{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:44:03Z","timestamp":1789991043579,"version":"4.0.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s00424-013-1389-7","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T06:14:56Z","timestamp":1384236896000},"page":"611-621","source":"Crossref","is-referenced-by-count":25,"title":["Insulin downregulates the expression of the Ca2+-activated nonselective cation channel TRPM5 in pancreatic islets from leptin-deficient mouse models"],"prefix":"10.1007","volume":"466","author":[{"given":"Barbara","family":"Colsoul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griet","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koenraad","family":"Philippaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Owsianik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Nilius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Schuit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Vennekens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,13]]},"reference":[{"key":"1389_CR1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1463-1326.2008.00852.x","volume":"10","author":"Anubhuti","year":"2008","unstructured":"Anubhuti, Arora S (2008) Leptin and its metabolic interactions: an update. Diabetes Obes Metab 10:973\u2013993","journal-title":"Diabetes Obes Metab"},{"key":"1389_CR2","doi-asserted-by":"crossref","unstructured":"Ashcroft F, Rorsman P (2004) Type 2 diabetes mellitus: not quite exciting enough? Hum Mol Genet 13 Spec No 1:R21-31","DOI":"10.1093\/hmg\/ddh066"},{"key":"1389_CR3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00424-010-0835-z","volume":"460","author":"LR Brixel","year":"2010","unstructured":"Brixel LR, Monteilh-Zoller MK, Ingenbrandt CS, Fleig A, Penner R, Enklaar T, Zabel BU, Prawitt D (2010) TRPM5 regulates glucose-stimulated insulin secretion. Pflugers Arch 460:69\u201376","journal-title":"Pflugers Arch"},{"key":"1389_CR4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0092-8674(00)81294-5","volume":"84","author":"H Chen","year":"1996","unstructured":"Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db\/db mice. Cell 84:491\u2013495","journal-title":"Cell"},{"key":"1389_CR5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00429772","volume":"14","author":"DL Coleman","year":"1978","unstructured":"Coleman DL (1978) Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14:141\u2013148","journal-title":"Diabetologia"},{"key":"1389_CR6","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1073\/pnas.0913107107","volume":"107","author":"B Colsoul","year":"2010","unstructured":"Colsoul B, Schraenen A, Lemaire K, Quintens R, Van Lommel L, Segal A, Owsianik G, Talavera K, Voets T, Margolskee RF, Kokrashvili Z, Gilon P, Nilius B, Schuit FC, Vennekens R (2010) Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5\u2212\/\u2212 mice. Proc Natl Acad Sci USA 107:5208\u20135213","journal-title":"Proc Natl Acad Sci USA"},{"key":"1389_CR7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/112_2011_2","volume":"161","author":"B Colsoul","year":"2011","unstructured":"Colsoul B, Vennekens R, Nilius B (2011) Transient receptor potential cation channels in pancreatic beta cells. Rev Physiol Biochem Pharmacol 161:87\u2013110","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"1389_CR8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cmet.2013.06.004","volume":"18","author":"O Dumortier","year":"2013","unstructured":"Dumortier O, Hinault C, Van Obberghen E (2013) MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab 18:312\u2013324","journal-title":"Cell Metab"},{"key":"1389_CR9","doi-asserted-by":"crossref","first-page":"647514","DOI":"10.1155\/2011\/647514","volume":"2011","author":"D Fradin","year":"2011","unstructured":"Fradin D, Bougneres P (2011) T2DM: why epigenetics? J Nutr Metab 2011:647514","journal-title":"J Nutr Metab"},{"key":"1389_CR10","unstructured":"Gees M, Colsoul B, Nilius B (2011) The role of transient receptor potential cation channels in Ca2+ signalingCold Spring Harb Perspect Biol. United States, pp. a003962"},{"key":"1389_CR11","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0960-9822(03)00431-7","volume":"13","author":"T Hofmann","year":"2003","unstructured":"Hofmann T, Chubanov V, Gudermann T, Montell C (2003) TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol 13:1153\u20131158","journal-title":"Curr Biol"},{"key":"1389_CR12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20120693","volume":"446","author":"JL Kerschner","year":"2012","unstructured":"Kerschner JL, Harris A (2012) Transcriptional networks