{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:27:36Z","timestamp":1762867656372,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s00424-018-2237-6","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T07:34:01Z","timestamp":1544772841000},"page":"647-654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Electrophysiology of the pancreatic islet \u03b2-cell sweet taste receptor TIR3"],"prefix":"10.1007","volume":"471","author":[{"given":"Juan V.","family":"Sanchez-Andres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0375-7036","authenticated-orcid":false,"given":"Willy J.","family":"Malaisse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"2237_CR1","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00125-017-4326-z","volume":"60","author":"D Avrahami","year":"2017","unstructured":"Avrahami D, Klochendler A, Dor Y, Glaser B (2017) Beta cell heterogeneity: an evolving concept. Diabetologia 60:1363\u20131369","journal-title":"Diabetologia"},{"key":"2237_CR2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nature18907","volume":"535","author":"S Bonner-Weir","year":"2016","unstructured":"Bonner-Weir S, Aguayo-Mazzucato C (2016) Pancreatic \u03b2-cell heterogeneity revisited. Nature 535:365\u2013366","journal-title":"Nature"},{"issue":"4","key":"2237_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nrn3687","volume":"15","author":"G Buzs\u00e1ki","year":"2014","unstructured":"Buzs\u00e1ki G, Mizuseki K (2014) The log-dynamic brain: how skewed distributions affect network operations. Nat Rev Neurosci 15(4):264\u2013278","journal-title":"Nat Rev Neurosci"},{"key":"2237_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF02924429","volume":"8","author":"F Fichaux","year":"1991","unstructured":"Fichaux F, Marchand J, Yaylali B, Leclercq-Meyer V, Catala J, Malaisse WJ (1991) Altered anomeric specificity of glucose-induced insulin release in rabbits with duct-ligated pancreas. Int J Pancreatol 8:151\u2013167","journal-title":"Int J Pancreatol"},{"key":"2237_CR5","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1530\/acta.0.XXXIV0449","volume":"34","author":"C Hellerstrom","year":"1960","unstructured":"Hellerstrom C, Petersson B, Hellman B (1960) Some properties of the \u03b2 cells in the islet of Langerhans studied with regard to the position of the cells. Acta Endocrinol 34:449\u2013456","journal-title":"Acta Endocrinol"},{"key":"2237_CR6","doi-asserted-by":"publisher","first-page":"pe36","DOI":"10.1126\/scisignal.2003325","volume":"5","author":"JC Henquin","year":"2012","unstructured":"Henquin JC (2012) Do pancreatic \u03b2-cells \u201ctaste\u201d nutrients to secrete insulin? Sci Signal 5:pe36","journal-title":"Sci Signal"},{"key":"2237_CR7","doi-asserted-by":"publisher","unstructured":"Holz G, Chepurny OG, Leech CA, Song W-J, Hussain MA (2015) Molecular basis of cAMP signaling in pancreatic \u03b2-cells. In: Islets of Langerhans, 2nd ed., Md. Shahidul Islam ed, chapter 20. Springer, Dordrecht, pp. 565\u2013603. https:\/\/doi.org\/10.1007\/978-94-007-6686-0","DOI":"10.1007\/978-94-007-6686-0"},{"key":"2237_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.pharmthera.2017.05.003","volume":"179","author":"MA Kalwat","year":"2017","unstructured":"Kalwat MA, Cobb MH (2017) Mechanisms of the amplifying pathway of insulin secretion in the \u03b2 cell. Pharmacol Ther 179:17\u201330","journal-title":"Pharmacol Ther"},{"key":"2237_CR9","doi-asserted-by":"publisher","first-page":"451","DOI":"10.4093\/dmj.2011.35.5.451","volume":"34","author":"I Kojima","year":"2011","unstructured":"Kojima I, Nakagawa Y (2011) The role of the sweet taste receptor in enteroendocrine cells and pancreatic \u03b2-cells. Diabetes Metab J 34:451\u2013457","journal-title":"Diabetes Metab J"},{"key":"2237_CR10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3803\/EnM.2014.29.1.12","volume":"29","author":"I Kojima","year":"2014","unstructured":"Kojima I, Nakagawa Y, Ohtsu Y, Medina A, Nagasawa M (2014) Sweet taste-sensing receptors expressed in pancreatic \u03b2-cells: sweet molecules act as biased agonists. Endocrinol Metab 29:12\u201319","journal-title":"Endocrinol Metab"},{"key":"2237_CR11","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/jdi.12304","volume":"6","author":"I Kojima","year":"2015","unstructured":"Kojima I, Nakagawa Y, Ohtsu Y, Hamano K, Medina J, Nagasawa M (2015) Return of the glucoreceptor: glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic \u03b2-cells. J Diabetes