{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T21:44:35Z","timestamp":1774302275069,"version":"3.50.1"},"reference-count":130,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T00:00:00Z","timestamp":1344470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1007\/s00424-012-1142-7","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T09:26:37Z","timestamp":1344417997000},"page":"239-248","source":"Crossref","is-referenced-by-count":26,"title":["The role of chemosensitive afferent nerves and TRP ion channels in the pathomechanism of headaches"],"prefix":"10.1007","volume":"464","author":[{"given":"M\u00e1ria","family":"Dux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"S\u00e1ntha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Jancs\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,9]]},"reference":[{"key":"1142_CR1","first-page":"2574","volume":"118","author":"E Andr\u00e8","year":"2008","unstructured":"Andr\u00e8 E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R (2008) Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118:2574\u20132582","journal-title":"J Clin Invest"},{"key":"1142_CR2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF00309843","volume":"175","author":"KH Andres","year":"1987","unstructured":"Andres KH, von D\u00fcring M, Muszynski K, Schmidt RF (1987) Nerve fibres and their terminals of the dura mater encephali of the rat. Anat Embryol (Berl) 175:289\u2013301","journal-title":"Anat Embryol (Berl)"},{"key":"1142_CR3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1476-5381.1977.tb06977.x","volume":"59","author":"PT Arvier","year":"1977","unstructured":"Arvier PT, Chahl LA, Ladd RJ (1977) Modification by capsaicin and compound 48\/80 of dye leakage induced by irritants in the rat. Br J Pharmacol 59:61\u201368","journal-title":"Br J Pharmacol"},{"key":"1142_CR4","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","volume":"41","author":"M Bandell","year":"2004","unstructured":"Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849\u2013857","journal-title":"Neuron"},{"issue":"Pt 8","key":"1142_CR5","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/brain\/awg190","volume":"126","author":"T Bartsch","year":"2003","unstructured":"Bartsch T, Goadsby PJ (2003) Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater. Brain 126(Pt 8):1801\u20131813","journal-title":"Brain"},{"key":"1142_CR6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1748-1716.2010.02217.x","volume":"203","author":"RL Baylie","year":"2011","unstructured":"Baylie RL, Brayden JE (2011) TRPV channels and vascular function. Acta Physiol (Oxf) 203:99\u2013116","journal-title":"Acta Physiol (Oxf)"},{"key":"1142_CR7","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1378\/chest.10-3327","volume":"140","author":"MG Belvisi","year":"2011","unstructured":"Belvisi MG, Dubuis E, Birrell MA (2011) Transient receptor potential A1 channels: insights into cough and airway inflammatory disease. Chest 140:1040\u20131047","journal-title":"Chest"},{"key":"1142_CR8","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1172\/JCI34192","volume":"118","author":"BF Bessac","year":"2008","unstructured":"Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest 118:1899\u20131910","journal-title":"J Clin Invest"},{"key":"1142_CR9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1526-4610.2011.02081.x","volume":"52","author":"A Blumenfeld","year":"2012","unstructured":"Blumenfeld A, Evans RW (2012) OnabotulinumtoxinA for chronic migraine. Headache 52:142\u2013148","journal-title":"Headache"},{"issue":"5 Suppl 2","key":"1142_CR10","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1212\/WNL.59.5_suppl_2.S2","volume":"59","author":"H Bolay","year":"2002","unstructured":"Bolay H, Moskowitz MA (2002) Mechanisms of pain modulation in chronic syndromes. Neurology 59(5 Suppl 2):S2\u2013S7","journal-title":"Neurology"},{"key":"1142_CR11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1749-6632.2011.06326.x","volume":"1245","author":"SD Brain","year":"2011","unstructured":"Brain SD (2011) TRPV1 and TRPA1 channels in inflammatory pain: elucidating mechanisms. Ann N Y Acad Sci 1245:36\u201337","journal-title":"Ann N Y Acad Sci"},{"key":"1142_CR12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pain.2005.02.010","volume":"115","author":"NM Breese","year":"2005","unstructured":"Breese NM, George AC, Pauers LE, Stucky CL (2005) Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse. Pain 115:37\u201349","journal-title":"Pain"},{"key":"1142_CR13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3233\/VES-2012-0433","volume":"21","author":"R Burstein","year":"2011","unstructured":"Burstein R, Jakubowski M, Rauch SD (2011) The science of migraine. J Vestib Res 21:305\u2013314","journal-title":"J Vestib Res"},{"key":"1142_CR14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1468-2982.1995.1504277.x","volume":"15","author":"MG Buzzi","year":"1995","unstructured":"Buzzi MG, Bonamini M, Moskowitz MA (1995) Neurogenic model of migraine. Cephalalgia 15:277\u2013280","journal-title":"Cephalalgia"},{"issue":"5","key":"1142_CR15","doi-asserted-by":"crossref","first-page":"e38005","DOI":"10.1371\/journal.pone.0038005","volume":"7","author":"DS Cao","year":"2012","unstructured":"Cao DS, Zhong L, Hsieh TH, Abooj M, Bishnoi M, Hughes L, Premkumar LS (2012) Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. PLoS One 7(5):e38005","journal-title":"PLoS One"},{"key":"1142_CR16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.neuro.24.1.487","volume":"24","author":"MJ Caterina","year":"2001","unstructured":"Caterina MJ, Julius D (2001) The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 24:487\u2013517","journal-title":"Annu Rev