{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:41:21Z","timestamp":1757454081768},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s00424-016-1865-y","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T07:30:51Z","timestamp":1472542251000},"page":"1697-1707","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Regulation of myoglobin in hypertrophied rat cardiomyocytes in experimental pulmonary hypertension"],"prefix":"10.1007","volume":"468","author":[{"given":"E. L.","family":"Peters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Offringa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. J.","family":"Van der Laarse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Jaspers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"1865_CR1","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/nature06613","volume":"451","author":"Z Arany","year":"2008","unstructured":"Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM (2008) HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 451:1008\u20131012. doi: 10.1038\/nature06613","journal-title":"Nature"},{"key":"1865_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12931-015-0178-6","volume":"16","author":"GM Balestra","year":"2015","unstructured":"Balestra GM, Mik EG, Eerbeek O, Specht P, van der Laarse WJ, Zuurbier CJ (2015) Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure? Respir Res 16:6. doi: 10.1186\/s12931-015-0178-6","journal-title":"Respir Res"},{"key":"1865_CR3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1113\/jphysiol.1988.sp017379","volume":"406","author":"SM Baylor","year":"1988","unstructured":"Baylor SM, Pape PC (1988) Measurement of myoglobin diffusivity in the myoplasm of frog skeletal muscle fibres. J Physiol 406:247\u2013275. doi: 10.1113\/jphysiol.1988.sp017379","journal-title":"J Physiol"},{"key":"1865_CR4","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1073\/pnas.95.13.7631","volume":"95","author":"E Clementi","year":"1998","unstructured":"Clementi E, Brown GC, Feelisch M, Moncada S (1998) Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci U S A 95:7631\u20137636","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1865_CR5","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1172\/JCI105269","volume":"35","author":"PR Dallman","year":"1965","unstructured":"Dallman PR, Schwartz HC (1965) Distribution of cytochrome C and myoglobin in rats with dietary iron deficiency. Pediatrics 35:677\u2013686. doi: 10.1172\/JCI105269","journal-title":"Pediatrics"},{"key":"1865_CR6","doi-asserted-by":"publisher","unstructured":"des Tombe AL, van Beek-Harmsen BJ, Lee-de Groot MBE, Van der Laarse WJ (2002) Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium. Microsc Res Tech 58:412\u2013420. doi: 10.1002\/jemt.10153","DOI":"10.1002\/jemt.10153"},{"key":"1865_CR7","doi-asserted-by":"publisher","unstructured":"Endeward V (2012) The rate of the deoxygenation reaction limits myoglobin- and hemoglobin-facilitated O(2) diffusion in cells. J Appl Physiol 112:1466\u20131473. doi: 10.1152\/japplphysiol.00835.2011","DOI":"10.1152\/japplphysiol.00835.2011"},{"key":"1865_CR8","doi-asserted-by":"publisher","unstructured":"Enoki Y, Matsumura K, Ohga Y, Kohzuki H, Hattori M (1995) Oxygen affinities (P50) of myoglobins from four vertebrate species (Canis familiaris, Rattus norvegicus, Mus musculus and Gallus domesticus) as determined by a kinetic and an equilibrium method. Comp Biochem Physiol B Biochem Mol Biol 110:193\u2013199. doi: 10.1016\/0305-0491(94)00119-F","DOI":"10.1016\/0305-0491(94)00119-F"},{"key":"1865_CR9","doi-asserted-by":"publisher","unstructured":"Fl\u00f6gel U, Godecke A, Klotz LO, Schrader J (2004) Role of myoglobin in the antioxidant defense of the heart. FASEB 18:1156\u20131158. doi: 10.1096\/fj.03-1382fje","DOI":"10.1096\/fj.03-1382fje"},{"key":"1865_CR10","doi-asserted-by":"publisher","unstructured":"Fl\u00f6gel U, Laussmann T, Godecke A, Abanador N, Schafers M, Fingas CD, Metzger S, Levkau B, Jacoby C, Schrader J (2005) Lack of myoglobin causes a switch in cardiac substrate selection. Circ Res 96:e68\u2013e75. doi: 10.1161\/01.RES.0000165481.36288.d2","DOI":"10.1161\/01.RES.0000165481.36288.d2"},{"key":"1865_CR11","doi-asserted-by":"publisher","unstructured":"Fl\u00f6gel