{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:19:39Z","timestamp":1792667979327,"version":"4.5.0"},"reference-count":136,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s00424-016-1903-9","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T07:56:59Z","timestamp":1479369419000},"page":"3-14","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Tight junctions in skin inflammation"],"prefix":"10.1007","volume":"469","author":[{"given":"Katja","family":"B\u00e4sler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M.","family":"Brandner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"1903_CR1","doi-asserted-by":"crossref","first-page":"e0116751","DOI":"10.1371\/journal.pone.0116751","volume":"10","author":"MP Adams","year":"2015","unstructured":"Adams MP, Mallet DG, Pettet GJ (2015) Towards a quantitative theory of epidermal calcium profile formation in unwounded skin. PLoS One 10:e0116751","journal-title":"PLoS One"},{"key":"1903_CR2","doi-asserted-by":"crossref","first-page":"C2029","DOI":"10.1152\/ajpcell.2001.281.6.C2029","volume":"281","author":"M Ahdieh","year":"2001","unstructured":"Ahdieh M, Vandenbos T, Youakim A (2001) Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-\u03b3. Am J Physiol Cell Physiol 281:C2029\u2013C2038","journal-title":"Am J Physiol Cell Physiol"},{"key":"1903_CR3","doi-asserted-by":"crossref","unstructured":"Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S (2014) The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function. J Innate Immun 6(6):739\u2013753","DOI":"10.1159\/000362789"},{"key":"1903_CR4","first-page":"25","volume-title":"Textbook of dermatology & sexually transmitted diseases","author":"E Alessi","year":"2013","unstructured":"Alessi E, Caputo R (2013) Histology of the skin and skin appendages. In: Giannetti A (ed) Textbook of dermatology & sexually transmitted diseases. Picci Nuova Libraria S.P.A, Padova, pp 25\u201359"},{"key":"1903_CR5","first-page":"126","volume":"16","author":"JM Anderson","year":"2001","unstructured":"Anderson JM (2001) Molecular structure of tight junctions and their role in epithelial transport. News Physiol Sci 16:126\u2013130","journal-title":"News Physiol Sci"},{"key":"1903_CR6","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1016\/j.yexcr.2008.08.012","volume":"314","author":"S Aono","year":"2008","unstructured":"Aono S, Hirai Y (2008) Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. Exp Cell Res 314:3326\u20133339","journal-title":"Exp Cell Res"},{"key":"1903_CR7","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1111\/jdv.13806","volume":"30","author":"S Asad","year":"2016","unstructured":"Asad S, Winge MCG, Wahlgren CF, Bilcha KD, Nordenskj\u00f6ld M, Taylan F, Bradley M (2016) The tight junction gene Claudin-1 is associated with atopic dermatitis among Ethiopians. J Eur Acad Dermatol Venerol 30:1939\u20131941","journal-title":"J Eur Acad Dermatol Venerol"},{"key":"1903_CR8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2009.11.008","volume":"125","author":"KC Barnes","year":"2010","unstructured":"Barnes KC (2010) An update on the genetics of atopic dermatitis: scratching the surface in 2009. J Aller Clin Immunol 125:16\u201329.e11","journal-title":"J Aller Clin Immunol"},{"key":"1903_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.08.007","author":"K B\u00e4sler","year":"2016","unstructured":"B\u00e4sler K, Bergmann S, Heisig M, Naegel A, Zorn-Kruppa M, Brandner JM (2016) The role of tight junctions in skin barrier function and dermal absorption. J Control Release. doi: 10.1016\/j.jconrel.2016.08.007","journal-title":"J Control Release"},{"key":"1903_CR10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/jdv.12753","volume":"29","author":"DI Batista","year":"2015","unstructured":"Batista DI, Perez L, Orfali RL, Zaniboni MC, Samorano LP, Pereira NV, Sotto MN, Ishizaki AS, Oliveira LM, Sato MN, Aoki V (2015) Profile of skin barrier proteins (filaggrin, claudins 1 and 4) and Th1\/Th2\/Th17 cytokines in adults with atopic dermatitis. J Eur Acad Dermatol Venereol 29:1091\u20131095","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1903_CR11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/1523-1747.ep12398607","volume":"103","author":"U Behrends","year":"1994","unstructured":"Behrends U, Ei\u00dfner G, Bornkamm GW, Peter RU, Hintermeier-Knabe R, Holler E, Caughman SW, Degitz K (1994) Ionizing radiation induces human intercellular adhesion molecule-1 in vitro. J Invest Dermatol 103:726\u2013730","journal-title":"J Invest Dermatol"},{"key":"1903_CR12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/jid.2014.354","volume":"135","author":"AW Borkowski","year":"2015","unstructured":"Borkowski AW, Kuo IH, Bernard JJ, Yoshida T, Williams MR, Hung NJ, Yu BD, Beck LA, Gallo RL (2015) Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage. J Invest Dermatol 135:569\u2013578","journal-title":"J Invest Dermatol"},{"key":"1903_CR13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ejpb.2008.08.007","volume":"72","author":"JM Brandner","year":"2009","unstructured":"Brandner JM (2009) Tight junctions and tight junction proteins in mammalian epidermis. Eur J Pharm Biopharm 72:289\u2013294","journal-title":"Eur J Pharm Biopharm"},{"key":"1903_CR14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1078\/0171-9335-00244","volume":"81","author":"JM Brandner","year":"2002","unstructured":"Brandner JM, Kief S, Grund C, Rendl M, Houdek P, Kuhn C, Tschachler E, Franke WW, Moll I (2002) Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. Eur J Cell Biol 81:253\u2013263","journal-title":"Eur J Cell Biol"},{"key":"1903_CR15","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00441-014-2096-1","volume":"360","author":"JM Brandner","year":"2015","unstructured":"Brandner JM, Schulzke JD (2015) Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine. Cell Tissue Res 360:723\u2013748","journal-title":"Cell Tissue Res"},{"key":"1903_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/path.4810","author":"SJ Brown","year":"2016","unstructured":"Brown SJ (2016) Molecular mechanisms in atopic eczema: insight gained from genetic studies. J Pathol. doi: 10.1002\/path.4810","journal-title":"J Pathol"},{"key":"1903_CR17","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1128\/IAI.61.7.2755-2762.1993","volume":"61","author":"C Canil","year":"1993","unstructured":"Canil C, Rosenshine I, Ruschkowski S, Donnenberg MS, Kaper JB, Finlay BB (1993) Enteropathogenic Escherichia coli