driving enhancer function in the CFTR gene. Biochem J 446:203\u2013212","journal-title":"Biochem J"},{"key":"1389_CR13","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.metabol.2011.02.002","volume":"60","author":"C Ketterer","year":"2011","unstructured":"Ketterer C, Mussig K, Heni M, Dudziak K, Randrianarisoa E, Wagner R, Machicao F, Stefan N, Holst JJ, Fritsche A, Haring HU, Staiger H (2011) Genetic variation within the TRPM5 locus associates with pre-diabetic phenotypes in subjects at increased risk for type 2 diabetes. Metabolism 60:1325\u20131333","journal-title":"Metabolism"},{"key":"1389_CR14","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.2337\/diabetes.50.10.2192","volume":"50","author":"FA Khan","year":"2001","unstructured":"Khan FA, Goforth PB, Zhang M, Satin LS (2001) Insulin activates ATP-sensitive K(+) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway. Diabetes 50:2192\u20132198","journal-title":"Diabetes"},{"key":"1389_CR15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1097-2765(01)00203-9","volume":"7","author":"B Leibiger","year":"2001","unstructured":"Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, de Vargas LM, Berggren PO (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 7:559\u2013570","journal-title":"Mol Cell"},{"key":"1389_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(02)03627-X","volume":"532","author":"IB Leibiger","year":"2002","unstructured":"Leibiger IB, Leibiger B, Berggren PO (2002) Insulin feedback action on pancreatic beta-cell function. FEBS Lett 532:1\u20136","journal-title":"FEBS Lett"},{"key":"1389_CR17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.nutr.28.061807.155530","volume":"28","author":"IB Leibiger","year":"2008","unstructured":"Leibiger IB, Leibiger B, Berggren PO (2008) Insulin signaling in the pancreatic beta-cell. Annu Rev Nutr 28:233\u2013251","journal-title":"Annu Rev Nutr"},{"key":"1389_CR18","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1100\/tsw.2007.117","volume":"7","author":"P Lindstrom","year":"2007","unstructured":"Lindstrom P (2007) The physiology of obese-hyperglycemic mice [ob\/ob mice]. ScientificWorldJournal 7:666\u2013685","journal-title":"ScientificWorldJournal"},{"key":"1389_CR19","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.2337\/db09-1003","volume":"58","author":"C Ling","year":"2009","unstructured":"Ling C, Groop L (2009) Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 58:2718\u20132725","journal-title":"Diabetes"},{"key":"1389_CR20","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1530\/JME-12-0025","volume":"49","author":"L Marroqui","year":"2012","unstructured":"Marroqui L, Gonzalez A, Neco P, Caballero-Garrido E, Vieira E, Ripoll C, Nadal A, Quesada I (2012) Role of leptin in the pancreatic beta-cell: effects and signaling pathways. J Mol Endocrinol 49:R9\u2013R17","journal-title":"J Mol Endocrinol"},{"key":"1389_CR21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0083-6729(08)00617-1","volume":"80","author":"GA Martens","year":"2009","unstructured":"Martens GA, Pipeleers D (2009) Glucose, regulator of survival and phenotype of pancreatic beta cells. Vitam Horm 80:507\u2013539","journal-title":"Vitam Horm"},{"key":"1389_CR22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.00021.2006","volume":"87","author":"B Nilius","year":"2007","unstructured":"Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165\u2013217","journal-title":"Physiol Rev"},{"key":"1389_CR23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00424-010-0788-2","volume":"460","author":"B Nilius","year":"2010","unstructured":"Nilius B, Owsianik G (2010) Transient receptor potential channelopathies. Pflugers Arch 460:437\u2013450","journal-title":"Pflugers Arch"},{"key":"1389_CR24","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1152\/physrev.1996.76.4.1109","volume":"76","author":"RM O\u2019Brien","year":"1996","unstructured":"O\u2019Brien RM, Granner DK (1996) Regulation of gene expression by insulin. Physiol Rev 76:1109\u20131161","journal-title":"Physiol Rev"},{"key":"1389_CR25","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1056\/NEJM198805123181902","volume":"318","author":"S O\u2019Rahilly","year":"1988","unstructured":"O\u2019Rahilly S, Turner RC, Matthews DR (1988) Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 318:1225\u20131230","journal-title":"N Engl J Med"},{"key":"1389_CR26","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/nar\/gkr754","volume":"40","author":"CJ Ott","year":"2012","unstructured":"Ott CJ, Bischof JM, Unti KM, Gillen AE, Leir SH, Harris A (2012) Nucleosome