{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:16:05Z","timestamp":1789240565301,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100015644","name":"Pancreas Research Foundation of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015644","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI (24790226)"],"award-info":[{"award-number":["KAKENHI (24790226)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008394","name":"Natur og Univers, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["DFF 4002-00162"],"award-info":[{"award-number":["DFF 4002-00162"]}],"id":[{"id":"10.13039\/100008394","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00424-016-1806-9","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T01:38:21Z","timestamp":1457660301000},"page":"1171-1181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The adenosine A2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells"],"prefix":"10.1007","volume":"468","author":[{"given":"M.","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"1806_CR1","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/j.bbamem.2010.05.016","volume":"1808","author":"CM Aherne","year":"2011","unstructured":"Aherne CM, Kewley EM, Eltzschig HK (2011) The resurgence of A2B adenosine receptor signaling. Biochim Biophys Acta 1808:1329\u20131339. doi:\n                    10.1016\/j.bbamem.2010.05.016","journal-title":"Biochim Biophys Acta"},{"key":"1806_CR2","doi-asserted-by":"publisher","first-page":"17236","DOI":"10.1074\/jbc.M011763200","volume":"276","author":"W Ahn","year":"2001","unstructured":"Ahn W, Kim KH, Lee JA, Kim JY, Choi JY, Moe OW, Milgram SL, Muallem S, Lee MG (2001) Regulatory interaction between the cystic fibrosis transmembrane conductance regulator and HCO3\n                           \u2212 salvage mechanisms in model systems and the mouse pancreatic duct. J Biol Chem 276:17236\u201317243. doi:\n                    10.1074\/jbc.M011763200","journal-title":"J Biol Chem"},{"key":"1806_CR3","doi-asserted-by":"crossref","first-page":"C197","DOI":"10.1152\/ajpcell.1989.256.1.C197","volume":"256","author":"KE Barrett","year":"1989","unstructured":"Barrett KE, Huott PA, Shah SS, Dharmsathaphorn K, Wasserman SI (1989) Differing effects of apical and basolateral adenosine on colonic epithelial cell line T84. Am J Physiol 256:C197\u2013C203","journal-title":"Am J Physiol"},{"key":"1806_CR4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1177\/43.3.7532655","volume":"43","author":"L Bouwens","year":"1995","unstructured":"Bouwens L, Braet F, Heimberg H (1995) Identification of rat pancreatic duct cells by their expression of cytokeratins 7, 19, and 20 in vivo and after isolation and culture. J Histochem Cytochem 43:245\u2013253. doi:\n                    10.1177\/43.3.7532655","journal-title":"J Histochem Cytochem"},{"key":"1806_CR5","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1113\/jphysiol.2003.056697","volume":"555","author":"RE Bucheimer","year":"2004","unstructured":"Bucheimer RE, Linden J (2004) Purinergic regulation of epithelial transport. J Physiol 555:311\u2013321. doi:\n                    10.1113\/jphysiol.2003.056697","journal-title":"J Physiol"},{"key":"1806_CR6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1530\/JOE-11-0434","volume":"213","author":"G Burnstock","year":"2012","unstructured":"Burnstock G, Novak I (2012) Purinergic signalling in the pancreas in health and disease. J Endocrinol 213:123\u2013141. doi:\n                    10.1530\/JOE-11-0434","journal-title":"J Endocrinol"},{"key":"1806_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s002329900401","volume":"164","author":"HS Cheng","year":"1998","unstructured":"Cheng HS, Leung PY, Cheng Chew SB, Leung PS, Lam SY, Wong WS, Wang ZD, Chan HC (1998) Concurrent and independent HCO3\n                           \u2212 and Cl\u2212 secretion in a human pancreatic duct cell line (CAPAN-1). J Membr Biol 