{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:54:19Z","timestamp":1781790859452,"version":"3.54.5"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,10,3]],"date-time":"2015-10-03T00:00:00Z","timestamp":1443830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s00424-015-1737-x","type":"journal-article","created":{"date-parts":[[2015,10,3]],"date-time":"2015-10-03T02:03:29Z","timestamp":1443837809000},"page":"257-267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of angiotensin II-induced arterial hypertension on the voltage-dependent contractions of mouse arteries"],"prefix":"10.1007","volume":"468","author":[{"given":"Paul","family":"Fransen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cor E.","family":"Van Hove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J. A.","family":"Leloup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorien M.","family":"Schrijvers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido R. Y.","family":"De Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles W.","family":"De Keulenaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,3]]},"reference":[{"key":"1737_CR1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/HYPERTENSIONAHA.109.142190","volume":"55","author":"J Bellien","year":"2010","unstructured":"Bellien J, Favre J, Iacob M, Gao J, Thuillez C, Richard V, Joannides R (2010) Arterial stiffness is regulated by nitric oxide and endothelium-derived hyperpolarizing factor during changes in blood flow in humans. Hypertension 55:674\u2013680","journal-title":"Hypertension"},{"key":"1737_CR2","doi-asserted-by":"crossref","first-page":"H1648","DOI":"10.1152\/ajpheart.00824.2001","volume":"282","author":"IN Bratz","year":"2002","unstructured":"Bratz IN, Falcon R, Partridge LD, Kanagy NL (2002) Vascular smooth muscle cell membrane depolarization after NOS inhibition hypertension. Am J Physiol Heart Circ Physiol 282:H1648\u2013H1655","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1737_CR3","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1097\/HJH.0b013e32834d2554","volume":"29","author":"H Choi","year":"2011","unstructured":"Choi H, Allahdadi KJ, Tostes RC, Webb RC (2011) Augmented S-nitrosylation contributes to impaired relaxation in angiotensin II hypertensive mouse aorta: role of thioredoxin reductase. J Hypertens 29:2359\u20132368","journal-title":"J Hypertens"},{"key":"1737_CR4","author":"RH Cox","year":"2015","unstructured":"Cox RH, Fromme S (2015) Expression of calcium channel subunit variants in small mesenteric arteries of WKY and SHR. Am J Hypertens. doi: 10.1093\/ajh\/hpv024","journal-title":"Am J Hypertens"},{"key":"1737_CR5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0014-2999(00)00619-1","volume":"404","author":"HM Crauwels","year":"2000","unstructured":"Crauwels HM, Van Hove CE, Herman AG, Bult H (2000) Heterogeneity in relaxation mechanisms in the carotid and the femoral artery of the mouse. Eur J Pharmacol 404:341\u2013351","journal-title":"Eur J Pharmacol"},{"key":"1737_CR6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1124\/jpet.108.145326","volume":"328","author":"S Dal-Ros","year":"2009","unstructured":"Dal-Ros S, Bronner C, Schott C, Kane MO, Chataigneau M, Schini-Kerth VB, Chataigneau T (2009) Angiotensin II-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery. J Pharmacol Exp Ther 328:478\u2013486","journal-title":"J Pharmacol Exp Ther"},{"key":"1737_CR7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1472-6793-12-9","volume":"12","author":"P Fransen","year":"2012","unstructured":"Fransen P, Van Hove CE, van Langen J, Schrijvers DM, Martinet W, De Meyer GR, Bult H (2012) Contribution of transient and sustained calcium influx, and sensitization to depolarization-induced contractions of the intact mouse aorta. BMC Physiol 12:9. doi: 10.1186\/1472-6793-12-9-","journal-title":"BMC Physiol"},{"key":"1737_CR8","doi-asserted-by":"crossref","unstructured":"Fransen P, Van Hove C, van Langen J, Bult H (2012) Contraction by Ca2+ influx via the L-type Ca2+ channel voltage window in mouse aortic segments is modulated by nitric oxide. In: Sugi H (ed) Current basic and pathological approaches to the function of muscle cells and tissues\u2014from molecules to humans. Rijeka, Croatia: Intech (www.intech.com) 69\u201392","DOI":"10.5772\/47771"},{"key":"1737_CR9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/01.HYP.14.4.453","volume":"14","author":"K Hermsmeyer","year":"1989","unstructured":"Hermsmeyer K, Rusch NJ (1989) Calcium channel alterations in genetic hypertension. Hypertension 