Neurosci"},{"key":"1142_CR17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816\u2013824","journal-title":"Nature"},{"key":"1142_CR18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1046\/j.1526-4610.1998.3805352.x","volume":"38","author":"D Cavallotti","year":"1998","unstructured":"Cavallotti D, Artico M, De Santis S, Iannetti G, Cavallotti C (1998) Catecholaminergic innervation of the human dura mater involved in headache. Headache 38:352\u2013355","journal-title":"Headache"},{"key":"1142_CR19","doi-asserted-by":"crossref","first-page":"10119","DOI":"10.1523\/JNEUROSCI.1299-11.2011","volume":"31","author":"DJ Cavanaugh","year":"2011","unstructured":"Cavanaugh DJ, Chesler AT, Br\u00e1z JM, Shah NM, Julius D, Basbaum AI (2011) Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci 31:10119\u201310127","journal-title":"J Neurosci"},{"key":"1142_CR20","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s11916-009-0078-x","volume":"13","author":"Y Chen","year":"2009","unstructured":"Chen Y (2009) Advances in the pathophysiology of tension-type headache: from stress to central sensitization. Curr Pain Headache Rep 13:484\u2013494","journal-title":"Curr Pain Headache Rep"},{"key":"1142_CR21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.brainres.2011.02.009","volume":"1383","author":"MJ Choi","year":"2011","unstructured":"Choi MJ, Jin Z, Park YS, Rhee YK, Jin YH (2011) Transient receptor potential (TRP) A1 activated currents in TRPV1 and cholecystokinin-sensitive cranial visceral afferent neurons. Brain Res 1383:36\u201342","journal-title":"Brain Res"},{"key":"1142_CR22","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/35082088","volume":"411","author":"HH Chuang","year":"2001","unstructured":"Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411:957\u2013962","journal-title":"Nature"},{"key":"1142_CR23","series-title":"Neurogenic Inflammation in Health and Disease","first-page":"101","volume-title":"Neuroimmune biology","author":"DN Cortright","year":"2009","unstructured":"Cortright DN, Szallasi A (2009) The role of the vanilloid and related receptor sin nociceptor function and neuroimmune regulation. In: Jancs\u00f3 G (ed) Neuroimmune biology, vol 8, 1st edn, Neurogenic Inflammation in Health and Disease. Elsevier, Amsterdam, pp 101\u2013120","edition":"1"},{"key":"1142_CR24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/jphysiol.1984.sp015021","volume":"346","author":"R Couture","year":"1984","unstructured":"Couture R, Cuello AC (1984) Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat. J Physiol 346:273\u2013285","journal-title":"J Physiol"},{"key":"1142_CR25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1744-8069-4-30","volume":"4","author":"L Cruz-Orengo","year":"2008","unstructured":"Cruz-Orengo L, Dhaka A, Heuermann RJ, Young TJ, Montana MC, Cavanaugh EJ, Kim D, Story GM (2008) Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain 4:30","journal-title":"Mol Pain"},{"key":"1142_CR26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-2999(03)02117-4","volume":"476","author":"T Csont","year":"2003","unstructured":"Csont T, Csonka C, Kov\u00e1cs P, Jancs\u00f3 G, Ferdinandy P (2003) Capsaicin-sensitive sensory neurons regulate myocardial nitric oxide and cGMP signaling. Eur J Pharmacol 476:107\u2013113","journal-title":"Eur J Pharmacol"},{"key":"1142_CR27","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI30951","volume":"117","author":"Y Dai","year":"2007","unstructured":"Dai Y, Wang S, Tominaga M, Yamamoto S, Fukuoka T, Higashi T, Kobayashi K, Obata K, Yamanaka H, Noguchi K (2007) Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest 117:1979\u20131987","journal-title":"J Clin Invest"},{"key":"1142_CR28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/sj.bjp.0705924","volume":"143","author":"L Petrocellis De","year":"2004","unstructured":"De Petrocellis L, Chu CJ, Moriello AS, Kellner JC, Walker JM, Di Marzo V (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br J Pharmacol 143:251\u2013256","journal-title":"Br J Pharmacol"},{"key":"1142_CR29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1468-2982.2003.00496.x","volume":"23","author":"HC Diener","year":"2003","unstructured":"Diener HC, RPR100893 Study Group (2003) RPR100893, a substance-P antagonist, is not effective in the treatment of migraine attacks. Cephalalgia 23:183\u2013185","journal-title":"Cephalalgia"},{"key":"1142_CR30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0306-4522(91)90253-K","volume":"44","author":"V Dimitriadou","year":"1991","unstructured":"Dimitriadou V, Buzzi MG, Moskowitz MA, Theoharides TC (1991) Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells. Neuroscience 44:97\u2013112","journal-title":"Neuroscience"},{"key":"1142_CR31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0169-328X(92)90204-O","volume":"16","author":"LF Donaldson","year":"1992","unstructured":"Donaldson LF, Harmar AJ, McQueen DS, Seckl JR (1992) Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat. Brain Res Mol Brain Res 16:143\u2013149","journal-title":"Brain Res Mol Brain Res"},{"key":"1142_CR32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0006-8993(87)90073-4","volume":"403","author":"AW Duggan","year":"1987","unstructured":"Duggan AW, Morton CR, Zhao ZQ, Hendry IA (1987) Noxious heating of the skin releases immunoreactive substance P in the substantia gelatinosa of the cat: a study with antibody microprobes. Brain Res 403:345\u2013349","journal-title":"Brain Res"},{"key":"1142_CR33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/BF02263498","volume":"45","author":"M Dux","year":"1996","unstructured":"Dux M, Jancs\u00f3 G, Sann H, Pierau FK (1996) Inhibition of the neurogenic inflammatory response by lidocaine in rat skin. Inflamm Res 45:10\u201313","journal-title":"Inflamm Res"},{"key":"1142_CR34","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1113\/jphysiol.2003.050633","volume":"552","author":"M