{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:32:22Z","timestamp":1790645542400,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A4A1023822"],"award-info":[{"award-number":["2018R1A4A1023822"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00424-019-02289-w","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T21:03:21Z","timestamp":1561064601000},"page":"1045-1053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["TRPC1 as a negative regulator for TRPC4 and TRPC5 channels"],"prefix":"10.1007","volume":"471","author":[{"given":"Jinsung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyeon","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongyun","family":"Myeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misun","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chansik","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2294-2050","authenticated-orcid":false,"given":"Insuk","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"2289_CR1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ceca.2008.03.001","volume":"44","author":"S Alicia","year":"2008","unstructured":"Alicia S, Angelica Z, Carlos S, Alfonso S, Vaca L (2008) STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts. Cell Calcium 44:479\u2013491. \n                    https:\/\/doi.org\/10.1016\/j.ceca.2008.03.001","journal-title":"Cell Calcium"},{"key":"2289_CR2","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1113\/JP271143","volume":"594","author":"IS Ambudkar","year":"2016","unstructured":"Ambudkar IS (2016) Calcium signalling in salivary gland physiology and dysfunction. J Physiol 594:2813\u20132824. \n                    https:\/\/doi.org\/10.1113\/JP271143","journal-title":"J Physiol"},{"key":"2289_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ceca.2016.12.009","volume":"63","author":"IS Ambudkar","year":"2017","unstructured":"Ambudkar IS, de Souza LB, Ong HL (2017) TRPC1, Orai1, and STIM1 in SOCE: friends in tight spaces. Cell Calcium 63:33\u201339. \n                    https:\/\/doi.org\/10.1016\/j.ceca.2016.12.009","journal-title":"Cell Calcium"},{"key":"2289_CR4","doi-asserted-by":"publisher","unstructured":"Avila-Medina J, Calderon-Sanchez E, Gonzalez-Rodriguez P, Monje-Quiroga F, Rosado JA, Castellano A, Ordonez A, Smani T (2016) Orai1 and TRPC1 proteins co-localize with CaV1.2 channels to form a signal complex in vascular smooth muscle cells. J Biol Chem 291:21148\u201321159. \n                    https:\/\/doi.org\/10.1074\/jbc.M116.742171","DOI":"10.1074\/jbc.M116.742171"},{"key":"2289_CR5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.pharmthera.2011.03.005","volume":"130","author":"KH Banner","year":"2011","unstructured":"Banner KH, Igney F, Poll C (2011) TRP channels: emerging targets for respiratory disease. Pharmacol Ther 130:371\u2013384. \n                    https:\/\/doi.org\/10.1016\/j.pharmthera.2011.03.005","journal-title":"Pharmacol Ther"},{"key":"2289_CR6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1113\/jphysiol.2004.068734","volume":"559","author":"DJ Beech","year":"2004","unstructured":"Beech DJ, Muraki K, Flemming R (2004) Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol 559:685\u2013706. \n                    https:\/\/doi.org\/10.1113\/jphysiol.2004.068734","journal-title":"J Physiol"},{"key":"2289_CR7","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/glia.23180","volume":"65","author":"T Belkacemi","year":"2017","unstructured":"Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, Beck A (2017) TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Glia 65:1535\u20131549. \n                    https:\/\/doi.org\/10.1002\/glia.23180","journal-title":"Glia"},{"key":"2289_CR8","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.15252\/embj.201696369","volume":"36","author":"J Broker-Lai","year":"2017","unstructured":"Broker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weissgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Kohr