14:453\u2013456","journal-title":"Hypertension"},{"key":"1737_CR10","doi-asserted-by":"crossref","unstructured":"Hofmann F, Flockerzi V, Kahl S, Wegener JW (2014) L-type CaV1.2 calcium channels: from in vitro findings to in vivo function. Physiol Rev 94:303\u2013326","DOI":"10.1152\/physrev.00016.2013"},{"key":"1737_CR11","first-page":"H2756","volume":"273","author":"NL Kanagy","year":"1997","unstructured":"Kanagy NL (1997) Increased vascular responsiveness to alpha 2-adrenergic stimulation during NOS inhibition-induced hypertension. Am J Physiol 273:H2756\u2013H2764","journal-title":"Am J Physiol"},{"key":"1737_CR12","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1161\/01.RES.0000105920.33926.60","volume":"93","author":"H Kanaide","year":"2003","unstructured":"Kanaide H, Ichiki T, Nishimura J, Hirano K (2003) Cellular mechanism of vasoconstriction induced by angiotensin II: it remains to be determined. Circ Res 93:1015\u20131017","journal-title":"Circ Res"},{"key":"1737_CR13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00424-009-0759-7","volume":"459","author":"MO Kane","year":"2010","unstructured":"Kane MO, Etienne-Selloum N, Madeira SV, Sarr M, Walter A, Dal-Ros S, Schott C, Chataigneau T, Schini-Kerth VB (2010) Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols. Pflugers Arch 459:671\u2013679","journal-title":"Pflugers Arch"},{"key":"1737_CR14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.amjhyper.2003.08.012","volume":"17","author":"K Kisters","year":"2004","unstructured":"Kisters K, Wessels F, Kuper H, Tokmak F, Krefting ER, Gremmler B, Kosch M, Barenbrock M, Hausberg M (2004) Increased calcium and decreased magnesium concentrations and an increased calcium\/magnesium ratio in spontaneously hypertensive rats versus Wistar-Kyoto rats: relation to arteriosclerosis. Am J Hypertens 17:59\u201362","journal-title":"Am J Hypertens"},{"issue":"Pt 1","key":"1737_CR15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1469-7793.1998.199br.x","volume":"508","author":"HJ Knot","year":"1998","unstructured":"Knot HJ, Nelson MT (1998) Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J Physiol 508(Pt 1):199\u2013209","journal-title":"J Physiol"},{"key":"1737_CR16","doi-asserted-by":"crossref","first-page":"17786","DOI":"10.1016\/S0021-9258(18)38232-2","volume":"265","author":"WJ Koch","year":"1990","unstructured":"Koch WJ, Ellinor PT, Schwartz A (1990) cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms. J Biol Chem 265:17786\u201317791","journal-title":"J Biol Chem"},{"key":"1737_CR17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2165\/11599040-000000000-00000","volume":"12","author":"C Koumaras","year":"2012","unstructured":"Koumaras C, Tzimou M, Stavrinou E, Griva T, Gossios TD, Katsiki N, Athyros VG, Mikhailidis DP, Karagiannis A (2012) Role of antihypertensive drugs in arterial \u2018de-stiffening\u2019 and central pulsatile hemodynamics. Am J Cardiovasc Drugs 12:143\u2013156","journal-title":"Am J Cardiovasc Drugs"},{"key":"1737_CR18","doi-asserted-by":"crossref","first-page":"35133","DOI":"10.1074\/jbc.M705478200","volume":"282","author":"P Liao","year":"2007","unstructured":"Liao P, Yu D, Li G, Yong TF, Soon JL, Chua YL, Soong TW (2007) A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine. J Biol Chem 282:35133\u201335142","journal-title":"J Biol Chem"},{"key":"1737_CR19","doi-asserted-by":"crossref","first-page":"50329","DOI":"10.1074\/jbc.M409436200","volume":"279","author":"P Liao","year":"2004","unstructured":"Liao P, Yu D, Lu S, Tang Z, Liang MC, Zeng S, Lin W, Soong TW (2004) Smooth muscle-selective alternatively spliced exon generates functional variation in Cav1.2 calcium channels. J Biol Chem 279:50329\u201350335","journal-title":"J Biol Chem"},{"key":"1737_CR20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3317\/jraas.2004.025","volume":"5","author":"A Mahmud","year":"2004","unstructured":"Mahmud A, Feely J (2004) Arterial stiffness and the renin-angiotensin-aldosterone system. J Renin-Angiotensin-Aldosterone Syst 5:102\u2013108","journal-title":"J Renin-Angiotensin-Aldosterone Syst"},{"key":"1737_CR21","doi-asserted-by":"crossref","first-page":"30H","DOI":"10.1016\/S0002-9149(03)00432-6","volume":"91","author":"SI McFarlane","year":"2003","unstructured":"McFarlane SI, Kumar A, Sowers JR (2003) Mechanisms by which angiotensin-converting enzyme inhibitors prevent diabetes and cardiovascular disease. Am J Cardiol 91:30H\u201337H","journal-title":"Am J Cardiol"},{"key":"1737_CR22","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1093\/emboj\/cdg583","volume":"22","author":"S Moosmang","year":"2003","unstructured":"Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, Hofmann