{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T01:10:04Z","timestamp":1750641004681,"version":"3.41.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s00424-017-2031-x","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T06:12:01Z","timestamp":1500271921000},"page":"1651-1662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prolonged bed rest impairs rapid CPI-17 phosphorylation and contraction in rat mesenteric resistance arteries to cause orthostatic hypotension"],"prefix":"10.1007","volume":"469","author":[{"given":"Toshio","family":"Kitazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyo","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"2031_CR1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1161\/01.RES.62.4.854","volume":"62","author":"T Ashida","year":"1988","unstructured":"Ashida T, Schaeffer J, Goldman WF, Wade JB, Blaustein MP (1988) Role of sarcoplasmic reticulum in arterial contraction: comparison of ryanodines\u2019s effect in a conduit and a muscular artery. Circ Res 62:854\u2013863","journal-title":"Circ Res"},{"key":"2031_CR2","doi-asserted-by":"publisher","first-page":"R1577","DOI":"10.1152\/ajpregu.00084.2008","volume":"294","author":"PN Colleran","year":"2008","unstructured":"Colleran PN, Behnke BJ, Wilkerson MK, Donato AJ, Delp MD (2008) Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca(2+) release mechanism. Am J Physiol Regul Integr Comp Physiol 294:R1577\u2013R1585. doi: 10.1152\/ajpregu.00084.2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2031_CR3","doi-asserted-by":"crossref","first-page":"9596","DOI":"10.1074\/jbc.275.13.9596","volume":"275","author":"F Coussin","year":"2000","unstructured":"Coussin F, Macrez N, Morel JL, Mironneau J (2000) Requirement of ryanodine receptor subtypes 1 and 2 for Ca(2+)-induced Ca(2+) release in vascular myocytes. J Biol Chem 275:9596\u20139603","journal-title":"J Biol Chem"},{"key":"2031_CR4","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1152\/japplphysiol.01055.2009","volume":"108","author":"Y Cui","year":"2010","unstructured":"Cui Y, Zhang SM, Zhang QY, Fan R, Li J, Guo HT, Bi H, Wang YM, Hu YZ, Zheng QJ, Gu CH, Yu SQ, Yi DH, Li ZC, Pei JM (2010) Modulation of intracellular calcium transient in response to beta-adrenoceptor stimulation in the hearts of 4-wk-old rats during simulated weightlessness. J Appl Physiol (1985) 108:838\u2013844. doi: 10.1152\/japplphysiol.01055.2009","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR5","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1152\/japplphysiol.00733.2011","volume":"112","author":"F Dabertrand","year":"2012","unstructured":"Dabertrand F, Porte Y, Macrez N, Morel JL (2012) Spaceflight regulates ryanodine receptor subtype 1 in portal vein myocytes in the opposite way of hypertension. J Appl Physiol (1985) 112:471\u2013480. doi: 10.1152\/japplphysiol.00733.2011","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR6","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1152\/jappl.1993.75.6.2620","volume":"1993","author":"MD Delp","year":"1993","unstructured":"Delp MD, Holder-Binkley T, Laughlin MH, Hasser EM (1993) Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting. J Appl Physiol (1985) 1993:2620\u20132628","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1161\/01.RES.0000253902.90489.df","volume":"100","author":"GJ Dimopoulos","year":"2007","unstructured":"Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T (2007) Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle. Circ Res 100:121\u2013129. doi: 10.1161\/01.RES.0000253902.90489.df","journal-title":"Circ Res"},{"key":"2031_CR8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00018-009-0174-4","volume":"67","author":"JR Docherty","year":"2010","unstructured":"Docherty JR (2010) Subtypes of functional alpha1-adrenoceptor. Cell Mol Life Sci 67:405\u2013417. doi: 