Dux","year":"2003","unstructured":"Dux M, S\u00e1ntha P, Jancs\u00f3 G (2003) Capsaicin-sensitive neurogenic sensory vasodilatation in the dura mater of the rat. J Physiol 552:859\u2013867","journal-title":"J Physiol"},{"key":"1142_CR35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuroscience.2007.09.001","volume":"150","author":"M Dux","year":"2007","unstructured":"Dux M, Rosta J, Pint\u00e9r S, S\u00e1ntha P, Jancs\u00f3 G (2007) Loss of capsaicin-induced meningeal neurogenic sensory vasodilatation in diabetic rats. Neuroscience 150:194\u2013201","journal-title":"Neuroscience"},{"key":"1142_CR36","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.neuroscience.2009.04.010","volume":"161","author":"M Dux","year":"2009","unstructured":"Dux M, Rosta J, S\u00e1ntha P, Jancs\u00f3 G (2009) Involvement of capsaicin-sensitive afferent nerves in the proteinase-activated receptor 2-mediated vasodilatation in the rat dura mater. Neuroscience 161:887\u2013894","journal-title":"Neuroscience"},{"key":"1142_CR37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/187152311795325569","volume":"10","author":"M Dux","year":"2011","unstructured":"Dux M, Rosta J, Jancs\u00f3 G (2011) Capsaicin-sensitive nociceptive innervation of the dura mater: implications for the pathomechanism of headache. Anti Inflamm Anti Allergy Agents Med Chem 10:31\u201342","journal-title":"Anti Inflamm Anti Allergy Agents Med Chem"},{"key":"1142_CR38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1468-2982.1981.0104175.x","volume":"1","author":"L Edvinsson","year":"1981","unstructured":"Edvinsson L, Uddman R (1981) Adrenergic, cholinergic and peptidergic nerve fibres in dura mater\u2014involvement in headache? Cephalalgia 1:175\u2013179","journal-title":"Cephalalgia"},{"key":"1142_CR39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(01)01532-1","volume":"434","author":"L Edvinsson","year":"2002","unstructured":"Edvinsson L, Alm R, Shaw D, Rutledge RZ, Koblan KS, Longmore J, Kane SA (2002) Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells. Eur J Pharmacol 434:49\u201353","journal-title":"Eur J Pharmacol"},{"key":"1142_CR40","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.2174\/156802611796904898","volume":"11","author":"SR Eid","year":"2011","unstructured":"Eid SR (2011) Therapeutic targeting of TRP channels\u2014the TR(i)P to pain relief. Curr Top Med Chem 11:2118\u20132130","journal-title":"Curr Top Med Chem"},{"key":"1142_CR41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.regpep.2006.12.018","volume":"141","author":"K Elekes","year":"2007","unstructured":"Elekes K, Helyes Z, N\u00e9meth J, S\u00e1ndor K, Pozsgai G, Kereskai L, B\u00f6rzsei R, Pint\u00e9r E, Szab\u00f3 A, Szolcs\u00e1nyi J (2007) Role of capsaicin-sensitive afferents and sensory neuropeptides in endotoxin-induced airway inflammation and consequent bronchial hyperreactivity in the mouse. Regul Pept 141:44\u201354","journal-title":"Regul Pept"},{"key":"1142_CR42","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1476-5381.1993.tb13878.x","volume":"110","author":"KJ Escott","year":"1993","unstructured":"Escott KJ, Brain SD (1993) Effect of a calcitonin gene-related peptide antagonist (CGRP8-37) on skin vasodilatation and oedema induced by stimulation of the rat saphenous nerve. Br J Pharmacol 110:772\u2013776","journal-title":"Br J Pharmacol"},{"key":"1142_CR43","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cub.2011.01.031","volume":"21","author":"W Everaerts","year":"2011","unstructured":"Everaerts W, Gees M, Alpizar YA, Farre R, Leten C, Apetrei A, Dewachter I, van Leuven F, Vennekens R, De Ridder D, Nilius B, Voets T, Talavera K (2011) The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr Biol 21:316\u2013321","journal-title":"Curr Biol"},{"key":"1142_CR44","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1212\/WNL.10.6.555","volume":"10","author":"W Feindel","year":"1960","unstructured":"Feindel W, Penfield W, McNaughton F (1960) The tentorial nerves and localization of intracranial pain in man. Neurology 10:555\u2013563","journal-title":"Neurology"},{"key":"1142_CR45","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1111\/j.1460-9568.2007.05582.x","volume":"25","author":"MJ Fischer","year":"2007","unstructured":"Fischer MJ, Reeh PW (2007) Sensitization to heat through G-protein-coupled receptor pathways in the isolated sciatic mouse nerve. Eur J Neurosci 25:3570\u20133575","journal-title":"Eur J Neurosci"},{"key":"1142_CR46","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/jemt.1074","volume":"53","author":"B Fricke","year":"2001","unstructured":"Fricke B, Andres KH, Von D\u00fcring M (2001) Nerve fibers innervating the cranial and spinal meninges: morphology of nerve fiber terminals and their structural integration. Microsc Res Tech 53:96\u2013105","journal-title":"Microsc Res Tech"},{"key":"1142_CR47","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1172\/JCI35957","volume":"118","author":"F Fujita","year":"2008","unstructured":"Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M (2008) Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest 118:4049\u20134057","journal-title":"J Clin Invest"},{"key":"1142_CR48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1476-5381.1980.tb10409.x","volume":"68","author":"R Gamse","year":"1980","unstructured":"Gamse R, Holzer P, Lembeck F (1980) Decrease of substance P in primary afferent neurons and impairment of neurogenic plasma extravasation by capsaicin. Br J Pharmacol 68:207\u2013213","journal-title":"Br J Pharmacol"},{"key":"1142_CR49","first-page":"343","volume":"69","author":"R Gamse","year":"1987","unstructured":"Gamse R, Posch M, Saria A, Jancs\u00f3 G (1987) Several mediators appear to interact in neurogenic inflammation. Acta Physiol Hung 69:343\u2013354","journal-title":"Acta Physiol