{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:09:04Z","timestamp":1781197744145,"version":"3.54.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T00:00:00Z","timestamp":1526083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TRR152 P16"],"award-info":[{"award-number":["SFB TRR152 P16"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00424-018-2148-6","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T23:34:29Z","timestamp":1526081669000},"page":"1231-1241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["TRPA1 channels: expression in non-neuronal murine lung tissues and dispensability for hyperoxia-induced alveolar epithelial hyperplasia"],"prefix":"10.1007","volume":"470","author":[{"given":"Martina","family":"Kannler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"L\u00fcling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali \u00d6nder","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gudermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Steinritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-8707","authenticated-orcid":false,"given":"Alexander","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,12]]},"reference":[{"key":"2148_CR1","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","volume":"28","author":"DA Andersson","year":"2008","unstructured":"Andersson DA, Gentry C, Moss S, Bevan S (2008) Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci 28:2485\u20132494. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.5369-07.2008","journal-title":"J Neurosci"},{"key":"2148_CR2","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1172\/JCI34192","volume":"118","author":"BF Bessac","year":"2008","unstructured":"Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest 118:1899\u20131910. \n                    https:\/\/doi.org\/10.1172\/JCI34192","journal-title":"J Clin Invest"},{"key":"2148_CR3","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1096\/fj.08-117812","volume":"23","author":"BF Bessac","year":"2009","unstructured":"Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE (2009) Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J 23:1102\u20131114. \n                    https:\/\/doi.org\/10.1096\/fj.08-117812","journal-title":"FASEB J"},{"key":"2148_CR4","doi-asserted-by":"publisher","unstructured":"Buch T, Schafer E, Steinritz D, Dietrich A, Gudermann T (2013) Chemosensory TRP channels in the respiratory tract: role in toxic lung injury and potential as \"sweet spots\" for targeted therapies. Rev Physiol Biochem Pharmacol. \n                    https:\/\/doi.org\/10.1007\/112_2012_10","DOI":"10.1007\/112_2012_10"},{"key":"2148_CR5","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.cbi.2013.08.012","volume":"206","author":"TR Buch","year":"2013","unstructured":"Buch TR, Schafer EA, Demmel MT, Boekhoff I, Thiermann H, Gudermann T, Steinritz D, Schmidt A (2013) Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells. Chem Biol Interact 206:462\u2013471. \n                    https:\/\/doi.org\/10.1016\/j.cbi.2013.08.012","journal-title":"Chem Biol Interact"},{"key":"2148_CR6","doi-asserted-by":"publisher","first-page":"e20914","DOI":"10.7554\/eLife.20914","volume":"5","author":"V Chubanov","year":"2016","unstructured":"Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim OA, Sotlar K, Schurmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T (2016) Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. eLife 5:e20914. \n                    https:\/\/doi.org\/10.7554\/eLife.20914","journal-title":"eLife"},{"key":"2148_CR7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1165\/ajrcmb.14.4.8600933","volume":"14","author":"M Corti","year":"1996","unstructured":"Corti M, Brody AR, Harrison JH (1996) Isolation and primary culture of murine alveolar type II cells. Am J Respir Cell Mol Biol 14:309\u2013315. \n                    https:\/\/doi.org\/10.1165\/ajrcmb.14.4.8600933","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2148_CR8","doi-asserted-by":"publisher","first-page":"L766","DOI":"10.1152\/ajplung.2000.279.4.L766","volume":"279","author":"DJ Davidson","year":"2000","unstructured":"Davidson DJ, Kilanowski FM, Randell SH, Sheppard DN, Dorin JR (2000) A primary culture model of differentiated murine tracheal epithelium. Am J Physiol Lung Cell Mol Physiol 279:L766\u2013L778","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2148_CR9","doi-asserted-by":"publisher","first-page":"47842","DOI":"10.1074\/jbc.M302983200","volume":"278","author":"A Dietrich","year":"2003","unstructured":"Dietrich A, Mederos y Schnitzler M, Emmel J, Kalwa H, Hofmann T, Gudermann T (2003) N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. J Biol Chem 278:47842\u201347852. \n                    https:\/\/doi.org\/10.1074\/jbc.M302983200","journal-title":"J Biol Chem"},{"key":"2148_CR10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ceca.2017.04.005","volume":"67","author":"A Dietrich","year":"2017","unstructured":"Dietrich A, Steinritz D, Gudermann T (2017) Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases. Cell Calcium 67:123\u2013137. \n                    https:\/\/doi.org\/10.1016\/j.ceca.2017.04.005","journal-title":"Cell Calcium"},{"key":"2148_CR11","doi-asserted-by":"publisher","first-page":"981","DOI":"10.2165\/11591490-000000000-00000","volume":"71","author":"Q Ding","year":"2011","unstructured":"Ding Q, Luckhardt T, Hecker L, Zhou Y, Liu G, Antony VB, deAndrade J, Thannickal VJ (2011) New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis. Drugs 71:981\u20131001. \n                    https:\/\/doi.org\/10.2165\/11591490-000000000-00000","journal-title":"Drugs"},{"key":"2148_CR12","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/0891-5849(91)90062-8","volume":"11","author":"L Frank","year":"1991","unstructured":"Frank L (1991) Developmental aspects of experimental pulmonary oxygen toxicity. Free Radic Biol Med 11:463\u2013494","journal-title":"Free Radic Biol Med"},{"key":"2148_CR13","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.redox.2017.04.033","volume":"12","author":"L Gao","year":"2017","unstructured":"Gao L, Gonzalez-Rodriguez P, Ortega-Saenz P, Lopez-Barneo J (2017) Redox signaling in acute oxygen sensing. Redox Biol 12:908\u2013915. \n                    https:\/\/doi.org\/10.1016\/j.redox.2017.04.033","journal-title":"Redox Biol"},{"key":"2148_CR14","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nbt1385","volume":"26","author":"GK Geiss","year":"2008","unstructured":"Geiss GK, Bumgarner RE, Birditt B, Dahl T, Dowidar N, Dunaway DL, Fell HP, Ferree S, George RD, Grogan T, James JJ, Maysuria M, Mitton JD, Oliveri P, Osborn JL, Peng T, Ratcliffe AL, Webster PJ, Davidson EH, Hood L, Dimitrov K (2008) Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol 26:317\u2013325. \n                    https:\/\/doi.org\/10.1038\/nbt1385","journal-title":"Nat Biotechnol"},{"key":"2148_CR15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1183\/09031936.04.00137203","volume":"25","author":"TS Hallstrand","year":"2005","unstructured":"Hallstrand TS, Boitano LJ, Johnson WC, Spada CA, Hayes JG, Raghu G (2005) The timed walk test as a measure of severity and survival in idiopathic pulmonary fibrosis. Eur Respir J 25:96\u2013103. \n                    https:\/\/doi.org\/10.1183\/09031936.04.00137203","journal-title":"Eur Respir J"},{"key":"2148_CR16","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.bbadis.2016.12.002","volume":"1863","author":"K Hofmann","year":"2017","unstructured":"Hofmann K, Fiedler S, Vierkotten S, Weber J, Klee S, Jia J, Zwickenpflug W, Flockerzi V, Storch U, Yildirim AO, Gudermann T, Konigshoff M, Dietrich A (2017) Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis. Biochim Biophys Acta 1863:560\u2013568. \n                    https:\/\/doi.org\/10.1016\/j.bbadis.2016.12.002","journal-title":"Biochim Biophys Acta"},{"key":"2148_CR17","doi-asserted-by":"publisher","first-page":"7325","DOI":"10.1074\/jbc.274.11.7325","volume":"274","author":"D Jaquemar","year":"1999","unstructured":"Jaquemar D, Schenker T, Trueb B (1999) An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J