10.1007\/s00018-009-0174-4","journal-title":"Cell Mol Life Sci"},{"key":"2031_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1540\/jsmr.53.1","volume":"53","author":"M Eto","year":"2017","unstructured":"Eto M, Kitazawa T (2017) Diversity and plasticity in signaling pathways that regulate smooth muscle responsiveness: paradigms and paradoxes for the myosin phosphatase, the master regulator of smooth muscle contraction. J Smooth Muscle Res 53:1\u201319. doi: 10.1540\/jsmr.53.1","journal-title":"J Smooth Muscle Res"},{"key":"2031_CR10","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S1566-0702(00)00212-5","volume":"86","author":"JO Fortrat","year":"2001","unstructured":"Fortrat JO, Sigaudo D, Hughson RL, Maillet A, Yamamoto Y, Gharib C (2001) Effect of prolonged head-down bed rest on complex cardiovascular dynamics. Auton Neurosci 86:192\u2013201. doi: 10.1016\/S1566-0702(00)00212-5","journal-title":"Auton Neurosci"},{"key":"2031_CR11","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1152\/japplphysiol.00997.2015","volume":"120","author":"RK Globus","year":"2016","unstructured":"Globus RK, Morey-Holton E (2016) Hindlimb unloading: rodent analog for microgravity. J Appl Physiol (1985) 120:1196\u20131206. doi: 10.1152\/japplphysiol.00997.2015","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR12","doi-asserted-by":"publisher","unstructured":"Guillaume P, Herve S, Picard S, Lacroix P (2008) Orthostatic hypotension induced by postural change in the rat (tilt test). Curr Protoc Pharmacol 5(5 45). doi: 10.1002\/0471141755.ph0545s40","DOI":"10.1002\/0471141755.ph0545s40"},{"key":"2031_CR13","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1749-6632.2001.tb03698.x","volume":"940","author":"E Hasser","year":"2001","unstructured":"Hasser E, Moffitt J (2001) Regulation of sympathetic nervous system function after cardiovascular deconditioning. Ann N Y Acad Sci 940:454\u2013468","journal-title":"Ann N Y Acad Sci"},{"key":"2031_CR14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/jappl.1994.77.1.69","volume":"77","author":"RL Hughson","year":"1994","unstructured":"Hughson RL, Maillet A, Gharib C, Fortrat JO, Yamamoto Y, Pavy-Letraon A, Rivi\u00e8re D, G\u00fcell A (1994) Reduced spontaneous baroreflex response slope during lower body negative pressure after 28 days of head-down bed rest. J Appl Physiol (1985) 77:69\u201377","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0160-5402(82)90055-9","volume":"7","author":"S Humphrey","year":"1982","unstructured":"Humphrey S, McCall R (1982) A rat model for predicting orthostatic hypotension during acute and chronic antihypertensive drug therapy. J Pharmacol Methods 7:25\u201334","journal-title":"J Pharmacol Methods"},{"key":"2031_CR16","first-page":"R445","volume":"278","author":"A Kamiya","year":"2000","unstructured":"Kamiya A, Iwase S, Kitazawa H, Mano T, Vinogradova OL, Kharchenko IB (2000) Baroreflex control of muscle sympathetic nerve activity after 120 days of 6\u00b0 head-down bed rest. Am J Physiol 278:R445\u2013R452","journal-title":"Am J Physiol"},{"key":"2031_CR17","doi-asserted-by":"crossref","first-page":"9897","DOI":"10.1074\/jbc.275.14.9897","volume":"275","author":"T Kitazawa","year":"2000","unstructured":"Kitazawa T, Eto M, Woodsome TP, Brautigan DL (2000) Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem 275:9897\u20139900","journal-title":"J Biol Chem"},{"issue":"Pt 2","key":"2031_CR18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1113\/jphysiol.1997.sp021944","volume":"499","author":"T Kitazawa","year":"1997","unstructured":"Kitazawa T, Hamada E, Kitazawa K, Gaznabi AK (1997) Non-genomic mechanism of 17 beta-oestradiol-induced inhibition of contraction in mammalian vascular smooth muscle. J Physiol 499(Pt 2):497\u2013511","journal-title":"J