decreases the transepithelial electrical resistance of polarized epithelial monolayers. Infect Immun 61:2755\u20132762","journal-title":"Infect Immun"},{"key":"1903_CR18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/ni.2240","volume":"13","author":"G Chodaczek","year":"2012","unstructured":"Chodaczek G, Papanna V, Zal MA, Zal T (2012) Body-barrier surveillance by epidermal [gamma][delta] TCRs. Nat Immunol 13:272\u2013282","journal-title":"Nat Immunol"},{"key":"1903_CR19","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1038\/jid.2010.102","volume":"130","author":"A Clemmensen","year":"2010","unstructured":"Clemmensen A, Andersen KE, Clemmensen O, Tan Q, Petersen TK, Kruse TA, Thomassen M (2010) Genome-wide expression analysis of human in vivo irritated epidermis: differential profiles induced by sodium lauryl sulfate and nonanoic acid. J Invest Dermatol 130:2201\u20132210","journal-title":"J Invest Dermatol"},{"key":"1903_CR20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1440-1711.2001.01047.x","volume":"79","author":"GJ Clydesdale","year":"2001","unstructured":"Clydesdale GJ, Dandie GW, Muller HK (2001) Ultraviolet light induced injury: immunological and inflammatory effects. Immunol Cell Biol 79:547\u2013568","journal-title":"Immunol Cell Biol"},{"key":"1903_CR21","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/jid.2009.133","volume":"129","author":"MJ Cork","year":"2009","unstructured":"Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Guy RH, MacGowan AL, Tazi-Ahnini R, Ward SJ (2009) Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol 129:1892\u20131908","journal-title":"J Invest Dermatol"},{"key":"1903_CR22","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.3390\/ijms140612222","volume":"14","author":"J D\u2019Orazio","year":"2013","unstructured":"D\u2019Orazio J, Jarrett S, Amaro-Ortiz A, Scott T (2013) UV radiation and the skin. Int J Mol Sci 14:12222\u201312248","journal-title":"Int J Mol Sci"},{"key":"1903_CR23","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/jid.2014.83","volume":"134","author":"MO Danso","year":"2014","unstructured":"Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, El Ghalbzouri A, Bouwstra JA (2014) TNF-\u03b1 and Th2 cytokines induce atopic dermatitis\u2013like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents. J Invest Dermatol 134:1941\u20131950","journal-title":"J Invest Dermatol"},{"key":"1903_CR24","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2010.10.018","volume":"127","author":"A De Benedetto","year":"2011","unstructured":"De Benedetto A, Rafaels NM, McGirt LY, Ivanov AI, Georas SN, Cheadle C, Berger AE, Zhang K, Vidyasagar S, Yoshida T, Boguniewicz M, Hata T, Schneider LC, Hanifin JM, Gallo RL, Novak N, Weidinger S, Beaty TH, Leung DY, Barnes KC, Beck LA (2011) Tight junction defects in patients with atopic dermatitis. J Allergy Clin Immunol 127:773\u2013786 e771-777","journal-title":"J Allergy Clin Immunol"},{"key":"1903_CR25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jaci.2011.02.014","volume":"128","author":"A De Benedetto","year":"2011","unstructured":"De Benedetto A, Slifka MK, Rafaels NM, Kuo IH, Georas SN, Boguniewicz M, Hata T, Schneider LC, Hanifin JM, Gallo RL, Johnson DC, Barnes KC, Leung DY, Beck LA (2011) Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis. J Allergy Clin Immunol 128:242\u2013246.e5","journal-title":"J Allergy Clin Immunol"},{"key":"1903_CR26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/000155500750042943","volume":"80","author":"B Eberlein-Konig","year":"2000","unstructured":"Eberlein-Konig B, Schafer T, Huss-Marp J, Darsow U, Mohrenschlager M, Herbert O, Abeck D, Kramer U, Behrendt H, Ring J (2000) Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children. Acta Derm Venereol 80:188\u2013191","journal-title":"Acta Derm Venereol"},{"key":"1903_CR27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ddr.430130203","volume":"13","author":"PM Elias","year":"1988","unstructured":"Elias PM (1988) Structure and function of the stratum corneum permeability barrier. Drug Dev Res 13:97\u2013105","journal-title":"Drug Dev Res"},{"key":"1903_CR28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11882-009-0037-y","volume":"9","author":"PM Elias","year":"2009","unstructured":"Elias PM, Schmuth M (2009) Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Allergy Asthma Rep 9:265\u2013272","journal-title":"Curr Allergy Asthma Rep"},{"key":"1903_CR29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1242\/dmm.002634","volume":"3","author":"A Enikanolaiye","year":"2010","unstructured":"Enikanolaiye A, Lariviere N, Troy TC, Arabzadeh A, Atasoy E, Turksen K (2010) Involucrin-claudin-6 tail deletion mutant (CDelta206) transgenic mice: a model of delayed epidermal permeability barrier formation and repair. Dis Model Mech 3:167\u2013180","journal-title":"Dis Model Mech"},{"key":"1903_CR30","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/all.12184","volume":"68","author":"K Eyerich","year":"2013","unstructured":"Eyerich K, Novak N (2013) Immunology of atopic eczema: overcoming the Th1\/Th2 paradigm. Allergy 68:974\u2013982","journal-title":"Allergy"},{"key":"1903_CR31","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/humu.20333","volume":"27","author":"L Feldmeyer","year":"2006","unstructured":"Feldmeyer L, Huber M, Fellmann F, Beckmann JS, Frenk E, Hohl D (2006) Confirmation of the origin of NISCH syndrome. Hum Mutat 27:408\u2013410","journal-title":"Hum Mutat"},{"key":"1903_CR32","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0891-5849(98)00132-4","volume":"25","author":"J Fuchs","year":"1998","unstructured":"Fuchs J, Kern H (1998) Modulation of UV-light-induced skin inflammation by d-alpha-tocopherol and l-ascorbic acid: a clinical study using solar simulated radiation. Free Radic Biol Med 25:1006\u20131012","journal-title":"Free Radic Biol Med"},{"key":"1903_CR33","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200110122","volume":"156","author":"M Furuse","year":"2002","unstructured":"Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S (2002) Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 156:1099\u20131111","journal-title":"J Cell Biol"},{"key":"1903_CR34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ad.2011.12.008","volume":"104","author":"G Garnacho-Saucedo","year":"2013","unstructured":"Garnacho-Saucedo G, Salido-Vallejo R, Moreno-Gimenez JC (2013) Atopic dermatitis: update and proposed management algorithm. Actas Dermosifiliogr 104:4\u201316","journal-title":"Actas Dermosifiliogr"},{"key":"1903_CR35","first-page":"122","volume-title":"Textbook of dermatology & sexually transmitted diseases","author":"G Girolomoni","year":"2013","unstructured":"Girolomoni G, Pastore S, Cavani A (2013) Skin immune system. In: Giannetti A (ed) Textbook of dermatology & sexually transmitted diseases. Piccini Nuova Libraria S.P.A, Padova, pp 122\u2013136"},{"key":"1903_CR36","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1600-0765.2007.01019.x","volume":"43","author":"S Gr\u00f6ger","year":"2008","unstructured":"Gr\u00f6ger S, Michel J, Meyle J (2008) Establishment and characterization of immortalized human gingival keratinocyte cell lines. J Periodontal Res 43:604\u2013614","journal-title":"J Periodontal Res"},{"key":"1903_CR37","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1016\/j.ajpath.2015.06.021","volume":"185","author":"R Gruber","year":"2015","unstructured":"Gruber R, Bornchen C, Rose K, Daubmann A, Volksdorf T, Wladykowski E, Vidal YSS, Peters EM, Danso M, Bouwstra JA, Hennies HC, Moll I, Schmuth M, Brandner JM (2015) Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis. Am J Pathol 185:2777\u20132789","journal-title":"Am J Pathol"},{"key":"1903_CR38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/all.12051","volume":"68","author":"M Gschwandtner","year":"2013","unstructured":"Gschwandtner M, Mildner M, Mlitz V, Gruber F, Eckhart L, Werfel T, Gutzmer R, Elias PM, Tschachler E (2013) Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model. Allergy 68:37\u201347","journal-title":"Allergy"},{"key":"1903_CR39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1600-0625.2011.01412.x","volume":"21","author":"D Gutowska-Owsiak","year":"2012","unstructured":"Gutowska-Owsiak D, Schaupp AL, Salimi M, Selvakumar TA, McPherson T, Taylor S, Ogg GS (2012) IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion. Exp Dermatol 21:104\u2013110","journal-title":"Exp Dermatol"},{"key":"1903_CR40","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.bbamem.2008.10.028","volume":"1788","author":"JA Guttman","year":"2009","unstructured":"Guttman JA, Finlay BB (2009) Tight junctions as targets of infectious agents. BBA-Biomembranes 1788:832\u2013841","journal-title":"BBA-Biomembranes"},{"key":"1903_CR41","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1053\/j.gastro.2004.07.022","volume":"127","author":"S Hadj-Rabia","year":"2004","unstructured":"Hadj-Rabia S, Baala L, Vabres P, Hamel-Teillac D, Jacquemin E, Fabre M, Lyonnet S, De Prost Y, Munnich A, Hadchouel M, Smahi A (2004) Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. Gastroenterology 127:1386\u20131390","journal-title":"Gastroenterology"},{"key":"1903_CR42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/1523-1747.ep12292052","volume":"57","author":"K Hashimoto","year":"1971","unstructured":"Hashimoto K (1971) Intercellular spaces of the human epidermis as demonstrated with lanthanum. J Invest Dermatol 57:17\u201331","journal-title":"J Invest Dermatol"},{"key":"1903_CR43","doi-asserted-by":"crossref","unstructured":"Hattori F, Kiatsurayanon C, Okumura K, Ogawa H, Ikeda S, Okamoto K, and Niyonsaba F. The antimicrobial protein S100A7\/psoriasin enhances expression of keratinocyte differentiation markers and strengthens the skin tight junction barrier. Br J Dermatol 171:742\u2013753 2014.","DOI":"10.1111\/bjd.13125"},{"key":"1903_CR44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clim.2016.03.002","volume":"165","author":"CM Hedrich","year":"2016","unstructured":"Hedrich CM (2016) Shaping the spectrum\u2014from autoinflammation to autoimmunity. Clin Immunol 165:21\u201328","journal-title":"Clin Immunol"},{"key":"1903_CR45","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/vde.12229","volume":"26","author":"KK Ho","year":"2015","unstructured":"Ho KK, Campbell KL, Lavergne SN (2015) Contact dermatitis: a comparative and translational review of the literature. Vet Dermatol 26:314\u2013327 e366-317","journal-title":"Vet Dermatol"},{"key":"1903_CR46","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jaci.2007.10.025","volume":"120","author":"ST Holgate","year":"2007","unstructured":"Holgate ST (2007) Epithelium dysfunction in asthma. J Allergy Clin Immunol 120:1233\u20131244 quiz 1245-1236","journal-title":"J Allergy Clin Immunol"},{"key":"1903_CR47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jid.2015.11.007","volume":"136","author":"S H\u00f6nzke","year":"2016","unstructured":"H\u00f6nzke S, Wallmeyer L, Ostrowski A, Radbruch M, Mundhenk L, Schafer-Korting M, Hedtrich S (2016) Influence of Th2 cytokines on the cornified envelope, tight junction proteins, and ?-defensins in filaggrin-deficient skin equivalents. J Invest Dermatol 136:631\u2013639","journal-title":"J Invest Dermatol"},{"key":"1903_CR48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaci.2007.04.031","volume":"120","author":"MD Howell","year":"2007","unstructured":"Howell MD, Kim BE, Gao P, Grant AV, Boguniewicz M, DeBenedetto A, Schneider L, Beck LA, Barnes KC, Leung DYM (2007) Cytokine modulation of atopic dermatitis filaggrin skin expression. J Aller Clin Immunol 120:150\u2013155","journal-title":"J Aller Clin Immunol"},{"key":"1903_CR49","doi-asserted-by":"crossref","first-page":"e808","DOI":"10.1542\/peds.2008-2217","volume":"123","author":"JT Huang","year":"2009","unstructured":"Huang JT, Abrams M, Tlougan B, Rademaker A, Paller AS (2009) Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics 123:e808\u2013e814","journal-title":"Pediatrics"},{"key":"1903_CR50","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/1523-1747.ep12470233","volume":"96","author":"G Imokawa","year":"1991","unstructured":"Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A (1991) Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 96:523\u2013526","journal-title":"J Invest Dermatol"},{"key":"1903_CR51","doi-asserted-by":"crossref","first-page":"e31641","DOI":"10.1371\/journal.pone.0031641","volume":"7","author":"A Ishida-Yamamoto","year":"2012","unstructured":"Ishida-Yamamoto A, Kishibe M, Murakami M, Honma M, Takahashi H, Iizuka H (2012) Lamellar granule secretion starts before the establishment of tight junction barrier for paracellular tracers in mammalian epidermis. PLoS One 7:e31641","journal-title":"PLoS One"},{"key":"1903_CR52","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2133.2006.07319.x","volume":"155","author":"I Jakasa","year":"2006","unstructured":"Jakasa