{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:01:35Z","timestamp":1773043295041,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Enterprise Ireland (IE)","award":["ARE20080001"],"award-info":[{"award-number":["ARE20080001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s00424-017-2028-5","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T05:37:07Z","timestamp":1500615427000},"page":"1443-1455","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal"],"prefix":"10.1007","volume":"469","author":[{"given":"Stephen","family":"Fedigan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eamonn","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roddy J.","family":"Large","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Hollywood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith D.","family":"Thornbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel G.","family":"McHale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard P.","family":"Sergeant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"issue":"42","key":"2028_CR1","doi-asserted-by":"crossref","first-page":"28571","DOI":"10.1074\/jbc.M109.010074","volume":"284","author":"J Alma\u00e7a","year":"2009","unstructured":"Alma\u00e7a J, Tian Y, Aldehni F, Ousingsawat J, Kongsuphol P, Rock JR, Harfe BD, Schreiber R, Kunzelmann K (2009 Oct 16) TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem 284(42):28571\u201328578","journal-title":"J Biol Chem"},{"issue":"16","key":"2028_CR2","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1111\/bph.13201","volume":"172","author":"DM Boedtkjer","year":"2015","unstructured":"Boedtkjer DM, Kim S, Jensen AB, Matchkov VM, Andersson KE (2015 Aug) New selective inhibitors of calcium-activated chloride channels\u2014T16A(inh)-A01, CaCC(inh)-A01 and MONNA\u2014what do they inhibit? Br J Pharmacol 172(16):4158\u20134172","journal-title":"Br J Pharmacol"},{"issue":"4","key":"2028_CR3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4161\/chan.28065","volume":"8","author":"E Bradley","year":"2014","unstructured":"Bradley E, Fedigan S, Webb T, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP (2014) Pharmacological characterization of TMEM16A currents. Channels (Austin) 8(4):308\u2013320","journal-title":"Channels (Austin)"},{"issue":"8","key":"2028_CR4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/CIRCRESAHA.112.277145","volume":"111","author":"S Bulley","year":"2012","unstructured":"Bulley S, Neeb ZP, Burris SK, Bannister JP, Thomas-Gatewood CM, Jangsangthong W, Jaggar JH (2012 Sep 28) TMEM16A\/ANO1 channels contribute to the myogenic response in cerebral arteries. Circ Res 111(8):1027\u20131036","journal-title":"Circ Res"},{"issue":"5901","key":"2028_CR5","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1126\/science.1163518","volume":"322","author":"A Caputo","year":"2008","unstructured":"Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ (2008) TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 322(5901):590\u2013594. doi:\n10.1126\/science.1163518","journal-title":"Science"},{"issue":"Pt 1","key":"2028_CR6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1469-7793.1997.121bc.x","volume":"505","author":"KD Cotton","year":"1997","unstructured":"Cotton KD, Hollywood MA, McHale NG, Thornbury KD (1997) Ca2+ current and Ca(2+)-activated chloride current in isolated smooth muscle cells of the sheep urethra. J Physiol 505(Pt 1):121\u2013131","journal-title":"J Physiol"},{"issue":"8","key":"2028_CR7","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/sj.bjp.0705571","volume":"140","author":"SF Cruickshank","year":"2003","unstructured":"Cruickshank SF, Baxter LM, Drummond RM (2003 Dec) The Cl(-) channel blocker niflumic acid releases Ca(2+) from an intracellular store in rat pulmonary artery smooth muscle cells. Br J Pharmacol 140(8):1442\u20131450","journal-title":"Br J Pharmacol"},{"issue":"3","key":"2028_CR8","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1476-5381.2012.02199.x","volume":"168","author":"AJ Davis","year":"2013","unstructured":"Davis AJ, Shi J, Pritchard HA, Chadha PS, Leblanc N, Vasilikostas G, Yao Z, Verkman AS, Albert AP, Greenwood IA (2013) Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh)-A01. Br J Pharmacol 168(3):773\u2013784","journal-title":"Br J Pharmacol"},{"issue":"Suppl 1","key":"2028_CR9","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1002\/nau.20888","volume":"29","author":"JO Delancey","year":"2010","unstructured":"Delancey JO (2010) Why do women have stress urinary incontinence? Neurourol Urodyn 29(Suppl 1):S13\u2013S17","journal-title":"Neurourol Urodyn"},{"issue":"1","key":"2028_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.111.095554","volume":"86","author":"RE Dixon","year":"2012","unstructured":"Dixon RE, Hennig GW, Baker SA, Britton FC, Harfe BD, Rock JR, Sanders KM, Ward SM (2012) Electrical slow waves in the mouse oviduct