{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:05:39Z","timestamp":1774645539723,"version":"3.50.1"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00424-019-02291-2","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T22:13:35Z","timestamp":1561414415000},"page":"1079-1094","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats"],"prefix":"10.1007","volume":"471","author":[{"given":"Anders","family":"Nordholm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Egstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Gravesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Mace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marya","family":"Morevati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Olgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,24]]},"reference":[{"key":"2291_CR1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.kint.2016.02.002","volume":"89","author":"OA Agapova","year":"2016","unstructured":"Agapova OA, Fang Y, Sugatani T, Seifert ME, Hruska KA (2016) Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease. Kidney Int 89:1231\u20131243. \n                    https:\/\/doi.org\/10.1016\/j.kint.2016.02.002","journal-title":"Kidney Int"},{"key":"2291_CR2","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1007\/s00198-012-2198-0","volume":"24","author":"AD Anastasilakis","year":"2013","unstructured":"Anastasilakis AD, Polyzos SA, Makras P, Gkiomisi A, Savvides M, Papatheodorou A, Terpos E (2013) Circulating activin-a is elevated in postmenopausal women with low bone mass: the three-month effect of zoledronic acid treatment. Osteoporos Int 24:2127\u20132132. \n                    https:\/\/doi.org\/10.1007\/s00198-012-2198-0","journal-title":"Osteoporos Int"},{"key":"2291_CR3","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1002\/jbmr.2527","volume":"30","author":"O Andrukhova","year":"2015","unstructured":"Andrukhova O, Slavic S, Odorfer KI, Erben RG (2015) Experimental myocardial infarction upregulates circulating fibroblast growth factor-23. J Bone Miner Res 30:1831\u20131839. \n                    https:\/\/doi.org\/10.1002\/jbmr.2527","journal-title":"J Bone Miner Res"},{"key":"2291_CR4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/ndt\/gfu291","volume":"30","author":"SL Barker","year":"2015","unstructured":"Barker SL, Pastor J, Carranza D, Quinones H, Griffith C, Goetz R, Mohammadi M, Ye J, Zhang J, Hu MC, Kuro-o M, Moe OW, Sidhu SS (2015) The demonstration of alphaKlotho deficiency in human chronic kidney disease with a novel synthetic antibody. Nephrol Dial Transplant 30:223\u2013233. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfu291","journal-title":"Nephrol Dial Transplant"},{"key":"2291_CR5","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1093\/ndt\/gfp220","volume":"24","author":"GJ Becker","year":"2009","unstructured":"Becker GJ, Walker RG, Hewitson TD, Pedagogos E (2009) Phosphate levels--time for a rethink? Nephrol Dial Transplant 24:2321\u20132324. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfp220","journal-title":"Nephrol Dial Transplant"},{"key":"2291_CR6","doi-asserted-by":"publisher","first-page":"11085","DOI":"10.1073\/pnas.0704446104","volume":"104","author":"T Berndt","year":"2007","unstructured":"Berndt T, Thomas LF, Craig TA, Sommer S, Li X, Bergstralh EJ, Kumar R (2007) Evidence for a signaling axis by which intestinal phosphate rapidly modulates renal phosphate reabsorption. Proc Natl Acad Sci U S A 104:11085\u201311090. \n                    https:\/\/doi.org\/10.1073\/pnas.0704446104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2291_CR7","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1152\/physrev.00002.2018","volume":"99","author":"E Bloise","year":"2019","unstructured":"Bloise E, Ciarmela P, Dela Cruz C, Luisi S, Petraglia F, Reis FM (2019) Activin a in mammalian physiology. Physiol Rev 99:739\u2013780. \n                    https:\/\/doi.org\/10.1152\/physrev.00002.2018","journal-title":"Physiol Rev"},{"key":"2291_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.molmet.2018.02.007","volume":"11","author":"N Bon","year":"2018","unstructured":"Bon N, Frangi G, Sourice S, Guicheux J, Beck-Cormier S, Beck L (2018) Phosphate-dependent FGF23 secretion is modulated by PiT2\/Slc20a2. Mol Metab 11:197\u2013204. \n                    https:\/\/doi.org\/10.1016\/j.molmet.2018.02.007","journal-title":"Mol Metab"},{"key":"2291_CR9","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/s41574-018-0076-3","volume":"14","author":"S Chande","year":"2018","unstructured":"Chande S, Bergwitz C (2018) Role of