{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:45:50Z","timestamp":1759146350188,"version":"3.41.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"KAKENHI","award":["25430012"],"award-info":[{"award-number":["25430012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00424-017-2074-z","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T21:37:17Z","timestamp":1506721037000},"page":"385-394","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of eugenol on respiratory burst generation in newborn rat brainstem-spinal cord preparations"],"prefix":"10.1007","volume":"470","author":[{"given":"Sayumi","family":"Kotani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Irie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Izumizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Onimaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,29]]},"reference":[{"key":"2074_CR1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0301-0082(99)00009-X","volume":"59","author":"K Ballanyi","year":"1999","unstructured":"Ballanyi K, Onimaru H, Homma I (1999) Respiratory network function in the isolated brainstem-spinal cord of newborn rats. Prog Neurobiol 59:583\u2013634","journal-title":"Prog Neurobiol"},{"key":"2074_CR2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-009-0645-3","volume":"458","author":"K Ballanyi","year":"2009","unstructured":"Ballanyi K, Ruangkittisakul A, Onimaru H (2009) Opioids prolong and anoxia shortens delay between onset of preinspiratory (pFRG) and inspiratory (preBotC) network bursting in newborn rat brainstems. Pflugers Arch 458:571\u2013587","journal-title":"Pflugers Arch"},{"key":"2074_CR3","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1460-9568.2010.07156.x","volume":"31","author":"F Ben-Mabrouk","year":"2010","unstructured":"Ben-Mabrouk F, Tryba AK (2010) Substance P modulation of TRPC3\/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Eur J Neurosci 31:1219\u20131232","journal-title":"Eur J Neurosci"},{"key":"2074_CR4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2008.09.030","volume":"1243","author":"JS Cho","year":"2008","unstructured":"Cho JS, Kim TH, Lim JM, Song JH (2008) Effects of eugenol on Na+ currents in rat dorsal root ganglion neurons. Brain Res 1243:53\u201362","journal-title":"Brain Res"},{"key":"2074_CR5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuroscience.2013.12.047","volume":"261","author":"G Chung","year":"2014","unstructured":"Chung G, Im ST, Kim YH, Jung SJ, Rhyu MR, Oh SB (2014) Activation of transient receptor potential ankyrin 1 by eugenol. Neuroscience 261:153\u2013160","journal-title":"Neuroscience"},{"key":"2074_CR6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/154405910808700201","volume":"87","author":"G Chung","year":"2008","unstructured":"Chung G, Rhee JN, Jung SJ, Kim JS, Oh SB (2008) Modulation of CaV2.3 calcium channel currents by eugenol. J Dent Res 87:137\u2013141","journal-title":"J Dent Res"},{"key":"2074_CR7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.ph.58.030196.002025","volume":"58","author":"WE Crill","year":"1996","unstructured":"Crill WE (1996) Persistent sodium current in mammalian central neurons. Annu Rev Physiol 58:349\u2013362","journal-title":"Annu Rev Physiol"},{"key":"2074_CR8","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1113\/jphysiol.2007.134577","volume":"582","author":"EA Crowder","year":"2007","unstructured":"Crowder EA, Saha MS, Pace RW, Zhang H, Prestwich GD, Del Negro CA (2007) Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBotzinger complex. J Physiol 582:1047\u20131058","journal-title":"J Physiol"},{"key":"2074_CR9","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1152\/jn.00081.2002","volume":"88","author":"CA Negro Del","year":"2002","unstructured":"Del Negro CA, Koshiya N, Butera RJ Jr, Smith JC (2002) Persistent sodium current, membrane properties and bursting behavior of pre-botzinger complex inspiratory neurons in vitro. J Neurophysiol 88:2242\u20132250","journal-title":"J Neurophysiol"},{"key":"2074_CR10","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1476-5381.2012.01851.x","volume":"166","author":"ES Fernandes","year":"2012","unstructured":"Fernandes ES, Fernandes MA, Keeble JE (2012) The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol 166:510\u2013521","journal-title":"Br J Pharmacol"},{"key":"2074_CR11","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.104.079855","volume":"313","author":"NR Gavva","year":"2005","unstructured":"Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F, Doherty EM, Norman MH, Wild KD, Bannon AW, Louis JC, Treanor JJ (2005) AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther 313:474\u2013484","journal-title":"J Pharmacol Exp