are dependent upon a calcium activated chloride conductance encoded by Tmem16a. Biol Reprod 86(1):1\u20137","journal-title":"Biol Reprod"},{"issue":"15","key":"2028_CR11","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1113\/JP270883","volume":"593","author":"BT Drumm","year":"2015","unstructured":"Drumm BT, Large RJ, Hollywood MA, Thornbury KD, Baker SA, Harvey BJ, McHale NG, Sergeant GP (2015) The role of Ca(2+) influx in spontaneous Ca(2+) wave propagation in interstitial cells of Cajal from the rabbit urethra. J Physiol 593(15):3333\u20133350","journal-title":"J Physiol"},{"issue":"1","key":"2028_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tips.2006.11.004","volume":"28","author":"IA Greenwood","year":"2007","unstructured":"Greenwood IA, Leblanc N (2007) Overlapping pharmacology of Ca2+-activated Cl- and K+ channels. Trends Pharmacol Sci 28(1):1\u20135","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"2028_CR13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1085\/jgp.201210861","volume":"141","author":"S Grubb","year":"2013","unstructured":"Grubb S, Poulsen KA, Juul CA, Kyed T, Klausen TK, Larsen EH, Hoffmann EK (2013) TMEM16F (Anoctamin 6), an anion channel of delayed Ca(2+) activation. J Gen Physiol 141(5):585\u2013600","journal-title":"J Gen Physiol"},{"issue":"Pt 2","key":"2028_CR14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1469-7793.1999.459ae.x","volume":"514","author":"H Hashitani","year":"1999","unstructured":"Hashitani H, Edwards FR (1999) Spontaneous and neurally activated depolarizations in smooth muscle cells of the guinea-pig urethra. J Physiol 514(Pt 2):459\u2013470","journal-title":"J Physiol"},{"issue":"7","key":"2028_CR15","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/j.1476-5381.1996.tb15584.x","volume":"118","author":"H Hashitani","year":"1996","unstructured":"Hashitani H, Van Helden DF, Suzuki H (1996) Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra. Br J Pharmacol 118(7):1627\u20131632","journal-title":"Br J Pharmacol"},{"issue":"Pt 3","key":"2028_CR16","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1113\/jphysiol.2003.043695","volume":"550","author":"MA Hollywood","year":"2003","unstructured":"Hollywood MA, Woolsey S, Walsh IK, Keane PF, McHale NG, Thornbury KD (2003) T- and L- type Ca2+ currents in freshly dispersed smooth muscle cells from the human proximal urethra. J Physiol 550(Pt 3):753\u2013764","journal-title":"J Physiol"},{"issue":"50","key":"2028_CR17","doi-asserted-by":"crossref","first-page":"21413","DOI":"10.1073\/pnas.0911935106","volume":"106","author":"F Huang","year":"2009","unstructured":"Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY (2009) Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A 106(50):21413\u201321418","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"40","key":"2028_CR18","doi-asserted-by":"crossref","first-page":"16354","DOI":"10.1073\/pnas.1214596109","volume":"109","author":"F Huang","year":"2012","unstructured":"Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR (2012) Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A 109(40):16354\u201316359","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"2028_CR19","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/bph.13431","volume":"173","author":"SJ Hwang","year":"2016","unstructured":"Hwang SJ, Basma N, Sanders KM, Ward SM (2016) Effects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract. Br J Pharmacol 173(8):1339\u20131349","journal-title":"Br J Pharmacol"},{"issue":"Pt 20","key":"2028_CR20","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1113\/jphysiol.2009.176198","volume":"587","author":"SJ Hwang","year":"2009","unstructured":"Hwang SJ, Blair PJ, Britton FC, O'Driscoll KE, Hennig G, Bayguinov YR, Rock JR, Harfe BD, Sanders KM, Ward SM (2009) Expression of anoctamin 1\/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol 587(Pt 20):4887\u20134904","journal-title":"J Physiol"},{"issue":"Pt 2","key":"2028_CR21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.2004.078097","volume":"565","author":"L Johnston","year":"2005","unstructured":"Johnston L, Sergeant GP, Hollywood MA, Thornbury KD, McHale NG (2005) Calcium oscillations in interstitial cells of the rabbit urethra. J Physiol 565(Pt 2):449\u2013461","journal-title":"J Physiol"},{"issue":"Pt 3","key":"2028_CR22","first-page":"803","volume":"540","author":"SD Koh","year":"2002","unstructured":"Koh SD, Jun JY, Kim TW, Sanders KM (2002) A Ca(2+)-inhibited non-selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal. J Physiol 540(Pt 3):803\u2013814","journal-title":"J Physiol"},{"issue":"Pt 13","key":"2028_CR23","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1113\/jphysiol.2010.189506","volume":"588","author":"B Manoury","year":"2010","unstructured":"Manoury B, Tamuleviciute A, Tammaro P (2010) TMEM16A\/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells. J Physiol 