Invest 6:256\u2013263","journal-title":"J Diabetes Invest"},{"key":"2237_CR12","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1097\/00006676-198711000-00004","volume":"2","author":"V Leclercq-Meyer","year":"1987","unstructured":"Leclercq-Meyer V, Marchand J, Malaisse WJ (1987a) Anomeric specificity of the insulin and glucagon secretory response to D-glucose in lean and obese Zucker rats. Pancreas 2:645\u2013652","journal-title":"Pancreas"},{"key":"2237_CR13","first-page":"1535","volume":"15","author":"V Leclercq-Meyer","year":"1987","unstructured":"Leclercq-Meyer V, Marchand J, Malaisse WJ (1987b) Alteration of the insulin secretory response to D-glucose anomers in diabetic BB rats. Med Sci Res 15:1535\u20131536","journal-title":"Med Sci Res"},{"key":"2237_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1055\/s-2007-1003668","volume":"23","author":"V Leclercq-Meyer","year":"1991","unstructured":"Leclercq-Meyer V, Marchand J, Malaisse WJ (1991) Attenuated anomeric difference of glucose-induced insulin release in the perfused pancreas of diazoxide-treated rats. Horm Metab Res 23:257\u2013261","journal-title":"Horm Metab Res"},{"issue":"8","key":"2237_CR15","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1507\/endocrj.EJ16-0217","volume":"63","author":"L Li","year":"2016","unstructured":"Li L, Ohtsu Y, Nakagawa Y, Masuda K, Kojima I (2016) Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms. Endocr J 63(8):715\u2013725","journal-title":"Endocr J"},{"key":"2237_CR16","first-page":"65","volume":"15","author":"WJ Malaisse","year":"1987","unstructured":"Malaisse WJ (1987) Insulin release: the glucoreceptor myth. Med Sci Res 15:65\u201367","journal-title":"Med Sci Res"},{"key":"2237_CR17","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1055\/s-2007-1003684","volume":"23","author":"WJ Malaisse","year":"1991","unstructured":"Malaisse WJ (1991) The anomeric malaise: a manifestation of B-cell glucotoxicity. Horm Metab Res 23:307\u2013311","journal-title":"Horm Metab Res"},{"key":"2237_CR18","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s00125-014-3221-0","volume":"57","author":"WJ Malaisse","year":"2014","unstructured":"Malaisse WJ (2014) Insulin release: the receptor hypothesis. Diabetologia 57:1287\u20131290","journal-title":"Diabetologia"},{"key":"2237_CR19","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0026-0495(79)90111-2","volume":"28","author":"WJ Malaisse","year":"1979","unstructured":"Malaisse WJ, Sener A, Herchuelz A, Hutton JC (1979) Insulin release: the fuel hypothesis. Metabolism 28:373\u2013386","journal-title":"Metabolism"},{"key":"2237_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/BF02354884","volume":"37","author":"WJ Malaisse","year":"1981","unstructured":"Malaisse WJ, Sener A, Malaisse-Lagae F (1981) Insulin release: reconciliation of the receptor and metabolic hypotheses. Nutrient receptors in islet cells. Mol Cell Biochem 37:157\u2013165","journal-title":"Mol Cell Biochem"},{"key":"2237_CR21","unstructured":"Malaisse WJ, Strange G, Kojima I (2014) Presence of the sweet taste TIR3 receptor in human and rat pancreatic islet cells. Abstract Book Autumn Meeting Belg Soc Physiol Pharmacol: P-02. http:\/\/users.ugent.be\/jvdvoord\/physiology&pharmacology\/2014AutumnMeetingabstractbook.pdf"},{"key":"2237_CR22","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/BF00452076","volume":"29","author":"F Malaisse-Lagae","year":"1986","unstructured":"Malaisse-Lagae F, Malaisse WJ (1986) Abnormal identification of the sweet taste of D-glucose anomers. Diabetologia 29:344\u2013345","journal-title":"Diabetologia"},{"issue":"44","key":"2237_CR23","doi-asserted-by":"publisher","first-page":"23126","DOI":"10.1074\/jbc.M116.729863","volume":"291","author":"J Medina","year":"2016","unstructured":"Medina J, Nakagawa Y, Nagasawa M, Fernandez A, Sakaguchi K, Kitaguchi T, Kojima I (2016) Positive allosteric modulation of the calcium-sensing receptor by physiological concentrations of glucose. J Biol Chem 291(44):23126\u201323135","journal-title":"J Biol Chem"},{"key":"2237_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005106","volume":"4","author":"Y Nakagawa","year":"2009","unstructured":"Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I (2009) Sweet taste receptor expressed in pancreatic beta-cells activate the calcium and cyclic AMP signaling systems and stimulate insulin secretion. PLoS One 4:e5106","journal-title":"PLoS