phosphate sensing in bone and mineral metabolism. Nat Rev Endocrinol 14:637\u2013655. \n                    https:\/\/doi.org\/10.1038\/s41574-018-0076-3","journal-title":"Nat Rev Endocrinol"},{"key":"2291_CR10","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1016\/j.ajpath.2015.08.003","volume":"185","author":"WD Chen","year":"2015","unstructured":"Chen WD, Yeh JK, Peng MT, Shie SS, Lin SL, Yang CH, Chen TH, Hung KC, Wang CC, Hsieh IC, Wen MS, Wang CY (2015) Circadian CLOCK mediates activation of transforming growth factor-beta signaling and renal fibrosis through cyclooxygenase 2. Am J Pathol 185:3152\u20133163. \n                    https:\/\/doi.org\/10.1016\/j.ajpath.2015.08.003","journal-title":"Am J Pathol"},{"key":"2291_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1742-4682-11-16","volume":"11","author":"G Cornelissen","year":"2014","unstructured":"Cornelissen G (2014) Cosinor-based rhythmometry. Theor Biol Med Model 11:16. \n                    https:\/\/doi.org\/10.1186\/1742-4682-11-16","journal-title":"Theor Biol Med Model"},{"key":"2291_CR12","doi-asserted-by":"publisher","first-page":"319","DOI":"10.2147\/DMSO.S13476","volume":"3","author":"J Ditzel","year":"2010","unstructured":"Ditzel J, Lervang HH (2010) Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis. Diabetes Metab Syndr Obes 3:319\u2013324. \n                    https:\/\/doi.org\/10.2147\/DMSOTT.S13476","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2291_CR13","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.2215\/CJN.00810110","volume":"5","author":"H Eddington","year":"2010","unstructured":"Eddington H, Hoefield R, Sinha S, Chrysochou C, Lane B, Foley RN, Hegarty J, New J, O\u2019Donoghue DJ, Middleton RJ, Kalra PA (2010) Serum phosphate and mortality in patients with chronic kidney disease. Clin J Am Soc Nephrol 5:2251\u20132257. \n                    https:\/\/doi.org\/10.2215\/CJN.00810110","journal-title":"Clin J Am Soc Nephrol"},{"key":"2291_CR14","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1172\/JCI46122","volume":"121","author":"C Faul","year":"2011","unstructured":"Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutierrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John SM, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-o M, Kusek JW, Keane MG, Wolf M (2011) FGF23 induces left ventricular hypertrophy. J Clin Invest 121:4393\u20134408. \n                    https:\/\/doi.org\/10.1172\/JCI46122","journal-title":"J Clin Invest"},{"key":"2291_CR15","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1046\/j.1523-1755.2000.00259.x","volume":"58","author":"AJ Felsenfeld","year":"2000","unstructured":"Felsenfeld AJ, Jara A, Avedian G, Kleeman CR (2000) Effects of fasting, feeding, and bisphosphonate administration on serum calcitriol levels in phosphate-deprived rats. Kidney Int 58:1016\u20131022. \n                    https:\/\/doi.org\/10.1046\/j.1523-1755.2000.00259.x","journal-title":"Kidney Int"},{"key":"2291_CR16","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.2215\/CJN.01660309","volume":"4","author":"RN Foley","year":"2009","unstructured":"Foley RN (2009) Phosphate levels and cardiovascular disease in the general population. Clin J Am Soc Nephrol 4:1136\u20131139. \n                    https:\/\/doi.org\/10.2215\/CJN.01660309","journal-title":"Clin J Am Soc Nephrol"},{"key":"2291_CR17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF02672507","volume":"8","author":"WD Fraser","year":"1998","unstructured":"Fraser WD, Logue FC, Christie JP, Gallacher SJ, Cameron D, O\u2019Reilly DS, Beastall GH, Boyle IT (1998) Alteration of the circadian rhythm of intact parathyroid hormone and serum phosphate in women with established postmenopausal osteoporosis. Osteoporos Int 8:121\u2013126. \n                    https:\/\/doi.org\/10.1007\/BF02672507","journal-title":"Osteoporos Int"},{"key":"2291_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nut.2017.09.007","volume":"47","author":"N Friedli","year":"2018","unstructured":"Friedli N, Stanga Z, Culkin A, Crook M, Laviano A, Sobotka L, Kressig RW, Kondrup J, Mueller B, Schuetz P (2018) Management and prevention of refeeding syndrome in medical inpatients: an evidence-based and consensus-supported algorithm. Nutrition 47:13\u201320. \n                    https:\/\/doi.org\/10.1016\/j.nut.2017.09.007","journal-title":"Nutrition"},{"key":"2291_CR19","doi-asserted-by":"publisher","unstructured":"Geng Y, Mosyak L, Kurinov I, Zuo H, Sturchler E, Cheng TC, Subramanyam P, Brown AP, Brennan SC, Mun HC, Bush M, Chen Y, Nguyen TX, Cao B, Chang DD, Quick