{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:10:47Z","timestamp":1793214647919,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004359","name":"the Swedish Research Council","doi-asserted-by":"publisher","award":["325-2012-6778"],"award-info":[{"award-number":["325-2012-6778"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["55X-06240"],"award-info":[{"award-number":["55X-06240"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Diabetes Foundation","id":[{"id":"https:\/\/ror.org\/03d78g823","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000273","name":"Diabetes Research & Wellness Foundation","doi-asserted-by":"publisher","award":["670_2015PG"],"award-info":[{"award-number":["670_2015PG"]}],"id":[{"id":"10.13039\/501100000273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EXODIAB"},{"DOI":"10.13039\/501100006415","name":"Stiftelsen Familjen Ernfors Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006415","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s00424-016-1864-z","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T17:42:17Z","timestamp":1471542137000},"page":"1765-1777","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging"],"prefix":"10.1007","volume":"468","author":[{"given":"Hongyan","family":"Shuai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Gylfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4508-0836","authenticated-orcid":false,"given":"Anders","family":"Tengholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,18]]},"reference":[{"key":"1864_CR1","doi-asserted-by":"publisher","first-page":"3924","DOI":"10.1210\/en.2015-1301","volume":"156","author":"A Adriaenssens","year":"2015","unstructured":"Adriaenssens A, Lam BY, Billing L, Skeffington K, Sewing S, Reimann F, Gribble F (2015) A transcriptome-led exploration of molecular mechanisms regulating somatostatin-producing D-cells in the gastric epithelium. Endocrinology 156:3924\u20133936. doi: 10.1210\/en.2015-1301","journal-title":"Endocrinology"},{"key":"1864_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.bbagen.2014.11.005","volume":"1850","author":"F Aragon","year":"2015","unstructured":"Aragon F, Karaca M, Novials A, Maldonado R, Maechler P, Rubi B (2015) Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells. Biochim Biophys Acta 1850:343\u2013351. doi: 10.1016\/j.bbagen.2014.11.005","journal-title":"Biochim Biophys Acta"},{"key":"1864_CR3","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.2337\/diabetes.49.9.1500","volume":"49","author":"S Barg","year":"2000","unstructured":"Barg S, Galvanovskis J, G\u00f6pel SO, Rorsman P, Eliasson L (2000) Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting \u03b1-cells. Diabetes 49:1500\u20131510","journal-title":"Diabetes"},{"key":"1864_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.virusres.2005.07.001","volume":"115","author":"S Berenjian","year":"2006","unstructured":"Berenjian S, Akusj\u00e4rvi G (2006) Binary AdEasy vector systems designed for Tet-ON or Tet-OFF regulated control of transgene expression. Virus Res 115:16\u201323. doi: 10.1016\/j.virusres.2005.07.001","journal-title":"Virus Res"},{"key":"1864_CR5","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1210\/endo.137.2.8593819","volume":"137","author":"A Berts","year":"1996","unstructured":"Berts A, Ball A, Dryselius G, Gylfe E, Hellman B (1996) Glucose stimulation of somatostatin-producing islet cells involves oscillatory Ca2+ signaling. Endocrinology 137:693\u2013697. doi: 10.1210\/endo.137.2.8593819","journal-title":"Endocrinology"},{"key":"1864_CR6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF02738806","volume":"6","author":"A Berts","year":"1997","unstructured":"Berts A, Gylfe E, Hellman B (1997) Cytoplasmic Ca2+ in glucagon-producing pancreatic \u03b1-cells exposed to carbachol and agents affecting Na+ fluxes. Endocrine 6:79\u201383. doi: 10.1007\/BF02738806","journal-title":"Endocrine"},{"key":"1864_CR7","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1172\/JCI66514","volume":"123","author":"NC Bramswig","year":"2013","unstructured":"Bramswig NC, Everett LJ, Schug J, Dorrell C, Liu C, Luo Y, Streeter PR, Naji A, Grompe M, Kaestner KH (2013) Epigenomic plasticity enables human pancreatic \u03b1 to \u03b2 cell reprogramming. J Clin Invest 123:1275\u20131284. doi: 10.1172\/JCI66514","journal-title":"J Clin Invest"},{"key":"1864_CR8","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1007\/s00125-009-1382-z","volume":"52","author":"M Braun","year":"2009","unstructured":"Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, Johnson PR, Rorsman P (2009) Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia 52:1566\u20131578. doi: 10.1007\/s00125-009-1382-z","journal-title":"Diabetologia"},{"key":"1864_CR9","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.cmet.2008.03.004","volume":"7","author":"O Cabrera","year":"2008","unstructured":"Cabrera O, Jacques-Silva MC, Speier S, Yang SN, Kohler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO (2008) Glutamate is a positive autocrine signal for glucagon release. Cell Metab 7:545\u2013554. doi: 10.1016\/j.cmet.2008.03.004","journal-title":"Cell Metab"},{"issue":"Pt 3","key":"1864_CR10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1113\/jphysiol.1995.sp020756","volume":"485","author":"RH Chow","year":"1995","unstructured":"Chow RH, Lund PE, L\u00f6ser S, Panten U, Gylfe E (1995) Coincidence of early glucose-induced depolarization with lowering of cytoplasmic Ca2+ in mouse pancreatic \u03b2-cells. J Physiol 485(Pt 3):607\u2013617","journal-title":"J Physiol"},{"key":"1864_CR11","doi-asserted-by":"crossref","first-page":"15659","DOI":"10.1016\/S0021-9258(18)47777-0","volume":"262","author":"DJ Drucker","year":"1987","unstructured":"Drucker DJ, Philippe J, Jepeal L, Habener JF (1987) Glucagon gene 5\u2032-flanking sequences promote islet cell-specific gene transcription. J Biol Chem 262:15659\u201315665","journal-title":"J Biol Chem"},{"key":"1864_CR12","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cmet.2008.06.003","volume":"8","author":"O Dyachok","year":"2008","unstructured":"Dyachok O, Idevall-Hagren O, S\u00e5getorp J, Tian G, Wuttke A, Arrieumerlou C, Akusj\u00e4rvi G, Gylfe E, Tengholm A (2008) Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion. Cell Metab 8:26\u201337. doi: 10.1016\/j.cmet.2008.06.003","journal-title":"Cell Metab"},{"key":"1864_CR13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature04410","volume":"439","author":"O Dyachok","year":"2006","unstructured":"Dyachok O, Isakov Y, S\u00e5getorp J, Tengholm A (2006) Oscillations of cyclic AMP in hormone-stimulated insulin-secreting \u03b2-cells. Nature 439:349\u2013352","journal-title":"Nature"},{"key":"1864_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.diabres.2013.11.019","volume":"103","author":"E Gylfe","year":"2014","unstructured":"Gylfe E, Gilon P (2014) Glucose regulation of glucagon secretion. Diabetes Res Clin Pract 103:1\u201310. doi: 10.1016\/j.diabres.2013.11.019","journal-title":"Diabetes Res Clin Pract"},{"issue":"Suppl 1","key":"1864_CR15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/dom.12345","volume":"16","author":"E Gylfe","year":"2014","unstructured":"Gylfe E, Tengholm A (2014) Neurotransmitter control of islet hormone pulsatility. Diabetes, Obesity and Metabolism 16(Suppl 1):102\u2013110","journal-title":"Diabetes, Obesity and Metabolism"},{"key":"1864_CR16","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1469-7793.2000.00497.x","volume":"528","author":"SO G\u00f6pel","year":"2000","unstructured":"G\u00f6pel SO, Kanno T, Barg S, Rorsman P (2000) Patch-clamp characterisation of somatostatin-secreting \u03b4-cells in intact mouse pancreatic islets. J Physiol 528:497\u2013507","journal-title":"J Physiol"},{"key":"1864_CR17","doi-asserted-by":"publisher","first-page":"E177","DOI":"10.1152\/ajpendo.00321.2002","volume":"284","author":"M Hara","year":"2003","unstructured":"Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, Magnuson MA, Bell GI (2003) Transgenic mice with green fluorescent protein-labeled pancreatic \u03b2-cells. Am J Physiol Endocrinol Metab 284:E177\u2013E183. doi: 10.1152\/ajpendo.00321.2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1864_CR18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2337\/db08-0792","volume":"58","author":"AC Hauge-Evans","year":"2009","unstructured":"Hauge-Evans AC, King AJ, Carmignac D, Richardson CC, Robinson IC, Low MJ, Christie MR, Persaud SJ, Jones PM (2009) Somatostatin secreted by islet \u03b4-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 58:403\u2013411. doi: 10.2337\/db08-0792","journal-title":"Diabetes"},{"key":"1864_CR19","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1210\/endo.138.8.5296","volume":"138","author":"B Hellman","year":"1997","unstructured":"Hellman B, Gylfe E, Bergsten P, Grapengiesser E, Berts A, Liu YJ, Tengholm A, Westerlund J (1997) Oscillatory signaling and insulin release in human pancreatic \u03b2-cells exposed to strontium. Endocrinology 138:3161\u20133165. doi: 10.1210\/endo.138.8.5296","journal-title":"Endocrinology"},{"key":"1864_CR20","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.bbrc.2011.12.113","volume":"417","author":"B Hellman","year":"2012","unstructured":"Hellman B, Salehi A, Grapengiesser E, Gylfe E (2012) Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon. Biochem Biophys Res Commun 417:1219\u20131223. doi: 10.1016\/j.bbrc.2011.12.113","journal-title":"Biochem Biophys Res Commun"},{"key":"1864_CR21","doi-asserted-by":"publisher","first-page":"5334","DOI":"10.1210\/en.2009-0600","volume":"150","author":"B Hellman","year":"2009","unstructured":"Hellman B, Salehi A, Gylfe E, Dansk H, Grapengiesser E (2009) Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets. Endocrinology 150:5334\u20135340. doi: 10.1210\/en.2009-0600","journal-title":"Endocrinology"},{"key":"1864_CR22","doi-asserted-by":"crossref","first-page":"12999","DOI":"10.1073\/pnas.91.26.12999","volume":"91","author":"PL Herrera","year":"1994","unstructured":"Herrera PL, Huarte J, Zufferey R, Nichols A, Mermillod B, Philippe J, Muniesa P, Sanvito F, Orci L, Vassalli JD (1994) Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. Proc Natl Acad Sci U S A 91:12999\u201313003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1864_CR23","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.2337\/db15-0488","volume":"64","author":"T Hutchens","year":"2015","unstructured":"Hutchens T, Piston DW (2015) EphA4 receptor forward signaling inhibits glucagon secretion from \u03b1-cells. Diabetes 64:3839\u20133851. doi: 10.2337\/db15-0488","journal-title":"Diabetes"},{"key":"1864_CR24","first-page":"E215","volume":"251","author":"JB Jaspan","year":"1986","unstructured":"Jaspan JB, Lever E, Polonsky KS, Van Cauter E (1986) In vivo pulsatility of pancreatic islet peptides. Am J Phys 251:E215\u2013E226","journal-title":"Am J Phys"},{"key":"1864_CR25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1677\/joe-08-0085","volume":"198","author":"T Jin","year":"2008","unstructured":"Jin T (2008) Mechanisms underlying proglucagon gene expression. J Endocrinol 198:17\u201328. doi: 10.1677\/joe-08-0085","journal-title":"J Endocrinol"},{"key":"1864_CR26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0168-0102(01)00318-2","volume":"42","author":"T Kanno","year":"2002","unstructured":"Kanno T, G\u00f6pel SO, Rorsman P, Wakui M (2002) Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on \u03b1-, \u03b2- and \u03b4-cells of the pancreatic islet. Neurosci Res 42:79\u201390","journal-title":"Neurosci Res"},{"key":"1864_CR27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2337\/diab.30.5.435","volume":"30","author":"DA Lang","year":"1981","unstructured":"Lang DA, Matthews DR, Burnett M, Turner RC (1981) Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes 30:435\u2013439","journal-title":"Diabetes"},{"key":"1864_CR28","doi-asserted-by":"publisher","first-page":"14389","DOI":"10.1074\/jbc.M109.069195","volume":"285","author":"SJ Le Marchand","year":"2010","unstructured":"Le Marchand SJ, Piston DW (2010) Glucose suppression of glucagon secretion: metabolic and calcium responses from \u03b1-cells in intact mouse pancreatic islets. J Biol Chem 285:14389\u201314398. doi: 10.1074\/jbc.M109.069195","journal-title":"J Biol Chem"},{"key":"1864_CR29","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1096\/fj.14-265918","volume":"29","author":"J Li","year":"2015","unstructured":"Li J, Yu Q, Ahooghalandari P, Gribble FM, Reimann F, Tengholm A, Gylfe E (2015) Submembrane ATP and Ca2+ kinetics in \u03b1-cells: unexpected signaling for glucagon secretion. FASEB J 29:3379\u20133388. doi: 10.1096\/fj.14-265918","journal-title":"FASEB J"},{"key":"1864_CR30","doi-asserted-by":"publisher","first-page":"5524","DOI":"10.1210\/endo.140.12.7198","volume":"140","author":"YJ Liu","year":"1999","unstructured":"Liu YJ, Hellman B, Gylfe E (1999) Ca2+ signaling in mouse pancreatic polypeptide cells. Endocrinology 140:5524\u20135529. doi: 10.1210\/endo.140.12.7198","journal-title":"Endocrinology"},{"key":"1864_CR31","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ceca.2003.10.002","volume":"35","author":"YJ Liu","year":"2004","unstructured":"Liu YJ, Vieira E, Gylfe E (2004) A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic \u03b1-cell. Cell Calcium 35:357\u2013365. doi: 10.1016\/j.ceca.2003.10.002","journal-title":"Cell Calcium"},{"key":"1864_CR32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/1472-6750-10-81","volume":"10","author":"R Loew","year":"2010","unstructured":"Loew R, Heinz N, Hampf M, Bujard H, Gossen M (2010) Improved Tet-responsive promoters with minimized background expression. BMC Biotechnol 10:81. doi: 10.1186\/1472-6750-10-81","journal-title":"BMC Biotechnol"},{"key":"1864_CR33","first-page":"G829","volume":"277","author":"M Nian","year":"1999","unstructured":"Nian M, Drucker DJ, Irwin D (1999) Divergent regulation of human and rat proglucagon gene promoters in vivo. Am J Phys 277:G829\u2013G837","journal-title":"Am J Phys"},{"key":"1864_CR34","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1056\/nejm198805123181902","volume":"318","author":"S O\u2019Rahilly","year":"1988","unstructured":"O\u2019Rahilly S, Turner RC, Matthews DR (1988) Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 318:1225\u20131230. doi: 10.1056\/nejm198805123181902","journal-title":"N Engl J Med"},{"key":"1864_CR35","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.1210\/en.2005-0800","volume":"146","author":"HL Olsen","year":"2005","unstructured":"Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB, Gromada J (2005) Glucose stimulates glucagon release in single rat \u03b1-cells by mechanisms that mirror the stimulus-secretion coupling in \u03b2-cells. Endocrinology 146:4861\u20134870. doi: 10.1210\/en.2005-0800","journal-title":"Endocrinology"},{"key":"1864_CR36","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2337\/diab.31.6.538","volume":"31","author":"L Orci","year":"1982","unstructured":"Orci L (1982) Macro- and micro-domains in the endocrine pancreas. Diabetes 31:538\u2013565","journal-title":"Diabetes"},{"key":"1864_CR37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s125-002-8240-x","volume":"45","author":"N P\u00f8rksen","year":"2002","unstructured":"P\u00f8rksen