One"},{"key":"2237_CR25","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1507\/endocrj.EJ13-0282","volume":"60","author":"Y Nakagawa","year":"2013","unstructured":"Nakagawa Y, Nagasawa M, Mogani H, Lohse M, Ninomiya Y, Kojima I (2013a) Multimodel function of the sweet taste receptor expressed in pancreatic \u03b2-cells: generation of diverse patterns of intracellular signals by sweet agonists. Endocr J 60:1191\u20131206","journal-title":"Endocr J"},{"key":"2237_CR26","first-page":"1507","volume":"10","author":"Y Nakagawa","year":"2013","unstructured":"Nakagawa Y, Ohtsu Y, Nagasawa M, Shibata H, Kojima I (2013b) Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor TIR3. Endocr J 10:1507","journal-title":"Endocr J"},{"issue":"12","key":"2237_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144053","volume":"10","author":"Y Nakagawa","year":"2015","unstructured":"Nakagawa Y, Nagasawa M, Medina J, Kojima I (2015) Glucose evokes rapid Ca2+ and cyclic AMP signals by activating the cell-surface glucose-sensing receptor in pancreatic \u03b2-cells. PLoS One 10(12):e0144053","journal-title":"PLoS One"},{"issue":"3","key":"2237_CR28","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0092-8674(01)00451-2","volume":"106","author":"G Nelson","year":"2001","unstructured":"Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJP, Zuker CS (2001) Mammalian sweet taste receptors. Cell 106(3):381\u2013390","journal-title":"Cell"},{"key":"2237_CR29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00279137","volume":"31","author":"A Niki","year":"1988","unstructured":"Niki A, Niki H, Niki I, Kunoh Y (1988) Insulin release by glucose anomers in a rat model of non-insulin-dependent diabetes. Diabetologia 31:65\u201367","journal-title":"Diabetologia"},{"issue":"supl","key":"2237_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1679\/aohc.52.Suppl_33","volume":"52","author":"A Niki","year":"1989","unstructured":"Niki A, Niki H, Hashioka T (1989) Receptors of paraneurons, with special reference to glucoreceptors. Arch Histol Cytol 52(supl):33\u201338","journal-title":"Arch Histol Cytol"},{"key":"2237_CR31","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s00424-007-0247-x","volume":"454","author":"SD Roper","year":"2007","unstructured":"Roper SD (2007) Signal transduction and information processing in mammalian taste buds. Pflugers Arch 454:759\u2013776","journal-title":"Pflugers Arch"},{"key":"2237_CR32","first-page":"119","volume":"5","author":"A Rovira","year":"1987","unstructured":"Rovira A, Garrotte FJ, Valverde I, Malaisse WJ (1987) Anomeric specificity of glucose-induced insulin release in normal and diabetic subjects. Diab Res 5:119\u2013124","journal-title":"Diab Res"},{"key":"2237_CR33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0014-5793(88)80719-1","volume":"231","author":"JV Sanchez-Andres","year":"1988","unstructured":"Sanchez-Andres JV, Ripoll C, Soria B (1988) Evidence that muscarinic potentiation of insulin release is initiated by an early transient calcium entry. FEBS Lett 231:143\u2013147","journal-title":"FEBS Lett"},{"key":"2237_CR34","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/288187a0","volume":"288","author":"A Sener","year":"1980","unstructured":"Sener A, Malaisse WJ (1980) L-leucine and a nonmetabolized analogue activate glutamate dehydrogenase. Nature 288:187\u2013189","journal-title":"Nature"},{"key":"2237_CR35","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S1043-4526(07)53006-8","volume":"53","author":"P Temussi","year":"2007","unstructured":"Temussi P (2007) The sweet taste receptor: a single receptor with multiple sites and modes of interaction. Adv Food Nutr Res 53:199\u2013239","journal-title":"Adv Food Nutr Res"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-018-2237-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-018-2237-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-018-2237-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T07:38:06Z","timestamp":1662622686000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-018-2237-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,14]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["2237"],"URL":"https:\/\/doi.org\/10.1007\/s00424-018-2237-6","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"type":"print","value":"0031-6768"},{"type":"electronic","value":"1432-2013"}],"subject":[],"published":{"date-parts":[[2018,12,14]]},"assertion":[{"value":"26 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}