M, Conigrave AD, Colecraft HM, McDonald P, Fan QR (2016) Structural mechanism of ligand activation in human calcium-sensing receptor. Elife 5. \n                    https:\/\/doi.org\/10.7554\/eLife.13662","DOI":"10.7554\/eLife.13662"},{"key":"2291_CR20","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/1471-2369-14-281","volume":"14","author":"E Gravesen","year":"2013","unstructured":"Gravesen E, Hofman-Bang J, Mace ML, Lewin E, Olgaard K (2013) High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats. BMC Nephrol 14:281. \n                    https:\/\/doi.org\/10.1186\/1471-2369-14-281","journal-title":"BMC Nephrol"},{"key":"2291_CR21","doi-asserted-by":"publisher","first-page":"e0190820","DOI":"10.1371\/journal.pone.0190820","volume":"13","author":"E Gravesen","year":"2018","unstructured":"Gravesen E, Lerche Mace M, Nordholm A, Hofman-Bang J, Hruska K, Haagen Nielsen C, Kjaer A, Olgaard K, Lewin E (2018) Exogenous BMP7 in aortae of rats with chronic uremia ameliorates expression of profibrotic genes, but does not reverse established vascular calcification. PLoS One 13:e0190820. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0190820","journal-title":"PLoS One"},{"key":"2291_CR22","doi-asserted-by":"publisher","first-page":"e0201936","DOI":"10.1371\/journal.pone.0201936","volume":"13","author":"E Gravesen","year":"2018","unstructured":"Gravesen E, Nordholm A, Mace M, Morevati M, Hogdall E, Nielsen C, Kjaer A, Olgaard K, Lewin E (2018) Effect of inhibition of CBP-coactivated beta-catenin-mediated Wnt signalling in uremic rats with vascular calcifications. PLoS One 13:e0201936. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0201936","journal-title":"PLoS One"},{"key":"2291_CR23","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1210\/jcem.81.6.8964839","volume":"81","author":"K Harada","year":"1996","unstructured":"Harada K, Shintani Y, Sakamoto Y, Wakatsuki M, Shitsukawa K, Saito S (1996) Serum immunoreactive activin a levels in normal subjects and patients with various diseases. J Clin Endocrinol Metab 81:2125\u20132130. \n                    https:\/\/doi.org\/10.1210\/jcem.81.6.8964839","journal-title":"J Clin Endocrinol Metab"},{"key":"2291_CR24","doi-asserted-by":"publisher","unstructured":"Hastings MH, Maywood ES, Brancaccio M (2019) The mammalian circadian timing system and the suprachiasmatic nucleus as its pacemaker. Biology (Basel) 8. \n                    https:\/\/doi.org\/10.3390\/biology8010013","DOI":"10.3390\/biology8010013"},{"key":"2291_CR25","doi-asserted-by":"publisher","first-page":"512","DOI":"10.2486\/indhealth.2018-0018","volume":"56","author":"BM Hittle","year":"2018","unstructured":"Hittle BM, Gillespie GL (2018) Identifying shift worker chronotype: implications for health. Ind Health 56:512\u2013523. \n                    https:\/\/doi.org\/10.2486\/indhealth.2018-0018","journal-title":"Ind Health"},{"key":"2291_CR26","doi-asserted-by":"publisher","unstructured":"Hruska KA, Sugatani T, Agapova O, Fang Y (2017) The chronic kidney disease - mineral bone disorder (CKD-MBD): advances in pathophysiology. Bone. \n                    https:\/\/doi.org\/10.1016\/j.bone.2017.01.023","DOI":"10.1016\/j.bone.2017.01.023"},{"key":"2291_CR27","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1681\/ASN.2009121311","volume":"22","author":"MC Hu","year":"2011","unstructured":"Hu MC, Shi M, Zhang J, Quinones H, Griffith C, Kuro-o M, Moe OW (2011) Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol 22:124\u2013136. \n                    https:\/\/doi.org\/10.1681\/ASN.2009121311","journal-title":"J Am Soc Nephrol"},{"key":"2291_CR28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.semnephrol.2012.12.013","volume":"33","author":"MC Hu","year":"2013","unstructured":"Hu MC, Kuro-o M, Moe OW (2013) Renal and extrarenal actions of klotho. Semin Nephrol 33:118\u2013129. \n                    https:\/\/doi.org\/10.1016\/j.semnephrol.2012.12.013","journal-title":"Semin Nephrol"},{"key":"2291_CR29","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1681\/ASN.2014050465","volume":"26","author":"MC Hu","year":"2015","unstructured":"Hu MC, Shi M, Cho HJ, Adams-Huet B, Paek J, Hill K, Shelton J, Amaral AP, Faul C, Taniguchi M, Wolf M, Brand M, Takahashi M, Kuro-o M, Hill JA, Moe OW (2015) Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol 26:1290\u20131302. \n                    https:\/\/doi.org\/10.1681\/ASN.2014050465","journal-title":"J Am Soc Nephrol"},{"key":"2291_CR30","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1681\/ASN.2005101136","volume":"17","author":"J Huan","year":"2006","unstructured":"Huan