164:155\u2013167. doi:\n                    10.1007\/s002329900401","journal-title":"J Membr Biol"},{"key":"1806_CR8","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1124\/mol.109.059345","volume":"76","author":"CW Dessauer","year":"2009","unstructured":"Dessauer CW (2009) Adenylyl cyclase\u2013A-kinase anchoring protein complexes: the next dimension in cAMP signaling. Mol Pharmacol 76:935\u2013941. doi:\n                    10.1124\/mol.109.059345","journal-title":"Mol Pharmacol"},{"key":"1806_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/B978-0-12-385526-8.00005-9","volume":"61","author":"I Feoktistov","year":"2011","unstructured":"Feoktistov I, Biaggioni I (2011) Role of adenosine A2B receptors in inflammation. Adv Pharmacol 61:115\u2013144. doi:\n                    10.1016\/B978-0-12-385526-8.00005-9","journal-title":"Adv Pharmacol"},{"key":"1806_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/pr.110.003285","volume":"63","author":"BB Fredholm","year":"2011","unstructured":"Fredholm BB, IJzerman AP, Jacobson KA, Linden J, M\u00fcller CE (2011) International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors\u2014an update. Pharmacol Rev 63:1\u201334. doi:\n                    10.1124\/pr.110.003285","journal-title":"Pharmacol Rev"},{"key":"1806_CR11","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0006-2952(00)00570-0","volume":"61","author":"BB Fredholm","year":"2001","unstructured":"Fredholm BB, Irenius E, Kull B, Schulte G (2001) Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem Pharmacol 61:443\u2013448. doi:\n                    10.1016\/S0006-2952(00)00570-0","journal-title":"Biochem Pharmacol"},{"key":"1806_CR12","doi-asserted-by":"publisher","first-page":"a009563","DOI":"10.1101\/cshperspect.a009563","volume":"2","author":"RA Frizzell","year":"2012","unstructured":"Frizzell RA, Hanrahan JW (2012) Physiology of epithelial chloride and fluid secretion. Cold Spring Harb Perspect Med 2:a009563. doi:\n                    10.1101\/cshperspect.a009563","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1806_CR13","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1046\/j.1365-201x.1998.00330.x","volume":"163","author":"M Furukawa","year":"1998","unstructured":"Furukawa M, Ikeda K, Oshima T, Suzuki H, Yamaya M, Sasaki H, Takasaka T (1998) A2 adenosine receptors in Mongolian gerbil middle ear epithelium and their regulation of Cl\u2212 secretion. Acta Physiol Scand 163:103\u2013112. doi:\n                    10.1046\/j.1365-201x.1998.00330.x","journal-title":"Acta Physiol Scand"},{"key":"1806_CR14","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.2337\/diab.38.10.1291","volume":"38","author":"R Gross","year":"1989","unstructured":"Gross R, Hillaire-Buys D, Bertrand G, Ribes G, Loubatieres-Mariani MM (1989) Diabetes and impaired response of glucagon cells and vascular bed to adenosine in rat pancreas. Diabetes 38:1291\u20131295. doi:\n                    10.2337\/diab.38.10.1291","journal-title":"Diabetes"},{"key":"1806_CR15","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s11302-014-9406-7","volume":"10","author":"KA Haanes","year":"2014","unstructured":"Haanes KA, Kowal JM, Arpino G, Lange SC, Moriyama Y, Pedersen PA, Novak I (2014) Role of vesicular nucleotide transporter VNUT (SLC17A9) in release of ATP from AR42J cells and mouse pancreatic acinar cells. Purinergic Signal 10:431\u201340. doi:\n                    10.1007\/s11302-014-9406-7","journal-title":"Purinergic Signal"},{"key":"1806_CR16","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1042\/BJ20091337","volume":"429","author":"KA Haanes","year":"2010","unstructured":"Haanes KA, Novak I (2010) ATP storage and uptake by isolated pancreatic zymogen granules. Biochem J 429:303\u2013311. doi:\n                    10.1042\/BJ20091337","journal-title":"Biochem J"},{"key":"1806_CR17","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1124\/jpet.110.171520","volume":"335","author":"M