I, De Jongh CM, Verberk MM, Bos JD, Ke\u017ei\u0107 S (2006) Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. Brit J Dermatol 155:104\u2013109","journal-title":"Brit J Dermatol"},{"key":"1903_CR53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/sj.jid.5700582","volume":"127","author":"I Jakasa","year":"2007","unstructured":"Jakasa I, Verberk MM, Esposito M, Bos JD, Kezic S (2007) Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. J Invest Dermatol 127:129\u2013134","journal-title":"J Invest Dermatol"},{"key":"1903_CR54","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1194\/jlr.P030338","volume":"53","author":"M Janssens","year":"2012","unstructured":"Janssens M, van Smeden J, Gooris GS, Bras W, Portale G, Caspers PJ, Vreeken RJ, Hankemeier T, Kezic S, Wolterbeek R, Lavrijsen AP, Bouwstra JA (2012) Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res 53:2755\u20132766","journal-title":"J Lipid Res"},{"key":"1903_CR55","doi-asserted-by":"crossref","unstructured":"Jin S-P, Han SB, Kim YK, Park EE, Doh EJ, Kim KH, Lee DH, and Chung, JH (2016) Changes in tight junction protein expression in intrinsic aging and photoaging in human skin in vivo. J Dermatol Sci","DOI":"10.1016\/j.jdermsci.2016.07.002"},{"key":"1903_CR56","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1128\/IAI.00778-07","volume":"76","author":"KC Johnson-Henry","year":"2008","unstructured":"Johnson-Henry KC, Donato KA, Shen-Tu G, Gordanpour M, Sherman PM (2008) Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157:H7-induced changes in epithelial barrier function. Infect Immun 76:1340\u20131348","journal-title":"Infect Immun"},{"key":"1903_CR57","volume-title":"Dermatologie","author":"EG Jung","year":"2016","unstructured":"Jung EG, Augustin M, Bahmer FA, Bahmer JA, Bayerl C, Boonen HPJ, Coors E, Fischer M, Grimmel M, Hadshiew I, Hauswirth U, Hofmann H, Jung EG, Kimmig W, Knu\u00dfmann-Hartig E, K\u00f6berle M, Kohrmeyer K, Meissner M, Miller X, Moll I, Radtke M-A, Rauterberg A, Rose C, Schoch D, Schulze W, Siemann-Harms U, Stangl S, Tsianakas A, Varwig-Jan\u00dfen D, Voigtl\u00e4nder V, Wei\u00df J, We\u00dfbecher R, Witte J (2016) Dermatologie. Georg Thieme Verlag, Stuttgart"},{"key":"1903_CR58","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1398-9995.2010.02326.x","volume":"65","author":"JM Jungersted","year":"2010","unstructured":"Jungersted JM, Scheer H, Mempel M, Baurecht H, Cifuentes L, H\u00f8gh JK, Hellgren LI, Jemec GBE, Agner T, Weidinger S (2010) Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 65:911\u2013918","journal-title":"Allergy"},{"key":"1903_CR59","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","volume":"12","author":"DH Kaplan","year":"2012","unstructured":"Kaplan DH, Igy\u00e1rt\u00f3 BZ, Gaspari AA (2012) Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol 12:114\u2013124","journal-title":"Nat Rev Immunol"},{"key":"1903_CR60","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1271\/bbb.120874","volume":"77","author":"C Kawada","year":"2013","unstructured":"Kawada C, Hasegawa T, Watanabe M, Nomura Y (2013) Dietary glucosylceramide enhances tight junction function in skin epidermis via induction of claudin-1. Biosci Biotechnol Biochem 77:867\u2013869","journal-title":"Biosci Biotechnol Biochem"},{"key":"1903_CR61","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jaci.2012.01.068","volume":"129","author":"H Kawasaki","year":"2012","unstructured":"Kawasaki H, Nagao K, Kubo A, Hata T, Shimizu A, Mizuno H, Yamada T, Amagai M (2012) Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J Allergy Clin Immunol 129:1538\u20131546 e1536","journal-title":"J Allergy Clin Immunol"},{"key":"1903_CR62","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1038\/jid.2014.143","volume":"134","author":"C Kiatsurayanon","year":"2014","unstructured":"Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Hara M, Okumura K, Ikeda S, Ogawa H (2014) Host defense (antimicrobial) peptide, human beta-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes. J Invest Dermatol 134:2163\u20132173","journal-title":"J Invest Dermatol"},{"key":"1903_CR63","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/bjd.12724","volume":"170","author":"P Kirchmeier","year":"2014","unstructured":"Kirchmeier P, Sayar E, Hotz A, Hausser I, Islek A, Yilmaz A, Artan R, Fischer J (2014) Novel mutation in the CLDN1 gene in a Turkish family with neonatal ichthyosis sclerosing cholangitis (NISCH) syndrome. The British journal of dermatology 170:976\u2013978","journal-title":"The British journal of dermatology"},{"key":"1903_CR64","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1749-6632.2012.06554.x","volume":"1257","author":"N Kirschner","year":"2012","unstructured":"Kirschner N, Brandner JM (2012) Barriers and more: functions of tight junction proteins in the skin. Ann N Y Acad Sci 1257:158\u2013166","journal-title":"Ann N Y Acad Sci"},{"key":"1903_CR65","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ejcb.2010.07.010","volume":"89","author":"N Kirschner","year":"2010","unstructured":"Kirschner N, Houdek P, Fromm M, Moll I, Brandner JM (2010) Tight junctions form a barrier in human epidermis. Eur J Cell Biol 89:839\u2013842","journal-title":"Eur J Cell Biol"},{"key":"1903_CR66","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2353\/ajpath.2009.080973","volume":"175","author":"N Kirschner","year":"2009","unstructured":"Kirschner N, Poetzl C, von den Driesch P, Wladykowski E, Moll I, Behne MJ, Brandner JM (2009) Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines. Am J Pathol 175:1095\u20131106","journal-title":"Am J Pathol"},{"key":"1903_CR67","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/jid.2012.507","volume":"133","author":"N Kirschner","year":"2013","unstructured":"Kirschner N, Rosenthal R, Furuse M, Moll I, Fromm M, Brandner JM (2013) Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. J Invest Dermatol 133:1161\u20131169","journal-title":"J Invest Dermatol"},{"key":"1903_CR68","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2567.2005.02122.x","volume":"114","author":"G K\u00f6llisch","year":"2005","unstructured":"K\u00f6llisch G, Kalali BN, Voelcker V, Wallich R, Behrendt H, Ring J, Bauer S, Jakob T, Mempel M, Ollert M (2005) Various members of the toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology 114:531\u2013541","journal-title":"Immunology"},{"key":"1903_CR69","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1101\/gr.131029.111","volume":"22","author":"HH