G, Fakler B, Flockerzi V, Bruns D, Freichel M (2017) Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J 36:2770\u20132789. \n                    https:\/\/doi.org\/10.15252\/embj.201696369","journal-title":"EMBO J"},{"issue":"Pt 1","key":"2289_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1469-7793.1998.015bi.x","volume":"511","author":"C Dart","year":"1998","unstructured":"Dart C, Leyland ML, Barrett-Jolley R, Shelton PA, Spencer PJ, Conley EC, Sutcliffe MJ, Stanfield PR (1998) The dependence of Ag+ block of a potassium channel, murine kir2.1, on a cysteine residue in the selectivity filter. J Physiol 511(Pt 1):15\u201324","journal-title":"J Physiol"},{"key":"2289_CR10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0896-6273(02)00641-4","volume":"34","author":"P Delmas","year":"2002","unstructured":"Delmas P, Wanaverbecq N, Abogadie FC, Mistry M, Brown DA (2002) Signaling microdomains define the specificity of receptor-mediated InsP3 pathways in neurons. Neuron 34:209\u2013220","journal-title":"Neuron"},{"key":"2289_CR11","doi-asserted-by":"publisher","first-page":"939","DOI":"10.3390\/cells3040939","volume":"3","author":"A Dietrich","year":"2014","unstructured":"Dietrich A, Fahlbusch M, Gudermann T (2014) Classical transient receptor potential 1 (TRPC1): channel or channel regulator? Cells 3:939\u2013962. \n                    https:\/\/doi.org\/10.3390\/cells3040939","journal-title":"Cells"},{"key":"2289_CR12","doi-asserted-by":"publisher","first-page":"3102","DOI":"10.1038\/s41467-018-05247-9","volume":"9","author":"J Duan","year":"2018","unstructured":"Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J (2018) Structure of the mouse TRPC4 ion channel. Nat Commun 9:3102. \n                    https:\/\/doi.org\/10.1038\/s41467-018-05247-9","journal-title":"Nat Commun"},{"key":"2289_CR13","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1113\/jphysiol.2011.209783","volume":"589","author":"L El-Hassar","year":"2011","unstructured":"El-Hassar L, Hagenston AM, D'Angelo LB, Yeckel MF (2011) Metabotropic glutamate receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca2+ wave-dependent activation of SK and TRPC channels. J Physiol 589:3211\u20133229. \n                    https:\/\/doi.org\/10.1113\/jphysiol.2011.209783","journal-title":"J Physiol"},{"key":"2289_CR14","doi-asserted-by":"publisher","first-page":"7461","DOI":"10.1073\/pnas.102596199","volume":"99","author":"T Hofmann","year":"2002","unstructured":"Hofmann T, Schaefer M, Schultz G, Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A 99:7461\u20137466. \n                    https:\/\/doi.org\/10.1073\/pnas.102596199","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2289_CR15","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00424-014-1540-0","volume":"467","author":"C Hong","year":"2015","unstructured":"Hong C, Kwak M, Myeong J, Ha K, Wie J, Jeon JH, So I (2015) Extracellular disulfide bridges stabilize TRPC5 dimerization, trafficking, and activity. Pflugers Arch 467:703\u2013712. \n                    https:\/\/doi.org\/10.1007\/s00424-014-1540-0","journal-title":"Pflugers Arch"},{"key":"2289_CR16","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1093\/brain\/awv188","volume":"138","author":"C Hong","year":"2015","unstructured":"Hong C, Seo H, Kwak M, Jeon J, Jang J, Jeong EM, Myeong J, Hwang YJ, Ha K, Kang MJ, Lee KP, Yi EC, Kim IG, Jeon JH, Ryu H, So I (2015) Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease. Brain 138:3030\u20133047. \n                    https:\/\/doi.org\/10.1093\/brain\/awv188","journal-title":"Brain"},{"key":"2289_CR17","doi-asserted-by":"publisher","first-page":"C1173","DOI":"10.1152\/ajpcell.1990.258.6.C1173","volume":"258","author":"R Inoue","year":"1990","unstructured":"Inoue R, Isenberg G (1990) Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein. Am J Phys 