{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:54:47Z","timestamp":1790178887012,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s00424-013-1365-2","type":"journal-article","created":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T04:58:54Z","timestamp":1380517134000},"page":"1317-1327","source":"Crossref","is-referenced-by-count":19,"title":["Zebrafish and mouse TASK-2\u00a0K+ channels are inhibited by increased CO2 and intracellular acidification"],"prefix":"10.1007","volume":"466","author":[{"given":"Gaspar","family":"Pe\u00f1a-M\u00fcnzenmayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Niemeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco V.","family":"Sep\u00falveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Pablo","family":"Cid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"1365_CR1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-94-007-4584-1_20","volume":"758","author":"SJ Abdallah","year":"2012","unstructured":"Abdallah SJ, Perry SF, Jonz MG (2012) CO2 signaling in chemosensory neuroepithelial cells of the zebrafish gill filaments: role of intracellular Ca2+ and pH. Adv Exp Med Biol 758:143\u2013148","journal-title":"Adv Exp Med Biol"},{"key":"1365_CR2","author":"S Al-Samir","year":"2013","unstructured":"Al-Samir S, Papadopoulos S, Scheibe RJ, Meissner JD, Cartron JP, Sly WS, Alper SL, Gros G, Endeward V (2013) Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1\/SLC4A1. J Physiol. doi: 10.1113\/jphysiol.2013.251181","journal-title":"J Physiol"},{"key":"1365_CR3","author":"C A\u00f1azco","year":"2013","unstructured":"A\u00f1azco C, Pe\u00f1a-M\u00fcnzenmayer G, Araya C, Cid LP, Sep\u00falveda FV, Niemeyer MI (2013) G protein modulation of K2P potassium channel TASK-2: a role of basic residues in the C-terminus domain. Pflugers Arch. doi: 10.1007\/s00424-013-1314-0","journal-title":"Pflugers Arch"},{"key":"1365_CR4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.1996.sp021396","volume":"493","author":"KA Baxter","year":"1996","unstructured":"Baxter KA, Church J (1996) Characterization of acid extrusion mechanisms in cultured fetal rat hippocampal neurones. J Physiol 493:457\u2013470","journal-title":"J Physiol"},{"key":"1365_CR5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbapap.2009.10.021","volume":"1804","author":"WF Boron","year":"2010","unstructured":"Boron WF (2010) Evaluating the role of carbonic anhydrases in the transport of HCO3 \u2212-related species. Biochim Biophys Acta 1804:410\u2013421","journal-title":"Biochim Biophys Acta"},{"key":"1365_CR6","doi-asserted-by":"crossref","first-page":"C844","DOI":"10.1152\/ajpcell.1988.255.6.C844","volume":"255","author":"G Boyarsky","year":"1988","unstructured":"Boyarsky G, Ganz MB, Sterzel RB, Boron WF (1988) pH regulation in single glomerular mesangial cells: I. Acid extrusion in absence and presence of HCO3 \u2212. Am J Physiol 255:C844\u2013C856","journal-title":"Am J Physiol"},{"key":"1365_CR7","doi-asserted-by":"crossref","first-page":"7887","DOI":"10.1074\/jbc.274.12.7887","volume":"274","author":"RA Ch\u00e1vez","year":"1999","unstructured":"Ch\u00e1vez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (1999) TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. J Biol Chem 274:7887\u20137892","journal-title":"J Biol Chem"},{"key":"1365_CR8","doi-asserted-by":"crossref","first-page":"C1198","DOI":"10.1152\/ajpcell.2000.279.4.C1198","volume":"279","author":"LP Cid","year":"2000","unstructured":"Cid LP, Niemeyer MI, Ram\u00edrez A, Sep\u00falveda FV (2000) Splice variants of a ClC-2 chloride channel with differing functional characteristics. Am J Physiol 279:C1198\u2013C1210","journal-title":"Am J Physiol"},{"key":"1365_CR9","doi-asserted-by":"crossref","unstructured":"Cid LP, Roa-Rojas HA, Niemeyer MI, Gonz\u00e1lez W, Araki M, Araki K, Sep\u00falveda FV (2013) TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions. Frontiers in Physiology 4:doi: 10.3389\/fphys.2013.00198","DOI":"10.3389\/fphys.2013.00198"},{"key":"1365_CR10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/jeb.126.1.41","volume":"126","author":"JB Claiborne","year":"1986","unstructured":"Claiborne JB, Heisler N (1986) Acid\u2013base regulation and ion transfers in the carp (Cyprinus carpio): pH compensation during graded long- and short-term environmental hypercapnia, and the effect of bicarbonate infusion. J Exp Biol 126:41\u201361","journal-title":"J Exp Biol"},{"key":"1365_CR11","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.biocel.2007.03.015","volume":"39","author":"JJ Cotelesage","year":"2007","unstructured":"Cotelesage JJ, Puttick J, Goldie H, Rajabi B, Novakovski B, Delbaere LT (2007) How does an enzyme recognize CO2? Int J Biochem Cell Biol 39:1204\u20131210","journal-title":"Int J Biochem Cell Biol"},{"key":"1365_CR12","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1021\/ci9002377","volume":"49","author":"TR Cundari","year":"2009","unstructured":"Cundari TR, Wilson AK, Drummond ML, Gonzalez HE, Jorgensen KR, Payne S, Braunfeld J, De JM, Johnson VM (2009) CO2-formatics: how do proteins bind carbon dioxide? J Chem Inf Model 49:2111\u20132115","journal-title":"J Chem Inf Model"},{"key":"1365_CR13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1074\/jbc.M110.189290","volume":"286","author":"MC D'Adamo","year":"2011","unstructured":"D'Adamo MC, Shang L, Imbrici P, Brown SD, Pessia M, Tucker SJ (2011) Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2\/pH sensitivity. J Biol Chem 286:192\u2013198","journal-title":"J Biol Chem"},{"key":"1365_CR14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00029.2009","volume":"90","author":"P Enyedi","year":"2010","unstructured":"Enyedi P, Czirj\u00e1k G (2010) Molecular background of leak K+ currents: two-pore domain potassium channels. Physiol Rev 90:559\u2013605","journal-title":"Physiol Rev"},{"key":"1365_CR15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1113\/jphysiol.2001.014142","volume":"541","author":"JA Filosa","year":"2002","unstructured":"Filosa JA, Dean JB, Putnam RW (2002) Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones. J Physiol 541:493\u2013509","journal-title":"J Physiol"},{"key":"1365_CR16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/978-0-387-73693-8_56","volume":"605","author":"HV Forster","year":"2008","unstructured":"Forster HV, Martino P, Hodges M, Krause K, Bonis J, Davis S, Pan L (2008) The carotid chemoreceptors are a major determinant of ventilatory CO2 sensitivity and of PaCO2 during eupneic breathing. Adv Exp Med Biol 605:322\u2013326","journal-title":"Adv Exp Med Biol"},{"key":"1365_CR17","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0910059107","volume":"107","author":"C Gestreau","year":"2010","unstructured":"Gestreau C, Heitzmann D, Thomas J, Dubreuil V, Bandulik S, Reichold M, Bendahhou S, Pierson P, Sterner C, Peyronnet-Roux J, Benfriha C, Tegtmeier I, Ehnes H, Georgieff M, Lesage F, Brunet JF, Goridis C, Warth R, Barhanin J (2010) Task2 potassium channels set central respiratory CO2 and O2 sensitivity. Proc Natl Acad Sci U S A 107:2325\u20132330","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1365_CR18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbamem.2011.09.015","volume":"1818","author":"J Gierten","year":"2012","unstructured":"Gierten J, Hassel D, Schweizer PA, Becker R, Katus HA, Thomas D (2012) Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels. Biochim Biophys Acta 1818:33\u201341","journal-title":"Biochim Biophys Acta"},{"key":"1365_CR19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1152\/physrev.00021.2009","volume":"90","author":"H Hibino","year":"2010","unstructured":"Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y (2010) Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev 90:291\u2013366","journal-title":"Physiol Rev"},{"key":"1365_CR20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00424-010-0916-z","volume":"461","author":"RT Huckstepp","year":"2011","unstructured":"Huckstepp RT, Dale N (2011) CO2-dependent opening of an inwardly rectifying K+ channel. Pflugers Arch 461:337\u2013344","journal-title":"Pflugers Arch"},{"key":"1365_CR21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1242\/jeb.170.1.43","volume":"170","author":"A Ishimatsu","year":"1992","unstructured":"Ishimatsu A, Iwama GK, Bentley DB, Heisler N (1992) Contribution of the secondary circulatory system to acid\u2013base regulation during hypercapnia in rainbow trout (Onchrryncus mykiss). J Exp Biol 170:43\u201356","journal-title":"J Exp Biol"},{"key":"1365_CR22","first-page":"59","volume":"4","author":"Y Ito","year":"2013","unstructured":"Ito Y, Kobayashi S, Nakamura N, Miyagi H, Esaki M, Hoshijima K, Hirose S (2013) Close association of carbonic anhydrase (CA2a and CA15a), Na+\/H+ exchanger (Nhe3b), and ammonia transporter Rhcg1 in zebrafish ionocytes responsible for Na+ uptake. Front Physiol 4:59","journal-title":"Front Physiol"},{"key":"1365_CR23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.resp.2004.07.005","volume":"145","author":"C Jiang","year":"2005","unstructured":"Jiang C, Rojas A, Wang R, Wang X (2005) CO2 central chemosensitivity: why are there so many sensing molecules? Respir Physiol Neurobiol 145:115\u2013126","journal-title":"Respir Physiol Neurobiol"},{"key":"1365_CR24","first-page":"737","volume":"560","author":"MG Jonz","year":"2004","unstructured":"Jonz MG, Fearon IM, Nurse CA (2004) Neuroepithelial oxygen chemoreceptors of the zebrafish gill. J Ph 560:737\u2013752","journal-title":"J Ph"},{"key":"1365_CR25","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s004240000496","volume":"442","author":"Y Kim","year":"2001","unstructured":"Kim Y, Bang H, Gnatenco C, Kim D (2001) Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali. Pflugers Arch 442:64\u201372","journal-title":"Pflugers Arch"},{"key":"1365_CR26","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/j.1460-2075.1996.tb00437.x","volume":"15","author":"F Lesage","year":"1996","unstructured":"Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J (1996) TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J 15:1004\u20131011","journal-title":"EMBO J"},{"key":"1365_CR27","doi-asserted-by":"crossref","first-page":"28398","DOI":"10.1074\/jbc.M002822200","volume":"275","author":"F Lesage","year":"2000","unstructured":"Lesage F, Terrenoire C, Romey G, Lazdunski M (2000) Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem 275:28398\u201328405","journal-title":"J Biol Chem"},{"key":"1365_CR28","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1183\/09031936.00056408","volume":"32","author":"J L\u00f3pez-Barneo","year":"2008","unstructured":"L\u00f3pez-Barneo J, Ortega-S\u00e1enz P, Pardal R, Pascual A, Piruat JI (2008) Carotid body oxygen sensing. Eur Respir J 32:1386\u20131398","journal-title":"Eur Respir J"},{"key":"1365_CR29","doi-asserted-by":"crossref","first-page":"26691","DOI":"10.1074\/jbc.274.38.26691","volume":"274","author":"F Maingret","year":"1999","unstructured":"Maingret F, Patel AJ, Lesage F, Lazdunski M, Honore E (1999) Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 274:26691\u201326696","journal-title":"J Biol Chem"},{"key":"1365_CR30","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1242\/jeb.01878","volume":"208","author":"A M\u00f6lich","year":"2005","unstructured":"M\u00f6lich A, Heisler N (2005) Determination of pH by microfluorometry: intracellular and interstitial pH regulation in developing early-stage fish embryos (Danio rerio). J Exp Biol 208:4137\u20134149","journal-title":"J