{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:41:50Z","timestamp":1790502110550,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Korean Governmoent (MSIP)","award":["NRF 2007-0056092 & 2011-0017370"],"award-info":[{"award-number":["NRF 2007-0056092 & 2011-0017370"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s00424-015-1778-1","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T04:34:34Z","timestamp":1451882074000},"page":"705-716","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Wall stretch and thromboxane A2 activate NO synthase (eNOS) in pulmonary arterial smooth muscle cells via H2O2 and Akt-dependent phosphorylation"],"prefix":"10.1007","volume":"468","author":[{"given":"Hae Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Young","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Yue","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Yeong","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"1778_CR1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1540\/jsmr.47.55","volume":"47","author":"EB Baek","year":"2011","unstructured":"Baek EB, Kim SJ (2011) Mechanisms of myogenic response: Ca2+-dependent and -independent signaling. J Smooth Muscle Res 47:55\u201365","journal-title":"J Smooth Muscle Res"},{"key":"1778_CR2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1164\/ajrccm.164.4.2101023","volume":"164","author":"JA Barbera","year":"2001","unstructured":"Barbera JA, Peinado VI, Santos S, Ramirez J, Roca J, Rodriguez-Roisin R (2001) Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers. Am J Respir Crit Care Med 164:709\u2013713","journal-title":"Am J Respir Crit Care Med"},{"key":"1778_CR3","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1016\/j.ijcard.2012.08.050","volume":"167","author":"VA Barbosa","year":"2013","unstructured":"Barbosa VA, Luciano TF, Marques SO, Vitto MF, Souza DR, Silva LA, Santos JP, Moreira JC, Dal-Pizzol F, Lira FS, Pinho RA, De Souza CT (2013) Acute exercise induce endothelial nitric oxide synthase phosphorylation via Akt and AMP-activated protein kinase in aorta of rats: role of reactive oxygen species. Int J Cardiol 167:2983\u20132988","journal-title":"Int J Cardiol"},{"key":"1778_CR4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1203\/00006450-199407001-00006","volume":"36","author":"J Belik","year":"1994","unstructured":"Belik J (1994) Myogenic response in large pulmonary arteries and its ontogenesis. Pediatr Res 36:34\u201340","journal-title":"Pediatr Res"},{"key":"1778_CR5","first-page":"L602","volume":"263","author":"RA Bialecki","year":"1992","unstructured":"Bialecki RA, Kulik TJ, Colucci WS (1992) Stretching increases calcium influx and efflux in cultured pulmonary arterial smooth muscle cells. Am J Physiol 263:L602\u2013L606","journal-title":"Am J Physiol"},{"key":"1778_CR6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.toxicon.2006.09.030","volume":"49","author":"CL Bowman","year":"2007","unstructured":"Bowman CL, Gottlieb PA, Suchyna TM, Murphy YK, Sachs F (2007) Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon 49:249\u2013270","journal-title":"Toxicon"},{"key":"1778_CR7","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.bbrc.2008.10.019","volume":"377","author":"IB Buchwalow","year":"2008","unstructured":"Buchwalow IB, Cacanyiova S, Neumann J, Samoilova VE, Boecker W, Kristek F (2008) The role of arterial smooth muscle in vasorelaxation. Biochem Biophys Res Commun 377:504\u2013507","journal-title":"Biochem Biophys Res Commun"},{"key":"1778_CR8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1096\/fj.01-0842com","volume":"16","author":"IB Buchwalow","year":"2002","unstructured":"Buchwalow IB, Podzuweit T, Bocker W, Samoilova VE, Thomas S, Wellner M, Baba HA, Robenek H, Schnekenburger J, Lerch MM (2002) Vascular smooth muscle and nitric oxide synthase. FASEB J 16:500\u2013508","journal-title":"FASEB J"},{"key":"1778_CR9","first-page":"241","volume":"64","author":"S Cacanyiova","year":"2013","unstructured":"Cacanyiova S, Dovinova I, Kristek F (2013) The role of oxidative stress in acetylcholine-induced relaxation of endothelium-denuded arteries. J Physiol Pharmacol 64:241\u2013247","journal-title":"J Physiol Pharmacol"},{"key":"1778_CR10","doi-asserted-by":"crossref","first-page":"31858","DOI":"10.1074\/jbc.C100271200","volume":"276","author":"R Chen","year":"2001","unstructured":"Chen R, Kim O, Yang J, Sato K, Eisenmann KM, McCarthy J, Chen H, Qiu Y (2001) Regulation of Akt\/PKB