Biol Chem 274:7325\u20137333","journal-title":"J Biol Chem"},{"key":"2148_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/MOP.0b013e3283423e6b","volume":"23","author":"AH Jobe","year":"2011","unstructured":"Jobe AH (2011) The new bronchopulmonary dysplasia. Curr Opin Pediatr 23:167\u2013172. \n                    https:\/\/doi.org\/10.1097\/MOP.0b013e3283423e6b","journal-title":"Curr Opin Pediatr"},{"key":"2148_CR19","doi-asserted-by":"publisher","first-page":"L692","DOI":"10.1152\/ajplung.00092.2014","volume":"307","author":"G John-Schuster","year":"2014","unstructured":"John-Schuster G, Hager K, Conlon TM, Irmler M, Beckers J, Eickelberg O, Yildirim AO (2014) Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD. Am J Physiol Lung Cell Mol Physiol 307:L692\u2013L706. \n                    https:\/\/doi.org\/10.1152\/ajplung.00092.2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2148_CR20","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature02282","volume":"427","author":"SE Jordt","year":"2004","unstructured":"Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, Meng ID, Julius D (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260\u2013265. \n                    https:\/\/doi.org\/10.1038\/nature02282","journal-title":"Nature"},{"key":"2148_CR21","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1002\/jcp.24883","volume":"230","author":"H Kalwa","year":"2015","unstructured":"Kalwa H, Storch U, Demleitner J, Fiedler S, Mayer T, Kannler M, Fahlbusch M, Barth H, Smrcka A, Hildebrandt F, Gudermann T, Dietrich A (2015) Phospholipase C epsilon (PLCepsilon) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. J Cell Physiol 230:1389\u20131399. \n                    https:\/\/doi.org\/10.1002\/jcp.24883","journal-title":"J Cell Physiol"},{"key":"2148_CR22","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/j.freeradbiomed.2011.03.020","volume":"50","author":"D Kondrikov","year":"2011","unstructured":"Kondrikov D, Caldwell RB, Dong Z, Su Y (2011) Reactive oxygen species-dependent RhoA activation mediates collagen synthesis in hyperoxic lung fibrosis. Free Radic Biol Med 50:1689\u20131698. \n                    https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.03.020","journal-title":"Free Radic Biol Med"},{"key":"2148_CR23","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.cbi.2014.10.016","volume":"224","author":"VI Lushchak","year":"2014","unstructured":"Lushchak VI (2014) Free radicals, reactive oxygen species, oxidative stress and its classification. Chem Biol Interact 224:164\u2013175. \n                    https:\/\/doi.org\/10.1016\/j.cbi.2014.10.016","journal-title":"Chem Biol Interact"},{"key":"2148_CR24","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nature05544","volume":"445","author":"LJ Macpherson","year":"2007","unstructured":"Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541\u2013545. \n                    https:\/\/doi.org\/10.1038\/nature05544","journal-title":"Nature"},{"key":"2148_CR25","doi-asserted-by":"publisher","first-page":"464","DOI":"10.2183\/pjab.93.028","volume":"93","author":"Y Mori","year":"2017","unstructured":"Mori Y, Takahashi N, Kurokawa T, Kiyonaka S (2017) TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O2 sensing. Proc Jpn Acad Ser B Phys Biol Sci 93:464\u2013482. \n                    https:\/\/doi.org\/10.2183\/pjab.93.028","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"2148_CR26","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3109\/10799893.2011.602413","volume":"31","author":"I Mukhopadhyay","year":"2011","unstructured":"Mukhopadhyay I, Gomes P, Aranake S, Shetty M, Karnik P, Damle M, Kuruganti S, Thorat S, Khairatkar-Joshi N (2011) Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells. J Recept Signal Transduct Res 31:350\u2013358. \n                    https:\/\/doi.org\/10.3109\/10799893.2011.602413","journal-title":"J Recept Signal Transduct Res"},{"key":"2148_CR27","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1242\/dmm.019117","volume":"8","author":"K Mutze","year":"2015","unstructured":"Mutze