{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:30:38Z","timestamp":1782729038414,"version":"3.54.5"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2017S1A5A2A01024319"],"award-info":[{"award-number":["NRF-2017S1A5A2A01024319"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to investigate the effect of lithium on glucose disposal in a high-fat diet-induced type 2 diabetes mellitus (T2DM) and streptozotocin-induced type 1 diabetes mellitus (T1DM) animal model along with low-volume exercise and low-dose insulin. Lithium decreased body weight, fasting plasma glucose, and insulin levels when to treat with low-volume exercise training; however, there were no adaptive responses like an increase in GLUT4 content and translocation factor levels. We discovered that lithium enhanced glucose uptake by acute low-volume exercise-induced glycogen breakdown, which was facilitated by the dephosphorylation of serine 473-AKT (Ser473-AKT) and serine 9-GSK3\u03b2. In streptozotocin-induced T1DM mice, Li\/low-dose insulin facilitates glucose uptake through increase the level of exocyst complex component 7 (Exoc7) and Ser473-AKT. Thus, lithium enhances acute exercise-induced glycogen breakdown and insulin-induced AKT activation and could serve as a candidate therapeutic target to regulate glucose level of DM patients.<\/jats:p>","DOI":"10.1007\/s00424-021-02543-0","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T17:06:29Z","timestamp":1614791189000},"page":"673-682","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lithium enhances exercise-induced glycogen breakdown and insulin-induced AKT activation to facilitate glucose uptake in rodent skeletal muscle"],"prefix":"10.1007","volume":"473","author":[{"given":"Su-Ryun","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol-Yi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-4399","authenticated-orcid":false,"given":"Jin-Ho","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"2543_CR1","doi-asserted-by":"publisher","first-page":"C615","DOI":"10.1152\/ajpcell.00540.2019","volume":"318","author":"AM Abdelmoez","year":"2020","unstructured":"Abdelmoez AM, Sard\u00f3n Puig L, Smith JAB, Gabriel BM, Savikj M, Dollet L, Chibalin AV, Krook A, Zierath JR, Pillon NJ (2020) Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism. Am J Phys Cell Phys 318:C615\u2013c626. https:\/\/doi.org\/10.1152\/ajpcell.00540.2019","journal-title":"Am J Phys Cell Phys"},{"key":"2543_CR2","doi-asserted-by":"publisher","first-page":"17504","DOI":"10.1074\/jbc.273.28.17504","volume":"273","author":"H Al-Hasani","year":"1998","unstructured":"Al-Hasani H, Hinck CS, Cushman SW (1998) Endocytosis of the glucose transporter GLUT4 is mediated by the GTPase dynamin. J Biol Chem 273:17504\u201317510. https:\/\/doi.org\/10.1074\/jbc.273.28.17504","journal-title":"J Biol Chem"},{"key":"2543_CR3","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1152\/jappl.2001.91.3.1237","volume":"91","author":"R Aslesen","year":"1985","unstructured":"Aslesen R, Engebretsen EM, Franch J (1985) Jensen J (2001) Glucose uptake and metabolic stress in rat muscles stimulated electrically with different protocols. J Appl Physiol 91:1237\u20131244. https:\/\/doi.org\/10.1152\/jappl.2001.91.3.1237","journal-title":"J Appl Physiol"},{"key":"2543_CR4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000065414","volume":"46","author":"M Atmaca","year":"2002","unstructured":"Atmaca M, Kuloglu M, Tezcan E, Ustundag B (2002) Weight gain and serum leptin levels in patients on lithium treatment. Neuropsychobiology 