N (2002) The in vivo regulation of pulsatile insulin secretion. Diabetologia 45:3\u201320","journal-title":"Diabetologia"},{"key":"1864_CR38","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.1016\/j.febslet.2007.07.068","volume":"581","author":"N Quoix","year":"2007","unstructured":"Quoix N, Cheng-Xue R, Guiot Y, Herrera PL, Henquin JC, Gilon P (2007) The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic \u03b1-cells. FEBS Lett 581:4235\u20134240. doi: 10.1016\/j.febslet.2007.07.068","journal-title":"FEBS Lett"},{"key":"1864_CR39","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.2337\/diabetes.54.6.1798","volume":"54","author":"MA Ravier","year":"2005","unstructured":"Ravier MA, Guldenagel M, Charollais A, Gjinovci A, Caille D, Sohl G, Wollheim CB, Willecke K, Henquin JC, Meda P (2005) Loss of connexin36 channels alters \u03b2-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes 54:1798\u20131807","journal-title":"Diabetes"},{"key":"1864_CR40","doi-asserted-by":"publisher","first-page":"E791","DOI":"10.1210\/jc.2011-3439","volume":"97","author":"S Rohrer","year":"2012","unstructured":"Rohrer S, Menge BA, Gruber L, Deacon CF, Schmidt WE, Veldhuis JD, Holst JJ, Meier JJ (2012) Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals. J Clin Endocrinol Metab 97:E791\u2013E795. doi: 10.1210\/jc.2011-3439","journal-title":"J Clin Endocrinol Metab"},{"key":"1864_CR41","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.2337\/db06-0080","volume":"55","author":"A Salehi","year":"2006","unstructured":"Salehi A, Vieira E, Gylfe E (2006) Paradoxical stimulation of glucagon secretion by high glucose concentrations. Diabetes 55:2318\u20132323. doi: 10.2337\/db06-0080","journal-title":"Diabetes"},{"key":"1864_CR42","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.mam.2015.01.003","volume":"42","author":"LS Satin","year":"2015","unstructured":"Satin LS, Butler PC, Ha J, Sherman AS (2015) Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Asp Med 42:61\u201377. doi: 10.1016\/j.mam.2015.01.003","journal-title":"Mol Asp Med"},{"key":"1864_CR43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00265096","volume":"32","author":"FC Schuit","year":"1989","unstructured":"Schuit FC, Derde MP, Pipeleers DG (1989) Sensitivity of rat pancreatic A and B cells to somatostatin. Diabetologia 32:207\u2013212","journal-title":"Diabetologia"},{"key":"1864_CR44","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.2871625","volume":"232","author":"FC Schuit","year":"1986","unstructured":"Schuit FC, Pipeleers DG (1986) Differences in adrenergic recognition by pancreatic A and B cells. Science (New York, NY) 232:875\u2013877","journal-title":"Science (New York, NY)"},{"key":"1864_CR45","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/isl.2.3.11815","volume":"2","author":"DJ Steiner","year":"2010","unstructured":"Steiner DJ, Kim A, Miller K, Hara M (2010) Pancreatic islet plasticity: interspecies comparison of islet architecture and composition. Islets 2:135\u2013145","journal-title":"Islets"},{"key":"1864_CR46","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/nn.2104","volume":"11","author":"W Tan","year":"2008","unstructured":"Tan W, Janczewski WA, Yang P, Shao XM, Callaway EM, Feldman JL (2008) Silencing preBotzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat Neurosci 11:538\u2013540. doi: 10.1038\/nn.2104","journal-title":"Nat Neurosci"},{"key":"1864_CR47","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1002\/cne.22308","volume":"518","author":"W Tan","year":"2010","unstructured":"Tan W, Pagliardini S, Yang P, Janczewski WA, Feldman JL (2010) Projections of preBotzinger complex neurons in adult rats. J Comp Neurol 518:1862\u20131878. doi: 10.1002\/cne.22308","journal-title":"J Comp Neurol"},{"key":"1864_CR48","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/nature08894","volume":"464","author":"F