U, Merx MW, Godecke A, Decking UK, Schrader J (2001) Myoglobin: a scavenger of bioactive NO. Proc Natl Acad Sci U S A 98:735\u2013740. doi: 10.1073\/pnas.011460298","DOI":"10.1073\/pnas.011460298"},{"key":"1865_CR12","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1113\/jphysiol.2003.045104","volume":"551","author":"A Garnier","year":"2003","unstructured":"Garnier A, Fortin D, Delom\u00e9nie C, Momken I, Veksler V, Ventura-Clapier R (2003) Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol 551:491\u2013501. doi: 10.1113\/jphysiol.2003.045104","journal-title":"J Physiol"},{"key":"1865_CR13","first-page":"H522","volume":"260","author":"TE Gayeski","year":"1991","unstructured":"Gayeski TE, Honig CR (1991) Intracellular PO2 in individual cardiac myocytes in dogs, cats, rabbits, ferrets, and rats. Am J Phys 260:H522\u2013H531","journal-title":"Am J Phys"},{"key":"1865_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mce.2004.07.007","volume":"226","author":"G Giannocco","year":"2004","unstructured":"Giannocco G, DosSantos RA, Nunes MT (2004) Thyroid hormone stimulates myoglobin gene expression in rat cardiac muscle. Mol Cell Endocrinol 226:19\u201326. doi: 10.1016\/j.mce.2004.07.007","journal-title":"Mol Cell Endocrinol"},{"key":"1865_CR15","doi-asserted-by":"crossref","unstructured":"Goldspink G, Yang SY (2004) The splicing of the IGF-I gene to yield different muscle growth factors. In: Advances in Genetics. Academic Press, San Diego, p 23\u201349","DOI":"10.1016\/S0065-2660(04)52002-3"},{"key":"1865_CR16","doi-asserted-by":"publisher","unstructured":"Handoko ML, de Man FS, Happ\u00e9 CM, Schalij I, Musters RJ, Westerhof N, Postmus PE, Paulus WJ, van der Laarse WJ, Vonk-Noordegraaf A (2009) Opposite effects of training in rats with stable and progressive pulmonary hypertension. Circulation 120:42\u201349. doi: 10.1161\/circulationaha.108.829713","DOI":"10.1161\/circulationaha.108.829713"},{"key":"1865_CR17","volume-title":"Trials and trails in physiology","author":"AV Hill","year":"1965","unstructured":"Hill AV (1965) Trials and trails in physiology. Edward Arnold, London"},{"key":"1865_CR18","doi-asserted-by":"publisher","first-page":"12017","DOI":"10.1073\/pnas.0705070104","volume":"104","author":"S Jager","year":"2007","unstructured":"Jager S, Handschin C, St-Pierre J, Spiegelman BM (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 104:12017\u201312022. doi: 10.1073\/pnas.0705070104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1865_CR19","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1242\/bio.20149167","volume":"3","author":"RT Jaspers","year":"2014","unstructured":"Jaspers RT, Testerink J, Della Gaspera B, Chanoine C, Bagowski CP, van der Laarse WJ (2014) Increased oxidative metabolism and myoglobin expression in zebrafish muscle during chronic hypoxia. Biology open 3:718\u2013727. doi: 10.1242\/bio.20149167","journal-title":"Biology open"},{"key":"1865_CR20","doi-asserted-by":"publisher","unstructured":"Kanatous SB, Mammen PP, Rosenberg PB, Martin CM, White MD, Dimaio JM, Huang G, Muallem S, Garry DJ (2009) Hypoxia reprograms calcium signaling and regulates myoglobin expression. Am J Physiol Cell Physiol 296:C393\u2013C402. doi: 10.1152\/ajpcell.00428.2008","DOI":"10.1152\/ajpcell.00428.2008"},{"key":"1865_CR21","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1242\/jeb.041442","volume":"213","author":"SB Kanatous","year":"2010","unstructured":"Kanatous SB, Mammen PPA (2010) Regulation of myoglobin expression. J Exp Biol 213:2741\u20132747. doi: 10.1242\/jeb.041442","journal-title":"J Exp Biol"},{"key":"1865_CR22","doi-asserted-by":"publisher","unstructured":"Lee-de Groot MBE, des Tombe AL, Van der Laarse WJ (1998) Calibrated histochemistry of myoglobin concentration in cardiomyocytes. J Histochem Cytochem 46:1077\u20131084. doi: 10.1177\/002215549804600912","DOI":"10.1177\/002215549804600912"},{"key":"1865_CR23","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1172\/JCI10268","volume":"106","author":"JJ Lehman","year":"2000","unstructured":"Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106:847\u2013856. doi: 