Kong","year":"2012","unstructured":"Kong HH, J O, Deming C, Conlan S, Gricem EA, Beatson MA, Nomicos E, Polley EC, Komarow HD, Program NCS, Murray PR, Turner ML, Segre JA (2012) Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res 22:850\u2013859","journal-title":"Genome Res"},{"key":"1903_CR70","unstructured":"Koppes SA, Engebretsen K, Clausen ML, Jakasa I, Knykin D, Brans R, Ton\u010dic RJ, Molin S, Puppels G, Riethm\u00fcller C, Berents T, Oivind Holm J, Suomela S, Hummler E, Brandner J, Angelova-Fischer I, Agner T, Thierse H-J, John SM, Kezic S, Martin SF, and Thyssen JP. Biomarkers for allergic contact dermatitis and methods to determine them submitted"},{"key":"1903_CR71","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1172\/JCI57416","volume":"122","author":"A Kubo","year":"2012","unstructured":"Kubo A, Nagao K, Amagai M (2012) Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J Clin Invest 122:440\u2013447","journal-title":"J Clin Invest"},{"key":"1903_CR72","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1084\/jem.20091527","volume":"206","author":"A Kubo","year":"2009","unstructured":"Kubo A, Nagao K, Yokouchi M, Sasaki H, Amagai M (2009) External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers. J Exp Med 206:2937\u20132946","journal-title":"J Exp Med"},{"key":"1903_CR73","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbrc.2014.10.148","volume":"455","author":"T Kubo","year":"2014","unstructured":"Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S (2014) Tight junction protein claudin-4 is modulated via DeltaNp63 in human keratinocytes. Biochem Biophys Res Commun 455:205\u2013211","journal-title":"Biochem Biophys Res Commun"},{"key":"1903_CR74","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/jid.2012.437","volume":"133","author":"IH Kuo","year":"2013","unstructured":"Kuo IH, Carpenter-Mendini A, Yoshida T, McGirt LY, Ivanov AI, Barnes KC, Gallo RL, Borkowski AW, Yamasaki K, Leung DY, Georas SN, De Benedetto A, Beck LA (2013) Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair. J Invest Dermatol 133:988\u2013998","journal-title":"J Invest Dermatol"},{"key":"1903_CR75","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaci.2012.12.1563","volume":"131","author":"IH Kuo","year":"2013","unstructured":"Kuo IH, Yoshida T, De Benedetto A, Beck LA (2013) The cutaneous innate immune response in patients with atopic dermatitis. J Aller Clin Immunol 131:266\u2013278","journal-title":"J Aller Clin Immunol"},{"key":"1903_CR76","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1078\/0171-9335-00330","volume":"82","author":"L Langbein","year":"2003","unstructured":"Langbein L, Pape U-F, Grund C, Kuhn C, Praetzel S, Moll I, Moll R, Franke WW (2003) Tight junction-related strucutres in the absence of a lumen: occludin claudins and tight junction plaque proteins in densely packed cell formations of stratified epithalia and squamous cell carcinomas. Eur J Cell Biol 82:385\u2013400","journal-title":"Eur J Cell Biol"},{"key":"1903_CR77","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1365-2133.2006.07191.x","volume":"154","author":"CH Lee","year":"2006","unstructured":"Lee CH, Chuang HY, Shih CC, Jong SB, Chang CH, Yu HS (2006) Transepidermal water loss, serum IgE and \u03b2-endorphin as important and independent biological markers for development of itch intensity in atopic dermatitis. Brit J Dermatol 154:1100\u20131107","journal-title":"Brit J Dermatol"},{"key":"1903_CR78","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1172\/JCI21060","volume":"113","author":"DYM Leung","year":"2004","unstructured":"Leung DYM, Boguniewicz M, Howell MD, Nomura I, Hamid QA (2004) New insights into atopic dermatitis. J Clin Invest 113:651\u2013657","journal-title":"J Clin Invest"},{"key":"1903_CR79","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1600-0625.2012.01471.x","volume":"21","author":"SF Martin","year":"2012","unstructured":"Martin SF (2012) Contact dermatitis: from pathomechanisms to immunotoxicology. Exp Dermatol 21:382\u2013389","journal-title":"Exp Dermatol"},{"key":"1903_CR80","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/cod.12311","volume":"72","author":"SF Martin","year":"2015","unstructured":"Martin SF (2015) New concepts in cutaneous allergy. Contact Dermatitis 72:2\u201310","journal-title":"Contact Dermatitis"},{"key":"1903_CR81","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1128\/JVI.02617-08","volume":"83","author":"GR Medigeshi","year":"2009","unstructured":"Medigeshi GR, Hirsch AJ, Brien JD, Uhrlaub JL, Mason PW, Wiley C, Nikolich-Zugich J, Nelson JA (2009) West Nile virus capsid degradation of claudin proteins disrupts epithelial barrier function. J Virol 83:6125\u20136134","journal-title":"J Virol"},{"key":"1903_CR82","doi-asserted-by":"crossref","unstructured":"Midorikawa K, Ouhara K, Komatsuzawa H, Kawai T, Yamada S, Fujiwara T, Yamazaki K, Sayama K, Taubman MA, Kurihara H, Hashimoto K, Sugai M (2003) Staphylococcus aureus Susceptibility to innate antimicrobial peptides, \u03b2-defensins and CAP18. Expressed by Human Keratinocytes Infect Immun 71:3730\u20133739","DOI":"10.1128\/IAI.71.7.3730-3739.2003"},{"key":"1903_CR83","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nri3010","volume":"11","author":"LS Miller","year":"2011","unstructured":"Miller LS, Cho JS (2011) Immunity against Staphylococcus aureus cutaneous infections. Nat Rev Immunol 11:505\u2013518","journal-title":"Nat Rev Immunol"},{"key":"1903_CR84","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2133.2012.10863.x","volume":"166","author":"KJ Mills","year":"2012","unstructured":"Mills KJ, P H, Henry J, Tamura M, JP T, J X (2012) Dandruff\/seborrhoeic dermatitis is characterized by an inflammatory genomic signature and possible immune dysfunction: transcriptional analysis of the condition and treatment effects of zinc pyrithione. Brit J Dermatol 166:33\u201340","journal-title":"Brit J Dermatol"},{"key":"1903_CR85","doi-asserted-by":"crossref","DOI":"10.1055\/b-003-129293","volume-title":"Dermatologie","author":"I Moll","year":"2016","unstructured":"Moll I (2016) Dermatologie. Thieme, Stuttgart"},{"key":"1903_CR86","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1046\/j.1523-1747.1998.00209.x","volume":"110","author":"K Morita","year":"1998","unstructured":"Morita K, Itoh M, Saitou M, Ando-Akatsuka Y, Furuse M, Yoneda K, Imamura S, Fujimoto K, Tsukita S (1998) Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin. J Invest