F, Klugbauer N (2003) Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. EMBO J 22:6027\u20136034","journal-title":"EMBO J"},{"key":"1737_CR23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/157016106775203126","volume":"4","author":"H Nakashima","year":"2006","unstructured":"Nakashima H, Suzuki H, Ohtsu H, Chao JY, Utsunomiya H, Frank GD, Eguchi S (2006) Angiotensin II regulates vascular and endothelial dysfunction: recent topics of angiotensin II type-1 receptor signaling in the vasculature. Curr Vasc Pharmacol 4:67\u201378","journal-title":"Curr Vasc Pharmacol"},{"key":"1737_CR24","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.107.167809","volume":"102","author":"MF Navedo","year":"2008","unstructured":"Navedo MF, Nieves-Cintron M, Amberg GC, Yuan C, Votaw VS, Lederer WJ, McKnight GS, Santana LF (2008) AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. Circ Res 102:e1\u2013e11","journal-title":"Circ Res"},{"key":"1737_CR25","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1161\/01.HYP.31.5.1125","volume":"31","author":"Y Ohya","year":"1998","unstructured":"Ohya Y, Tsuchihashi T, Kagiyama S, Abe I, Fujishima M (1998) Single L-type calcium channels in smooth muscle cells from resistance arteries of spontaneously hypertensive rats. Hypertension 31:1125\u20131129","journal-title":"Hypertension"},{"key":"1737_CR26","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1161\/01.RES.63.6.997","volume":"63","author":"NJ Rusch","year":"1988","unstructured":"Rusch NJ, Hermsmeyer K (1988) Calcium currents are altered in the vascular muscle cell membrane of spontaneously hypertensive rats. Circ Res 63:997\u20131002","journal-title":"Circ Res"},{"key":"1737_CR27","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1161\/hy1201.096538","volume":"38","author":"M Safar","year":"2001","unstructured":"Safar M, Chamiot-Clerc P, Dagher G, Renaud JF (2001) Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats. Hypertension 38:1416\u20131421","journal-title":"Hypertension"},{"key":"1737_CR28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.amjhyper.2006.09.007","volume":"20","author":"AN Swafford Jr","year":"2007","unstructured":"Swafford AN Jr, Harrison-Bernard LM, Dick GM (2007) Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Am J Hypertens 20:335\u2013337","journal-title":"Am J Hypertens"},{"key":"1737_CR29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ceca.2006.08.002","volume":"41","author":"ZZ Tang","year":"2007","unstructured":"Tang ZZ, Hong X, Wang J, Soong TW (2007) Signature combinatorial splicing profiles of rat cardiac- and smooth-muscle Cav1.2 channels with distinct biophysical properties. Cell Calcium 41:417\u2013428","journal-title":"Cell Calcium"},{"key":"1737_CR30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbamcr.2007.11.003","volume":"1783","author":"ZZ Tang","year":"2008","unstructured":"Tang ZZ, Liao P, Li G, Jiang FL, Yu D, Hong X, Yong TF, Tan G, Lu S, Wang J, Soong TW (2008) Differential splicing patterns of L-type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats. Biochim Biophys Acta 1783:118\u2013130","journal-title":"Biochim Biophys Acta"},{"key":"1737_CR31","doi-asserted-by":"crossref","first-page":"17024","DOI":"10.1073\/pnas.0606539103","volume":"103","author":"S Tiwari","year":"2006","unstructured":"Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM (2006) Atherosclerosis-related molecular alteration of the human Cav1.2 calcium channel alpha1C subunit. Proc Natl Acad Sci U S A 103:17024\u201317029","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1737_CR32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/sj.bjp.0703092","volume":"129","author":"M Ushio-Fukai","year":"2000","unstructured":"Ushio-Fukai M, Yamamoto H, Toyofuku K, Nishimura J, Hirano K, Kanaide H (2000) Changes in the cytosolic Ca2+ concentration and Ca(2+)-sensitivity of the contractile apparatus during angiotensin II-induced desensitization in the rabbit femoral artery. Br J Pharmacol 129:425\u2013436","journal-title":"Br J Pharmacol"},{"key":"1737_CR33","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.1476-5381.2009.00396.x","volume":"158","author":"CE Hove Van","year":"2009","unstructured":"Van Hove CE, Van der Donckt C, Herman AG, Bult H, Fransen P (2009) Vasodilator efficacy of nitric oxide depends on mechanisms of intracellular calcium mobilization in mouse aortic smooth muscle cells. Br J Pharmacol 158:920\u2013930","journal-title":"Br J Pharmacol"},{"key":"1737_CR34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2012.09.016","volume":"696","author":"J Langen