Exp Biol"},{"key":"1365_CR31","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/nn1357","volume":"7","author":"DK Mulkey","year":"2004","unstructured":"Mulkey DK, Stornetta RL, Weston MC, Simmons JR, Parker A, Bayliss DA, Guyenet PG (2004) Respiratory control by ventral surface chemoreceptor neurons in rats. Nat Neurosci 7:1360\u20131369","journal-title":"Nat Neurosci"},{"key":"1365_CR32","doi-asserted-by":"crossref","first-page":"14049","DOI":"10.1523\/JNEUROSCI.4254-07.2007","volume":"27","author":"DK Mulkey","year":"2007","unstructured":"Mulkey DK, Talley EM, Stornetta RL, Siegel AR, West GH, Chen X, Sen N, Mistry AM, Guyenet PG, Bayliss DA (2007) TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity. J Neurosci 27:14049\u201314058","journal-title":"J Neurosci"},{"key":"1365_CR33","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1152\/japplphysiol.00112.2008","volume":"106","author":"E Nattie","year":"2009","unstructured":"Nattie E, Li A (2009) Central chemoreception is a complex system function that involves multiple brain stem sites. J Appl Physiol 106:1464\u20131466","journal-title":"J Appl Physiol"},{"key":"1365_CR34","doi-asserted-by":"crossref","first-page":"43166","DOI":"10.1074\/jbc.M107192200","volume":"276","author":"MI Niemeyer","year":"2001","unstructured":"Niemeyer MI, Cid LP, Barros LF, Sep\u00falveda FV (2001) Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume. J Biol Chem 276:43166\u201343174","journal-title":"J Biol Chem"},{"key":"1365_CR35","doi-asserted-by":"crossref","first-page":"16467","DOI":"10.1074\/jbc.M110.107060","volume":"285","author":"MI Niemeyer","year":"2010","unstructured":"Niemeyer MI, Cid LP, Pe\u00f1a-M\u00fcnzenmayer G, Sep\u00falveda FV (2010) Separate gating mechanisms mediate the regulation of K2P potassium channel TASK-2 by intra- and extracellular pH. J Biol Chem 285:16467\u201316475","journal-title":"J Biol Chem"},{"key":"1365_CR36","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1073\/pnas.0606173104","volume":"104","author":"MI Niemeyer","year":"2007","unstructured":"Niemeyer MI, Gonz\u00e1lez-Nilo FD, Z\u00fa\u00f1iga L, Gonz\u00e1lez W, Cid LP, Sep\u00falveda FV (2007) Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel. Proc Natl Acad Sci U S A 104:666\u2013671","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1365_CR37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1085\/jgp.200910302","volume":"135","author":"P Ortega-S\u00e1enz","year":"2010","unstructured":"Ortega-S\u00e1enz P, Levitsky KL, Marcos-Almaraz MT, Bonilla-Henao V, Pascual A, L\u00f3pez-Barneo J (2010) Carotid body chemosensory responses in mice deficient of TASK channels. J Gen Physiol 135:379\u2013392","journal-title":"J Gen Physiol"},{"key":"1365_CR38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.resp.2012.06.013","volume":"184","author":"SF Perry","year":"2012","unstructured":"Perry SF, Abdallah S (2012) Mechanisms and consequences of carbon dioxide sensing in fish. Respir Physiol Neurobiol 184:309\u2013315","journal-title":"Respir Physiol Neurobiol"},{"key":"1365_CR39","doi-asserted-by":"crossref","first-page":"C1493","DOI":"10.1152\/ajpcell.00282.2004","volume":"287","author":"RW Putnam","year":"2004","unstructured":"Putnam RW, Filosa JA, Ritucci NA (2004) Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons. Am J Physiol 287:C1493\u2013C1526","journal-title":"Am J Physiol"},{"key":"1365_CR40","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1113\/jphysiol.2009.184739","volume":"588","author":"Z Qin","year":"2010","unstructured":"Qin Z, Lewis JE, Perry SF (2010) Zebrafish (Danio rerio) gill neuroepithelial cells are sensitive chemoreceptors for environmental CO2. J Physiol 588:861\u2013872","journal-title":"J Physiol"},{"key":"1365_CR41","doi-asserted-by":"crossref","first-page":"30863","DOI":"10.1074\/jbc.273.47.30863","volume":"273","author":"R