258:C1173\u2013C1178. \n                    https:\/\/doi.org\/10.1152\/ajpcell.1990.258.6.C1173","journal-title":"Am J Phys"},{"key":"2289_CR18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ceca.2013.07.006","volume":"54","author":"JP Jeon","year":"2013","unstructured":"Jeon JP, Roh SE, Wie J, Kim J, Kim H, Lee KP, Yang D, Jeon JH, Cho NH, Kim IG, Kang DE, Kim HJ, So I (2013) Activation of TRPC4\u03b2 by G\u03b1i subunit increases Ca2+ selectivity and controls neurite morphogenesis in cultured hippocampal neuron. Cell Calcium 54:307\u2013319. \n                    https:\/\/doi.org\/10.1016\/j.ceca.2013.07.006","journal-title":"Cell Calcium"},{"key":"2289_CR19","doi-asserted-by":"publisher","first-page":"e0191225","DOI":"10.1371\/journal.pone.0191225","volume":"13","author":"S Just","year":"2018","unstructured":"Just S, Chenard BL, Ceci A, Strassmaier T, Chong JA, Blair NT, Gallaschun RJ, Del Camino D, Cantin S, D'Amours M, Eickmeier C, Fanger CM, Hecker C, Hessler DP, Hengerer B, Kroker KS, Malekiani S, Mihalek R, McLaughlin J, Rast G, Witek J, Sauer A, Pryce CR, Moran MM (2018) Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One 13:e0191225. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0191225","journal-title":"PLoS One"},{"key":"2289_CR20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.4161\/chan.21198","volume":"6","author":"H Kim","year":"2012","unstructured":"Kim H, Kim J, Jeon JP, Myeong J, Wie J, Hong C, Kim HJ, Jeon JH, So I (2012) The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels. Channels (Austin) 6:333\u2013343. \n                    https:\/\/doi.org\/10.4161\/chan.21198","journal-title":"Channels (Austin)"},{"key":"2289_CR21","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00424-013-1332-y","volume":"466","author":"J Kim","year":"2014","unstructured":"Kim J, Kwak M, Jeon JP, Myeong J, Wie J, Hong C, Kim SY, Jeon JH, Kim HJ, So I (2014) Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1\/4 channels. Pflugers Arch 466:491\u2013504. \n                    https:\/\/doi.org\/10.1007\/s00424-013-1332-y","journal-title":"Pflugers Arch"},{"key":"2289_CR22","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4196\/kjpp.2017.21.1.133","volume":"21","author":"J Ko","year":"2017","unstructured":"Ko J, Myeong J, Yang D, So I (2017) Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s. Korean J Physiol Pharmacol 21:133\u2013140. \n                    https:\/\/doi.org\/10.4196\/kjpp.2017.21.1.133","journal-title":"Korean J Physiol Pharmacol"},{"key":"2289_CR23","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1038\/s41598-018-38443-0","volume":"9","author":"J Ko","year":"2019","unstructured":"Ko J, Myeong J, Shin YC, So I (2019) Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1\/4, C1\/5 heteromeric channels. Sci Rep 9:1849. \n                    https:\/\/doi.org\/10.1038\/s41598-018-38443-0","journal-title":"Sci Rep"},{"key":"2289_CR24","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3389\/fncel.2018.00318","volume":"12","author":"S Lepannetier","year":"2018","unstructured":"Lepannetier S, Gualdani R, Tempesta S, Schakman O, Seghers F, Kreis A, Yerna X, Slimi A, de Clippele M, Tajeddine N, Voets T, Bon RS, Beech DJ, Tissir F, Gailly P (2018) Activation of TRPC1 channel by metabotropic glutamate receptor mGluR5 modulates synaptic plasticity and spatial working memory. Front Cell Neurosci 12:318. \n                    https:\/\/doi.org\/10.3389\/fncel.2018.00318","journal-title":"Front Cell Neurosci"},{"key":"2289_CR25","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.1074\/jbc.275.5.3403","volume":"275","author":"X Liu","year":"2000","unstructured":"Liu X, Wang W, Singh BB, Lockwich T, Jadlowiec J, O'Connell B, Wellner R, Zhu MX, Ambudkar IS (2000) Trp1, a candidate protein for the store-operated Ca2+ influx mechanism in salivary gland cells. J Biol Chem 275:3403\u20133411","journal-title":"J Biol