Dermatol 110:862\u2013866","journal-title":"J Invest Dermatol"},{"key":"1903_CR87","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1124\/jpet.115.225391","volume":"354","author":"M Nakajima","year":"2015","unstructured":"Nakajima M, Nagase S, Iida M, Takeda S, Yamashita M, Watari A, Shirasago Y, Fukasawa M, Takeda H, Sawasaki T, Yagi K, Kondoh M (2015) Claudin-1 binder enhances epidermal permeability in a human keratinocyte model. J Pharmacol Exp Ther 354:440\u2013447","journal-title":"J Pharmacol Exp Ther"},{"key":"1903_CR88","doi-asserted-by":"crossref","unstructured":"Niehues H, Schalkwijk J, van Vlijmen-Willems IM, Rodijk-Olthuis D, van Rossum MM, Wladykowski E, Brandner JM, van den Bogaard EH, and Zeeuwen PL (2016) Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function. J Allergy Clin Immunol","DOI":"10.1016\/j.jaci.2016.09.016"},{"key":"1903_CR89","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0625.2010.01206.x","volume":"20","author":"CA O\u2019Neill","year":"2011","unstructured":"O\u2019Neill CA, Garrod D (2011) Tight junction proteins and the epidermis. Exp Dermatol 20:88\u201391","journal-title":"Exp Dermatol"},{"key":"1903_CR90","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/sj.jid.5701070","volume":"128","author":"U Ohnemus","year":"2008","unstructured":"Ohnemus U, Kohrmeyer K, Houdek P, Rohde H, Wladykowski E, Vidal S, Horstkotte MA, Aepfelbacher M, Kirschner N, Behne MJ, Moll I, Brandner JM (2008) Regulation of epidermal tight-junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains. J Invest Dermatol 128:906\u2013916","journal-title":"J Invest Dermatol"},{"key":"1903_CR91","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/vde.12188","volume":"26","author":"T Olivry","year":"2015","unstructured":"Olivry T, Dunston SM (2015) Expression patterns of superficial epidermal adhesion molecules in an experimental dog model of acute atopic dermatitis skin lesions. Vet Dermatol 26:53\u201356 e-17-58","journal-title":"Vet Dermatol"},{"key":"1903_CR92","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","volume":"38","author":"CN Palmer","year":"2006","unstructured":"Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O\u2019Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, DiGiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El Houate B, McElreavey K, Halkjaer LB, Bisgaard H, Mukhopadhyay S, McLean WH (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 38:441\u2013446","journal-title":"Nat Genet"},{"key":"1903_CR93","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2133.2006.07642.x","volume":"156","author":"S Peltonen","year":"2007","unstructured":"Peltonen S, Riehokainen J, Pummi K, Peltonen J (2007) Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis. The British journal of dermatology 156:466\u2013472","journal-title":"The British journal of dermatology"},{"key":"1903_CR94","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/nmo.12315","volume":"26","author":"T Piche","year":"2014","unstructured":"Piche T (2014) Tight junctions and IBS\u2014the link between epithelial permeability, low-grade inflammation, and symptom generation? Neurogastroenterol Motil 26:296\u2013302","journal-title":"Neurogastroenterol Motil"},{"key":"1903_CR95","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","volume":"17","author":"E Proksch","year":"2008","unstructured":"Proksch E, Brandner JM, Jensen JM (2008) The skin: an indispensable barrier. Exp Dermatol 17:1063\u20131072","journal-title":"Exp Dermatol"},{"key":"1903_CR96","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jdermsci.2006.06.003","volume":"43","author":"E Proksch","year":"2006","unstructured":"Proksch E, Folster-Holst R, Jensen JM (2006) Skin barrier function, epidermal proliferation and differentiation in eczema. J Dermatol Sci 43:159\u2013169","journal-title":"J Dermatol Sci"},{"key":"1903_CR97","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1046\/j.0022-202x.2001.01493.x","volume":"117","author":"K Pummi","year":"2001","unstructured":"Pummi K, Malminen M, Aho H, Karvonen S-L, Peltonen J, Peltonen S (2001) Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes. J Invest Dermatol 117:1050\u20131058","journal-title":"J Invest Dermatol"},{"key":"1903_CR98","doi-asserted-by":"crossref","first-page":"e55116","DOI":"10.1371\/journal.pone.0055116","volume":"8","author":"S Rachow","year":"2013","unstructured":"Rachow S, Zorn-Kruppa M, Ohnemus U, Kirschner N, Vidal-y-Sy S, von den Driesch P, Bornchen C, Eberle J, Mildner M, Vettorazzi E, Rosenthal R, Moll I, Brandner JM (2013) Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: implications for tumorigenesis. PLoS One 8:e55116","journal-title":"PLoS One"},{"key":"1903_CR99","volume-title":"Dermatologie : Lehrbuch und Atlas (Dermatology, textbook and atlas)","author":"G Rassner","year":"2009","unstructured":"Rassner G (2009) Dermatologie : Lehrbuch und Atlas (Dermatology, textbook and atlas). M\u00fcnchen, Elsevier, Urban & Fischer"},{"key":"1903_CR100","doi-asserted-by":"crossref","unstructured":"R\u00f6hl M, Tjernlund A, Mehta SD, Pettersson P, Bailey RC, and Broliden K (2015) Comparable mRNA expression of inflammatory markers but lower claudin-1 mRNA levels in foreskin tissue of HSV-2 seropositive versus seronegative asymptomatic Kenyan young men. BMJ Open 5","DOI":"10.1136\/bmjopen-2014-006627"},{"key":"1903_CR101","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/bjd.12126","volume":"168","author":"K Ross-Hansen","year":"2013","unstructured":"Ross-Hansen K, Linneberg A, Johansen JD, Hersoug LG, Brasch-Andersen C, Menne T, Thyssen JP (2013) The role of glutathione S-transferase and claudin-1 gene polymorphisms in contact sensitization: a cross-sectional study. The British journal of dermatology 168:762\u2013770","journal-title":"The British journal of dermatology"},{"key":"1903_CR102","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.ph.06.030144.001211","volume":"6","author":"PF Rothman","year":"1944","unstructured":"Rothman PF (1944) The physiology of the skin. Ann Rev Physiol 6:195\u2013224","journal-title":"Ann Rev Physiol"},{"key":"1903_CR103","doi-asserted-by":"crossref","unstructured":"Rustemeyer T, van Hoogstraten IM, von Blomberg BME, Gibbs S, and Scheper RJ (2011) Mechanisms of irritant and allergic contact dermatitis. In: Contact dermatitis. Springer p. 43\u201390","DOI":"10.1007\/978-3-642-03827-3_3"},{"key":"1903_CR104","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1067\/mjd.2003.105","volume":"48","author":"P-G