Ham","year":"2010","unstructured":"Ham M, Mizumori M, Watanabe C, Wang JH, Inoue T, Nakano T, Guth PH, Engel E, Kaunitz JD, Akiba Y (2010) Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. J Pharmacol Exp Ther 335:607\u2013613. doi:\n                    10.1124\/jpet.110.171520","journal-title":"J Pharmacol Exp Ther"},{"key":"1806_CR18","doi-asserted-by":"publisher","first-page":"C151","DOI":"10.1152\/ajpcell.00089.2012","volume":"303","author":"M Hayashi","year":"2012","unstructured":"Hayashi M, Wang J, Hede SE, Novak I (2012) An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cells. Am J Physiol Cell Physiol 303:C151\u2013C159. doi:\n                    10.1152\/ajpcell.00089.2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"1806_CR19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s002320010054","volume":"180","author":"C Hirono","year":"2001","unstructured":"Hirono C, Nakamoto T, Sugita M, Iwasa Y, Akagawa Y, Shiba Y (2001) Gramicidin-perforated patch analysis on HCO3\n                           \u2212 secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells. J Membr Biol 180:11\u201319. doi:\n                    10.1007\/s002320010054","journal-title":"J Membr Biol"},{"key":"1806_CR20","doi-asserted-by":"publisher","first-page":"14120","DOI":"10.1073\/pnas.241318498","volume":"98","author":"P Huang","year":"2001","unstructured":"Huang P, Lazarowski ER, Tarran R, Milgram SL, Boucher RC, Stutts MJ (2001) Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells. Proc Natl Acad Sci U S A 98:14120\u201314125. doi:\n                    10.1073\/pnas.241318498","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1806_CR21","doi-asserted-by":"crossref","first-page":"C417","DOI":"10.1152\/ajpcell.2000.278.2.C417","volume":"278","author":"P Huang","year":"2000","unstructured":"Huang P, Trotter K, Boucher RC, Milgram SL, Stutts MJ (2000) PKA holoenzyme is functionally coupled to CFTR by AKAPs. Am J Physiol Cell Physiol 278:C417\u2013C422","journal-title":"Am J Physiol Cell Physiol"},{"key":"1806_CR22","doi-asserted-by":"publisher","first-page":"C380","DOI":"10.1152\/ajpcell.00373.2003","volume":"286","author":"A Inagaki","year":"2004","unstructured":"Inagaki A, Yamaguchi S, Ishikawa T (2004) Amiloride-sensitive epithelial Na+ channel currents in surface cells of rat rectal colon. Am J Physiol Cell Physiol 286:C380\u2013C390. doi:\n                    10.1152\/ajpcell.00373.2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"1806_CR23","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00424-013-1333-x","volume":"466","author":"L Jud\u00e1k","year":"2014","unstructured":"Jud\u00e1k L, Hegyi P, Rakonczay Z Jr, Mal\u00e9th J, Gray MA, Venglovecz V (2014) Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation. Pflugers Arch 466:549\u2013562. doi:\n                    10.1007\/s00424-013-1333-x","journal-title":"Pflugers Arch"},{"key":"1806_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12964-015-0107-9","volume":"13","author":"JM Kowal","year":"2015","unstructured":"Kowal JM, Haanes KA, Christensen NM, Novak I (2015) Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells. Cell Commun Signal 13:28. doi:\n                    10.1186\/s12964-015-0107-9","journal-title":"Cell Commun Signal"},{"key":"1806_CR25","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s11302-015-9472-5","volume":"11","author":"JM Kowal","year":"2015","unstructured":"Kowal JM, Yegutkin GG, Novak I (2015) ATP release, generation and hydrolysis in exocrine pancreatic duct cells. Purinergic Signal 11:533\u2013550. doi:\n                    10.1007\/s11302-015-9472-5","journal-title":"Purinergic Signal"},{"key":"1806_CR26","first-page":"250","volume":"106","author":"AP Kyriazis","year":"1982","unstructured":"Kyriazis AP, Kyriazis AA, Scarpelli DG, Fogh J, Rao MS, Lepera R (1982) Human pancreatic adenocarcinoma line Capan-1 in tissue culture and the nude mouse: morphologic, biologic, and