Physiol"},{"key":"2031_CR19","doi-asserted-by":"publisher","first-page":"5401","DOI":"10.1113\/jphysiol.2012.241315","volume":"590","author":"T Kitazawa","year":"2012","unstructured":"Kitazawa T, Kitazawa K (2012) Size-dependent heterogeneity of contractile Ca2+ sensitization in rat arterial smooth muscle. J Physiol 590:5401\u20135423. doi: 10.1113\/jphysiol.2012.241315","journal-title":"J Physiol"},{"key":"2031_CR20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0022-3565(25)10708-8","volume":"274","author":"SM Knepper","year":"1995","unstructured":"Knepper SM, Buckner SA, Brune ME, DeBernardis JF, Meyer MD, Hancock AA (1995) A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype. J Pharmacol Exp Ther 274:97\u2013103","journal-title":"J Pharmacol Exp Ther"},{"key":"2031_CR21","doi-asserted-by":"crossref","first-page":"15709","DOI":"10.1016\/S0021-9258(18)66775-4","volume":"261","author":"S Kobayashi","year":"1986","unstructured":"Kobayashi S, Kanaide H, Nakamura M (1986) Complete overlap of caffeine- and K+ depolarization-sensitive intracellular calcium storage site in cultured rat arterial smooth muscle cells. J Biol Chem 261:15709\u201315713","journal-title":"J Biol Chem"},{"key":"2031_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/europace\/eun277","volume":"11","author":"M Lelonek","year":"2009","unstructured":"Lelonek M, Pietrucha T, Matyjaszczyk M, Goch JH (2009) A novel approach to syncopal patients: association analysis of polymorphisms in G-protein genes and tilt outcome. Europace 11:89\u201393. doi: 10.1093\/europace\/eun277","journal-title":"Europace"},{"key":"2031_CR23","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1152\/japplphysiol.00493.2009","volume":"107","author":"LJ Lin","year":"2009","unstructured":"Lin LJ, Gao F, Bai YG, Bao JX, Huang XF, Ma J, Zhang LF (2009) Contrasting effects of simulated microgravity with and without daily -Gx gravitation on structure and function of cerebral and mesenteric small arteries in rats. J Appl Physiol (1985) 107:1710\u20131721. doi: 10.1152\/japplphysiol.00493.2009","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR24","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrcardio.2010.136","volume":"7","author":"G Loirand","year":"2010","unstructured":"Loirand G, Pacaud P (2010) The role of rho protein signaling in hypertension. Nat Rev Cardiol 7:637\u2013647. doi: 10.1038\/nrcardio.2010.136","journal-title":"Nat Rev Cardiol"},{"key":"2031_CR25","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1474-8673.2007.00403.x","volume":"27","author":"SG Mart\u00ednez-Salas","year":"2007","unstructured":"Mart\u00ednez-Salas SG, Campos-Peralta JM, Pares-Hipolito J, Gallardo-Ort\u00edz IA, Ibarra M, Villalobos-Molina R (2007) Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. Auton Autacoid Pharmacol 27:137\u2013142. doi: 10.1111\/j.1474-8673.2007.00403.x","journal-title":"Auton Autacoid Pharmacol"},{"key":"2031_CR26","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1152\/jappl.1992.72.6.2210","volume":"72","author":"KS McDonald","year":"1992","unstructured":"McDonald KS, Delp MD, Fitts RH (1992) Effect of hindlimb unweighting on tissue blood flow in the rat. J Appl Physiol 72:2210\u20132218","journal-title":"J Appl Physiol"},{"key":"2031_CR27","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1152\/japplphysiol.00969.2001","volume":"92","author":"ER Morey-Holton","year":"2002","unstructured":"Morey-Holton ER, Globus RK (2002) Hindlimb unloading rodent model: technical aspects. J Appl Physiol (1985) 92:1367\u20131377. doi: 10.1152\/japplphysiol.00969.2001","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR28","doi-asserted-by":"publisher","first-page":"R140","DOI":"10.1152\/ajpregu.00820.2004","volume":"289","author":"PJ Mueller","year":"2005","unstructured":"Mueller PJ, Foley CM, Hasser EM (2005) Hindlimb unloading alters nitric oxide and autonomic