46:67\u201369. https:\/\/doi.org\/10.1159\/000065414","journal-title":"Neuropsychobiology"},{"key":"2543_CR5","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/j.1399-5618.2006.00344.x","volume":"8","author":"RJ Baldessarini","year":"2006","unstructured":"Baldessarini RJ, Tondo L, Davis P, Pompili M, Goodwin FK, Hennen J (2006) Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. Bipolar Disord 8:625\u2013639. https:\/\/doi.org\/10.1111\/j.1399-5618.2006.00344.x","journal-title":"Bipolar Disord"},{"key":"2543_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0278-5846(99)00085-8","volume":"24","author":"T Baptista","year":"2000","unstructured":"Baptista T, Lacruz A, de Mendoza S, Guill\u00e9n MM, Burguera JL, de Burguera M, Hern\u00e1ndez L (2000) Endocrine effects of lithium carbonate in healthy premenopausal women: relationship with body weight regulation. Prog Neuro-Psychopharmacol Biol Psychiatry 24:1\u201316. https:\/\/doi.org\/10.1016\/s0278-5846(99)00085-8","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"2543_CR7","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.athoracsur.2007.02.015","volume":"84","author":"R Barillas","year":"2007","unstructured":"Barillas R, Friehs I, Cao-Danh H, Martinez JF, del Nido PJ (2007) Inhibition of glycogen synthase kinase-3beta improves tolerance to ischemia in hypertrophied hearts. Ann Thorac Surg 84:126\u2013133. https:\/\/doi.org\/10.1016\/j.athoracsur.2007.02.015","journal-title":"Ann Thorac Surg"},{"key":"2543_CR8","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/0304-4165(64)90347-2","volume":"93","author":"G Bhattacharya","year":"1964","unstructured":"Bhattacharya G (1964) INFLUENCE OF LI+ ON GLUCOSE METABOLISM IN RATS AND RABBITS. Biochim Biophys Acta 93:644\u2013646. https:\/\/doi.org\/10.1016\/0304-4165(64)90347-2","journal-title":"Biochim Biophys Acta"},{"key":"2543_CR9","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1681\/asn.2006020135","volume":"17","author":"DG Bichet","year":"2006","unstructured":"Bichet DG (2006) Lithium, cyclic AMP signaling, A-kinase anchoring proteins, and aquaporin-2. J Am Soc Nephrol 17:920\u2013922. https:\/\/doi.org\/10.1681\/asn.2006020135","journal-title":"J Am Soc Nephrol"},{"key":"2543_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1083\/jcb.201509052","volume":"214","author":"J Bruno","year":"2016","unstructured":"Bruno J, Brumfield A, Chaudhary N, Iaea D, McGraw TE (2016) SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. J Cell Biol 214:61\u201376. https:\/\/doi.org\/10.1083\/jcb.201509052","journal-title":"J Cell Biol"},{"key":"2543_CR11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/s0304-4165(00)00068-4","volume":"1475","author":"WS Choi","year":"2000","unstructured":"Choi WS, Sung CK (2000) Effects of lithium and insulin on glycogen synthesis in L6 myocytes: additive effects on inactivation of glycogen synthase kinase-3. Biochim Biophys Acta 1475:225\u2013230. https:\/\/doi.org\/10.1016\/s0304-4165(00)00068-4","journal-title":"Biochim Biophys Acta"},{"key":"2543_CR12","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/0005-2736(68)90009-6","volume":"150","author":"T Clausen","year":"1968","unstructured":"Clausen T (1968) The relationship between the transport of glucose and cations across cell membranes in isolated tissues. Biochim Biophys Acta 150:66\u201372. https:\/\/doi.org\/10.1016\/0005-2736(68)90009-6","journal-title":"Biochim Biophys Acta"},{"key":"2543_CR13","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.amjmed.2005.11.003","volume":"119","author":"MP Freeman","year":"2006","unstructured":"Freeman MP, Freeman SA (2006) Lithium: clinical considerations in internal medicine. Am