biochemical characteristics. Am J Pathol 106:250\u2013260","journal-title":"Am J Pathol"},{"key":"1806_CR27","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1039\/b924455g","volume":"2","author":"C Li","year":"2010","unstructured":"Li C, Naren AP (2010) CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners. Integr Biol (Camb) 2:161\u2013177. doi:\n                    10.1039\/b924455g","journal-title":"Integr Biol (Camb)"},{"key":"1806_CR28","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.humpath.2010.04.008","volume":"41","author":"DF Ma","year":"2010","unstructured":"Ma DF, Kondo T, Nakazawa T, Niu DF, Mochizuki K, Kawasaki T, Yamane T, Katoh R (2010) Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells. Hum Pathol 41:1550\u20131557. doi:\n                    10.1016\/j.humpath.2010.04.008","journal-title":"Hum Pathol"},{"key":"1806_CR29","doi-asserted-by":"publisher","first-page":"39271","DOI":"10.1074\/jbc.M109.098293","volume":"285","author":"K Moriyama","year":"2010","unstructured":"Moriyama K, Sitkovsky MV (2010) Adenosine A2A receptor is involved in cell surface expression of A2B receptor. J Biol Chem 285:39271\u201339288. doi:\n                    10.1074\/jbc.M109.098293","journal-title":"J Biol Chem"},{"key":"1806_CR30","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/j.1476-5381.2009.00598.x","volume":"159","author":"SJ Mundell","year":"2010","unstructured":"Mundell SJ, Matharu AL, Nisar S, Palmer TM, Benovic JL, Kelly E (2010) Deletion of the distal COOH-terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling. Br J Pharmacol 159:518\u2013533. doi:\n                    10.1111\/j.1476-5381.2009.00598.x","journal-title":"Br J Pharmacol"},{"key":"1806_CR31","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1074\/jbc.M207199200","volume":"278","author":"W Namkung","year":"2003","unstructured":"Namkung W, Lee JA, Ahn W, Han W, Kwon SW, Ahn DS, Kim KH, Lee MG (2003) Ca2+ activates cystic fibrosis transmembrane conductance regulator- and Cl\u2212-dependent HCO3\n                           \u2212 transport in pancreatic duct cells. J Biol Chem 278:200\u2013207. doi:\n                    10.1074\/jbc.M207199200","journal-title":"J Biol Chem"},{"key":"1806_CR32","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00424-007-0403-3","volume":"456","author":"I Novak","year":"2008","unstructured":"Novak I, Hede SE, Hansen MR (2008) Adenosine receptors in rat and human pancreatic ducts stimulate chloride transport. Pflugers Arch 456:437\u2013447. doi:\n                    10.1007\/s00424-007-0403-3","journal-title":"Pflugers Arch"},{"key":"1806_CR33","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/sj.bjp.0701990","volume":"124","author":"CM O\u2019Reilly","year":"1998","unstructured":"O\u2019Reilly CM, O\u2019Farrell AM, Ryan MP (1998) Purinoceptor activation of chloride transport in cystic fibrosis and CFTR-transfected pancreatic cell lines. Br J Pharmacol 124:1597\u20131606. doi:\n                    10.1038\/sj.bjp.0701990","journal-title":"Br J Pharmacol"},{"key":"1806_CR34","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/HYPERTENSIONAHA.109.143404","volume":"55","author":"M Rajagopal","year":"2010","unstructured":"Rajagopal M, Pao AC (2010) Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells. Hypertension 55:1123\u20131128. doi:\n                    10.1161\/HYPERTENSIONAHA.109.143404","journal-title":"Hypertension"},{"key":"1806_CR35","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1113\/jphysiol.2012.249698","volume":"591","author":"ME Sabbatini","year":"2013","unstructured":"Sabbatini ME, D\u2019Alecy L, Lentz SI, Tang T, Williams JA (2013) Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation. J Physiol 591:3693\u20133707. doi:\n                    10.1113\/jphysiol.2012.249698","journal-title":"J Physiol"},{"key":"1806_CR36","doi-asserted-by":"publisher","first-page":"19797","DOI":"10.1074\/jbc.273.31.19797","volume":"273","author":"DB