Ther"},{"key":"2074_CR12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2885.2006.00740.x","volume":"29","author":"SA Guenette","year":"2006","unstructured":"Guenette SA, Beaudry F, Marier JF, Vachon P (2006) Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats. J Vet Pharmacol Ther 29:265\u2013270","journal-title":"J Vet Pharmacol Ther"},{"key":"2074_CR13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00213-011-2603-y","volume":"221","author":"CW Huang","year":"2011","unstructured":"Huang CW, Chow JC, Tsai JJ, Wu SN (2011) Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability. Psychopharmacology 221:575\u2013587","journal-title":"Psychopharmacology"},{"key":"2074_CR14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.neuroscience.2012.02.040","volume":"210","author":"M Inoue","year":"2012","unstructured":"Inoue M, Fujita T, Goto M, Kumamoto E (2012) Presynaptic enhancement by eugenol of spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons is mediated by transient receptor potential A1 channels. Neuroscience 210:403\u2013415","journal-title":"Neuroscience"},{"key":"2074_CR15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0006-8993(02)04050-7","volume":"963","author":"Y Irie","year":"2003","unstructured":"Irie Y, Keung WM (2003) Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-beta peptide. Brain Res 963:282\u2013289","journal-title":"Brain Res"},{"key":"2074_CR16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1600-051X.1990.tb00028.x","volume":"17","author":"L Jorkjend","year":"1990","unstructured":"Jorkjend L, Skoglund LA (1990) Effect of non-eugenol- and eugenol-containing periodontal dressings on the incidence and severity of pain after periodontal soft tissue surgery. J Clin Periodontol 17:341\u2013344","journal-title":"J Clin Periodontol"},{"key":"2074_CR17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1248\/bpb.30.423","volume":"30","author":"H Kabuto","year":"2007","unstructured":"Kabuto H, Tada M, Kohno M (2007) Eugenol [2-methoxy-4-(2-propenyl)phenol] prevents 6-hydroxydopamine-induced dopamine depression and lipid peroxidation inductivity in mouse striatum. Biol Pharm Bull 30:423\u2013427","journal-title":"Biol Pharm Bull"},{"key":"2074_CR18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1113\/jphysiol.2005.102533","volume":"572","author":"A Kawai","year":"2006","unstructured":"Kawai A, Onimaru H, Homma I (2006) Mechanisms of CO2\/H+ chemoreception by respiratory rhythm generator neurons in the medulla from newborn rats in vitro. J Physiol 572:525\u2013537","journal-title":"J Physiol"},{"key":"2074_CR19","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/j.pain.2013.06.025","volume":"154","author":"AH Klein","year":"2013","unstructured":"Klein AH, Carstens MI, Carstens E (2013) Eugenol and carvacrol induce temporally desensitizing patterns of oral irritation and enhance innocuous warmth and noxious heat sensation on the tongue. Pain 154:2078\u20132087","journal-title":"Pain"},{"key":"2074_CR20","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1523\/JNEUROSCI.3916-07.2008","volume":"28","author":"H Koizumi","year":"2008","unstructured":"Koizumi H, Smith JC (2008) Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-Botzinger complex in vitro. J Neurosci 28:1773\u20131785","journal-title":"J Neurosci"},{"key":"2074_CR21","first-page":"s280","volume":"64","author":"S Kotani","year":"2014","unstructured":"Kotani S, Onimaru H (2014) Neuronal mechanisms of shortening of respiratory neuron burst by eugenol. J Physiol Sci 64:s280","journal-title":"J Physiol Sci"},{"key":"2074_CR22","first-page":"S113","volume":"67","author":"S Kotani","year":"2017","unstructured":"Kotani S, Onimaru H (2017) Neuronal mechanisms of inhibitory effects of eugenol on respiratory neuron activity in the brainstem-spinal cord preparation. J Physiol Sci 67:S113","journal-title":"J Physiol Sci"},{"key":"2074_CR23","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1177\/154405910508400913","volume":"84","author":"MH Lee","year":"2005","unstructured":"Lee MH, Yeon KY, Park CK, Li HY, Fang Z, Kim MS, Choi SY, Lee SJ, Lee S, Park K, Lee JH, Kim JS, Oh SB (2005) Eugenol inhibits calcium currents in dental afferent neurons. J Dent Res 84:848\u2013851","journal-title":"J Dent Res"},{"key":"2074_CR24","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1177\/154405910708600918","volume":"86","author":"HY Li","year":"2007","unstructured":"Li HY, Park CK, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB (2007) Eugenol inhibits K+ currents in trigeminal ganglion neurons. J Dent Res 86:898\u2013902","journal-title":"J Dent Res"},{"key":"2074_CR25","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1523\/JNEUROSCI.6555-10.2011","volume":"31","author":"J