J, Olgaard K, Nielsen LB, Lewin E (2006) Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands. J Am Soc Nephrol 17:1923\u20131930. \n                    https:\/\/doi.org\/10.1681\/ASN.2005101136","journal-title":"J Am Soc Nephrol"},{"key":"2291_CR31","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/ki.2011.47","volume":"79","author":"T Isakova","year":"2011","unstructured":"Isakova T, Wahl P, Vargas GS, Gutierrez OM, Scialla J, Xie H, Appleby D, Nessel L, Bellovich K, Chen J, Hamm L, Gadegbeku C, Horwitz E, Townsend RR, Anderson CA, Lash JP, Hsu CY, Leonard MB, Wolf M (2011) Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int 79:1370\u20131378. \n                    https:\/\/doi.org\/10.1038\/ki.2011.47","journal-title":"Kidney Int"},{"key":"2291_CR32","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1172\/JCI107010","volume":"51","author":"W Jubiz","year":"1972","unstructured":"Jubiz W, Canterbury JM, Reiss E, Tyler FH (1972) Circadian rhythm in serum parathyroid hormone concentration in human subjects: correlation with serum calcium, phosphate, albumin, and growth hormone levels. J Clin Invest 51:2040\u20132046. \n                    https:\/\/doi.org\/10.1172\/JCI107010","journal-title":"J Clin Invest"},{"key":"2291_CR33","doi-asserted-by":"publisher","first-page":"F297","DOI":"10.1152\/ajprenal.00191.2016","volume":"312","author":"AT Kadiombo","year":"2017","unstructured":"Kadiombo AT, Maeshima A, Kayakabe K, Ikeuchi H, Sakairi T, Kaneko Y, Hiromura K, Nojima Y (2017) Involvement of infiltrating macrophage-derived activin a in the progression of renal damage in MRL-lpr mice. Am J Physiol Renal Physiol 312:F297\u2013F304. \n                    https:\/\/doi.org\/10.1152\/ajprenal.00191.2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"2291_CR34","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/MNH.0000000000000503","volume":"28","author":"HK Kim","year":"2019","unstructured":"Kim HK, Mizuno M, Vongpatanasin W (2019) Phosphate, the forgotten mineral in hypertension. Curr Opin Nephrol Hypertens 28:345\u2013351. \n                    https:\/\/doi.org\/10.1097\/MNH.0000000000000503","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2291_CR35","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/ncb1806","volume":"10","author":"N Kon","year":"2008","unstructured":"Kon N, Hirota T, Kawamoto T, Kato Y, Tsubota T, Fukada Y (2008) Activation of TGF-beta\/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts. Nat Cell Biol 10:1463\u20131469. \n                    https:\/\/doi.org\/10.1038\/ncb1806","journal-title":"Nat Cell Biol"},{"key":"2291_CR36","doi-asserted-by":"publisher","first-page":"9957","DOI":"10.1038\/s41598-018-27795-2","volume":"8","author":"CS Kuo","year":"2018","unstructured":"Kuo CS, Lu YW, Hsu CY, Chang CC, Chou RH, Liu LK, Chen LK, Huang PH, Chen JW, Lin SJ (2018) Increased activin a levels in prediabetes and association with carotid intima-media thickness: a cross-sectional analysis from I-Lan longitudinal aging study. Sci Rep 8:9957. \n                    https:\/\/doi.org\/10.1038\/s41598-018-27795-2","journal-title":"Sci Rep"},{"key":"2291_CR37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/36285","volume":"390","author":"M Kuro-o","year":"1997","unstructured":"Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45\u201351. \n                    https:\/\/doi.org\/10.1038\/36285","journal-title":"Nature"},{"key":"2291_CR38","doi-asserted-by":"publisher","first-page":"6120","DOI":"10.1074\/jbc.C500457200","volume":"281","author":"H Kurosu","year":"2006","unstructured":"Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-o M (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281:6120\u20136123. \n                    https:\/\/doi.org\/10.1074\/jbc.C500457200","journal-title":"J Biol Chem"},{"key":"2291_CR39","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1113\/EP086062","volume":"102","author":"GJ Lee","year":"2017","unstructured":"Lee GJ, Mossa-Al Hashimi L, Debnam ES, Unwin RJ, Marks J (2017) Postprandial adjustments in renal phosphate excretion do not involve a gut-derived phosphaturic factor. Exp Physiol 102:462\u2013474. \n                    https:\/\/doi.org\/10.1113\/EP086062","journal-title":"Exp Physiol"},{"key":"2291_CR40","first-page":"184","volume":"51","author":"E Lewin","year":"2004","unstructured":"Lewin E (2004) Parathyroid hormone regulation in normal and uremic rats. Reversibility of secondary hyperparathyroidism after experimental kidney transplantation. Dan Med Bull 51:184\u2013206","journal-title":"Dan Med Bull"},{"key":"2291_CR41","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1093\/ndt\/gfl178","volume":"21","author":"E Lewin","year":"2006","unstructured":"Lewin E, Olgaard K (2006) Klotho, an important new factor for the activity of Ca2+ channels, connecting calcium homeostasis, ageing and uraemia. Nephrol Dial Transplant 21:1770\u20131772. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfl178","journal-title":"Nephrol Dial Transplant"},{"key":"2291_CR42","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/ki.2015.80","volume":"87","author":"E Lewin","year":"2015","unstructured":"Lewin E, Olgaard K (2015) The vascular secret of klotho. Kidney Int 87:1089\u20131091. \n                    https:\/\/doi.org\/10.1038\/ki.2015.80","journal-title":"Kidney Int"},{"key":"2291_CR43","doi-asserted-by":"publisher","first-page":"222","DOI":"10.5414\/CN109650","volume":"91","author":"F Lima","year":"2019","unstructured":"Lima F, Mawad H, El-Husseini AA, Davenport DL, Malluche HH (2019) Serum bone markers in ROD patients across the spectrum of decreases in GFR: activin a increases before all other markers. Clin Nephrol 91:222\u2013230. \n                    https:\/\/doi.org\/10.5414\/CN109650","journal-title":"Clin Nephrol"},{"key":"2291_CR44","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1681\/ASN.2013111209","volume":"25","author":"K Lindberg","year":"2014","unstructured":"Lindberg K, Amin R, Moe OW, Hu MC, Erben RG, Ostman WA, Lanske B, Olauson H, Larsson TE (2014) The kidney is the principal organ mediating klotho effects. J Am Soc Nephrol 25:2169\u20132175. \n                    https:\/\/doi.org\/10.1681\/ASN.2013111209","journal-title":"J Am Soc Nephrol"},{"key":"2291_CR45","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1530\/eje.0.1390487","volume":"139","author":"P Loria","year":"1998","unstructured":"Loria P, Petraglia F, Concari M, Bertolotti M, Martella P, Luisi S, Grisolia C, Foresta C, Volpe A, Genazzani AR, Carulli N (1998) Influence of age and sex on serum concentrations of total dimeric activin a. Eur J Endocrinol 139:487\u2013492","journal-title":"Eur J Endocrinol"},{"key":"2291_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000452880","volume":"3","author":"X Lu","year":"2017","unstructured":"Lu X, Hu MC (2017) Klotho\/FGF23 axis in chronic kidney disease and cardiovascular disease. Kidney Dis (Basel) 3:15\u201323. \n                    https:\/\/doi.org\/10.1159\/000452880","journal-title":"Kidney Dis (Basel)"},{"key":"2291_CR47","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/ki.2015.231","volume":"88","author":"ML Mace","year":"2015","unstructured":"Mace ML, Gravesen E, Hofman-Bang J, Olgaard K, Lewin E (2015) Key role of the kidney in the regulation of fibroblast growth factor 23. Kidney Int 88:1304\u20131313. \n                    https:\/\/doi.org\/10.1038\/ki.2015.231","journal-title":"Kidney Int"},{"key":"2291_CR48","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.kint.2017.01.015","volume":"92","author":"ML Mace","year":"2017","unstructured":"Mace ML, Gravesen E, Nordholm A, Hofman-Bang J, Secher T, Olgaard K, Lewin E (2017) Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia. Kidney Int 92:165\u2013178. \n                    https:\/\/doi.org\/10.1016\/j.kint.2017.01.015","journal-title":"Kidney Int"},{"key":"2291_CR49","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00223-017-0333-9","volume":"102","author":"ML Mace","year":"2017","unstructured":"Mace ML, Gravesen E, Nordholm A, Olgaard K, Lewin E (2017) Fibroblast growth factor (FGF) 23 regulates the plasma levels of parathyroid hormone in vivo through the FGF receptor in normocalcemia, but not in hypocalcemia. Calcif Tissue Int 102:85\u201392. \n                    https:\/\/doi.org\/10.1007\/s00223-017-0333-9","journal-title":"Calcif Tissue Int"},{"key":"2291_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1507\/endocrj.KR-113","volume":"55","author":"A Maeshima","year":"2008","unstructured":"Maeshima A, Miya M, Mishima K, Yamashita S, Kojima I, Nojima Y (2008) Activin a: autocrine regulator of kidney development and repair. Endocr J 55:1\u20139","journal-title":"Endocr J"},{"key":"2291_CR51","doi-asserted-by":"publisher","first-page":"376191","DOI":"10.1155\/2014\/376191","volume":"2014","author":"A Maeshima","year":"2014","unstructured":"Maeshima A, Mishima K, Yamashita S, Nakasatomi M, Miya M, Sakurai N, Sakairi T, Ikeuchi H, Hiromura K, Hasegawa Y, Kojima I, Nojima Y (2014) Follistatin, an activin antagonist, ameliorates renal interstitial fibrosis in a rat model of unilateral ureteral obstruction. Biomed Res Int 