Sator","year":"2003","unstructured":"Sator P-G, Schmidt JB, H\u00f6nigsmann H (2003) Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. J Am Acad Dermatol 48:352\u2013358","journal-title":"J Am Acad Dermatol"},{"key":"1903_CR105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2340\/00015555-1382","volume":"93","author":"JR Schwartz","year":"2013","unstructured":"Schwartz JR, Messenger AG, Tosti A, Todd G, Hordinsky M, Hay RJ, Wang X, Zachariae C, Kerr KM, Henry JP, Rust RC, Robinson MK (2013) A comprehensive pathophysiology of dandruff and seborrheic dermatitis – towards a more precise definition of scalp health. Acta Derm Venereol 93:131\u2013137","journal-title":"Acta Derm Venereol"},{"key":"1903_CR106","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/BF02505232","volume":"288","author":"T Seguchi","year":"1996","unstructured":"Seguchi T, Chang-Yi C, Kusuda S, Takahashi M, Aisu K, Tezuka T (1996) Decreased expression of filaggrin in atopic skin. Arch Dermatol Res 288:442\u2013446","journal-title":"Arch Dermatol Res"},{"key":"1903_CR107","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/MOP.0000000000000120","volume":"26","author":"M Shaker","year":"2014","unstructured":"Shaker M (2014) New insights into the allergic march. Curr Opin Pediatr 26:516\u2013520","journal-title":"Curr Opin Pediatr"},{"key":"1903_CR108","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1128\/AAC.48.12.4673-4679.2004","volume":"48","author":"M Sieprawska-Lupa","year":"2004","unstructured":"Sieprawska-Lupa M, Mydel P, Krawczyk K, W\u00f3jcik K, Puklo M, Lupa B, Suder P, Silberring J, Reed M, Pohl J, Shafer W, McAleese F, Foster T, Travis J, Potempa J (2004) Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Ch 48:4673\u20134679","journal-title":"Antimicrob Agents Ch"},{"key":"1903_CR109","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2012.05.052","volume":"130","author":"MB Soyka","year":"2012","unstructured":"Soyka MB, Wawrzyniak P, Eiwegger T, Holzmann D, Treis A, Wanke K, Kast JI, Akdis CA (2012) Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-\u03b3 and IL-4. J Aller Clin Immunol 130:1087\u20131096.e1010","journal-title":"J Aller Clin Immunol"},{"key":"1903_CR110","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jaci.2015.03.003","volume":"135","author":"M Suarez-Farinas","year":"2015","unstructured":"Suarez-Farinas M, Ungar B, Correa da Rosa J, Ewald DA, Rozenblit M, Gonzalez J, H X, Zheng X, Peng X, Estrada YD, Dillon SR, Krueger JG, Guttman-Yassky E (2015) RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications. J Allergy Clin Immunol 135:1218\u20131227","journal-title":"J Allergy Clin Immunol"},{"key":"1903_CR111","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jdermsci.2013.01.002","volume":"70","author":"T Sugawara","year":"2013","unstructured":"Sugawara T, Iwamoto N, Akashi M, Kojima T, Hisatsune J, Sugai M, Furuse M (2013) Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice. J Dermatol Sci 70:12\u201318","journal-title":"J Dermatol Sci"},{"key":"1903_CR112","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1128\/AEM.00982-13","volume":"79","author":"R Sultana","year":"2013","unstructured":"Sultana R, McBain AJ, O\u2019Neill CA (2013) Strain-dependent augmentation of tight-junction barrier function in human primary epidermal keratinocytes by Lactobacillus and Bifidobacterium lysates. Appl Environ Microb 79:4887\u20134894","journal-title":"Appl Environ Microb"},{"key":"1903_CR113","doi-asserted-by":"crossref","first-page":"20069","DOI":"10.1038\/srep20069","volume":"7","author":"T Sumitomo","year":"2016","unstructured":"Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S (2016) Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions. Scientific Reports 7:20069","journal-title":"Scientific Reports"},{"key":"1903_CR114","doi-asserted-by":"crossref","first-page":"E4061","DOI":"10.1073\/pnas.1525474113","volume":"113","author":"R Tokumasu","year":"2016","unstructured":"Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I, Tsukita S (2016) Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A 113:E4061\u2013E4068","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1903_CR115","doi-asserted-by":"crossref","first-page":"e7814","DOI":"10.1371\/journal.pone.0007814","volume":"4","author":"TC Troy","year":"2009","unstructured":"Troy TC, Arabzadeh A, Lariviere NM, Enikanolaiye A, Turksen K (2009) Dermatitis and aging-related barrier dysfunction in transgenic mice overexpressing an epidermal-targeted claudin 6 tail deletion mutant. PLoS One 4:e7814","journal-title":"PLoS One"},{"key":"1903_CR116","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.emboj.7600605","volume":"24","author":"JA Tunggal","year":"2005","unstructured":"Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M, Kemler R, Krieg T, Niessen CM (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24:1146\u20131156","journal-title":"EMBO J"},{"key":"1903_CR117","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/dev.129.7.1775","volume":"129","author":"K Turksen","year":"2002","unstructured":"Turksen K, Troy TC (2002) Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development 129:1775\u20131784","journal-title":"Development"},{"key":"1903_CR118","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3945\/jn.110.135657","volume":"141","author":"D Ulluwishewa","year":"2011","unstructured":"Ulluwishewa D, Anderson RC, McNabb WC, Moughan PJ, Wells JM, Roy NC (2011) Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr 141:769\u2013776","journal-title":"J Nutr"},{"key":"1903_CR119","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/exd.12293","volume":"23","author":"J Smeden van","year":"2014","unstructured":"van Smeden J, Janssens M, Kaye ECJ, Caspers PJ, Lavrijsen AP, Vreeken RJ, Bouwstra JA (2014) The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients. Exp Dermatol 23:45\u201352","journal-title":"Exp Dermatol"},{"key":"1903_CR120","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/path.2200","volume":"212","author":"RE Watson","year":"2007","unstructured":"Watson RE, Poddar R, Walker JM, McGuill I, Hoare LM, Griffiths CE, O\u2019Neill CA (2007) Altered claudin expression is a feature of chronic plaque psoriasis. J Pathol 212:450\u2013458","journal-title":"J Pathol"},{"key":"1903_CR121","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jaci.2016.06.010","volume":"138","author":"T Werfel","year":"2016","unstructured":"Werfel T, Allam J-P, Biedermann