10.1172\/JCI10268","journal-title":"J Clin Invest"},{"key":"1865_CR24","doi-asserted-by":"publisher","unstructured":"Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306\u20131309. doi: 10.1126\/science.2479986","DOI":"10.1126\/science.2479986"},{"key":"1865_CR25","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1172\/JCI22220","volume":"114","author":"H-H Li","year":"2004","unstructured":"Li H-H, Kedar V, Zhang C, McDonough H, Arya R, Wang D-Z, Patterson C (2004) Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J Clin Invest 114:1058\u20131071. doi: 10.1172\/JCI22220","journal-title":"J Clin Invest"},{"key":"1865_CR26","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1152\/ajpheart.00147.2003","volume":"285","author":"PP Mammen","year":"2003","unstructured":"Mammen PP, Kanatous SB, Yuhanna IS, Shaul PW, Garry MW, Balaban RS, Garry DJ (2003) Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice. Am J Physiol Heart Circ Physiol 285:2132\u20132142. doi: 10.1152\/ajpheart.00147.2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1865_CR27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11010-013-1689-4","volume":"381","author":"E Mavrommatis","year":"2013","unstructured":"Mavrommatis E, Shioura KM, Los T, Goldspink PH (2013) The E-domain region of mechano-growth factor inhibits cellular apoptosis and preserves cardiac function during myocardial infarction. Mol Cell Biochem 381:69\u201383. doi: 10.1007\/s11010-013-1689-4","journal-title":"Mol Cell Biochem"},{"key":"1865_CR28","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/241204a0","volume":"241","author":"DJ Millward","year":"1973","unstructured":"Millward DJ, Garlick PJ, James WP, Nnanyelugo DO, Ryatt JS (1973) Relationship between protein synthesis and RNA content in skeletal muscle. Nature 241:204\u2013205. doi: 10.1038\/241204a0","journal-title":"Nature"},{"key":"1865_CR29","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0092-8674(00)81573-1","volume":"93","author":"JD Molkentin","year":"1998","unstructured":"Molkentin JD, LU JR, Antos CL, Markham B, Richardson JA, Robbins J, Grant SR, Olson EN (1998) A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93:215\u2013228. doi: 10.1016\/S0092-8674(00)81573-1","journal-title":"Cell"},{"key":"1865_CR30","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1152\/physiolgenomics.90297.2008","volume":"41","author":"A Molojavyi","year":"2010","unstructured":"Molojavyi A, Lindecke A, Raupach A, Moellendorf S, Kohrer K, Godecke A (2010) Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Physiol Genomics 41:137\u2013145. doi: 10.1152\/physiolgenomics.90297.2008","journal-title":"Physiol Genomics"},{"key":"1865_CR31","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1152\/ajpheart.00893.2008","volume":"297","author":"KT Mouchaers","year":"2009","unstructured":"Mouchaers KT, Schalij I, Versteilen AM, Hadi AM, van Nieuw Amerongen GP, van Hinsbergh VW, Postmus PE, van der Laarse WJ, Vonk-Noordegraaf A (2009) Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol 297:200\u2013207. doi: 10.1152\/ajpheart.00893.2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1865_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0022-5193(74)90102-7","volume":"47","author":"JD Murray","year":"1974","unstructured":"Murray JD (1974) On the role of myoglobin in muscle respiration. J Theor Biol 47:115\u2013126. doi: 10.1016\/0022-5193(74)90102-7","journal-title":"J Theor Biol"},{"key":"1865_CR33","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/0022-2828(92)93386-X","volume":"24","author":"PJ O\u2019Brien","year":"1992","unstructured":"O\u2019Brien PJ, O\u2019Grady M, McCutcheon LJ, Shen H, Nowack L, Horne RD, Mirsalimi SM, Julian RJ, Grima EA, Moe GW, Armstrong PW (1992) Myocardial myoglobin deficiency in various animal models of congestive heart failure. J Mol Cell Cardiol 24:721\u2013730. doi: 10.1016\/0022-2828(92)93386-X","journal-title":"J Mol Cell Cardiol"},{"key":"1865_CR34","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF00495025","volume":"64","author":"CW Pool","year":"1979","unstructured":"Pool CW, Scholten G, Diegenbach PC (1979) Quantitative succinate dehydrogenase