Chem"},{"key":"2289_CR26","doi-asserted-by":"publisher","unstructured":"Ludlow MJ, Gaunt HJ, Rubaiy HN, Musialowski KE, Blythe NM, Vasudev NS, Muraki K, Beech DJ (2017) Englerin A-evoked cytotoxicity is mediated by Na+ influx and counteracted by Na+\/K+-ATPase. J Biol Chem 292:723\u2013731. \n                    https:\/\/doi.org\/10.1074\/jbc.M116.755678","DOI":"10.1074\/jbc.M116.755678"},{"key":"2289_CR27","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1164\/rccm.201307-1252OC","volume":"188","author":"M Malczyk","year":"2013","unstructured":"Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ahlbrecht K, Fecher-Trost C, Flockerzi V, Ghofrani HA, Grimminger F, Seeger W, Gudermann T, Dietrich A, Weissmann N (2013) Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med 188:1451\u20131459. \n                    https:\/\/doi.org\/10.1164\/rccm.201307-1252OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2289_CR28","doi-asserted-by":"publisher","unstructured":"Minard A, Bauer CC, Wright DJ, Rubaiy HN, Muraki K, Beech DJ, Bon RS (2018) Remarkable progress with small-molecule modulation of TRPC1\/4\/5 channels: implications for understanding the channels in health and disease. Cells 7. \n                    https:\/\/doi.org\/10.3390\/cells7060052","DOI":"10.3390\/cells7060052"},{"key":"2289_CR29","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1038\/s41598-018-21064-y","volume":"8","author":"J Morand","year":"2018","unstructured":"Morand J, Arnaud C, Pepin JL, Godin-Ribuot D (2018) Chronic intermittent hypoxia promotes myocardial ischemia-related ventricular arrhythmias and sudden cardiac death. Sci Rep 8:2997. \n                    https:\/\/doi.org\/10.1038\/s41598-018-21064-y","journal-title":"Sci Rep"},{"key":"2289_CR30","doi-asserted-by":"publisher","first-page":"16988","DOI":"10.1038\/s41598-017-17303-3","volume":"7","author":"K Muraki","year":"2017","unstructured":"Muraki K, Ohnishi K, Takezawa A, Suzuki H, Hatano N, Muraki Y, Hamzah N, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Beech DJ (2017) Na+ entry through heteromeric TRPC4\/C1 channels mediates (\u2212)Englerin A-induced cytotoxicity in synovial sarcoma cells. Sci Rep 7:16988. \n                    https:\/\/doi.org\/10.1038\/s41598-017-17303-3","journal-title":"Sci Rep"},{"key":"2289_CR31","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.bbrc.2016.04.138","volume":"474","author":"J Myeong","year":"2016","unstructured":"Myeong J, Ko J, Hong C, Yang D, Lee KP, Jeon JH, So I (2016) The interaction domains of transient receptor potential canonical (TRPC)1\/4 and TRPC1\/5 heteromultimeric channels. Biochem Biophys Res Commun 474:476\u2013481. \n                    https:\/\/doi.org\/10.1016\/j.bbrc.2016.04.138","journal-title":"Biochem Biophys Res Commun"},{"key":"2289_CR32","doi-asserted-by":"publisher","first-page":"12117","DOI":"10.1038\/s41598-018-30625-0","volume":"8","author":"J Myeong","year":"2018","unstructured":"Myeong J, Ko J, Kwak M, Kim J, Woo J, Ha K, Hong C, Yang D, Kim HJ, Jeon JH, So I (2018) Dual action of the G\u03b1q-PLC\u03b2-PI(4,5)P2 pathway on TRPC1\/4 and TRPC1\/5 heterotetramers. Sci Rep 8:12117. \n                    https:\/\/doi.org\/10.1038\/s41598-018-30625-0","journal-title":"Sci Rep"},{"key":"2289_CR33","doi-asserted-by":"publisher","unstructured":"Otsuguro K, Tang J, Tang Y, Xiao R, Freichel M, Tsvilovskyy V, Ito S, Flockerzi V, Zhu MX, Zholos AV (2008) Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem 283:10026\u201310036. \n                    https:\/\/doi.org\/10.1074\/jbc.M707306200","DOI":"10.1074\/jbc.M707306200"},{"key":"2289_CR34","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1124\/mol.111.075341","volume":"81","author":"KD Phelan","year":"2012","unstructured":"Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A, Birnbaumer L, Freichel M, Flockerzi V, Zheng F (2012) Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol Pharmacol 