J Med 119:478\u2013481. https:\/\/doi.org\/10.1016\/j.amjmed.2005.11.003","journal-title":"Am J Med"},{"key":"2543_CR14","doi-asserted-by":"publisher","first-page":"E782","DOI":"10.1152\/ajpendo.00477.2004","volume":"288","author":"PC Geiger","year":"2005","unstructured":"Geiger PC, Wright DC, Han DH, Holloszy JO (2005) Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin. Am J Physiol Endocrinol Metab 288:E782\u2013E788. https:\/\/doi.org\/10.1152\/ajpendo.00477.2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2543_CR15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev.med.49.1.235","volume":"49","author":"LJ Goodyear","year":"1998","unstructured":"Goodyear LJ, Kahn BB (1998) Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 49:235\u2013261. https:\/\/doi.org\/10.1146\/annurev.med.49.1.235","journal-title":"Annu Rev Med"},{"key":"2543_CR16","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2165\/00023210-200923050-00004","volume":"23","author":"EM Grandjean","year":"2009","unstructured":"Grandjean EM, Aubry JM (2009) Lithium: updated human knowledge using an evidence-based approach: part III: clinical safety. CNS Drugs 23:397\u2013418. https:\/\/doi.org\/10.2165\/00023210-200923050-00004","journal-title":"CNS Drugs"},{"key":"2543_CR17","doi-asserted-by":"publisher","first-page":"e19739","DOI":"10.1371\/journal.pone.0019739","volume":"6","author":"DH Han","year":"2011","unstructured":"Han DH, Hancock CR, Jung SR, Higashida K, Kim SH, Holloszy JO (2011) Deficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance. PLoS One 6:e19739. https:\/\/doi.org\/10.1371\/journal.pone.0019739","journal-title":"PLoS One"},{"key":"2543_CR18","doi-asserted-by":"publisher","first-page":"E347","DOI":"10.1152\/ajpendo.00434.2003","volume":"286","author":"DH Han","year":"2004","unstructured":"Han DH, Nolte LA, Ju JS, Coleman T, Holloszy JO, Semenkovich CF (2004) UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. Am J Physiol Endocrinol Metab 286:E347\u2013E353. https:\/\/doi.org\/10.1152\/ajpendo.00434.2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2543_CR19","doi-asserted-by":"publisher","first-page":"7815","DOI":"10.1073\/pnas.0802057105","volume":"105","author":"CR Hancock","year":"2008","unstructured":"Hancock CR, Han DH, Chen M, Terada S, Yasuda T, Wright DC, Holloszy JO (2008) High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci U S A 105:7815\u20137820. https:\/\/doi.org\/10.1073\/pnas.0802057105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2543_CR20","doi-asserted-by":"publisher","first-page":"18173","DOI":"10.1074\/jbc.273.29.18173","volume":"273","author":"PA Hansen","year":"1998","unstructured":"Hansen PA, Wang W, Marshall BA, Holloszy JO, Mueckler M (1998) Dissociation of GLUT4 translocation and insulin-stimulated glucose transport in transgenic mice overexpressing GLUT1 in skeletal muscle. J Biol Chem 273:18173\u201318179. https:\/\/doi.org\/10.1074\/jbc.273.29.18173","journal-title":"J Biol Chem"},{"key":"2543_CR21","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/0006-2952(74)90394-3","volume":"23","author":"ES Haugaard","year":"1974","unstructured":"Haugaard ES, Mickel RA, Haugaard N (1974) Actions of lithium ions and insulin on glucose utilization, glycogen synthesis and glycogen synthase in the isolated rat diaphragm. Biochem Pharmacol 23:1675\u20131685. https:\/\/doi.org\/10.1016\/0006-2952(74)90394-3","journal-title":"Biochem Pharmacol"},{"key":"2543_CR22","doi-asserted-by":"publisher","first-page":"E1039","DOI":"10.1152\/ajpendo.1997.273.6.E1039","volume":"273","author":"T Hayashi","year":"1997","unstructured":"Hayashi