Hung"},{"key":"1142_CR50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejphar.2005.12.063","volume":"533","author":"P Geppetti","year":"2006","unstructured":"Geppetti P, Materazzi S, Nicoletti P (2006) The transient receptor potential vanilloid 1: role in airway inflammation and disease. Eur J Pharmacol 533:207\u2013214","journal-title":"Eur J Pharmacol"},{"key":"1142_CR51","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molmed.2006.11.005","volume":"13","author":"PJ Goadsby","year":"2007","unstructured":"Goadsby PJ (2007) Recent advances in understanding migraine mechanisms, molecules and therapeutics. Trends Mol Med 13:39\u201344","journal-title":"Trends Mol Med"},{"key":"1142_CR52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ana.410280213","volume":"28","author":"PJ Goadsby","year":"1990","unstructured":"Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28:183\u2013187","journal-title":"Ann Neurol"},{"key":"1142_CR53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1468-2982.2004.00649.x","volume":"24","author":"R Gottselig","year":"2004","unstructured":"Gottselig R, Messlinger K (2004) Noxious chemical stimulation of rat facial mucosa increases intracranial blood flow through a trigemino-parasympathetic reflex\u2014an experimental model for vascular dysfunctions in cluster headache. Cephalalgia 24:206\u2013214","journal-title":"Cephalalgia"},{"key":"1142_CR54","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1073\/pnas.1110460109","volume":"109","author":"AM Gregus","year":"2012","unstructured":"Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL (2012) Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A 109:6721\u20136726","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1142_CR55","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3748\/wjg.v10.i3.309","volume":"10","author":"SH He","year":"2004","unstructured":"He SH (2004) Key role of mast cells and their major secretory products in inflammatory bowel disease. World J Gastroenterol 10:309\u2013318","journal-title":"World J Gastroenterol"},{"key":"1142_CR56","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/284515a0","volume":"284","author":"T H\u00f6kfelt","year":"1980","unstructured":"H\u00f6kfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M (1980) Peptidergic neurones. Nature 284:515\u2013521","journal-title":"Nature"},{"key":"1142_CR57","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1526-4610.2007.00958.x","volume":"48","author":"K Imamura","year":"2008","unstructured":"Imamura K, Takeshima T, Fusayasu E, Nakashima K (2008) Increased plasma matrix metalloproteinase-9 levels in migraineurs. Headache 48:135\u2013139","journal-title":"Headache"},{"key":"1142_CR58","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.semcdb.2006.09.004","volume":"17","author":"DC Immke","year":"2006","unstructured":"Immke DC, Gavva NR (2006) The TRPV1 receptor and nociception. Semin Cell Dev Biol 17:582\u2013591","journal-title":"Semin Cell Dev Biol"},{"key":"1142_CR59","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/cne.901900409","volume":"190","author":"G Jancs\u00f3","year":"1980","unstructured":"Jancs\u00f3 G, Kir\u00e1ly E (1980) Distribution of chemosensitive primary sensory afferents in the central nervous system of the rat. J Comp Neurol 190:781\u2013792","journal-title":"J Comp Neurol"},{"key":"1142_CR60","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1476-5381.1967.tb01984.x","volume":"31","author":"N Jancs\u00f3","year":"1967","unstructured":"Jancs\u00f3 N, Jancs\u00f3-G\u00e1bor A, Szolcs\u00e1nyi J (1967) Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol Chemother 31:138\u2013151","journal-title":"Br J Pharmacol Chemother"},{"key":"1142_CR61","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/270741a0","volume":"270","author":"G Jancs\u00f3","year":"1977","unstructured":"Jancs\u00f3 G, Kir\u00e1ly E, Jancs\u00f3-G\u00e1bor A (1977) Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 270:741\u2013743","journal-title":"Nature"},{"key":"1142_CR62","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/BF01258524","volume":"10","author":"G Jancs\u00f3","year":"1981","unstructured":"Jancs\u00f3 G, H\u00f6kfelt T, Lundberg JM, Kiraly E, Hal\u00e1sz N, Nilsson G, Terenius L, Rehfeld J, Steinbusch H, Verhofstad A, Elde R, Said S, Brown M (1981) Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin\/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine. J Neurocytol 10:963\u2013980","journal-title":"J Neurocytol"},{"key":"1142_CR63","first-page":"449","volume":"7","author":"G Jancs\u00f3","year":"1985","unstructured":"Jancs\u00f3 G, Ob\u00e1l F Jr, T\u00f3th-K\u00e1sa I, Katona M, Husz S (1985) The modulation of cutaneous inflammatory reactions by peptide-containing sensory nerves. Int J Tissue React 7:449\u2013457","journal-title":"Int J Tissue React"},{"key":"1142_CR64","series-title":"Neurogenic Inflammation in Health and Disease","first-page":"3","volume-title":"Neuroimmune biology","author":"G Jancs\u00f3","year":"2009","unstructured":"Jancs\u00f3 G, Katona M, Horv\u00e1th V, S\u00e1ntha P, Nagy J (2009) Sensory nerves as modulators of cutaneous inflammatory reactions in health and disease. In: Jancs\u00f3 G (ed) Neuroimmune biology, vol 8, 1st edn, Neurogenic Inflammation in Health and Disease. Elsevier, Amsterdam, pp 3\u201338","edition":"1"},{"key":"1142_CR65","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.3181\/00379727-142-37219","volume":"142","author":"AR Johnson","year":"1973","unstructured":"Johnson AR, Erd\u00f6s EG (1973) Release of histamine from mast cells by vasoactive peptides. Proc Soc Exp Biol Med 142:1252\u20131256","journal-title":"Proc Soc Exp Biol Med"},{"key":"1142_CR66","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature02282","volume":"427","author":"SE