81:384\u2013392. \n                    https:\/\/doi.org\/10.1124\/mol.111.075341","journal-title":"Mol Pharmacol"},{"key":"2289_CR35","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1124\/mol.112.082271","volume":"83","author":"KD Phelan","year":"2013","unstructured":"Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F (2013) Canonical transient receptor channel 5 (TRPC5) and TRPC1\/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol 83:429\u2013438. \n                    https:\/\/doi.org\/10.1124\/mol.112.082271","journal-title":"Mol Pharmacol"},{"key":"2289_CR36","doi-asserted-by":"publisher","first-page":"6166","DOI":"10.1002\/j.1460-2075.1996.tb01004.x","volume":"15","author":"S Philipp","year":"1996","unstructured":"Philipp S, Cavalie A, Freichel M, Wissenbach U, Zimmer S, Trost C, Marquart A, Murakami M, Flockerzi V (1996) A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. EMBO J 15:6166\u20136171","journal-title":"EMBO J"},{"key":"2289_CR37","doi-asserted-by":"publisher","first-page":"G782","DOI":"10.1152\/ajpgi.00441.2005","volume":"290","author":"JN Rao","year":"2006","unstructured":"Rao JN, Platoshyn O, Golovina VA, Liu L, Zou T, Marasa BS, Turner DJ, Yuan JX, Wang JY (2006) TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding. Am J Physiol Gastrointest Liver Physiol 290:G782\u2013G792. \n                    https:\/\/doi.org\/10.1152\/ajpgi.00441.2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2289_CR38","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.cell.2009.03.039","volume":"137","author":"A Riccio","year":"2009","unstructured":"Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA Jr, Bolshakov VY, Clapham DE (2009) Essential role for TRPC5 in amygdala function and fear-related behavior. Cell 137:761\u2013772. \n                    https:\/\/doi.org\/10.1016\/j.cell.2009.03.039","journal-title":"Cell"},{"key":"2289_CR39","doi-asserted-by":"publisher","first-page":"3653","DOI":"10.1523\/JNEUROSCI.2274-13.2014","volume":"34","author":"A Riccio","year":"2014","unstructured":"Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE (2014) Decreased anxiety-like behavior and G\u03b1q\/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci 34:3653\u20133667. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.2274-13.2014","journal-title":"J Neurosci"},{"key":"2289_CR40","doi-asserted-by":"publisher","unstructured":"Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ (2017) Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1\/4\/5 channels. J Biol Chem 292:8158\u20138173. \n                    https:\/\/doi.org\/10.1074\/jbc.M116.773556","DOI":"10.1074\/jbc.M116.773556"},{"key":"2289_CR41","doi-asserted-by":"publisher","unstructured":"Sabourin J, Bartoli F, Antigny F, Gomez AM, Benitah JP (2016) Transient receptor potential canonical (TRPC)\/Orai1-dependent store-operated Ca2+ channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES. J Biol Chem 291:13394\u201313409. \n                    https:\/\/doi.org\/10.1074\/jbc.M115.693911","DOI":"10.1074\/jbc.M115.693911"},{"key":"2289_CR42","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.yjmcc.2018.04.003","volume":"118","author":"J Sabourin","year":"2018","unstructured":"Sabourin J, Boet A, Rucker-Martin C, Lambert M, Gomez AM, Benitah JP, Perros F, Humbert M, Antigny F (2018) Ca2+ handling remodeling and STIM1L\/Orai1\/TRPC1\/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy. J Mol Cell Cardiol 118:208\u2013224. \n                    https:\/\/doi.org\/10.1016\/j.yjmcc.2018.04.003","journal-title":"J Mol Cell Cardiol"},{"key":"2289_CR43","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1113\/jphysiol.2007.133165","volume":"582","author":"T Sakamoto","year":"2007","unstructured":"Sakamoto T, Unno T, Kitazawa T, Taneike T, Yamada M, Wess J, Nishimura M, Komori S (2007) Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells. J Physiol 582:41\u201361. \n                    