2014:376191. \n                    https:\/\/doi.org\/10.1155\/2014\/376191","journal-title":"Biomed Res Int"},{"key":"2291_CR52","doi-asserted-by":"publisher","unstructured":"Maury E (2019) Off the clock: from circadian disruption to metabolic disease. Int J Mol Sci 20. \n                    https:\/\/doi.org\/10.3390\/ijms20071597","DOI":"10.3390\/ijms20071597"},{"key":"2291_CR53","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1002\/jbmr.1924","volume":"28","author":"JD McElderry","year":"2013","unstructured":"McElderry JD, Zhao G, Khmaladze A, Wilson CG, Franceschi RT, Morris MD (2013) Tracking circadian rhythms of bone mineral deposition in murine calvarial organ cultures. J Bone Miner Res 28:1846\u20131854. \n                    https:\/\/doi.org\/10.1002\/jbmr.1924","journal-title":"J Bone Miner Res"},{"key":"2291_CR54","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.kint.2017.11.022","volume":"93","author":"A Miyagawa","year":"2018","unstructured":"Miyagawa A, Tatsumi S, Takahama W, Fujii O, Nagamoto K, Kinoshita E, Nomura K, Ikuta K, Fujii T, Hanazaki A, Kaneko I, Segawa H, Miyamoto KI (2018) The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of plasma inorganic phosphate concentration. Kidney Int 93:1073\u20131085. \n                    https:\/\/doi.org\/10.1016\/j.kint.2017.11.022","journal-title":"Kidney Int"},{"key":"2291_CR55","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","volume":"69","author":"S Moe","year":"2006","unstructured":"Moe S, Drueke T, Cunningham J, Goodman W, Martin K, Olgaard K, Ott S, Sprague S, Lameire N, Eknoyan G (2006) Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 69:1945\u20131953. \n                    https:\/\/doi.org\/10.1038\/sj.ki.5000414","journal-title":"Kidney Int"},{"key":"2291_CR56","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1093\/ndt\/11.9.1762","volume":"11","author":"PK Nielsen","year":"1996","unstructured":"Nielsen PK, Feldt-Rasmussen U, Olgaard K (1996) A direct effect in vitro of phosphate on PTH release from bovine parathyroid tissue slices but not from dispersed parathyroid cells. Nephrol Dial Transplant 11:1762\u20131768","journal-title":"Nephrol Dial Transplant"},{"key":"2291_CR57","doi-asserted-by":"publisher","first-page":"13756","DOI":"10.1038\/s41598-018-31830-7","volume":"8","author":"T Noguchi","year":"2018","unstructured":"Noguchi T, Hussein AI, Horowitz N, Carroll D, Gower AC, Demissie S, Gerstenfeld LC (2018) Hypophosphatemia regulates molecular mechanisms of circadian rhythm. Sci Rep 8:13756. \n                    https:\/\/doi.org\/10.1038\/s41598-018-31830-7","journal-title":"Sci Rep"},{"key":"2291_CR58","doi-asserted-by":"publisher","first-page":"F753","DOI":"10.1152\/ajprenal.00528.2017","volume":"314","author":"A Nordholm","year":"2018","unstructured":"Nordholm A, Mace ML, Gravesen E, Hofman-Bang J, Morevati M, Olgaard K, Lewin E (2018) Klotho and activin a in kidney injury: plasma klotho is maintained in unilateral obstruction despite no upregulation of klotho biosynthesis in the contralateral kidney. Am J Physiol Renal Physiol 314:F753\u2013F762. \n                    https:\/\/doi.org\/10.1152\/ajprenal.00528.2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"2291_CR59","doi-asserted-by":"publisher","first-page":"e1435185","DOI":"10.1080\/23723556.2018.1435185","volume":"5","author":"RJ Perry","year":"2018","unstructured":"Perry RJ (2018) Leptin revisited: the role of leptin in starvation. Mol Cell Oncol 5:e1435185. \n                    https:\/\/doi.org\/10.1080\/23723556.2018.1435185","journal-title":"Mol Cell Oncol"},{"key":"2291_CR60","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1210\/en.2005-0777","volume":"146","author":"F Perwad","year":"2005","unstructured":"Perwad F, Azam N, Zhang MY, Yamashita T, Tenenhouse HS, Portale AA (2005) Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology 146:5358\u20135364. \n                    https:\/\/doi.org\/10.1210\/en.2005-0777","journal-title":"Endocrinology"},{"key":"2291_CR61","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.metabol.2016.07.009","volume":"65","author":"SA Polyzos","year":"2016","unstructured":"Polyzos SA, Kountouras J, Anastasilakis AD, Triantafyllou G, Mantzoros CS (2016) Activin a and follistatin in patients with nonalcoholic fatty liver disease. Metabolism 65:1550\u20131558. \n                    https:\/\/doi.org\/10.1016\/j.metabol.2016.07.009","journal-title":"Metabolism"},{"key":"2291_CR62","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1172\/JCI113172","volume":"80","author":"AA Portale","year":"1987","unstructured":"Portale