588(Pt 13):2305\u20132314. doi:\n10.1113\/jphysiol.2010.189506","journal-title":"J Physiol"},{"issue":"44","key":"2028_CR24","doi-asserted-by":"crossref","first-page":"18168","DOI":"10.1073\/pnas.1108094108","volume":"108","author":"JR Martins","year":"2011","unstructured":"Martins JR, Faria D, Kongsuphol P, Reisch B, Schreiber R, Kunzelmann K (2011) Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proc Natl Acad Sci U S A 108(44):18168\u201318172","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"2028_CR25","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1096\/fj.11-191627","volume":"25","author":"W Namkung","year":"2011","unstructured":"Namkung W, Yao Z, Finkbeiner WE, Verkman AS (2011) Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J 25(11):4048\u20134062","journal-title":"FASEB J"},{"issue":"1","key":"2028_CR26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jmb.2014.09.028","volume":"427","author":"A Picollo","year":"2015","unstructured":"Picollo A, Malvezzi M, Accardi A (2015) TMEM16 proteins: unknown structure and confusing functions. J Mol Biol 427(1):94\u2013105","journal-title":"J Mol Biol"},{"issue":"6","key":"2028_CR27","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00424-009-0684-9","volume":"458","author":"S Pifferi","year":"2009","unstructured":"Pifferi S, Dibattista M, Menini A (2009) TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflugers Arch 458(6):1023\u20131038","journal-title":"Pflugers Arch"},{"issue":"1","key":"2028_CR28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0165-0270(91)90017-T","volume":"37","author":"J Rae","year":"1991","unstructured":"Rae J, Cooper K, Gates P, Watsky M (1991) Low access resistance perforated patch recordings using amphotericin B. J Neurosci Methods 37(1):15\u201326","journal-title":"J Neurosci Methods"},{"issue":"3","key":"2028_CR29","doi-asserted-by":"publisher","first-page":"F390","DOI":"10.1152\/ajprenal.00344.2011","volume":"302","author":"M Sancho","year":"2011","unstructured":"Sancho M, Garc\u00eda-Pascual A, Triguero D (2011) Presence of the Ca2+-activated chloride channel anoctamin 1 in the urethra and its role in excitatory neurotransmission. Am J Physiol Renal Physiol 302(3):F390\u2013F400. doi:\n10.1152\/ajprenal.00344.2011","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"2028_CR30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1113\/expphysiol.2011.058248","volume":"97","author":"KM Sanders","year":"2012","unstructured":"Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM (2012) Anoctamins and gastrointestinal smooth muscle excitability. Exp Physiol 97(2):200\u2013206","journal-title":"Exp Physiol"},{"issue":"6","key":"2028_CR31","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.09.003","volume":"134","author":"BC Schroeder","year":"2008","unstructured":"Schroeder BC, Cheng T, Jan YN, Jan LY (2008) Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134(6):1019\u20131029","journal-title":"Cell"},{"issue":"Pt 19","key":"2028_CR32","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1113\/jphysiol.2008.159194","volume":"586","author":"GP Sergeant","year":"2008","unstructured":"Sergeant GP, Bradley E, Thornbury KD, McHale NG, Hollywood MA (2008) Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra. J Physiol 586(Pt 19):4631\u20134642","journal-title":"J Physiol"},{"issue":"Pt 2","key":"2028_CR33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1469-7793.2000.t01-2-00359.x","volume":"526","author":"GP Sergeant","year":"2000","unstructured":"Sergeant GP, Hollywood MA, McCloskey KD, Thornbury KD, McHale NG (2000) Specialised pacemaking cells in the rabbit urethra. J Physiol 526(Pt 2):359\u2013366","journal-title":"J Physiol"},{"issue":"3","key":"2028_CR34","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0022-5347(05)65939-3","volume":"166","author":"GP Sergeant","year":"2001","unstructured":"Sergeant GP, Hollywood MA, McHale NG, Thornbury KD (2001) Spontaneous Ca2+ activated Cl- currents in isolated urethral smooth muscle cells. J Urol 166(3):1161\u20131166","journal-title":"J Urol"},{"issue":"3","key":"2028_CR35","doi-asserted-by":"crossref","first-page":"C885","DOI":"10.1152\/ajpcell.00085.2002","volume":"283","author":"GP Sergeant","year":"2002","unstructured":"Sergeant GP, Thornbury KD, McHale NG, Hollywood MA (2002) Characterization of norepinephrine-evoked inward currents in interstitial cells isolated from the rabbit urethra. Am J Physiol Cell Physiol. 283(3):C885\u2013C894","journal-title":"Am J Physiol Cell Physiol."