control of resting arterial pressure in conscious rats. Am J Physiol Regul Integr Comp Physiol 289:R140\u2013R147. doi: 10.1152\/ajpregu.00820.2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2031_CR29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0749-0690(02)00008-3","volume":"18","author":"S Mukai","year":"2002","unstructured":"Mukai S, Lipsitz LA (2002) Orthostatic hypotension. Clin Geriatr Med 18:253\u2013268","journal-title":"Clin Geriatr Med"},{"key":"2031_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00213-007-1064-9","volume":"199","author":"Z Nourian","year":"2008","unstructured":"Nourian Z, Mow T, Muftic D, Burek S, Pedersen ML, Matz J, Mulvany MJ (2008) Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function. Psychopharmacology 199:15\u201327. doi: 10.1007\/s00213-007-1064-9","journal-title":"Psychopharmacology"},{"key":"2031_CR31","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1152\/japplphysiol.00734.2002","volume":"94","author":"A Papadopoulos","year":"2003","unstructured":"Papadopoulos A, Delp MD (2003) Effects of hindlimb unweighting on the mechanical and structure properties of the rat abdominal aorta. J Appl Physiol (1985) 94:439\u2013445. doi: 10.1152\/japplphysiol.00734.2002","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR32","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00421-007-0474-z","volume":"101","author":"A Pavy-Le Traon","year":"2007","unstructured":"Pavy-Le Traon A, Heer M, Narici MV, Rittweger J, Vernikos J (2007) From space to earth: advances in human physiology from 20 years of bed rest studies (1986-2006). Eur J Appl Physiol 101:143\u2013194. doi: 10.1007\/s00421-007-0474-z","journal-title":"Eur J Appl Physiol"},{"key":"2031_CR33","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1152\/jappl.1998.85.4.1307","volume":"85","author":"RE Purdy","year":"1998","unstructured":"Purdy RE, Duckles SP, Krause DN, Rubera KM, Sara D (1998) Effect of simulated microgravity on vascular contractility. J Appl Physiol (1985) 85:1307\u20131315","journal-title":"J Appl Physiol (1985)"},{"key":"2031_CR34","doi-asserted-by":"publisher","first-page":"22512","DOI":"10.1074\/jbc.M113.525444","volume":"289","author":"YN Qiao","year":"2014","unstructured":"Qiao YN, He WQ, Chen CP, Zhang CH, Zhao W, Wang P, Zhang L, Wu YZ, Yang X, Peng YJ, Gao JM, Kamm KE, Stull JT, Zhu MS (2014) Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. J Biol Chem 289:22512\u201322523. doi: 10.1074\/jbc.M113.525444","journal-title":"J Biol Chem"},{"key":"2031_CR35","first-page":"R1241","volume":"267","author":"DC Randall","year":"1994","unstructured":"Randall DC, Brown DR, Brown LV, Kilgore JM (1994) Sympathetic nervous activity and arterial blood pressure control in conscious rat during rest and behavioral stress. Am J Phys 267:R1241\u2013R1249","journal-title":"Am J Phys"},{"key":"2031_CR36","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1152\/jappl.2001.91.3.1207","volume":"91","author":"CA Ray","year":"2001","unstructured":"Ray CA, Vasques M, Miller TA, Wilkerson MK, Delp MD (2001) Effect of short-term microgravity and long-term hindlimb unloading on rat cardiac mass and function. J Appl Physiol 91:1207\u20131213","journal-title":"J Appl Physiol"},{"issue":"Suppl 1","key":"2031_CR37","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s10286-007-1004-0","volume":"18","author":"D Robertson","year":"2008","unstructured":"Robertson D (2008) The pathophysiology and diagnosis of orthostatic hypotension. Clin Auton Res 18(Suppl 1):2\u20137. doi: 10.1007\/s10286-007-1004-0","journal-title":"Clin Auton Res"},{"key":"2031_CR38","doi-asserted-by":"publisher","first-page":"9474","DOI":"10.1073\/pnas.132552699","volume":"99","author":"DG Rokosh","year":"2002","unstructured":"Rokosh DG, Simpson PC (2002) Knockout of the alpha1AC-adrenergic receptor subtype: the