Short","year":"1998","unstructured":"Short DB, Trotter KW, Reczek D, Kreda SM, Bretscher A, Boucher RC, Stutts MJ, Milgram SL (1998) An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. J Biol Chem 273:19797\u201319801. doi:\n                    10.1074\/jbc.273.31.19797","journal-title":"J Biol Chem"},{"key":"1806_CR37","doi-asserted-by":"publisher","first-page":"33188","DOI":"10.1074\/jbc.M202522200","volume":"277","author":"SV Sitaraman","year":"2002","unstructured":"Sitaraman SV, Wang L, Wong M, Bruewer M, Hobert M, Yun CH, Merlin D, Madara JL (2002) The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. J Biol Chem 277:33188\u201333195. doi:\n                    10.1074\/jbc.M202522200","journal-title":"J Biol Chem"},{"key":"1806_CR38","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1113\/jphysiol.2003.049411","volume":"551","author":"CE S\u00f8rensen","year":"2003","unstructured":"S\u00f8rensen CE, Amstrup J, Rasmussen HN, Ankorina-Stark I, Novak I (2003) Rat pancreas secretes particulate ecto-nucleotidase CD39. J Physiol 551:881\u2013892. doi:\n                    10.1111\/j.1469-7793.2003.00881.x","journal-title":"J Physiol"},{"key":"1806_CR39","doi-asserted-by":"publisher","first-page":"32925","DOI":"10.1074\/jbc.M103313200","volume":"276","author":"CE S\u00f8rensen","year":"2001","unstructured":"S\u00f8rensen CE, Novak I (2001) Visualization of ATP release in pancreatic acini in response to cholinergic stimulus. Use of fluorescent probes and confocal microscopy. J Biol Chem 276:32925\u201332932. doi:\n                    10.1074\/jbc.M103313200","journal-title":"J Biol Chem"},{"key":"1806_CR40","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1073\/pnas.0908801107","volume":"107","author":"J Stagg","year":"2010","unstructured":"Stagg J, Divisekera U, McLaughlin N, Sharkey J, Pommey S, Denoyer D, Dwyer KM, Smyth MJ (2010) Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci U S A 107:1547\u20131552. doi:\n                    10.1073\/pnas.0908801107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1806_CR41","doi-asserted-by":"crossref","first-page":"C819","DOI":"10.1152\/ajpcell.1998.274.3.C819","volume":"274","author":"WK Steagall","year":"1998","unstructured":"Steagall WK, Kelley TJ, Marsick RJ, Drumm ML (1998) Type II protein kinase A regulates CFTR in airway, pancreatic, and intestinal cells. Am J Physiol 274:C819\u2013C826","journal-title":"Am J Physiol"},{"key":"1806_CR42","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1074\/jbc.270.5.2387","volume":"270","author":"GR Strohmeier","year":"1995","unstructured":"Strohmeier GR, Reppert SM, Lencer WI, Madara JL (1995) The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. J Biol Chem 270:2387\u20132394. doi:\n                    10.1074\/jbc.270.5.2387","journal-title":"J Biol Chem"},{"key":"1806_CR43","doi-asserted-by":"publisher","first-page":"29539","DOI":"10.1074\/jbc.M004961200","volume":"275","author":"F Sun","year":"2000","unstructured":"Sun F, Hug MJ, Lewarchik CM, Yun CH, Bradbury NA, Frizzell RA (2000) E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells. J Biol Chem 275:29539\u201329546. doi:\n                    10.1074\/jbc.M004961200","journal-title":"J Biol Chem"},{"key":"1806_CR44","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000097672","volume":"18","author":"A Sz\u0171cs","year":"2006","unstructured":"Sz\u0171cs A, Demeter I, Burghardt B, \u00d3v\u00e1ri G, Case RM, Steward MC, Varga G (2006) Vectorial bicarbonate transport by Capan-1 cells: a model for human pancreatic ductal secretion. Cell Physiol Biochem 18:253\u2013264. doi:\n                    10.1159\/000097672","journal-title":"Cell Physiol Biochem"},{"key":"1806_CR45","doi-asserted-by":"publisher","first-page":"e0126432","DOI":"10.1371\/journal.pone.0126432","volume":"10","author":"J Wang","year":"2015","unstructured":"Wang J, Barbuskaite D, Tozzi M, Giannuzzo