activation by tyrosine phosphorylation. J Biol Chem 276:31858\u201331862","journal-title":"J Biol Chem"},{"key":"1778_CR11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/01.CIR.93.2.266","volume":"93","author":"CJ Cooper","year":"1996","unstructured":"Cooper CJ, Landzberg MJ, Anderson TJ, Charbonneau F, Creager MA, Ganz P, Selwyn AP (1996) Role of nitric oxide in the local regulation of pulmonary vascular resistance in humans. Circulation 93:266\u2013271","journal-title":"Circulation"},{"key":"1778_CR12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.freeradbiomed.2013.04.027","volume":"61","author":"AS Dick","year":"2013","unstructured":"Dick AS, Ivanovska J, Kantores C, Belcastro R, Keith Tanswell A, Jankov RP (2013) Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle. Free Radic Biol Med 61:310\u2013319","journal-title":"Free Radic Biol Med"},{"key":"1778_CR13","doi-asserted-by":"crossref","first-page":"H2417","DOI":"10.1152\/ajpheart.00501.2008","volume":"295","author":"A Dossumbekova","year":"2008","unstructured":"Dossumbekova A, Berdyshev EV, Gorshkova I, Shao Z, Li C, Long P, Joshi A, Natarajan V, Vanden Hoek TL (2008) Akt activates NOS3 and separately restores barrier integrity in H2O2-stressed human cardiac microvascular endothelium. Am J Physiol Heart Circ Physiol 295:H2417\u2013H2426","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1778_CR14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ceca.2010.09.011","volume":"48","author":"T Ducret","year":"2010","unstructured":"Ducret T, El Arrouchi J, Courtois A, Quignard JF, Marthan R, Savineau JP (2010) Stretch-activated channels in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. Cell Calcium 48:251\u2013259","journal-title":"Cell Calcium"},{"key":"1778_CR15","doi-asserted-by":"crossref","first-page":"H1655","DOI":"10.1152\/ajpheart.00964.2002","volume":"284","author":"S Earley","year":"2003","unstructured":"Earley S, Walker BR (2003) Increased nitric oxide production following chronic hypoxia contributes to attenuated systemic vasoconstriction. Am J Physiol Heart Circ Physiol 284:H1655\u2013H1661","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1778_CR16","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2174\/138945012802002348","volume":"13","author":"PR Evora","year":"2012","unstructured":"Evora PR, Evora PM, Celotto AC, Rodrigues AJ, Joviliano EE (2012) Cardiovascular therapeutics targets on the NO-sGC-cGMP signaling pathway: a critical overview. Curr Drug Targets 13:1207\u20131214","journal-title":"Curr Drug Targets"},{"key":"1778_CR17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00424-009-0767-7","volume":"459","author":"I Fleming","year":"2010","unstructured":"Fleming I (2010) Molecular mechanisms underlying the activation of eNOS. Pflugers Arch 459:793\u2013806","journal-title":"Pflugers Arch"},{"key":"1778_CR18","doi-asserted-by":"crossref","first-page":"H2166","DOI":"10.1152\/ajpheart.00780.2011","volume":"302","author":"G Frazziano","year":"2012","unstructured":"Frazziano G, Champion HC, Pagano PJ (2012) NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone. Am J Physiol Heart Circ Physiol 302:H2166\u2013H2177","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1778_CR19","doi-asserted-by":"crossref","first-page":"26677","DOI":"10.1016\/S0021-9258(18)47072-X","volume":"269","author":"ES Furfine","year":"1994","unstructured":"Furfine ES, Harmon MF, Paith JE, Knowles RG, Salter M, Kiff RJ, Duffy C, Hazelwood R, Oplinger JA, Garvey EP (1994) Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline. J Biol Chem 269:26677\u201326683","journal-title":"J Biol Chem"},{"key":"1778_CR20","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1074\/jbc.272.8.4959","volume":"272","author":"EP Garvey","year":"1997","unstructured":"Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, Knowles RG (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272:4959\u20134963","journal-title":"J Biol Chem"},{"key":"1778_CR21","doi-asserted-by":"crossref","first-page":"C78","DOI":"10.1152\/ajpcell.00176.2012","volume":"304","author":"JA Han","year":"2013","unstructured":"Han JA, Seo EY, Kim HJ, Park SJ, Yoo HY, Kim JY, Shin DM, Kim JK, Zhang YH, Kim SJ (2013) Hypoxia-augmented constriction of deep femoral artery mediated by inhibition of eNOS in smooth muscle. Am J Physiol Cell Physiol 304:C78\u2013C88","journal-title":"Am J Physiol Cell Physiol"},{"key":"1778_CR22","first-page":"67","volume":"34","author":"MA