alpha1AC is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc Natl Acad Sci U S A 99:9474\u20139479. doi: 10.1073\/pnas.132552699","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2031_CR39","volume-title":"Human circulation regulation during physical stress","author":"LB Rowell","year":"1986","unstructured":"Rowell LB (1986) Human circulation regulation during physical stress. Oxford University Press, New York"},{"key":"2031_CR40","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195073621.001.0001","volume-title":"Human cardiovascular control","author":"LB Rowell","year":"1993","unstructured":"Rowell LB (1993) Human cardiovascular control. Oxford University Press, New York"},{"key":"2031_CR41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1152\/jappl.1972.32.2.213","volume":"32","author":"LB Rowell","year":"1972","unstructured":"Rowell LB, Detry JR, Blackmon JR, Wyss C (1972) Importance of the splanchnic vascular bed in human blood pressure regulation. J Appl Physiol 32:213\u2013220","journal-title":"J Appl Physiol"},{"key":"2031_CR42","doi-asserted-by":"publisher","first-page":"227","DOI":"10.7861\/clinmedicine.13-3-227","volume":"13","author":"K Sandhu","year":"2013","unstructured":"Sandhu K, Khan P, Panting J, Nadar S (2013) Tilt-table test: its role in modern practice. Clin Med 13:227\u2013232. doi: 10.7861\/clinmedicine.13-3-227","journal-title":"Clin Med"},{"key":"2031_CR43","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/jappl.2000.88.2.507","volume":"88","author":"DS Sangha","year":"2000","unstructured":"Sangha DS, Vaziri ND, Ding Y, Purdy RE (2000) Vascular hyporesponsiveness in simulated microgravity: role of nitric oxide-dependent mechanisms. J Appl Physiol 88:507\u2013517","journal-title":"J Appl Physiol"},{"key":"2031_CR44","first-page":"38","volume":"20","author":"R Sheldon","year":"2005","unstructured":"Sheldon R (2005) Tilt testing for syncope: a reappraisal. Curr Opin Cardiol 20:38\u201341","journal-title":"Curr Opin Cardiol"},{"key":"2031_CR45","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s10286-004-0187-x","volume":"14","author":"AA Smit","year":"2004","unstructured":"Smit AA, Wieling W, Fujimura J, Denq JC, Opfer-Gehrking TL, Akarriou M, Karemaker JM, Low PA (2004) Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction. Clin Auton Res 14:167\u2013175. doi: 10.1007\/s10286-004-0187-x","journal-title":"Clin Auton Res"},{"key":"2031_CR46","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.vph.2008.03.006","volume":"48","author":"SM Summers","year":"2008","unstructured":"Summers SM, Nguyen SV, Purdy RE (2008) Hindlimb unweighting induces changes in the RhoA-rho-kinase pathway of the rat abdominal aorta. Vasc Pharmacol 48:208\u2013214. doi: 10.1016\/j.vph.2008.03.006","journal-title":"Vasc Pharmacol"},{"key":"2031_CR47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1254\/jjp.77.61","volume":"77","author":"H Take","year":"1998","unstructured":"Take H, Shibata K, Awaji T, Hirasawa A, Ikegaki I, Asano T, Takada T, Tsujimoto G (1998) Vascular alpha1-adrenoceptor subtype selectivity and alpha1-blocker-induced orthostatic hypotension. Jpn J Pharmacol 77:61\u201370","journal-title":"Jpn J Pharmacol"},{"key":"2031_CR48","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3357\/asem.2062.2007","volume":"78","author":"O Tarasova","year":"2007","unstructured":"Tarasova O, Borovik A, Tsvirkoun D, Lebedev V, Steeves J, Krassioukov A (2007) Orthostatic response in rats after hindlimb unloading: effect of transcranial electrical stimulation. Aviat Space Environ Med 78:1023\u20131028. doi: 10.3357\/asem.2062.2007","journal-title":"Aviat Space Environ Med"},{"key":"2031_CR49","doi-asserted-by":"publisher","first-page":"C1377","DOI":"10.1152\/ajpcell.00501.2002","volume":"285","author":"NH Urban","year":"2003","unstructured":"Urban NH, Berg KM, Ratz