Jordt","year":"2004","unstructured":"Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, H\u00f6gest\u00e4tt ED, Meng ID, Julius D (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260\u2013265","journal-title":"Nature"},{"key":"1142_CR67","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35093019","volume":"413","author":"D Julius","year":"2001","unstructured":"Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203\u2013210","journal-title":"Nature"},{"key":"1142_CR68","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s00210-004-0985-7","volume":"370","author":"M Katona","year":"2004","unstructured":"Katona M, Boros K, S\u00e1ntha P, Ferdinandy P, Dux M, Jancs\u00f3 G (2004) Selective sensory denervation by capsaicin aggravates adriamycin-induced cardiomyopathy in rats. Naunyn Schmiedeberg\u2019s Arch Pharmacol 370:436\u2013443","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"1142_CR69","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1523\/JNEUROSCI.1771-06.2006","volume":"26","author":"H Katsura","year":"2006","unstructured":"Katsura H, Obata K, Mizushima T, Sakurai J, Kobayashi K, Yamanaka H, Dai Y, Fukuoka T, Sakagami M, Noguchi K (2006) Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury. J Neurosci 26:8680\u20138690","journal-title":"J Neurosci"},{"key":"1142_CR70","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/cne.902900210","volume":"290","author":"JT Keller","year":"1989","unstructured":"Keller JT, Marfurt CF, Dimlich RV, Tierney BE (1989) Sympathetic innervation of the supratentorial dura mater of the rat. J Comp Neurol 290:310\u2013321","journal-title":"J Comp Neurol"},{"key":"1142_CR71","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/cne.22238","volume":"518","author":"YS Kim","year":"2010","unstructured":"Kim YS, Son JY, Kim TH, Paik SK, Dai Y, Noguchi K, Ahn DK, Bae YC (2010) Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn. J Comp Neurol 518:687\u2013698","journal-title":"J Comp Neurol"},{"key":"1142_CR72","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0006-8993(91)90518-Z","volume":"540","author":"E Kir\u00e1ly","year":"1991","unstructured":"Kir\u00e1ly E, Jancs\u00f3 G, Haj\u00f3s M (1991) Possible morphological correlates of capsaicin desensitization. Brain Res 540:279\u2013282","journal-title":"Brain Res"},{"key":"1142_CR73","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/AJP.0b013e318158ed9e","volume":"24","author":"H Knotkova","year":"2008","unstructured":"Knotkova H, Pappagallo M, Szallasi A (2008) Capsaicin (TRPV1 agonist) therapy for pain relief: farewell or revival? Clin J Pain 24:142\u2013154","journal-title":"Clin J Pain"},{"key":"1142_CR74","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s002210050260","volume":"118","author":"E Knyih\u00e1r-Csillik","year":"1998","unstructured":"Knyih\u00e1r-Csillik E, Tajti J, Samsam M, S\u00e1ry G, Buz\u00e1s P, V\u00e9csei L (1998) Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion. Exp Brain Res 118:111\u2013114","journal-title":"Exp Brain Res"},{"key":"1142_CR75","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/cne.22049","volume":"515","author":"B Kosaras","year":"2009","unstructured":"Kosaras B, Jakubowski M, Kainz V, Burstein R (2009) Sensory innervation of the calvarial bones of the mouse. J Comp Neurol 515:331\u2013348","journal-title":"J Comp Neurol"},{"key":"1142_CR76","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pain.2010.08.021","volume":"152","author":"PE Kunkler","year":"2011","unstructured":"Kunkler PE, Ballard CJ, Oxford GS, Hurley JH (2011) TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation. Pain 152:38\u201344","journal-title":"Pain"},{"key":"1142_CR77","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1476-5381.1995.tb13361.x","volume":"114","author":"M Kurosawa","year":"1995","unstructured":"Kurosawa M, Messlinger K, Pawlak M, Schmidt RF (1995) Increase of meningeal blood flow after electrical stimulation of rat dura mater encephali: mediation by calcitonin gene-related peptide. Br J Pharmacol 114:1397\u20131402","journal-title":"Br J Pharmacol"},{"issue":"Pt 1","key":"1142_CR78","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/brain\/117.1.199","volume":"117","author":"M Lauritzen","year":"1994","unstructured":"Lauritzen M (1994) Pathophysiology of the migraine aura. The spreading depression theory. Brain 117(Pt 1):199\u2013210","journal-title":"Brain"},{"key":"1142_CR79","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0361-9230(93)90250-F","volume":"30","author":"SN Lawson","year":"1993","unstructured":"Lawson SN, Perry MJ, Prabhakar E, McCarthy PW (1993) Primary sensory neurones: neurofilament, neuropeptides, and conduction velocity. Brain Res Bull 30:239\u2013243","journal-title":"Brain Res Bull"},{"key":"1142_CR80","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1526-4610.2009.01444.x","volume":"49","author":"D Levy","year":"2009","unstructured":"Levy D, Strassman AM, Burstein R (2009) A critical view on the role of migraine triggers in the genesis of migraine pain. Headache 49:953\u2013957","journal-title":"Headache"},{"key":"1142_CR81","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1097\/ALN.0b013e31824bb303","volume":"116","author":"WW Li","year":"2012","unstructured":"Li WW, Guo TZ, Liang DY, Sun Y, Kingery WS, Clark JD (2012) Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndrome. Anesthesiology 116:882\u2013895","journal-title":"Anesthesiology"},{"key":"1142_CR82","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.neuroscience.2004.05.041","volume":"127","author":"M Liu","year":"2004","unstructured":"Liu M, Willmott NJ, Michael GJ, Priestley JV (2004) Differential pH and capsaicin responses of Griffonia simplicifolia IB4 (IB4)-positive and IB4-negative small sensory neurons. Neuroscience 