Hill","year":"2006","unstructured":"Hill MA, Davis MJ, Meininger GA, Potocnik SJ, Murphy TV (2006) Arteriolar myogenic signalling mechanisms: implications for local vascular function. Clin Hemorheol Microcirc 34:67\u201379","journal-title":"Clin Hemorheol Microcirc"},{"key":"1778_CR23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cellsig.2003.10.008","volume":"16","author":"JS Huang","year":"2004","unstructured":"Huang JS, Ramamurthy SK, Lin X, Le Breton GC (2004) Cell signalling through thromboxane A2 receptors. Cell Signal 16:521\u2013533","journal-title":"Cell Signal"},{"key":"1778_CR24","doi-asserted-by":"crossref","first-page":"L105","DOI":"10.1152\/ajplung.00290.2009","volume":"298","author":"S Kumar","year":"2010","unstructured":"Kumar S, Sud N, Fonseca FV, Hou Y, Black SM (2010) Shear stress stimulates nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity: role of protein kinase C delta. Am J Physiol Lung Cell Mol Physiol 298:L105\u2013L116","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1778_CR25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cardiores.2007.06.021","volume":"76","author":"HA Lee","year":"2007","unstructured":"Lee HA, Baek EB, Park KS, Jung HJ, Kim JI, Kim SJ, Earm YE (2007) Mechanosensitive nonselective cation channel facilitation by endothelin-1 is regulated by protein kinase C in arterial myocytes. Cardiovasc Res 76:224\u2013235","journal-title":"Cardiovasc Res"},{"key":"1778_CR26","first-page":"92","volume-title":"Nunn\u2019s applied respiratory physiology","author":"A Lumb","year":"2005","unstructured":"Lumb A (2005) Nunn\u2019s applied respiratory physiology, 6th edn. Elsevier, Italy, pp 92\u2013104","edition":"6"},{"key":"1778_CR27","doi-asserted-by":"crossref","first-page":"L288","DOI":"10.1152\/ajplung.00417.2004","volume":"289","author":"E Mata-Greenwood","year":"2005","unstructured":"Mata-Greenwood E, Grobe A, Kumar S, Noskina Y, Black SM (2005) Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species: a requirement for NAD(P)H oxidase. Am J Physiol Lung Cell Mol Physiol 289:L288\u2013L289","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1778_CR28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/01.crd.0000249381.49138.b9","volume":"15","author":"R Mathew","year":"2007","unstructured":"Mathew R, Huang J, Gewitz MH (2007) Pulmonary artery hypertension: caveolin-1 and eNOS interrelationship: a new perspective. Cardiol Rev 15:143\u2013149","journal-title":"Cardiol Rev"},{"key":"1778_CR29","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1111\/j.1742-4658.2011.08395.x","volume":"278","author":"JL McMurry","year":"2011","unstructured":"McMurry JL, Chrestensen CA, Scott IM, Lee EW, Rahn AM, Johansen AM, Forsberg BJ, Harris KD, Salerno JC (2011) Rate, affinity and calcium dependence of nitric oxide synthase isoform binding to the primary physiological regulator calmodulin. FEBS J 278:4943\u20134954","journal-title":"FEBS J"},{"key":"1778_CR30","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00424-009-0765-9","volume":"459","author":"T Michel","year":"2010","unstructured":"Michel T, Vanhoutte PM (2010) Cellular signaling and NO production. Pflugers Arch 459:807\u2013816","journal-title":"Pflugers Arch"},{"key":"1778_CR31","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1152\/japplphysiol.00819.2004","volume":"98","author":"JS Naik","year":"2005","unstructured":"Naik JS, Earley S, Resta TC, Walker BR (2005) Pressure-induced smooth muscle cell depolarization in pulmonary arteries from control and chronically hypoxic rats does not cause myogenic vasoconstriction. J Appl Physiol (1985) 98:1119\u20131124","journal-title":"J Appl Physiol (1985)"},{"key":"1778_CR32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.bjp.0701362","volume":"122","author":"K Nakayama","year":"1997","unstructured":"Nakayama K, Ueta K, Tanaka Y, Tanabe Y, Ishii K (1997) Stretch-induced contraction of rabbit isolated pulmonary artery and the involvement of endothelium-derived thromboxane A2. Br J Pharmacol 122:199\u2013208","journal-title":"Br J Pharmacol"},{"key":"1778_CR33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jash.2012.01.002","volume":"6","author":"TM Paravicini","year":"2012","unstructured":"Paravicini TM, Montezano AC, Yusuf H, Touyz RM (2012) Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II. J Am Soc Hypertens 6:169\u2013178","journal-title":"J Am Soc Hypertens"},{"key":"1778_CR34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1161\/01.RES.0000093204.25499.83","volume":"93","author":"KS