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Maintenance and manipulation protocols were performed following European guidelines (Directive 2010\/63\/EU) and Spanish legislation (R.D. 53\/2013) for the use and care of animals in Biomedical Research, in full compliance with (i) the guide for the Care and Use of Laboratory Animals in USA and (ii) the ARRIVE guidelines for reporting experiments involving animals [].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}