127:659\u2013672","journal-title":"Neuroscience"},{"key":"1142_CR83","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1523\/JNEUROSCI.18-16-06081.1998","volume":"18","author":"JC Lopshire","year":"1998","unstructured":"Lopshire JC, Nicol GD (1998) The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies. J Neurosci 18:6081\u20136092","journal-title":"J Neurosci"},{"key":"1142_CR84","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/302251a0","volume":"302","author":"JM Lundberg","year":"1983","unstructured":"Lundberg JM, Saria A (1983) Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature 302:251\u2013253","journal-title":"Nature"},{"key":"1142_CR85","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.cub.2005.04.018","volume":"15","author":"LJ Macpherson","year":"2005","unstructured":"Macpherson LJ, Geierstanger BH, Viswanath V, Bandell M, Eid SR, Hwang S, Patapoutian A (2005) The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol 15:929\u2013934","journal-title":"Curr Biol"},{"key":"1142_CR86","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","volume":"445","author":"LJ Macpherson","year":"2007","unstructured":"Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541\u2013545","journal-title":"Nature"},{"key":"1142_CR87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-3623(88)90002-X","volume":"19","author":"CA Maggi","year":"1988","unstructured":"Maggi CA, Meli A (1988) The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen Pharmacol 19:1\u201343","journal-title":"Gen Pharmacol"},{"key":"1142_CR88","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","volume":"104","author":"CR McNamara","year":"2007","unstructured":"McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM (2007) TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A 104:13525\u201313530","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1142_CR89","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.molmed.2010.02.004","volume":"16","author":"JE Meents","year":"2010","unstructured":"Meents JE, Neeb L, Reuter U (2010) TRPV1 in migraine pathophysiology. Trends Mol Med 16:153\u2013159","journal-title":"Trends Mol Med"},{"key":"1142_CR90","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jemt.1077","volume":"53","author":"K Messlinger","year":"2001","unstructured":"Messlinger K, Ellrich J (2001) Meningeal nociception: electrophysiological studies related to headache and referred pain. Microsc Res Tech 53:129\u2013137","journal-title":"Microsc Res Tech"},{"key":"1142_CR91","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00188214","volume":"188","author":"K Messlinger","year":"1993","unstructured":"Messlinger K, Hanesch U, Baumg\u00e4rtel M, Trost B, Schmidt RF (1993) Innervation of the dura mater encephali of cat and rat: ultrastructure and calcitonin gene-related peptide-like and substance P-like immunoreactivity. Anat Embryol 188:219\u2013237","journal-title":"Anat Embryol"},{"key":"1142_CR92","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF00319156","volume":"268","author":"MC Mione","year":"1992","unstructured":"Mione MC, Cavanagh JFR, Kirkpatrick KA, Burnstock G (1992) Plasticity in expression of calcitonin gene-related peptide and substance P immunoreactivity in ganglia and fibres following guanethidine and\/or capsaicin denervation. Cell Tissue Res 268:491\u2013504","journal-title":"Cell Tissue Res"},{"key":"1142_CR93","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00221-009-1814-5","volume":"196","author":"K Mizumura","year":"2009","unstructured":"Mizumura K, Sugiura T, Katanosaka K, Banik RK, Kozaki Y (2009) Excitation and sensitization of nociceptors by bradykinin: what do we know? Exp Brain Res 196:53\u201365","journal-title":"Exp Brain Res"},{"key":"1142_CR94","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0028-3908(02)00008-4","volume":"42","author":"MJ Moreno","year":"2002","unstructured":"Moreno MJ, Abounader R, H\u00e9bert E, Doods H, Hamel E (2002) Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment. Neuropharmacology 42:568\u2013576","journal-title":"Neuropharmacology"},{"key":"1142_CR95","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ejphar.2004.07.037","volume":"500","author":"I Nagy","year":"2004","unstructured":"Nagy I, S\u00e1ntha P, Jancs\u00f3 G, Urb\u00e1n L (2004) The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur J Pharmacol 500:351\u2013369","journal-title":"Eur J Pharmacol"},{"issue":"Pt 2","key":"1142_CR96","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/brain\/awr272","volume":"135","author":"R Nassini","year":"2012","unstructured":"Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andr\u00e8 E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P (2012) The \u2018headache tree\u2019 via umbellulone and TRPA1 activates the trigeminovascular system. Brain 135(Pt 2):376\u2013390","journal-title":"Brain"},{"key":"1142_CR97","first-page":"1401","volume":"15","author":"A Negro","year":"2011","unstructured":"Negro A, Rocchietti-March M, Fiorillo M, Martelletti P (2011) Chronic migraine: current concepts and ongoing treatments. Eur Rev Med Pharmacol Sci 15:1401\u20131420","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1142_CR98","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.00021.2006","volume":"87","author":"B Nilius","year":"2007","unstructured":"Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165\u2013217","journal-title":"Physiol Rev"},{"key":"1142_CR99","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1476-5381.1992.tb14348.x","volume":"106","author":"K Nozaki","year":"1992","unstructured":"Nozaki K, Moskowitz MA, Boccalini P (1992) CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges. Br J Pharmacol 106:409\u2013415","journal-title":"Br J Pharmacol"},{"key":"1142_CR100","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuroscience.2012.05.044","volume":"218","author":"H