histochemistry I. A methodological study on mammalian and fish muscle. Histochemistry 64:251\u2013262. doi: 10.1007\/BF00495025","journal-title":"Histochemistry"},{"key":"1865_CR35","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","volume":"92","author":"P Puigserver","year":"1998","unstructured":"Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829\u2013839. doi: 10.1016\/S0092-8674(00)81410-5","journal-title":"Cell"},{"key":"1865_CR36","doi-asserted-by":"publisher","first-page":"855","DOI":"10.4161\/auto.6.7.13005","volume":"6","author":"MN Quinsay","year":"2010","unstructured":"Quinsay MN, Thomas RL, Lee Y, Gustafsson AB (2010) Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy 6:855\u2013862. doi: 10.4161\/auto.6.7.13005","journal-title":"Autophagy"},{"key":"1865_CR37","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.cardiores.2007.05.012","volume":"75","author":"EM Redout","year":"2007","unstructured":"Redout EM, Wagner MJ, Zuidwijk MJ, Boer C, Musters RJ, van Hardeveld C, Paulus WJ, Simonides WS (2007) Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. Cardiovasc Res 75:770\u2013781. doi: 10.1016\/j.cardiores.2007.05.012","journal-title":"Cardiovasc Res"},{"key":"1865_CR38","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1161\/01.res.0000029232.42227.16","volume":"91","author":"KM Regula","year":"2002","unstructured":"Regula KM (2002) Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes. Circ Res 91:226\u2013231. doi: 10.1161\/01.res.0000029232.42227.16","journal-title":"Circ Res"},{"key":"1865_CR39","doi-asserted-by":"publisher","unstructured":"Ruiter G, Manders E, Happ\u00e9 CM, Schalij I, Groepenhoff H, Howard LS, Wilkins MR, Bogaard HJ, Westerhof N, van der Laarse WJ, de Man FS, Vonk-Noordegraaf A (2015) Intravenous iron therapy in patients with idiopathic pulmonary arterial hypertension and iron deficiency. Pulm Circ 5:466\u2013472. doi: 10.1086\/682217","DOI":"10.1086\/682217"},{"key":"1865_CR40","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.healun.2012.09.025","volume":"32","author":"G Ruiter","year":"2013","unstructured":"Ruiter G, Wong YY, de Man FS, Handoko LM, Jaspers RT, Postmus PE, Westerhof N, Niessen HWM, van der Laarse WJ, Vonk-Noordegraaf A (2013) Right ventricular oxygen supply parameters are decreased in human and experimental pulmonary hypertension. J Heart Lung Transplant 32:231\u2013240. doi: 10.1016\/j.healun.2012.09.025","journal-title":"J Heart Lung Transplant"},{"key":"1865_CR41","doi-asserted-by":"crossref","first-page":"15392","DOI":"10.1016\/S0021-9258(18)55409-0","volume":"265","author":"WL Rumsey","year":"1990","unstructured":"Rumsey WL, Schlosser C, Nuutinen EM, Robiolio M, Wilson DF (1990) Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat. J Biol Chem 265:15392\u201315402","journal-title":"J Biol Chem"},{"key":"1865_CR42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0008-6363(00)00076-6","volume":"47","author":"C Ruwhof","year":"2000","unstructured":"Ruwhof C, Van Der Laarse A (2000) Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc Res 47:23\u201337. doi: 10.1016\/S0008-6363(00)00076-6","journal-title":"Cardiovasc Res"},{"key":"1865_CR43","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1152\/ajpendo.00073.2004","volume":"287","author":"JM Sacheck","year":"2004","unstructured":"Sacheck JM, Ohtsuka A, McLary SC, Goldberg AL (2004) IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 287:591\u2013601. doi: 10.1152\/ajpendo.00073.2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1865_CR44","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/nature05602","volume":"446","author":"M Sano","year":"2007","unstructured":"Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I (2007) p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446:444\u2013448. doi: 10.1038\/nature05602","journal-title":"Nature"},{"key":"1865_CR45","doi-asserted-by":"crossref","unstructured":"Schenkman KA, Marble DR, Burns DH, Feigl EO (1997) Myoglobin oxygen dissociation by multiwavelength spectroscopy. J Appl Physiol 82:86\u201392","DOI":"10.1152\/jappl.1997.82.1.86"},{"key":"1865_CR46","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1152\/japplphysiol.00973.2013","volume":"117","author":"AE