Reyes","year":"1998","unstructured":"Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (1998) Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. J Biol Chem 273:30863\u201330869","journal-title":"J Biol Chem"},{"key":"1365_CR42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1152\/physrev.1981.61.2.296","volume":"61","author":"A Roos","year":"1981","unstructured":"Roos A, Boron WF (1981) Intracellular pH. Physiol Rev 61:296\u2013434","journal-title":"Physiol Rev"},{"key":"1365_CR43","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.1523\/JNEUROSCI.1810-08.2008","volume":"28","author":"S Trapp","year":"2008","unstructured":"Trapp S, Aller MI, Wisden W, Gourine AV (2008) A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing. J Neurosci 28:8844\u20138850","journal-title":"J Neurosci"},{"key":"1365_CR44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1113\/expphysiol.2010.055848","volume":"96","author":"S Trapp","year":"2011","unstructured":"Trapp S, Tucker SJ, Gourine AV (2011) Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16). Exp Physiol 96:451\u2013459","journal-title":"Exp Physiol"},{"key":"1365_CR45","doi-asserted-by":"crossref","first-page":"28430","DOI":"10.1074\/jbc.273.43.28430","volume":"273","author":"JW Vince","year":"1998","unstructured":"Vince JW, Reithmeier RA (1998) Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte Cl\u2212\/HCO3 \u2212 exchanger. J Biol Chem 273:28430\u201328437","journal-title":"J Biol Chem"},{"key":"1365_CR46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1469-7793.1998.433bh.x","volume":"511","author":"W Wang","year":"1998","unstructured":"Wang W, Pizzonia JH, Richerson GB (1998) Chemosensitivity of rat medullary raphe neurones in primary tissue culture. J Physiol 511:433\u2013450","journal-title":"J Physiol"},{"key":"1365_CR47","doi-asserted-by":"crossref","first-page":"8215","DOI":"10.1073\/pnas.0400081101","volume":"101","author":"R Warth","year":"2004","unstructured":"Warth R, Barri\u00e8re H, Meneton P, Bloch M, Thomas J, Tauc M, Heitzmann D, Romeo E, Verrey F, Mengual R, Guy N, Bendahhou S, Lesage F, Poujeol P, Barhanin J (2004) Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport. Proc Natl Acad Sci U S A 101:8215\u20138220","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1365_CR48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00232-004-0652-4","volume":"197","author":"J Wu","year":"2004","unstructured":"Wu J, Xu H, Shen W, Jiang C (2004) Expression and coexpression of CO2-sensitive Kir channels in brainstem neurons of rats. J Membr Biol 197:179\u2013191","journal-title":"J Membr Biol"},{"key":"1365_CR49","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1469-7793.2000.00725.x","volume":"524","author":"H Xu","year":"2000","unstructured":"Xu H, Cui N, Yang Z, Qu Z, Jiang C (2000) Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis. J Physiol 524:725\u2013735","journal-title":"J Physiol"},{"key":"1365_CR50","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1113\/jphysiol.2003.042341","volume":"549","author":"Y Yuan","year":"2003","unstructured":"Yuan Y, Shimura M, Hughes BA (2003) Regulation of inwardly rectifying K+ channels in retinal pigment epithelial cells by intracellular pH. J Physiol 549:429\u2013438","journal-title":"J Physiol"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-013-1365-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-013-1365-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-013-1365-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T04:45:20Z","timestamp":1646628320000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-013-1365-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["1365"],"URL":"https:\/\/doi.org\/10.1007\/s00424-013-1365-2","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,1]]}}}