T, Eyerich K, Gilles S, Guttman-Yassky E, Hoetzenecker W, Knol E, Simon H-U, Wollenberg A, Bieber T, Lauener R, Schmid-Grendelmeier P, Traidl-Hoffmann C, Akdis CA (2016) Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J Aller Clin Immunol 138:336\u2013349","journal-title":"J Aller Clin Immunol"},{"key":"1903_CR122","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/j.1365-2133.2011.10475.x","volume":"165","author":"MCG Winge","year":"2011","unstructured":"Winge MCG, Bilcha KD, Lied\u00e9n A, Shibeshi D, Sandilands A, Wahlgren CF, McLean WHI, Nordenskj\u00f6ld M, Bradley M (2011) Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis. Brit J Dermatol 165:1074\u20131080","journal-title":"Brit J Dermatol"},{"key":"1903_CR123","volume-title":"Fitzpatrick\u2019s color atlas & synopsis of clinical dermatology","author":"K Wolff","year":"2005","unstructured":"Wolff K, Johnson RA, Suurmond D (2005) Fitzpatrick\u2019s color atlas & synopsis of clinical dermatology. McGraw-Hill, New York City"},{"key":"1903_CR124","doi-asserted-by":"crossref","unstructured":"Woo YR, Lim JH, Cho DH, and Park HJ (2016) Rosacea: molecular mechanisms and management of a chronic cutaneous inflammatory condition. Int J Mol Sci 17","DOI":"10.3390\/ijms17091562"},{"key":"1903_CR125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00403-007-0817-y","volume":"300","author":"T Yamamoto","year":"2008","unstructured":"Yamamoto T, Kurasawa M, Hattori T, Maeda T, Nakano H, Sasaki H (2008) Relationship between expression of tight junction-related molecules and perturbed epidermal barrier function in UVB-irradiated hairless mice. Arch Dermatol Res 300:61\u201368","journal-title":"Arch Dermatol Res"},{"key":"1903_CR126","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jdermsci.2014.11.007","volume":"77","author":"M Yokouchi","year":"2015","unstructured":"Yokouchi M, Kubo A, Kawasaki H, Yoshida K, Ishii K, Furuse M, Amagai M (2015) Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum. J Dermatol Sci 77:28\u201336","journal-title":"J Dermatol Sci"},{"key":"1903_CR127","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jaci.2014.08.001","volume":"134","author":"K Yoshida","year":"2014","unstructured":"Yoshida K, Kubo A, Fujita H, Yokouchi M, Ishii K, Kawasaki H, Nomura T, Shimizu H, Kouyama K, Ebihara T, Nagao K, Amagai M (2014) Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis. J Allergy Clin Immunol 134:856\u2013864","journal-title":"J Allergy Clin Immunol"},{"key":"1903_CR128","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jdermsci.2013.04.021","volume":"71","author":"K Yoshida","year":"2013","unstructured":"Yoshida K, Yokouchi M, Nagao K, Ishii K, Amagai M, Kubo A (2013) Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis. J Dermatol Sci 71:89\u201399","journal-title":"J Dermatol Sci"},{"key":"1903_CR129","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jaci.2014.10.040","volume":"135","author":"HS Yu","year":"2015","unstructured":"Yu HS, Kang MJ, Kwon JW, Lee SY, Lee E, Yang SI, Jung YH, Hong K, Kim YJ, Lee SH, Kim HJ, Kim HY, Seo JH, Kim BJ, Kim HB, Hong SJ (2015) Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE. J Allergy Clin Immunol 135:827\u2013830 e825","journal-title":"J Allergy Clin Immunol"},{"key":"1903_CR130","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/jid.2010.385","volume":"131","author":"T Yuki","year":"2011","unstructured":"Yuki T, Hachiya A, Kusaka A, Sriwiriyanont P, Visscher MO, Morita K, Muto M, Miyachi Y, Sugiyama Y, Inoue S (2011) Characterization of tight junctions and their disruption by UVB in human epidermis and cultured keratinocytes. J Invest Dermatol 131:744\u2013752","journal-title":"J Invest Dermatol"},{"key":"1903_CR131","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-0625.2006.00539.x","volume":"16","author":"T Yuki","year":"2007","unstructured":"Yuki T, Haratake A, Koishikawa H, Morita K, Miyachi Y, Inoue S (2007) Tight junction proteins in keratinocytes: localization and contribution to barrier function. Exp Dermatol 16:324\u2013330","journal-title":"Exp Dermatol"},{"key":"1903_CR132","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jdermsci.2012.11.595","volume":"69","author":"T Yuki","year":"2013","unstructured":"Yuki T, Komiya A, Kusaka A, Kuze T, Sugiyama Y, Inoue S (2013) Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing. J Dermatol Sci 69:148\u2013158","journal-title":"J Dermatol Sci"},{"key":"1903_CR133","doi-asserted-by":"crossref","first-page":"e0161759","DOI":"10.1371\/journal.pone.0161759","volume":"11","author":"T Yuki","year":"2016","unstructured":"Yuki T, Tobiishi M, Kusaka-Kikushima A, Ota Y, Tokura Y (2016) Impaired tight junctions in atopic dermatitis skin and in a skin-equivalent model treated with interleukin-17. PLoS One 11:e0161759","journal-title":"PLoS One"},{"key":"1903_CR134","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.4049\/jimmunol.1100058","volume":"187","author":"T Yuki","year":"2011","unstructured":"Yuki T, Yoshida H, Akazawa Y, Komiya A, Sugiyama Y, Inoue S (2011) Activation of TLR2 enhances tight junction barrier in epidermal keratinocytes. J Immunol 187:3230\u20133237","journal-title":"J Immunol"},{"key":"1903_CR135","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/sj.jid.5700882","volume":"127","author":"SC Zimmerli","year":"2007","unstructured":"Zimmerli SC, Hauser C (2007) Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1. J Invest Dermatol 127:2381\u20132390","journal-title":"J Invest Dermatol"},{"key":"1903_CR136","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-0625.2007.00624.x","volume":"17","author":"SC Zimmerli","year":"2008","unstructured":"Zimmerli SC, Kerl K, Hadj-Rabia S, Hohl D, Hauser C (2008) Human epidermal Langerhans cells express the tight junction protein claudin-1 and are present in human genetic claudin-1 deficiency (NISCH syndrome). Exp Dermatol 17:20\u201323","journal-title":"Exp Dermatol"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1903-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-016-1903-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-016-1903-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T17:13:42Z","timestamp":1718903622000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-016-1903-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":136,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["1903"],"URL":"https:\/\/doi.org\/10.1007\/s00424-016-1903-9","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]}}}