},{"issue":"8","key":"2028_CR36","doi-asserted-by":"crossref","first-page":"C748","DOI":"10.1152\/ajpcell.00228.2012","volume":"304","author":"T Shimizu","year":"2013","unstructured":"Shimizu T, Iehara T, Sato K, Fujii T, Sakai H, Okada Y (2013) TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel. Am J Physiol Cell Physiol 304(8):C748\u2013C759","journal-title":"Am J Physiol Cell Physiol"},{"issue":"18","key":"2028_CR37","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1113\/jphysiol.2014.277152","volume":"592","author":"RD Singh","year":"2014","unstructured":"Singh RD, Gibbons SJ, Saravanaperumal SA, Du P, Hennig GW, Eisenman ST, Mazzone A, Hayashi Y, Cao C, Stoltz GJ, Ordog T, Rock JR, Harfe BD, Szurszewski JH, Farrugia G (2014) Ano1, a Ca2+-activated Cl- channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal. J Physiol 592(18):4051\u20134068","journal-title":"J Physiol"},{"issue":"28","key":"2028_CR38","doi-asserted-by":"crossref","first-page":"11776","DOI":"10.1073\/pnas.0903304106","volume":"106","author":"AB Stephan","year":"2009","unstructured":"Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H (2009) ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci U S A 106(28):11776\u201311781","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"2028_CR39","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1523\/JNEUROSCI.5546-08.2009","volume":"29","author":"H St\u00f6hr","year":"2009","unstructured":"St\u00f6hr H, Heisig JB, Benz PM, Sch\u00f6berl S, Milenkovic VM, Strauss O, Aartsen WM, Wijnholds J, Weber BH, Schulz HL (2009) TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci 29(21):6809\u20136818","journal-title":"J Neurosci"},{"issue":"19","key":"2028_CR40","doi-asserted-by":"crossref","first-page":"13305","DOI":"10.1074\/jbc.M113.457937","volume":"288","author":"J Suzuki","year":"2013","unstructured":"Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H, Nagata S (2013) Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem 288(19):13305\u201313316","journal-title":"J Biol Chem"},{"issue":"5","key":"2028_CR41","doi-asserted-by":"crossref","first-page":"H1819","DOI":"10.1152\/ajpheart.00404.2011","volume":"301","author":"C Thomas-Gatewood","year":"2011","unstructured":"Thomas-Gatewood C, Neeb ZP, Bulley S, Adebiyi A, Bannister JP, Leo MD, Jaggar JH (2011) TMEM16A channels generate Ca2+-activated Cl- currents in cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol 301(5):H1819\u2013H1827","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"2028_CR42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2012.07.036","volume":"151","author":"H Yang","year":"2012","unstructured":"Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY (2012) TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell 151(1):111\u2013122","journal-title":"Cell"},{"issue":"7217","key":"2028_CR43","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/nature07313","volume":"455","author":"YD Yang","year":"2008","unstructured":"Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U (2008) TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455(7217):1210\u20131215","journal-title":"Nature"},{"issue":"4","key":"2028_CR44","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1164\/rccm.201207-1303OC","volume":"187","author":"CH Zhang","year":"2013","unstructured":"Zhang CH, Li Y, Zhao W, Lifshitz LM, Li H, Harfe BD, Zhu MS, ZhuGe R (2013) The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness. Am J Respir Crit Care Med 187(4):374\u2013381","journal-title":"Am J Respir Crit Care Med"},{"key":"2028_CR45","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1038\/ncomms11358","volume":"7","author":"CH Zhang","year":"2016","unstructured":"Zhang CH, Wang P, Liu DH, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Lu P, Zheng K, Craige SM, Lifshitz LM, Keaney JF Jr, Fogarty KE, ZhuGe R, Zhu MS (2016) The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun 7:11358","journal-title":"Nat Commun"},{"issue":"Pt 20","key":"2028_CR46","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1113\/jphysiol.2009.176206","volume":"587","author":"MH Zhu","year":"2009","unstructured":"Zhu MH, Kim TW, Ro S, Yan W, Ward SM, Koh SD, Sanders KM (2009) A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity. J Physiol 587(Pt 20):4905\u20134918","journal-title":"J Physiol"},{"issue":"Pt 18","key":"2028_CR47","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1113\/jphysiol.2011.211094","volume":"589","author":"MH Zhu","year":"2011","unstructured":"Zhu MH, Sung IK, Zheng H, Sung TS, Britton FC, O'Driscoll K, Koh SD, Sanders KM (2011) Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal. J Physiol 589(Pt 18):4565\u20134582","journal-title":"J Physiol"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-017-2028-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-017-2028-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-017-2028-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T08:26:50Z","timestamp":1507192010000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-017-2028-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,21]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["2028"],"URL":"https:\/\/doi.org\/10.1007\/s00424-017-2028-5","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,21]]}}}