Ogawa","year":"2012","unstructured":"Ogawa H, Takahashi K, Miura S, Imagawa T, Saito S, Tominaga M, Ohta T (2012) H(2)S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation. Neuroscience 218:335\u2013343","journal-title":"Neuroscience"},{"key":"1142_CR101","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa030505","volume":"350","author":"J Olesen","year":"2004","unstructured":"Olesen J, Diener HC, Husstedt IW, Goadsby PJ, Hall D, Meier U, Pollentier S, Lesko LM, BIBN 4096 BS Clinical Proof of Concept Study Group (2004) Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N Engl J Med 350:1104\u20131110","journal-title":"N Engl J Med"},{"key":"1142_CR102","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/archneurpsyc.1940.02280070051003","volume":"44","author":"W Penfield","year":"1940","unstructured":"Penfield W, McNaughton FL (1940) Dural headache and innervation of the dura mater. Arch Neurol Psychiatr 44:43\u201375","journal-title":"Arch Neurol Psychiatr"},{"issue":"2 Suppl","key":"1142_CR103","doi-asserted-by":"crossref","first-page":"812s","DOI":"10.4049\/jimmunol.135.2.812","volume":"135","author":"B Pernow","year":"1985","unstructured":"Pernow B (1985) Role of tachykinins in neurogenic inflammation. J Immunol 135(2 Suppl):812s\u2013815s","journal-title":"J Immunol"},{"key":"1142_CR104","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1046\/j.0953-816x.2001.01651.x","volume":"14","author":"G Peth\u00f6","year":"2001","unstructured":"Peth\u00f6 G, Derow A, Reeh PW (2001) Bradykinin-induced nociceptor sensitization to heat is mediated by cyclooxygenase products in isolated rat skin. Eur J Neurosci 14:210\u2013218","journal-title":"Eur J Neurosci"},{"key":"1142_CR105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jpain.2006.09.005","volume":"8","author":"TJ Price","year":"2007","unstructured":"Price TJ, Flores CM (2007) Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse. J Pain 8:263\u2013272","journal-title":"J Pain"},{"key":"1142_CR106","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/archsurg.1940.01210040002001","volume":"41","author":"BS Ray","year":"1940","unstructured":"Ray BS, Wolff HG (1940) Experimental studies on headache. Pain sensitive structures of the head and their significance in headache. Arch Surg 41:813\u2013856","journal-title":"Arch Surg"},{"key":"1142_CR107","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/NDT.S17923","volume":"8","author":"CE Robertson","year":"2012","unstructured":"Robertson CE, Garza I (2012) Critical analysis of the use of onabotulinumtoxinA (botulinum toxin type A) in migraine. Neuropsychol Dis Treat 8:35\u201348","journal-title":"Neuropsychol Dis Treat"},{"key":"1142_CR108","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/0016-5085(86)90866-8","volume":"90","author":"Z R\u00f3zsa","year":"1986","unstructured":"R\u00f3zsa Z, Sharkey KA, Jancs\u00f3 G, Varr\u00f3 V (1986) Evidence for a role of capsaicin-sensitive mucosal afferent nerves in the regulation of mesenteric blood flow in the dog. Gastroenterology 90:906\u2013910","journal-title":"Gastroenterology"},{"key":"1142_CR109","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1111\/j.1460-9568.2009.06702.x","volume":"29","author":"MM Salas","year":"2009","unstructured":"Salas MM, Hargreaves KM, Akopian AN (2009) TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci 29:1568\u20131578","journal-title":"Eur J Neurosci"},{"key":"1142_CR110","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1124\/jpet.107.130344","volume":"324","author":"CA Salvatore","year":"2008","unstructured":"Salvatore CA, Hershey JC, Corcoran HA, Fay JF, JohnstonVK MEL, Mosser SD, Burgey CS, Paone DV, Shaw AW, Graham SL, Vacca JP, Williams TM, Koblan KS, Kane SA (2008) Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine. J Pharmacol Exp Ther 324:416\u2013421","journal-title":"J Pharmacol Exp Ther"},{"key":"1142_CR111","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0891-0618(01)00088-6","volume":"21","author":"M Samsam","year":"2001","unstructured":"Samsam M, Cove\u00f1as R, Csillik B, Ahangari R, Yajeya J, Riquelme R, Narv\u00e1ez JA, Tramu G (2001) Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanatomical link to generalized head pain. J Chem Neuroanat 21:161\u2013169","journal-title":"J Chem Neuroanat"},{"issue":"Suppl 2","key":"1142_CR112","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s003930050226","volume":"57","author":"H Sann","year":"1998","unstructured":"Sann H, Pierau FK (1998) Efferent functions of C-fiber nociceptors. Z Rheumatol 57(Suppl 2):8\u201313","journal-title":"Z Rheumatol"},{"key":"1142_CR113","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pain.2010.04.006","volume":"150","author":"P S\u00e1ntha","year":"2010","unstructured":"S\u00e1ntha P, Oszl\u00e1cs O, Dux M, Dobos I, Jancs\u00f3 G (2010) Inhibition of glucosylceramide synthase reversibly decreases the capsaicin-induced activation and TRPV1 expression of cultured dorsal root ganglion neurons. Pain 150:103\u2013112","journal-title":"Pain"},{"key":"1142_CR114","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF00503897","volume":"324","author":"A Saria","year":"1983","unstructured":"Saria A, Lundberg JM, Skofitsch G, Lembeck F (1983) Vascular protein linkage in various tissue induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge. Naunyn Schmiedeberg\u2019s Arch Pharmacol 324:212\u2013218","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"1142_CR115","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/j.1440-1681.1996.tb01139.x","volume":"23","author":"M Shimazawa","year":"1996","unstructured":"Shimazawa M, Hara H (1996) An experimental model of migraine with aura: cortical hypoperfusion following spreading depression in the awake and freely moving rat. Clin Exp Pharmacol Physiol 