Schlater","year":"2014","unstructured":"Schlater AE, De Miranda MA, Frye MA, Trumble SJ, Kanatous SB (2014) Changing the paradigm for myoglobin: a novel link between lipids and myoglobin. J Appl Physiol 117:307\u2013315. doi: 10.1152\/japplphysiol.00973.2013","journal-title":"J Appl Physiol"},{"key":"1865_CR47","doi-asserted-by":"publisher","unstructured":"Serneri GG, Modesti PA, Boddi M, Cecioni I, Paniccia R, Coppo M, Galanti G, Simonetti I, Vanni S, Papa L, Bandinelli B, Migliorini A, Modesti A, Maccherini M, Sani G, Toscano M (1999) Cardiac growth factors in human hypertrophy. Relations with myocardial contractility and wall stress. Circ Res 85:57\u201367. doi: 10.1161\/01.RES.85.1.57","DOI":"10.1161\/01.RES.85.1.57"},{"key":"1865_CR48","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1161\/ATVBAHA.108.181636","volume":"30","author":"J Shoag","year":"2010","unstructured":"Shoag J, Arany Z (2010) Regulation of hypoxia-inducible genes by PGC-1 alpha. Arterioscler Thromb Vasc Biol 30:662\u2013666. doi: 10.1161\/ATVBAHA.108.181636","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1865_CR49","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1172\/JCI32824","volume":"118","author":"WS Simonides","year":"2008","unstructured":"Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA (2008) Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest 118:975\u2013983. doi: 10.1172\/JCI32824","journal-title":"J Clin Invest"},{"key":"1865_CR50","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.1016\/j.febslet.2008.09.047","volume":"582","author":"R Sriram","year":"2008","unstructured":"Sriram R, Kreutzer U, Shih L, Jue T (2008) Interaction of fatty acid with myoglobin. FEBS Lett 582:3643\u20133649. doi: 10.1016\/j.febslet.2008.09.047","journal-title":"FEBS Lett"},{"key":"1865_CR51","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s00109-013-1059-4","volume":"91","author":"G Sutendra","year":"2013","unstructured":"Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J, Michelakis ED (2013) A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension. J Mol Med 91:1315\u20131327. doi: 10.1007\/s00109-013-1059-4","journal-title":"J Mol Med"},{"key":"1865_CR52","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1161\/circulationaha.105.583666","volume":"113","author":"YD Tang","year":"2006","unstructured":"Tang YD, Katz SD (2006) Anemia in chronic heart failure: prevalence, etiology, clinical correlates, and treatment options. Circulation 113:2454\u20132461. doi: 10.1161\/circulationaha.105.583666","journal-title":"Circulation"},{"key":"1865_CR53","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00418-004-0641-9","volume":"121","author":"BJ Beek-Harmsen van","year":"2004","unstructured":"van Beek-Harmsen BJ, Bekedam MA, Feenstra HM, Visser FC, van der Laarse WJ (2004) Determination of myoglobin concentration and oxidative capacity in cryostat sections of human and rat skeletal muscle fibres and rat cardiomyocytes. Histochem Cell Biol 121:335\u2013342. doi: 10.1007\/s00418-004-0641-9","journal-title":"Histochem Cell Biol"},{"key":"1865_CR54","doi-asserted-by":"crossref","unstructured":"van Beek-Harmsen BJ, Feenstra HM, van der Laarse WJ (2011) Inadequate myocardial oxygen supply\/demand in experimental pulmonary hypertension. In: Sulica R, Prestion I (eds) Pulmonary hypertension\u2014from bench research to clinical challenges. InTechEurope, Rijecka, Croatia, pp. 151\u2013166","DOI":"10.5772\/27192"},{"key":"1865_CR55","doi-asserted-by":"publisher","unstructured":"van der Laarse WJ, des Tombe AL, van Beek-Harmsen BJ, Lee-de Groot MBE, Jaspers RT (2005) Krogh\u2019s diffusion coefficient for oxygen in isolated Xenopus skeletal muscle fibers and rat myocardial trabeculae at maximum rates of oxygen consumption. J Appl Physiol 99:2173\u20132180. doi: 10.1152\/japplphysiol.00470.2005","DOI":"10.1152\/japplphysiol.00470.2005"},{"key":"1865_CR56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF01739812","volume":"10","author":"WJ Laarse van der","year":"1989","unstructured":"van der Laarse WJ, Diegenbach PC, Elzinga G (1989) Maximum rate of oxygen consumption and quantitative