A, S\u00f8rensen CE, Novak I (2015) Proton pump inhibitors inhibit pancreatic secretion: role of gastric and non-gastric H+\/K+-ATPases. PLoS One 10:e0126432. doi:\n                    10.1371\/journal.pone.0126432","journal-title":"PLoS One"},{"key":"1806_CR46","doi-asserted-by":"publisher","first-page":"C673","DOI":"10.1152\/ajpcell.00196.2012","volume":"304","author":"J Wang","year":"2013","unstructured":"Wang J, Haanes KA, Novak I (2013) Purinergic regulation of CFTR and Ca2+-activated Cl\u2212 channels and K+ channels in human pancreatic duct epithelium. Am J Physiol Cell Physiol 304:C673\u2013C684. doi:\n                    10.1152\/ajpcell.00196.2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"1806_CR47","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/MPA.0b013e318264c302","volume":"42","author":"J Wang","year":"2012","unstructured":"Wang J, Novak I (2012) Ion transport in human pancreatic duct epithelium, Capan-1 cells, is regulated by secretin, VIP, acetylcholine, and purinergic receptors. Pancreas 42:452\u2013460. doi:\n                    10.1097\/MPA.0b013e318264c302","journal-title":"Pancreas"},{"key":"1806_CR48","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1096\/fj.11-186080","volume":"25","author":"MJ Watson","year":"2011","unstructured":"Watson MJ, Worthington EN, Clunes LA, Rasmussen JE, Jones L, Tarran R (2011) Defective adenosine-stimulated cAMP production in cystic fibrosis airway epithelia: a novel role for CFTR in cell signaling. FASEB J 25:2996\u20133003. doi:\n                    10.1096\/fj.11-186080","journal-title":"FASEB J"},{"key":"1806_CR49","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s11302-012-9350-3","volume":"9","author":"Q Wei","year":"2013","unstructured":"Wei Q, Costanzi S, Balasubramanian R, Gao ZG, Jacobson KA (2013) A2B adenosine receptor blockade inhibits growth of prostate cancer cells. Purinergic Signal 9:271\u2013280. doi:\n                    10.1007\/s11302-012-9350-3","journal-title":"Purinergic Signal"},{"key":"1806_CR50","doi-asserted-by":"publisher","first-page":"a009746","DOI":"10.1101\/cshperspect.a009746","volume":"3","author":"M Wilschanski","year":"2013","unstructured":"Wilschanski M, Novak I (2013) The cystic fibrosis of exocrine pancreas. Cold Spring Harb Perspect Med 3:a009746. doi:\n                    10.1101\/cshperspect.a009746","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1806_CR51","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0014-2999(85)90130-X","volume":"118","author":"F Yamagishi","year":"1985","unstructured":"Yamagishi F, Homma N, Haruta K, Iwatsuki K, Chiba S (1985) Adenosine potentiates secretin-stimulated pancreatic exocrine secretion in the dog. Eur J Pharmacol 118:203\u2013209. doi:\n                    10.1016\/0014-2999(85)90130-X","journal-title":"Eur J Pharmacol"},{"key":"1806_CR52","doi-asserted-by":"publisher","first-page":"29441","DOI":"10.1074\/jbc.M602480200","volume":"281","author":"GG Yegutkin","year":"2006","unstructured":"Yegutkin GG, Samburski SS, Jalkanen S, Novak I (2006) ATP-consuming and ATP-generating enzymes secreted by pancreas. J Biol Chem 281:29441\u201329447. doi:\n                    10.1074\/jbc.M602480200","journal-title":"J Biol Chem"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1806-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-016-1806-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1806-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1806-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T13:18:35Z","timestamp":1589635115000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-016-1806-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,11]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["1806"],"URL":"https:\/\/doi.org\/10.1007\/s00424-016-1806-9","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,11]]},"assertion":[{"value":"1 September 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}