23:890\u2013892","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1142_CR116","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2007.07.068","volume":"1173","author":"T Shimizu","year":"2007","unstructured":"Shimizu T, Toriumi H, Sato H, Shibata M, Nagata E, Gotoh K, Suzuki N (2007) Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat. Brain Res 1173:84\u201391","journal-title":"Brain Res"},{"key":"1142_CR117","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neuroscience.2005.08.005","volume":"136","author":"A Singh Tahim","year":"2005","unstructured":"Singh Tahim A, S\u00e1ntha P, Nagy I (2005) Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons. Neuroscience 136:539\u2013548","journal-title":"Neuroscience"},{"key":"1142_CR118","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","volume":"112","author":"GM Story","year":"2003","unstructured":"Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819\u2013829","journal-title":"Cell"},{"key":"1142_CR119","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1152\/jn.01293.2005","volume":"95","author":"AM Strassman","year":"2006","unstructured":"Strassman AM, Levy D (2006) Response properties of dural nociceptors in relation to headache. J Neurophysiol 95:1298\u20131306","journal-title":"J Neurophysiol"},{"key":"1142_CR120","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0006-8993(86)90777-8","volume":"379","author":"AM Strassman","year":"1986","unstructured":"Strassman AM, Mason P, Moskowitz MA, Maciewicz RJ (1986) Response of brainstem trigeminal neurons to electrical stimulation of the dura. Brain Res 379:242\u2013250","journal-title":"Brain Res"},{"key":"1142_CR121","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/384560a0","volume":"384","author":"AM Strassman","year":"1996","unstructured":"Strassman AM, Raymond SA, Burstein R (1996) Sensitization of meningeal sensory neurons and the origin of headaches. Nature 384:560\u2013564","journal-title":"Nature"},{"key":"1142_CR122","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejphar.2007.01.058","volume":"562","author":"M Tr\u00f6ltzsch","year":"2007","unstructured":"Tr\u00f6ltzsch M, Denekas T, Messlinger K (2007) The calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS reduces neurogenic increases in dural blood flow. Eur J Pharmacol 562:103\u2013110","journal-title":"Eur J Pharmacol"},{"key":"1142_CR123","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1111\/j.1460-9568.2010.07255.x","volume":"31","author":"D Uta","year":"2010","unstructured":"Uta D, Furue H, Pickering AE, Rashid MH, Mizuguchi-Takase H, Katafuchi T, Imoto K, Yoshimura M (2010) TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. Eur J Neurosci 31:1960\u20131973","journal-title":"Eur J Neurosci"},{"issue":"Pt 3","key":"1142_CR124","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1469-7793.2001.00813.x","volume":"534","author":"V Vellani","year":"2001","unstructured":"Vellani V, Mapplebeck S, Moriondo A, Davis JB, McNaughton PA (2001) Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol 534(Pt 3):813\u2013825","journal-title":"J Physiol"},{"key":"1142_CR125","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF02433496","volume":"182","author":"M D\u00fcring von","year":"1990","unstructured":"von D\u00fcring M, Bauersachs M, B\u00f6hmer B, Veh RW, Andres KH (1990) Neuropeptide Y- and substance P-like immunoreactive nerve fibers in the rat dura mater encephali. Anat Embryol (Berl) 182:363\u2013373","journal-title":"Anat Embryol (Berl)"},{"key":"1142_CR126","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1074\/jbc.M111.329748","volume":"287","author":"L Wang","year":"2012","unstructured":"Wang L, Cvetkov TL, Chance MR, Moiseenkova-Bell VY (2012) Identification of in vivo disulfide conformation of TRPA1 ion channel. J Biol Chem 287:6169\u20136176","journal-title":"J Biol Chem"},{"key":"1142_CR127","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jemt.1081","volume":"53","author":"DJ Williamson","year":"2001","unstructured":"Williamson DJ, Hargreaves RJ (2001) Neurogenic inflammation in the context of migraine. Microsc Res Tech 53:167\u2013178","journal-title":"Microsc Res Tech"},{"key":"1142_CR128","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1468-2982.2007.01523.x","volume":"28","author":"XC Zhang","year":"2008","unstructured":"Zhang XC, Levy D (2008) Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. Cephalalgia 28:276\u2013284","journal-title":"Cephalalgia"},{"key":"1142_CR129","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1523\/JNEUROSCI.0511-10.2010","volume":"30","author":"X Zhang","year":"2010","unstructured":"Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R (2010) Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci 30:8807\u20138814","journal-title":"J Neurosci"},{"key":"1142_CR130","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/ALN.0b013e31820dee67","volume":"114","author":"H Zhang","year":"2011","unstructured":"Zhang H, Wickley PJ, Sinha S, Bratz IN, Damron DS (2011) Propofol restores transient receptor potential vanilloid receptor subtype-1 sensitivity via activation of transient receptor potential ankyrin receptor subtype-1 in sensory neurons. Anesthesiology 114:1169\u20131179","journal-title":"Anesthesiology"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-012-1142-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-012-1142-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-012-1142-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T07:39:17Z","timestamp":1714289957000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-012-1142-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,9]]},"references-count":130,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["1142"],"URL":"https:\/\/doi.org\/10.1007\/s00424-012-1142-7","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,9]]}}}