K, Vierkotten S, Milosevic J, Eickelberg O, Konigshoff M (2015) Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt\/beta-catenin-driven trans-differentiation of murine alveolar epithelial cells. Dis Model Mech 8:877\u2013890. \n                    https:\/\/doi.org\/10.1242\/dmm.019117","journal-title":"Dis Model Mech"},{"key":"2148_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042454","volume":"7","author":"R Nassini","year":"2012","unstructured":"Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, Facchinetti F, Viscomi AR, Pisano AR, Stokesberry S, Brunmark C, Svitacheva N, McGarvey L, Patacchini R, Damholt AB, Geppetti P, Materazzi S (2012) Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. PLoS One 7:e42454. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0042454","journal-title":"PLoS One"},{"key":"2148_CR29","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s00424-013-1237-9","volume":"465","author":"T Numata","year":"2013","unstructured":"Numata T, Ogawa N, Takahashi N, Mori Y (2013) TRP channels as sensors of oxygen availability. Pflugers Arch 465:1075\u20131085. \n                    https:\/\/doi.org\/10.1007\/s00424-013-1237-9","journal-title":"Pflugers Arch"},{"key":"2148_CR30","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1111\/j.1460-9568.2008.06093.x","volume":"27","author":"Y Sawada","year":"2008","unstructured":"Sawada Y, Hosokawa H, Matsumura K, Kobayashi S (2008) Activation of transient receptor potential ankyrin 1 by hydrogen peroxide. Eur J Neurosci 27:1131\u20131142. \n                    https:\/\/doi.org\/10.1111\/j.1460-9568.2008.06093.x","journal-title":"Eur J Neurosci"},{"key":"2148_CR31","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.bcp.2012.11.019","volume":"85","author":"EA Schaefer","year":"2013","unstructured":"Schaefer EA, Stohr S, Meister M, Aigner A, Gudermann T, Buech TR (2013) Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells. Biochem Pharmacol 85:426\u2013438. \n                    https:\/\/doi.org\/10.1016\/j.bcp.2012.11.019","journal-title":"Biochem Pharmacol"},{"key":"2148_CR32","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13104-016-1915-8","volume":"9","author":"JN Sleigh","year":"2016","unstructured":"Sleigh JN, Weir GA, Schiavo G (2016) A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia. BMC Res Notes 9:82. \n                    https:\/\/doi.org\/10.1186\/s13104-016-1915-8","journal-title":"BMC Res Notes"},{"key":"2148_CR33","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s00204-014-1414-4","volume":"89","author":"B Stenger","year":"2015","unstructured":"Stenger B, Zehfuss F, Muckter H, Schmidt A, Balszuweit F, Schafer E, Buch T, Gudermann T, Thiermann H, Steinritz D (2015) Activation of the chemosensing transient receptor potential channel A1 (TRPA1) by alkylating agents. Arch Toxicol 89:1631\u20131643. \n                    https:\/\/doi.org\/10.1007\/s00204-014-1414-4","journal-title":"Arch Toxicol"},{"key":"2148_CR34","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","volume":"112","author":"GM Story","year":"2003","unstructured":"Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819\u2013829","journal-title":"Cell"},{"key":"2148_CR35","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nchembio.640","volume":"7","author":"N Takahashi","year":"2011","unstructured":"Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, Mori Y (2011) TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol 7:701\u2013711. \n                    https:\/\/doi.org\/10.1038\/nchembio.640","journal-title":"Nat Chem Biol"},{"key":"2148_CR36","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.3390\/ijms18091914","volume":"18","author":"L Terraneo","year":"2017","unstructured":"Terraneo L, Samaja M (2017) Comparative response of brain to chronic hypoxia and Hyperoxia. Int J Mol Sci 18:1914. \n                    https:\/\/doi.org\/10.3390\/ijms18091914","journal-title":"Int J Mol Sci"},{"key":"2148_CR37","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1755-1536-7-8","volume":"7","author":"T