AA, Halloran BP, Morris RC Jr (1987) Dietary intake of phosphorus modulates the circadian rhythm in serum concentration of phosphorus. Implications for the renal production of 1,25-dihydroxyvitamin D. J Clin Invest 80:1147\u20131154. \n                    https:\/\/doi.org\/10.1172\/JCI113172","journal-title":"J Clin Invest"},{"key":"2291_CR63","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.2215\/CJN.11901115","volume":"11","author":"CS Ritter","year":"2016","unstructured":"Ritter CS, Slatopolsky E (2016) Phosphate toxicity in CKD: the killer among us. Clin J Am Soc Nephrol 11:1088\u20131100. \n                    https:\/\/doi.org\/10.2215\/CJN.11901115","journal-title":"Clin J Am Soc Nephrol"},{"key":"2291_CR64","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1359\/jbmr.081208","volume":"24","author":"J Ruckle","year":"2009","unstructured":"Ruckle J, Jacobs M, Kramer W, Pearsall AE, Kumar R, Underwood KW, Seehra J, Yang Y, Condon CH, Sherman ML (2009) Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women. J Bone Miner Res 24:744\u2013752. \n                    https:\/\/doi.org\/10.1359\/jbmr.081208","journal-title":"J Bone Miner Res"},{"key":"2291_CR65","doi-asserted-by":"publisher","first-page":"F477","DOI":"10.1152\/ajprenal.00472.2015","volume":"310","author":"JL Rukov","year":"2016","unstructured":"Rukov JL, Gravesen E, Mace ML, Hofman-Bang J, Vinther J, Andersen CB, Lewin E, Olgaard K (2016) Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing. Am J Physiol Renal Physiol 310:F477\u2013F491. \n                    https:\/\/doi.org\/10.1152\/ajprenal.00472.2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"2291_CR66","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2741\/1514","volume":"10","author":"T Sakaki","year":"2005","unstructured":"Sakaki T, Kagawa N, Yamamoto K, Inouye K (2005) Metabolism of vitamin D3 by cytochromes P450. Front Biosci 10:119\u2013134","journal-title":"Front Biosci"},{"key":"2291_CR67","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1017\/S0007114507764759","volume":"98","author":"S Salim","year":"2007","unstructured":"Salim S, Farooq N, Priyamvada S, Asghar M, Khundmiri SJ, Khan S, Khan F, Yusufi AN (2007) Influence of Ramadan-type fasting on carbohydrate metabolism, brush border membrane enzymes and phosphate transport in rat kidney used as a model. Br J Nutr 98:984\u2013990. \n                    https:\/\/doi.org\/10.1017\/S0007114507764759","journal-title":"Br J Nutr"},{"key":"2291_CR68","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nrneph.2013.176","volume":"9","author":"CM Shanahan","year":"2013","unstructured":"Shanahan CM (2013) Mechanisms of vascular calcification in CKD-evidence for premature ageing? Nat Rev Nephrol 9:661\u2013670. \n                    https:\/\/doi.org\/10.1038\/nrneph.2013.176","journal-title":"Nat Rev Nephrol"},{"key":"2291_CR69","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1172\/JCI200419081","volume":"113","author":"T Shimada","year":"2004","unstructured":"Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, Fukumoto S, Tomizuka K, Yamashita T (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113:561\u2013568. \n                    https:\/\/doi.org\/10.1172\/JCI19081","journal-title":"J Clin Invest"},{"key":"2291_CR70","first-page":"158","volume":"11","author":"H Shinoda","year":"1985","unstructured":"Shinoda H, Seto H (1985) Diurnal rhythms in calcium and phosphate metabolism in rodents and their relations to lighting and feeding schedules. Miner Electrolyte Metab 11:158\u2013166","journal-title":"Miner Electrolyte Metab"},{"key":"2291_CR71","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1681\/ASN.2010080803","volume":"22","author":"LR Stow","year":"2011","unstructured":"Stow LR, Gumz ML (2011) The circadian clock in the kidney. J Am Soc Nephrol 22:598\u2013604. \n                    https:\/\/doi.org\/10.1681\/ASN.2010080803","journal-title":"J Am Soc Nephrol"},{"key":"2291_CR72","doi-asserted-by":"publisher","unstructured":"Sugatani T (2018) Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder. Int J Mol Sci 19. \n                    https:\/\/doi.org\/10.3390\/ijms19092490","DOI":"10.3390\/ijms19092490"},{"key":"2291_CR73","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.kint.2016.07.039","volume":"91","author":"T Sugatani","year":"2017","unstructured":"Sugatani T, Agapova OA, Fang Y, Berman AG, Wallace JM, Malluche HH, Faugere MC, Smith W, Sung V, Hruska KA (2017) Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease. Kidney Int 91:86\u201395. \n                    