van","year":"2012","unstructured":"van Langen J, Fransen P, Van Hove CE, Schrijvers DM, Martinet W, De Meyer GR, Bult H (2012) Selective loss of basal but not receptor-stimulated relaxation by endothelial nitric oxide synthase after isolation of the mouse aorta. Eur J Pharmacol 696:111\u2013119","journal-title":"Eur J Pharmacol"},{"key":"1737_CR35","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/00004872-200403000-00016","volume":"22","author":"A Virdis","year":"2004","unstructured":"Virdis A, Neves MF, Amiri F, Touyz RM, Schiffrin EL (2004) Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. J Hypertens 22:535\u2013542","journal-title":"J Hypertens"},{"key":"1737_CR36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000089969","volume":"43","author":"D Wang","year":"2006","unstructured":"Wang D, Chabrashvili T, Borrego L, Aslam S, Umans JG (2006) Angiotensin II infusion alters vascular function in mouse resistance vessels: roles of O and endothelium. J Vasc Res 43:109\u2013119","journal-title":"J Vasc Res"},{"key":"1737_CR37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000318776","volume":"48","author":"W Wang","year":"2011","unstructured":"Wang W, Pang L, Palade P (2011) Angiotensin II upregulates Ca(V)1.2 protein expression in cultured arteries via endothelial H(2)O(2) production. J Vasc Res 48:67\u201378","journal-title":"J Vasc Res"},{"key":"1737_CR38","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.amjhyper.2006.01.020","volume":"19","author":"WZ Wang","year":"2006","unstructured":"Wang WZ, Saada N, Dai B, Pang L, Palade P (2006) Vascular-specific increase in exon 1B-encoded CAV1.2 channels in spontaneously hypertensive rats. Am J Hypertens 19:823\u2013831","journal-title":"Am J Hypertens"},{"key":"1737_CR39","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/CIRCRESAHA.111.248849","volume":"109","author":"J Wang","year":"2011","unstructured":"Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW (2011) Splice variant specific modulation of CaV1.2 calcium channel by galectin-1 regulates arterial constriction. Circ Res 109:1250\u20131258","journal-title":"Circ Res"},{"key":"1737_CR40","doi-asserted-by":"crossref","first-page":"H2559","DOI":"10.1152\/ajpheart.2001.281.6.H2559","volume":"281","author":"GC Wellman","year":"2001","unstructured":"Wellman GC, Cartin L, Eckman DM, Stevenson AS, Saundry CM, Lederer WJ, Nelson MT (2001) Membrane depolarization, elevated Ca(2+) entry, and gene expression in cerebral arteries of hypertensive rats. Am J Physiol Heart Circ Physiol 281:H2559\u2013H2567","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1737_CR41","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jash.2008.09.002","volume":"3","author":"BM Wynne","year":"2009","unstructured":"Wynne BM, Chiao CW, Webb RC (2009) Vascular smooth muscle cell signaling mechanisms for contraction to angiotensin II and endothelin-1. J Am Soc Hypertens 3:84\u201395","journal-title":"J Am Soc Hypertens"},{"key":"1737_CR42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.phrs.2011.07.002","volume":"65","author":"BM Wynne","year":"2012","unstructured":"Wynne BM, Labazi H, Tostes RC, Webb RC (2012) Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses. Pharmacol Res 65:41\u201347","journal-title":"Pharmacol Res"},{"key":"1737_CR43","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1161\/01.RES.0000101912.01071.FF","volume":"93","author":"Y Zhou","year":"2003","unstructured":"Zhou Y, Chen Y, Dirksen WP, Morris M, Periasamy M (2003) AT1b receptor predominantly mediates contractions in major mouse blood vessels. Circ Res 93:1089\u20131094","journal-title":"Circ Res"},{"key":"1737_CR44","doi-asserted-by":"crossref","first-page":"H2797","DOI":"10.1152\/ajpheart.00466.2003","volume":"285","author":"Y Zhou","year":"2003","unstructured":"Zhou Y, Dirksen WP, Babu GJ, Periasamy M (2003) Differential vasoconstrictions induced by angiotensin II: role of AT1 and AT2 receptors in isolated C57BL\/6J mouse blood vessels. Am J Physiol Heart Circ Physiol 285:H2797\u2013H2803","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-015-1737-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-015-1737-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-015-1737-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T16:35:41Z","timestamp":1653237341000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-015-1737-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,3]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["1737"],"URL":"https:\/\/doi.org\/10.1007\/s00424-015-1737-x","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,3]]}}}