PH (2003) K+ depolarization induces RhoA kinase translocation to caveolae and Ca2+ sensitization of arterial muscle. Am J Physiol Cell Physiol 285:C1377\u2013C1385. doi: 10.1152\/ajpcell.00501.2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"2031_CR50","doi-asserted-by":"publisher","first-page":"28743","DOI":"10.1074\/jbc.M304570200","volume":"278","author":"S Vogt","year":"2003","unstructured":"Vogt S, Grosse R, Schultz G, Offermanns S (2003) Receptor-dependent RhoA activation in G12\/G13-deficient cells: genetic evidence for an involvement of Gq\/G11. J Biol Chem 278:28743\u201328749. doi: 10.1074\/jbc.M304570200","journal-title":"J Biol Chem"},{"key":"2031_CR51","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s13105-015-0398-8","volume":"71","author":"Z-C Wang","year":"2015","unstructured":"Wang Z-C, Liu H, Bai Y-G, Yu J-W, Zhang H-J, Cheng Y-P, Bao J-X, Ren X-L, Ma H-Z, Ma J (2015) 28-Day hindlimb unweighting reduces expression of rho kinase and inhibits its effects in femoral artery of rat. J Physiol Biochem 71:205\u2013216. doi: 10.1007\/s13105-015-0398-8","journal-title":"J Physiol Biochem"},{"key":"2031_CR52","doi-asserted-by":"publisher","first-page":"H1652","DOI":"10.1152\/ajpheart.00925.2004","volume":"288","author":"MK Wilkerson","year":"2005","unstructured":"Wilkerson MK, Lesniewski LA, Golding EM, Bryan RM Jr, Amin A, Wilson E, Delp MD (2005) Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism. Am J Physiol Heart Circ Physiol 288:H1652\u2013H1661. doi: 10.1152\/ajpheart.00925.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2031_CR53","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1152\/jappl.1995.79.5.1762","volume":"79","author":"CR Woodman","year":"1995","unstructured":"Woodman CR, Sebastian LA, Tipton CM (1995) Influence of simulated microgravity on cardiac output and blood flow distribution during exercise. J Appl Physiol 79:1762\u20131768","journal-title":"J Appl Physiol"},{"key":"2031_CR54","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1242\/jcs.02805","volume":"119","author":"TP Woodsome","year":"2006","unstructured":"Woodsome TP, Polzin A, Kitazawa K, Eto M, Kitazawa T (2006) Agonist- and depolarization-induced signals for myosin light chain phosphorylation and force generation of cultured vascular smooth muscle cells. J Cell Sci 119:1769\u20131780. doi: 10.1242\/jcs.02805","journal-title":"J Cell Sci"},{"key":"2031_CR55","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1298\/jjpta.1.19","volume":"1","author":"T Yamazaki","year":"1998","unstructured":"Yamazaki T, Haida N, Tachino K (1998) Effects of weight bearing intervals on disuse atrophy of rat soleus muscle. J Jpn Phys Ther Assoc 1:19\u201324. doi: 10.1298\/jjpta.1.19","journal-title":"J Jpn Phys Ther Assoc"},{"key":"2031_CR56","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1152\/jappl.2001.90.6.2296","volume":"90","author":"LN Zhang","year":"2001","unstructured":"Zhang LN, Zhang LF, Ma J (2001) Simulated microgravity enhances vasoconstrictor responsiveness of rat basilar artery. J Appl Physiol (1985) 90:2296\u20132305","journal-title":"J Appl Physiol (1985)"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-017-2031-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-017-2031-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-017-2031-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:42:25Z","timestamp":1750639345000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-017-2031-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,17]]},"references-count":56,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2031"],"URL":"https:\/\/doi.org\/10.1007\/s00424-017-2031-x","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"type":"print","value":"0031-6768"},{"type":"electronic","value":"1432-2013"}],"subject":[],"published":{"date-parts":[[2017,7,17]]}}}