occupancy reveals regulatory elements of the CFTR promoter. Nucleic Acids Res 40:625\u2013637","journal-title":"Nucleic Acids Res"},{"key":"1389_CR27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ceca.2005.06.028","volume":"38","author":"SF Pedersen","year":"2005","unstructured":"Pedersen SF, Owsianik G, Nilius B (2005) TRP channels: an overview. Cell Calcium 38:233\u2013252","journal-title":"Cell Calcium"},{"key":"1389_CR28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.7624776","volume":"269","author":"MA Pelleymounter","year":"1995","unstructured":"Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F (1995) Effects of the obese gene product on body weight regulation in ob\/ob mice. Science 269:540\u2013543","journal-title":"Science"},{"key":"1389_CR29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s125-002-8240-x","volume":"45","author":"N Porksen","year":"2002","unstructured":"Porksen N (2002) The in vivo regulation of pulsatile insulin secretion. Diabetologia 45:3\u201320","journal-title":"Diabetologia"},{"key":"1389_CR30","doi-asserted-by":"crossref","first-page":"15166","DOI":"10.1073\/pnas.2334624100","volume":"100","author":"D Prawitt","year":"2003","unstructured":"Prawitt D, Monteilh-Zoller MK, Brixel L, Spangenberg C, Zabel B, Fleig A, Penner R (2003) TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. Proc Natl Acad Sci USA 100:15166\u201315171","journal-title":"Proc Natl Acad Sci USA"},{"key":"1389_CR31","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1007\/s00125-002-0883-9","volume":"45","author":"MA Ravier","year":"2002","unstructured":"Ravier MA, Sehlin J, Henquin JC (2002) Disorganization of cytoplasmic Ca(2+) oscillations and pulsatile insulin secretion in islets from ob\/ob mice. Diabetologia 45:1154\u20131163","journal-title":"Diabetologia"},{"key":"1389_CR32","doi-asserted-by":"crossref","first-page":"18279","DOI":"10.1016\/S0021-9258(17)32299-8","volume":"269","author":"MW Roe","year":"1994","unstructured":"Roe MW, Philipson LH, Frangakis CJ, Kuznetsov A, Mertz RJ, Lancaster ME, Spencer B, Worley JF 3rd, Dukes ID (1994) Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans. J Biol Chem 269:18279\u201318282","journal-title":"J Biol Chem"},{"key":"1389_CR33","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1073\/pnas.96.2.674","volume":"96","author":"J Seufert","year":"1999","unstructured":"Seufert J, Kieffer TJ, Habener JF (1999) Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob\/ob mice. Proc Natl Acad Sci USA 96:674\u2013679","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl 1","key":"1389_CR34","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.2337\/diabetes.53.2007.S152","volume":"53","author":"J Seufert","year":"2004","unstructured":"Seufert J (2004) Leptin effects on pancreatic beta-cell gene expression and function. Diabetes 53(Suppl 1):S152\u2013S158","journal-title":"Diabetes"},{"key":"1389_CR35","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1210\/en.2011-1759","volume":"153","author":"H Slomko","year":"2012","unstructured":"Slomko H, Heo HJ, Einstein FH (2012) Minireview: epigenetics of obesity and diabetes in humans. Endocrinology 153:1025\u20131030","journal-title":"Endocrinology"},{"key":"1389_CR36","doi-asserted-by":"crossref","unstructured":"Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"1389_CR37","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.biocel.2005.09.013","volume":"38","author":"BO Yildiz","year":"2006","unstructured":"Yildiz BO, Haznedaroglu IC (2006) Rethinking leptin and insulin action: therapeutic opportunities for diabetes. Int J Biochem Cell Biol 38:820\u2013830","journal-title":"Int J Biochem Cell Biol"},{"key":"1389_CR38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/gut.2008.148932","volume":"58","author":"RL Young","year":"2009","unstructured":"Young RL, Sutherland K, Pezos N, Brierley SM, Horowitz M, Rayner CK, Blackshaw LA (2009) Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut 58:337\u2013346","journal-title":"Gut"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-013-1389-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-013-1389-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-013-1389-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T10:38:17Z","timestamp":1716115097000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-013-1389-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,13]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["1389"],"URL":"https:\/\/doi.org\/10.1007\/s00424-013-1389-7","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,13]]}}}