Li","year":"2011","unstructured":"Li J, Baccei ML (2011) Pacemaker neurons within newborn spinal pain circuits. J Neurosci 31:9010\u20139022","journal-title":"J Neurosci"},{"key":"2074_CR26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neures.2014.12.001","volume":"94","author":"ST Lin","year":"2015","unstructured":"Lin ST, Onimaru H (2015) Effects of riluzole on respiratory rhythm generation in the brainstem-spinal cord preparation from newborn rat. Neurosci Res 94:28\u201336","journal-title":"Neurosci Res"},{"key":"2074_CR27","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0030-4220(92)90020-Q","volume":"73","author":"K Markowitz","year":"1992","unstructured":"Markowitz K, Moynihan M, Liu M, Kim S (1992) Biologic properties of eugenol and zinc oxide-eugenol: a clinically oriented review. Oral Surg Oral Med Oral Pathol 73:729\u2013737","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"2074_CR28","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1113\/jphysiol.2007.149021","volume":"586","author":"SL Mironov","year":"2008","unstructured":"Mironov SL (2008) Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice. J Physiol 586:2277\u20132291","journal-title":"J Physiol"},{"key":"2074_CR29","doi-asserted-by":"crossref","first-page":"19223","DOI":"10.1523\/JNEUROSCI.3041-13.2013","volume":"33","author":"DJ Moraes","year":"2013","unstructured":"Moraes DJ, da Silva MP, Bonagamba LG, Mecawi AS, Zoccal DB, Antunes-Rodrigues J, Varanda WA, Machado BH (2013) Electrophysiological properties of rostral ventrolateral medulla presympathetic neurons modulated by the respiratory network in rats. J Neurosci 33:19223\u201319237","journal-title":"J Neurosci"},{"key":"2074_CR30","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.conb.2004.05.003","volume":"14","author":"MM Moran","year":"2004","unstructured":"Moran MM, Xu H, Clapham DE (2004) TRP ion channels in the nervous system. Curr Opin Neurobiol 14:362\u2013369","journal-title":"Curr Opin Neurobiol"},{"key":"2074_CR31","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.neuroscience.2006.02.036","volume":"140","author":"M Muller","year":"2006","unstructured":"Muller M, Pape HC, Speckmann EJ, Gorji A (2006) Effect of eugenol on spreading depression and epileptiform discharges in rat neocortical and hippocampal tissues. Neuroscience 140:743\u2013751","journal-title":"Neuroscience"},{"key":"2074_CR32","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1113\/jphysiol.2003.049312","volume":"552","author":"H Onimaru","year":"2003","unstructured":"Onimaru H, Ballanyi K, Homma I (2003) Contribution of Ca2+-dependent conductances to membrane potential fluctuations of medullary respiratory neurons of newborn rats in vitro. J Physiol 552:727\u2013741","journal-title":"J Physiol"},{"key":"2074_CR33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/BF00374476","volume":"420","author":"H Onimaru","year":"1992","unstructured":"Onimaru H, Homma I (1992) Whole cell recordings from respiratory neurons in the medulla of brainstem-spinal cord preparations isolated from newborn rats. Pflugers Arch 420:399\u2013406","journal-title":"Pflugers Arch"},{"key":"2074_CR34","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1523\/JNEUROSCI.23-04-01478.2003","volume":"23","author":"H Onimaru","year":"2003","unstructured":"Onimaru H, Homma I (2003) A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J Neurosci 23:1478\u20131486","journal-title":"J Neurosci"},{"key":"2074_CR35","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.1523\/JNEUROSCI.3625-08.2008","volume":"28","author":"H Onimaru","year":"2008","unstructured":"Onimaru H, Ikeda K, Kawakami K (2008) CO2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat. J Neurosci 28:12845\u201312850","journal-title":"J Neurosci"},{"key":"2074_CR36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0168-0102(96)01048-6","volume":"25","author":"H Onimaru","year":"1996","unstructured":"Onimaru H, Kanamaru A, Homma I (1996) Optical imaging of respiratory burst activity in newborn rat medullary block preparations. Neurosci Res 25:183\u2013190","journal-title":"Neurosci Res"},{"key":"2074_CR37","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/154405910608501005","volume":"85","author":"CK Park","year":"2006","unstructured":"Park CK, Li HY, Yeon KY, Jung SJ, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB (2006) Eugenol inhibits sodium currents in dental afferent neurons. J Dent Res 85:900\u2013904","journal-title":"J Dent Res"},{"key":"2074_CR38","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ceca.2008.11.009","volume":"45","author":"M Parnas","year":"2009","unstructured":"Parnas M, Peters M, Dadon D, Lev S, Vertkin I, Slutsky