T, Wojtaszewski JF, Goodyear LJ (1997) Exercise regulation of glucose transport in skeletal muscle. Am J Phys 273:E1039\u2013E1051. https:\/\/doi.org\/10.1152\/ajpendo.1997.273.6.E1039","journal-title":"Am J Phys"},{"key":"2543_CR23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fphys.2011.00112","volume":"2","author":"J Jensen","year":"2011","unstructured":"Jensen J, Rustad PI, Kolnes AJ, Lai YC (2011) The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol 2:112. https:\/\/doi.org\/10.3389\/fphys.2011.00112","journal-title":"Front Physiol"},{"key":"2543_CR24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3177\/jnsv.63.365","volume":"63","author":"S Jung","year":"2017","unstructured":"Jung S, Koh J, Kim S, Kim K (2017) Effect of Lithium on the Mechanism of Glucose Transport in Skeletal Muscles. J Nutr Sci Vitaminol (Tokyo) 63:365\u2013371. https:\/\/doi.org\/10.3177\/jnsv.63.365","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"2543_CR25","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1152\/japplphysiol.00401.2009","volume":"108","author":"YC Lai","year":"1985","unstructured":"Lai YC, Zarrinpashneh E (1985) Jensen J (2010) Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents. J Appl Physiol 108:1106\u20131115. https:\/\/doi.org\/10.1152\/japplphysiol.00401.2009","journal-title":"J Appl Physiol"},{"key":"2543_CR26","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/jre.12387","volume":"52","author":"S Maekawa","year":"2017","unstructured":"Maekawa S, Katagiri S, Takeuchi Y, Komazaki R, Ohtsu A, Udagawa S, Izumi Y (2017) Bone metabolic microarray analysis of ligature-induced periodontitis in streptozotocin-induced diabetic mice. J Periodontal Res 52:233\u2013245. https:\/\/doi.org\/10.1111\/jre.12387","journal-title":"J Periodontal Res"},{"key":"2543_CR27","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1038\/s41598-020-58206-0","volume":"10","author":"M Magnone","year":"2020","unstructured":"Magnone M, Emionite L, Guida L, Vigliarolo T, Sturla L, Spinelli S, Buschiazzo A, Marini C, Sambuceti G, De Flora A, Orengo AM, Cossu V, Ferrando S, Barbieri O, Zocchi E (2020) Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation. Sci Rep 10:1454. https:\/\/doi.org\/10.1038\/s41598-020-58206-0","journal-title":"Sci Rep"},{"key":"2543_CR28","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/s0140-6736(11)61516-x","volume":"379","author":"RF McKnight","year":"2012","unstructured":"McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR (2012) Lithium toxicity profile: a systematic review and meta-analysis. Lancet 379:721\u2013728. https:\/\/doi.org\/10.1016\/s0140-6736(11)61516-x","journal-title":"Lancet"},{"key":"2543_CR29","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3389\/fnagi.2017.00434","volume":"9","author":"T Nguyen","year":"2017","unstructured":"Nguyen T, Fan T, George SR, Perreault ML (2017) Disparate Effects of Lithium and a GSK-3 Inhibitor on Neuronal Oscillatory Activity in Prefrontal Cortex and Hippocampus. Front Aging Neurosci 9:434. https:\/\/doi.org\/10.3389\/fnagi.2017.00434","journal-title":"Front Aging Neurosci"},{"key":"2543_CR30","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1046\/j.1523-1755.2003.00096.x","volume":"64","author":"C Presne","year":"2003","unstructured":"Presne C, Fakhouri F, No\u00ebl LH, Stengel B, Even C, Kreis H, Mignon F, Gr\u00fcnfeld JP (2003) Lithium-induced nephropathy: Rate of progression and prognostic factors. Kidney Int 64:585\u2013592. https:\/\/doi.org\/10.1046\/j.1523-1755.2003.00096.x","journal-title":"Kidney