Thorel","year":"2010","unstructured":"Thorel F, Nepote V, Avril I, Kohno K, Desgraz R, Chera S, Herrera PL (2010) Conversion of adult pancreatic \u03b1-cells to \u03b2-cells after extreme \u03b2-cell loss. Nature 464:1149\u20131154. doi: 10.1038\/nature08894","journal-title":"Nature"},{"key":"1864_CR49","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.2337\/db10-1087","volume":"60","author":"G Tian","year":"2011","unstructured":"Tian G, Sandler S, Gylfe E, Tengholm A (2011) Glucose- and hormone-induced cAMP oscillations in \u03b1- and \u03b2-cells within intact pancreatic islets. Diabetes 60:1535\u20131543. doi: 10.2337\/db10-1087","journal-title":"Diabetes"},{"key":"1864_CR50","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/BF00281991","volume":"28","author":"RH Unger","year":"1985","unstructured":"Unger RH (1985) Glucagon physiology and pathophysiology in the light of new advances. Diabetologia 28:574\u2013578","journal-title":"Diabetologia"},{"key":"1864_CR51","doi-asserted-by":"publisher","first-page":"R103","DOI":"10.1530\/JME-14-0290","volume":"54","author":"T Meulen van der","year":"2015","unstructured":"van der Meulen T, Huising MO (2015) Role of transcription factors in the transdifferentiation of pancreatic islet cells. J Mol Endocrinol 54:R103\u2013R117. doi: 10.1530\/JME-14-0290","journal-title":"J Mol Endocrinol"},{"key":"1864_CR52","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00210-003-0858-5","volume":"369","author":"E Vieira","year":"2004","unstructured":"Vieira E, Liu YJ, Gylfe E (2004) Involvement of \u03b11 and \u03b2-adrenoceptors in adrenaline stimulation of the glucagon-secreting mouse \u03b1-cell. Naunyn Schmiedeberg's Arch Pharmacol 369:179\u2013183. doi: 10.1007\/s00210-003-0858-5","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"1864_CR53","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00125-006-0511-1","volume":"50","author":"E Vieira","year":"2007","unstructured":"Vieira E, Salehi A, Gylfe E (2007) Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells. Diabetologia 50:370\u2013379","journal-title":"Diabetologia"},{"key":"1864_CR54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0167-0115(02)00067-8","volume":"107","author":"N Wierup","year":"2002","unstructured":"Wierup N, Svensson H, Mulder H, Sundler F (2002) The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 107:63\u201369","journal-title":"Regul Pept"},{"key":"1864_CR55","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1016\/S0021-9258(18)69165-3","volume":"263","author":"H Yonekura","year":"1988","unstructured":"Yonekura H, Nata K, Watanabe T, Kurashina Y, Yamamoto H, Okamoto H (1988) Mosaic evolution of prepropancreatic polypeptide. II. Structural conservation and divergence in pancreatic polypeptide gene. J Biol Chem 263:2990\u20132997","journal-title":"J Biol Chem"},{"key":"1864_CR56","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1038\/sj.gt.3302780","volume":"13","author":"X Zhou","year":"2006","unstructured":"Zhou X, Vink M, Klaver B, Berkhout B, Das AT (2006) Optimization of the Tet-On system for regulated gene expression through viral evolution. Gene Ther 13:1382\u20131390. doi: 10.1038\/sj.gt.3302780","journal-title":"Gene Ther"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1864-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-016-1864-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1864-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T02:08:53Z","timestamp":1657073333000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-016-1864-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,18]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["1864"],"URL":"https:\/\/doi.org\/10.1007\/s00424-016-1864-z","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,18]]}}}