I, Minke B (2009) Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium 45:300\u2013309","journal-title":"Cell Calcium"},{"key":"2074_CR39","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1152\/jn.1997.77.6.3021","volume":"77","author":"MM Segal","year":"1997","unstructured":"Segal MM, Douglas AF (1997) Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin. J Neurophysiol 77:3021\u20133034","journal-title":"J Neurophysiol"},{"key":"2074_CR40","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1213\/ANE.0000000000001205","volume":"122","author":"T Shakuo","year":"2016","unstructured":"Shakuo T, Lin ST, Onimaru H (2016) The Effects of lidocaine on central respiratory neuron activity and nociceptive-related responses in the brainstem-spinal cord preparation of the newborn rat. Anesth Analg 122:1586\u20131593","journal-title":"Anesth Analg"},{"key":"2074_CR41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1535-7511.2007.00156.x","volume":"7","author":"CE Stafstrom","year":"2007","unstructured":"Stafstrom CE (2007) Persistent sodium current and its role in epilepsy. Epilepsy Curr 7:15\u201322","journal-title":"Epilepsy Curr"},{"key":"2074_CR42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0165-6147(99)01393-0","volume":"20","author":"O Sterner","year":"1999","unstructured":"Sterner O, Szallasi A (1999) Novel natural vanilloid receptor agonists: new therapeutic targets for drug development. Trends Pharmacol Sci 20:459\u2013465","journal-title":"Trends Pharmacol Sci"},{"key":"2074_CR43","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1984.sp015370","volume":"354","author":"T Suzue","year":"1984","unstructured":"Suzue T (1984) Respiratory rhythm generation in the in vitro brain stem-spinal cord preparation of the neonatal rat. J Physiol 354:173\u2013183","journal-title":"J Physiol"},{"key":"2074_CR44","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","volume":"51","author":"A Szallasi","year":"1999","unstructured":"Szallasi A, Blumberg PM (1999) Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 51:159\u2013212","journal-title":"Pharmacol Rev"},{"key":"2074_CR45","doi-asserted-by":"crossref","unstructured":"Tani M, Kotani S, Hayakawa C, Lin ST, Irie S, Ikeda K, Kawakami K, Onimaru H (2016) Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats. Pflugers Arch in press","DOI":"10.1007\/s00424-016-1912-8"},{"key":"2074_CR46","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/WNR.0b013e3283405bad","volume":"21","author":"M Tani","year":"2010","unstructured":"Tani M, Onimaru H, Ikeda K, Kawakami K, Homma I (2010) Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats. Neuroreport 21:1095\u20131099","journal-title":"Neuroreport"},{"key":"2074_CR47","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1152\/jn.00282.2015","volume":"114","author":"M Tani","year":"2015","unstructured":"Tani M, Yazawa I, Ikeda K, Kawakami K, Onimaru H (2015) Long-lasting facilitation of respiratory rhythm by treatment with TRPA1 agonist, cinnamaldehyde. J Neurophysiol 114:989\u2013998","journal-title":"J Neurophysiol"},{"key":"2074_CR48","first-page":"27","volume":"163","author":"R Vennekens","year":"2012","unstructured":"Vennekens R, Menigoz A, Nilius B (2012) TRPs in the brain. Rev Physiol Biochem Pharmacol 163:27\u201364","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"2074_CR49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3940(98)00664-8","volume":"254","author":"MH Won","year":"1998","unstructured":"Won MH, Lee JC, Kim YH, Song DK, Suh HW, Oh YS, Kim JH, Shin TK, Lee YJ, Wie MB (1998) Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia in gerbils. Neurosci Lett 254:101\u2013104","journal-title":"Neurosci Lett"},{"key":"2074_CR50","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1177\/154405910308201004","volume":"82","author":"BH Yang","year":"2003","unstructured":"Yang BH, Piao ZG, Kim YB, Lee CH, Lee JK, Park K, Kim JS, Oh SB (2003) Activation of vanilloid receptor 1 (VR1) by eugenol. J Dent Res 82:781\u2013785","journal-title":"J Dent Res"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-017-2074-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-017-2074-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-017-2074-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T23:24:49Z","timestamp":1750893889000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-017-2074-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,29]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["2074"],"URL":"https:\/\/doi.org\/10.1007\/s00424-017-2074-z","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"type":"print","value":"0031-6768"},{"type":"electronic","value":"1432-2013"}],"subject":[],"published":{"date-parts":[[2017,9,29]]}}}