Volckaert","year":"2014","unstructured":"Volckaert T, De Langhe S (2014) Lung epithelial stem cells and their niches: Fgf10 takes center stage. Fibrogenesis Tissue Repair 7:8. \n                    https:\/\/doi.org\/10.1186\/1755-1536-7-8","journal-title":"Fibrogenesis Tissue Repair"},{"key":"2148_CR38","doi-asserted-by":"publisher","first-page":"L326","DOI":"10.1152\/ajplung.00074.2013","volume":"306","author":"S Vyas-Read","year":"2014","unstructured":"Vyas-Read S, Wang W, Kato S, Colvocoresses-Dodds J, Fifadara NH, Gauthier TW, Helms MN, Carlton DP, Brown LA (2014) Hyperoxia induces alveolar epithelial-to-mesenchymal cell transition. Am J Physiol Lung Cell Mol Physiol 306:L326\u2013L340. \n                    https:\/\/doi.org\/10.1152\/ajplung.00074.2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2148_CR39","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1056\/NEJMra050002","volume":"353","author":"EK Weir","year":"2005","unstructured":"Weir EK, Lopez-Barneo J, Buckler KJ, Archer SL (2005) Acute oxygen-sensing mechanisms. N Engl J Med 353:2042\u20132055. \n                    https:\/\/doi.org\/10.1056\/NEJMra050002","journal-title":"N Engl J Med"},{"key":"2148_CR40","doi-asserted-by":"publisher","first-page":"19093","DOI":"10.1073\/pnas.0606728103","volume":"103","author":"N Weissmann","year":"2006","unstructured":"Weissmann N, Dietrich A, Fuchs B, Kalwa H, Ay M, Dumitrascu R, Olschewski A, Storch U, Mederos y Schnitzler M, Ghofrani HA, Schermuly RT, Pinkenburg O, Seeger W, Grimminger F, Gudermann T (2006) Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci U S A 103:19093\u201319098","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2148_CR41","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/ncomms1660","volume":"3","author":"N Weissmann","year":"2012","unstructured":"Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T, Ghofrani HA, Dietrich A (2012) Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun 3:649. \n                    https:\/\/doi.org\/10.1038\/ncomms1660","journal-title":"Nat Commun"},{"key":"2148_CR42","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.bbagen.2014.11.010","volume":"1850","author":"ZW Ye","year":"2015","unstructured":"Ye ZW, Zhang J, Townsend DM, Tew KD (2015) Oxidative stress, redox regulation and diseases of cellular differentiation. Biochim Biophys Acta 1850:1607\u20131621. \n                    https:\/\/doi.org\/10.1016\/j.bbagen.2014.11.010","journal-title":"Biochim Biophys Acta"},{"key":"2148_CR43","doi-asserted-by":"publisher","first-page":"4350965","DOI":"10.1155\/2016\/4350965","volume":"2016","author":"J Zhang","year":"2016","unstructured":"Zhang J, Wang X, Vikash V, Ye Q, Wu D, Liu Y, Dong W (2016) ROS and ROS-mediated cellular signaling. Oxidative Med Cell Longev 2016:4350965. \n                    https:\/\/doi.org\/10.1155\/2016\/4350965","journal-title":"Oxidative Med Cell Longev"},{"key":"2148_CR44","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/978-3-642-54215-2_23","volume":"222","author":"PM Zygmunt","year":"2014","unstructured":"Zygmunt PM, Hogestatt ED (2014) Trpa1. Handb Exp Pharmacol 222:583\u2013630. \n                    https:\/\/doi.org\/10.1007\/978-3-642-54215-2_23","journal-title":"Handb Exp Pharmacol"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-018-2148-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-018-2148-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-018-2148-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T19:16:48Z","timestamp":1557602208000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-018-2148-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,12]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["2148"],"URL":"https:\/\/doi.org\/10.1007\/s00424-018-2148-6","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,12]]},"assertion":[{"value":"5 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were approved by the local authorities (Regierung Oberbayern) and are in compliance with ethical standards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}