https:\/\/doi.org\/10.1113\/jphysiol.2007.133165","journal-title":"J Physiol"},{"key":"2289_CR44","doi-asserted-by":"publisher","first-page":"17517","DOI":"10.1074\/jbc.275.23.17517","volume":"275","author":"M Schaefer","year":"2000","unstructured":"Schaefer M, Plant TD, Obukhov AG, Hofmann T, Gudermann T, Schultz G (2000) Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 275:17517\u201317526","journal-title":"J Biol Chem"},{"key":"2289_CR45","doi-asserted-by":"publisher","unstructured":"Schaefer M, Plant TD, Stresow N, Albrecht N, Schultz G (2002) Functional differences between TRPC4 splice variants. J Biol Chem 277:3752\u20133759. \n                    https:\/\/doi.org\/10.1074\/jbc.M109850200","DOI":"10.1074\/jbc.M109850200"},{"key":"2289_CR46","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1172\/JCI61332","volume":"122","author":"S Selvaraj","year":"2012","unstructured":"Selvaraj S, Sun Y, Watt JA, Wang S, Lei S, Birnbaumer L, Singh BB (2012) Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT\/mTOR signaling. J Clin Invest 122:1354\u20131367. \n                    https:\/\/doi.org\/10.1172\/JCI61332","journal-title":"J Clin Invest"},{"issue":"Pt 1","key":"2289_CR47","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1042\/bj3310331","volume":"331","author":"WG Sinkins","year":"1998","unstructured":"Sinkins WG, Estacion M, Schilling WP (1998) Functional expression of TrpC1: a human homologue of the Drosophila Trp channel. Biochem J 331(Pt 1):331\u2013339","journal-title":"Biochem J"},{"key":"2289_CR48","first-page":"267","volume":"7","author":"I So","year":"2003","unstructured":"So I, Ashmole I, Stanfield PR (2003) The substates with mutants that negatively charged aspartate in position 172 was replaced with positive charge in murine inward rectifier potassium channel (murine Kir2.1). Korean J Phiysiol Pharmacol 7:267\u2013273","journal-title":"Korean J Phiysiol Pharmacol"},{"key":"2289_CR49","doi-asserted-by":"publisher","first-page":"F1507","DOI":"10.1152\/ajprenal.00268.2005","volume":"290","author":"S Sours","year":"2006","unstructured":"Sours S, Du J, Chu S, Ding M, Zhou XJ, Ma R (2006) Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. Am J Physiol Renal Physiol 290:F1507\u2013F1515. \n                    https:\/\/doi.org\/10.1152\/ajprenal.00268.2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"2289_CR50","doi-asserted-by":"publisher","unstructured":"Storch U, Forst AL, Philipp M, Gudermann T, Mederos y Schnitzler M (2012) Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. J Biol Chem 287:3530\u20133540. \n                    https:\/\/doi.org\/10.1074\/jbc.M111.283218","DOI":"10.1074\/jbc.M111.283218"},{"key":"2289_CR51","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0896-6273(01)00240-9","volume":"29","author":"C Strubing","year":"2001","unstructured":"Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645\u2013655","journal-title":"Neuron"},{"key":"2289_CR52","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1523\/JNEUROSCI.3010-16.2017","volume":"37","author":"Y Sun","year":"2017","unstructured":"Sun Y, Zhang H, Selvaraj S, Sukumaran P, Lei S, Birnbaumer L, Singh BB (2017) Inhibition of L-type Ca2+ channels by TRPC1-STIM1 complex is essential for the protection of dopaminergic neurons. J Neurosci 37:3364\u20133377. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.3010-16.2017","journal-title":"J Neurosci"},{"key":"2289_CR53","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/j.2047-2927.2014.00214.x","volume":"2","author":"HH Sung","year":"2014","unstructured":"Sung HH, Choo SH, Ko M, Kang SJ, Chae MR, Kam SC, Han DH, So I, Lee SW (2014) Increased expression of TRPC4 channels associated with erectile dysfunction in diabetes. Andrology 2:550\u2013558. \n                    https:\/\/doi.org\/10.1111\/j.2047-2927.2014.00214.x","journal-title":"Andrology"},{"key":"2289_CR54","doi-asserted-by":"publisher","unstructured":"Tian