histochemistry of succinate dehydrogenase in single muscle fibres of Xenopus laevis. J Muscle Res Cell Motil 10:221\u2013228","journal-title":"J Muscle Res Cell Motil"},{"key":"1865_CR57","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10974-013-9373-6","volume":"35","author":"VW Eif van","year":"2014","unstructured":"van Eif VW, Bogaards SJ, van der Laarse WJ (2014) Intrinsic cardiac adrenergic (ICA) cell density and MAO-A activity in failing rat hearts. J Muscle Res Cell Motil 35:47\u201353. doi: 10.1007\/s10974-013-9373-6","journal-title":"J Muscle Res Cell Motil"},{"key":"1865_CR58","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1161\/01.RES.0000133247.69803.c3","volume":"95","author":"V Weel van","year":"2004","unstructured":"van Weel V, Deckers MM, Grimbergen JM, van Leuven KJ, Lardenoye JH, Schlingemann RO, van Nieuw Amerongen GP, van Bockel JH, van Hinsbergh VW, Quax PH (2004) Vascular endothelial growth factor overexpression in ischemic skeletal muscle enhances myoglobin expression in vivo. Circ Res 95:58\u201366. doi: 10.1161\/01.RES.0000133247.69803.c3","journal-title":"Circ Res"},{"key":"1865_CR59","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00421-010-1545-0","volume":"110","author":"T Wessel van","year":"2010","unstructured":"van Wessel T, de Haan A, van der Laarse WJ, Jaspers RT (2010) The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism? Eur J Appl Physiol 110:665\u2013694. doi: 10.1007\/s00421-010-1545-0","journal-title":"Eur J Appl Physiol"},{"key":"1865_CR60","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jacc.2013.10.027","volume":"62","author":"A Vonk-Noordegraaf","year":"2013","unstructured":"Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM (2013) Right heart adaptation to pulmonary arterial hypertension. J Am Coll Cardiol 62:22\u201333. doi: 10.1016\/j.jacc.2013.10.027","journal-title":"J Am Coll Cardiol"},{"key":"1865_CR61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1152\/physiol.00043.2010","volume":"26","author":"KL Weeks","year":"2011","unstructured":"Weeks KL, McMullen JR (2011) The Athlete\u2019s heart vs. the failing heart: can signaling explain the two distinct outcomes? Physiology 26:97\u2013105. doi: 10.1152\/physiol.00043.2010","journal-title":"Physiology"},{"key":"1865_CR62","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/sj.emboj.7601952","volume":"27","author":"CC Witt","year":"2008","unstructured":"Witt CC, Witt SH, Lerche S, Labeit D, Back W, Labeit S (2008) Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. EMBO J 27:350\u2013360. doi: 10.1038\/sj.emboj.7601952","journal-title":"EMBO J"},{"key":"1865_CR63","doi-asserted-by":"crossref","first-page":"9038","DOI":"10.1016\/S0021-9258(19)40690-X","volume":"250","author":"BA Wittenberg","year":"1975","unstructured":"Wittenberg BA, Wittenberg JB, Caldwell PR (1975) Role of myoglobin in the oxygen supply to red skeletal muscle. J Biol Chem 250:9038\u20139043","journal-title":"J Biol Chem"},{"key":"1865_CR64","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1242\/jeb.00243","volume":"206","author":"JB Wittenberg","year":"2003","unstructured":"Wittenberg JB (2003) Myoglobin function reassessed. J Exp Biol 206:2011\u20132020. doi: 10.1242\/jeb.00243","journal-title":"J Exp Biol"},{"key":"1865_CR65","doi-asserted-by":"publisher","first-page":"H1190","DOI":"10.1152\/ajpheart.00773.2009","volume":"298","author":"YY Wong","year":"2010","unstructured":"Wong YY, Handoko ML, Mouchaers KT, de Man FS, Vonk-Noordegraaf A, van der Laarse WJ (2010) Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes. Am J Physiol Heart Circ Physiol 298:H1190\u2013H1197. doi: 10.1152\/ajpheart.00773.2009","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1865-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-016-1865-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1865-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T09:06:53Z","timestamp":1657184813000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-016-1865-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["1865"],"URL":"https:\/\/doi.org\/10.1007\/s00424-016-1865-y","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]}}}