Park","year":"2003","unstructured":"Park KS, Kim Y, Lee YH, Earm YE, Ho WK (2003) Mechanosensitive cation channels in arterial smooth muscle cells are activated by diacylglycerol and inhibited by phospholipase C inhibitor. Circ Res 93:557\u2013564","journal-title":"Circ Res"},{"key":"1778_CR35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000093607","volume":"43","author":"KS Park","year":"2006","unstructured":"Park KS, Lee HA, Earm KH, Ko JH, Earm YE, Kim SJ (2006) Differential distribution of mechanosensitive nonselective cation channels in systemic and pulmonary arterial myocytes of rabbits. J Vasc Res 43:347\u2013354","journal-title":"J Vasc Res"},{"key":"1778_CR36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/bja\/aeq268","volume":"106","author":"SJ Park","year":"2011","unstructured":"Park SJ, Yoo HY, Earm YE, Kim SJ, Kim JK, Kim SD (2011) Role of arachidonic acid-derived metabolites in the control of pulmonary arterial pressure and hypoxic pulmonary vasoconstriction in rats. Br J Anaesth 106:31\u201337","journal-title":"Br J Anaesth"},{"key":"1778_CR37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/13813450902785267","volume":"115","author":"KC Sedoris","year":"2009","unstructured":"Sedoris KC, Ovechkin AV, Gozal E, Roberts AM (2009) Differential effects of nitric oxide synthesis on pulmonary vascular function during lung ischemia-reperfusion injury. Arch Physiol Biochem 115:34\u201346","journal-title":"Arch Physiol Biochem"},{"key":"1778_CR38","doi-asserted-by":"crossref","first-page":"17120","DOI":"10.1074\/jbc.M109.012583","volume":"284","author":"P Song","year":"2009","unstructured":"Song P, Zhang M, Wang S, Xu J, Choi HC, Zou MH (2009) Thromboxane A2 receptor activates a Rho-associated kinase\/LKB1\/PTEN pathway to attenuate endothelium insulin signaling. J Biol Chem 284:17120\u201317128","journal-title":"J Biol Chem"},{"key":"1778_CR39","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1074\/jbc.M109107200","volume":"277","author":"SR Thomas","year":"2002","unstructured":"Thomas SR, Chen K, Keaney JF Jr (2002) Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem 277:6017\u20136024","journal-title":"J Biol Chem"},{"key":"1778_CR40","doi-asserted-by":"crossref","first-page":"11892","DOI":"10.1074\/jbc.M806205200","volume":"284","author":"QK Tran","year":"2009","unstructured":"Tran QK, Leonard J, Black DJ, Nadeau OW, Boulatnikov IG, Persechini A (2009) Effects of combined phosphorylation at Ser-617 and Ser-1179 in endothelial nitric-oxide synthase on EC50 Ca2+ values for calmodulin binding and enzyme activation. J Biol Chem 284:11892\u201311899","journal-title":"J Biol Chem"},{"key":"1778_CR41","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4196\/kjpp.2013.17.5.463","volume":"17","author":"HY Yoo","year":"2013","unstructured":"Yoo HY, Kim SJ (2013) Disappearance of hypoxic pulmonary vasoconstriction and O2-sensitive nonselective cationic current in arterial myocytes of rats under ambient hypoxia. Korean J Physiol Pharmacol 17:463\u2013468","journal-title":"Korean J Physiol Pharmacol"},{"key":"1778_CR42","doi-asserted-by":"crossref","first-page":"C307","DOI":"10.1152\/ajpcell.00153.2011","volume":"302","author":"HY Yoo","year":"2012","unstructured":"Yoo HY, Park SJ, Seo EY, Park KS, Han JA, Kim KS, Shin DH, Earm YE, Zhang YH, Kim SJ (2012) Role of thromboxane A2-activated nonselective cation channels in hypoxic pulmonary vasoconstriction of rat. Am J Physiol Cell Physiol 302:C307\u2013C317","journal-title":"Am J Physiol Cell Physiol"},{"key":"1778_CR43","doi-asserted-by":"crossref","first-page":"H82","DOI":"10.1152\/ajpheart.00300.2012","volume":"304","author":"X Zhou","year":"2013","unstructured":"Zhou X, Yuan D, Wang M, He P (2013) H2O2-induced endothelial NO production contributes to vascular cell apoptosis and increased permeability in rat venules. Am J Physiol Heart Circ Physiol 304:H82\u2013H93","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-015-1778-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-015-1778-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-015-1778-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T18:45:29Z","timestamp":1654022729000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-015-1778-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["1778"],"URL":"https:\/\/doi.org\/10.1007\/s00424-015-1778-1","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,4]]}}}