unstructured":"Su Z, Sheets M, Ishida H, Li F, Barry WH (2004) Saxitoxin blocks L-type I Ca. J Pharmacol Exp Ther 308:324\u2013329","journal-title":"J Pharmacol Exp Ther"},{"key":"1114_CR25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1085\/jgp.200709883","volume":"132","author":"H Sun","year":"2008","unstructured":"Sun H, Varela D, Chartier D, Ruben PC, Nattel S, Zamponi GW, Leblanc N (2008) Differential interactions of Na+ channel toxins with T-type Ca2+ channels. J Gen Physiol 132:101\u2013113","journal-title":"J Gen Physiol"},{"key":"1114_CR26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00424-005-1445-z","volume":"450","author":"G Szab\u00f3","year":"2005","unstructured":"Szab\u00f3 G, Szentandr\u00e1ssy N, B\u00edr\u00f3 T, T\u00f3th IB, Czifra G, Magyar J, B\u00e1ny\u00e1sz T, Varr\u00f3 A, Kov\u00e1cs L, N\u00e1n\u00e1si PP (2005) Asymmetrical distribution of ion channels in canine and human left ventricular wall: epicardium versus midmyocardium. Pflugers Arch 450:307\u2013316","journal-title":"Pflugers Arch"},{"key":"1114_CR27","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.cardiores.2004.11.022","volume":"65","author":"N Szentandr\u00e1ssy","year":"2005","unstructured":"Szentandr\u00e1ssy N, B\u00e1ny\u00e1sz T, B\u00edr\u00f3 T, Szab\u00f3 G, T\u00f3th IB, Magyar J, L\u00e1z\u00e1r J, Varr\u00f3 A, Kov\u00e1cs L, N\u00e1n\u00e1si PP (2005) Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium. Cardiovasc Res 65:851\u2013860","journal-title":"Cardiovasc Res"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-012-1114-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-012-1114-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-012-1114-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T20:57:03Z","timestamp":1559077023000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-012-1114-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,22]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["1114"],"URL":"https:\/\/doi.org\/10.1007\/s00424-012-1114-y","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,22]]}}}