J, Zhu MX (2018) GABAB receptors augment TRPC3-mediated slow excitatory postsynaptic current to regulate cerebellar Purkinje neuron response to type-1 metabotropic glutamate receptor activation. Cells 7. \n                    https:\/\/doi.org\/10.3390\/cells7080090","DOI":"10.3390\/cells7080090"},{"key":"2289_CR55","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1053\/j.gastro.2009.06.046","volume":"137","author":"VV Tsvilovskyy","year":"2009","unstructured":"Tsvilovskyy VV, Zholos AV, Aberle T, Philipp SE, Dietrich A, Zhu MX, Birnbaumer L, Freichel M, Flockerzi V (2009) Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology 137:1415\u20131424. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2009.06.046","journal-title":"Gastroenterology"},{"key":"2289_CR56","doi-asserted-by":"publisher","unstructured":"Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S (2018) Electron cryo-microscopy structure of the canonical TRPC4 ion channel. Elife 7. \n                    https:\/\/doi.org\/10.7554\/eLife.36615","DOI":"10.7554\/eLife.36615"},{"key":"2289_CR57","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41586-018-0081-7","volume":"557","author":"RM Walsh Jr","year":"2018","unstructured":"Walsh RM Jr, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE (2018) Structural principles of distinct assemblies of the human alpha4beta2 nicotinic receptor. Nature 557:261\u2013265. \n                    https:\/\/doi.org\/10.1038\/s41586-018-0081-7","journal-title":"Nature"},{"key":"2289_CR58","doi-asserted-by":"publisher","first-page":"e8166","DOI":"10.1097\/MD.0000000000008166","volume":"96","author":"F Xu","year":"2017","unstructured":"Xu F, Liu XC, Li L, Ma CN, Zhang YJ (2017) Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease. Medicine (Baltimore) 96:e8166. \n                    https:\/\/doi.org\/10.1097\/MD.0000000000008166","journal-title":"Medicine (Baltimore)"},{"key":"2289_CR59","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0092-8674(03)00716-5","volume":"114","author":"JP Yuan","year":"2003","unstructured":"Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114:777\u2013789","journal-title":"Cell"},{"key":"2289_CR60","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/cells3020288","volume":"3","author":"F Zheng","year":"2014","unstructured":"Zheng F, Phelan KD (2014) The role of canonical transient receptor potential channels in seizure and excitotoxicity. Cells 3:288\u2013303. \n                    https:\/\/doi.org\/10.3390\/cells3020288","journal-title":"Cells"},{"key":"2289_CR61","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/sj.bjp.0701438","volume":"122","author":"AV Zholos","year":"1997","unstructured":"Zholos AV, Bolton TB (1997) Muscarinic receptor subtypes controlling the cationic current in guinea-pig ileal smooth muscle. Br J Pharmacol 122:885\u2013893. \n                    https:\/\/doi.org\/10.1038\/sj.bjp.0701438","journal-title":"Br J Pharmacol"},{"key":"2289_CR62","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/S0896-6273(00)80145-2","volume":"16","author":"C Zitt","year":"1996","unstructured":"Zitt C, Zobel A, Obukhov AG, Harteneck C, Kalkbrenner F, Luckhoff A, Schultz G (1996) Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. Neuron 16:1189\u20131196","journal-title":"Neuron"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-019-02289-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-019-02289-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-019-02289-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T23:12:02Z","timestamp":1592521922000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-019-02289-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["2289"],"URL":"https:\/\/doi.org\/10.1007\/s00424-019-02289-w","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]},"assertion":[{"value":"28 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}