https:\/\/doi.org\/10.1016\/j.kint.2016.07.039","journal-title":"Kidney Int"},{"key":"2291_CR74","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/BF02547282","volume":"17","author":"RV Talmage","year":"1975","unstructured":"Talmage RV, Roycroft JH, Anderson JJ (1975) Daily fluctuations in plasma calcium, phosphate, and their radionuclide concentrations in the rat. Calcif Tissue Res 17:91\u2013102","journal-title":"Calcif Tissue Res"},{"key":"2291_CR75","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.kint.2017.11.018","volume":"93","author":"L Toro","year":"2018","unstructured":"Toro L, Barrientos V, Leon P, Rojas M, Gonzalez M, Gonzalez-Ibanez A, Illanes S, Sugikawa K, Abarzua N, Bascunan C, Arcos K, Fuentealba C, Tong AM, Elorza AA, Pinto ME, Alzamora R, Romero C, Michea L (2018) Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury. Kidney Int 93:1131\u20131141. \n                    https:\/\/doi.org\/10.1016\/j.kint.2017.11.018","journal-title":"Kidney Int"},{"key":"2291_CR76","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/jmicro\/dfp032","volume":"58","author":"S Ubaidus","year":"2009","unstructured":"Ubaidus S, Li M, Sultana S, de Freitas PH, Oda K, Maeda T, Takagi R, Amizuka N (2009) FGF23 is mainly synthesized by osteocytes in the regularly distributed osteocytic lacunar canalicular system established after physiological bone remodeling. J Electron Microsc 58:381\u2013392. \n                    https:\/\/doi.org\/10.1093\/jmicro\/dfp032","journal-title":"J Electron Microsc"},{"key":"2291_CR77","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1177\/1479164111431171","volume":"9","author":"T Ueland","year":"2012","unstructured":"Ueland T, Aukrust P, Aakhus S, Smith C, Endresen K, Birkeland KI, Gullestad L, Johansen OE (2012) Activin A and cardiovascular disease in type 2 diabetes mellitus. Diab Vasc Dis Res 9:234\u2013237. \n                    https:\/\/doi.org\/10.1177\/1479164111431171","journal-title":"Diab Vasc Dis Res"},{"key":"2291_CR78","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/nature05315","volume":"444","author":"I Urakawa","year":"2006","unstructured":"Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770\u2013774. \n                    https:\/\/doi.org\/10.1038\/nature05315","journal-title":"Nature"},{"key":"2291_CR79","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1159\/000186729","volume":"60","author":"M Viljoen","year":"1992","unstructured":"Viljoen M, Steyn ME, van Rensburg BW, Reinach SG (1992) Melatonin in chronic renal failure. Nephron 60:138\u2013143. \n                    https:\/\/doi.org\/10.1159\/000186729","journal-title":"Nephron"},{"key":"2291_CR80","doi-asserted-by":"publisher","unstructured":"Williams MJ, Sugatani T, Agapova OA, Fang Y, Gaut JP, Faugere MC, Malluche HH, Hruska KA (2017) The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease. Kidney Int. \n                    https:\/\/doi.org\/10.1016\/j.kint.2017.06.016","DOI":"10.1016\/j.kint.2017.06.016"},{"key":"2291_CR81","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1681\/ASN.2014040325","volume":"26","author":"J Xie","year":"2015","unstructured":"Xie J, Yoon J, An SW, Kuro-o M, Huang CL (2015) Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate. J Am Soc Nephrol 26:1150\u20131160. \n                    https:\/\/doi.org\/10.1681\/ASN.2014040325","journal-title":"J Am Soc Nephrol"},{"key":"2291_CR82","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/ehf2.12409","volume":"6","author":"J Zeller","year":"2019","unstructured":"Zeller J, Kruger C, Lamounier-Zepter V, Sag S, Strack C, Mohr M, Loew T, Schmitz G, Maier L, Fischer M, Baessler A (2019) The adipo-fibrokine activin A is associated with metabolic abnormalities and left ventricular diastolic dysfunction in obese patients. ESC Heart Fail 6:362\u2013370. \n                    https:\/\/doi.org\/10.1002\/ehf2.12409","journal-title":"ESC Heart Fail"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-019-02291-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00424-019-02291-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-019-02291-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T23:19:21Z","timestamp":1592867961000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00424-019-02291-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,24]]},"references-count":82,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["2291"],"URL":"https:\/\/doi.org\/10.1007\/s00424-019-02291-2","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,24]]},"assertion":[{"value":"30 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}