Int"},{"key":"2543_CR31","doi-asserted-by":"publisher","first-page":"F257","DOI":"10.1152\/ajprenal.00491.2005","volume":"291","author":"JH Robben","year":"2006","unstructured":"Robben JH, Knoers NV, Deen PM (2006) Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus. Am J Physiol Ren Physiol 291:F257\u2013F270. https:\/\/doi.org\/10.1152\/ajprenal.00491.2005","journal-title":"Am J Physiol Ren Physiol"},{"key":"2543_CR32","doi-asserted-by":"publisher","first-page":"E380","DOI":"10.1152\/ajpendo.1993.265.3.E380","volume":"265","author":"JA Romijn","year":"1993","unstructured":"Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR (1993) Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Phys 265:E380\u2013E391. https:\/\/doi.org\/10.1152\/ajpendo.1993.265.3.E380","journal-title":"Am J Phys"},{"key":"2543_CR33","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1006\/bbrc.2000.4169","volume":"280","author":"WJ Ryves","year":"2001","unstructured":"Ryves WJ, Harwood AJ (2001) Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem Biophys Res Commun 280:720\u2013725. https:\/\/doi.org\/10.1006\/bbrc.2000.4169","journal-title":"Biochem Biophys Res Commun"},{"key":"2543_CR34","first-page":"289","volume-title":"Muscle glycogen utilization during work of different intensities","author":"B Saltin","year":"1971","unstructured":"Saltin B, Karlsson J (1971) Muscle glycogen utilization during work of different intensities. Muscle metabolism during exercise. Springer, In, pp 289\u2013299"},{"key":"2543_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/2230-973x.176456","volume":"6","author":"RB Shah","year":"2016","unstructured":"Shah RB, Patel M, Maahs DM, Shah VN (2016) Insulin delivery methods: Past, present and future. Int J Pharm Investig 6:1\u20139. https:\/\/doi.org\/10.4103\/2230-973x.176456","journal-title":"Int J Pharm Investig"},{"key":"2543_CR36","doi-asserted-by":"publisher","first-page":"5457","DOI":"10.1128\/mcb.18.9.5457","volume":"18","author":"SA Summers","year":"1998","unstructured":"Summers SA, Garza LA, Zhou H, Birnbaum MJ (1998) Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol 18:5457\u20135464. https:\/\/doi.org\/10.1128\/mcb.18.9.5457","journal-title":"Mol Cell Biol"},{"key":"2543_CR37","doi-asserted-by":"publisher","first-page":"903","DOI":"10.2337\/diab.43.7.903","volume":"43","author":"I Tabata","year":"1994","unstructured":"Tabata I, Schluter J, Gulve EA, Holloszy JO (1994) Lithium increases susceptibility of muscle glucose transport to stimulation by various agents. Diabetes 43:903\u2013907. https:\/\/doi.org\/10.2337\/diab.43.7.903","journal-title":"Diabetes"},{"key":"2543_CR38","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s40345-019-0151-2","volume":"7","author":"L Tondo","year":"2019","unstructured":"Tondo L, Alda M, Bauer M, Bergink V, Grof P, Hajek T, Lewitka U, Licht RW, Manchia M, M\u00fcller-Oerlinghausen B, Nielsen RE, Selo M, Simhandl C, Baldessarini RJ (2019) Clinical use of lithium salts: guide for users and prescribers. Int J Bipolar Disord 7:16. https:\/\/doi.org\/10.1186\/s40345-019-0151-2","journal-title":"Int J Bipolar Disord"},{"key":"2543_CR39","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.2337\/diabetes.50.8.1901","volume":"50","author":"F Tremblay","year":"2001","unstructured":"Tremblay F, Lavigne C, Jacques H, Marette A (2001) Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt\/protein kinase B and atypical protein kinase C (zeta\/lambda) activities. Diabetes 50:1901\u20131910. https:\/\/doi.org\/10.2337\/diabetes.50.8.1901","journal-title":"Diabetes"},{"issue":"Suppl 16","key":"2543_CR40","first-page":"S43","volume":"23","author":"F Trepiccione","year":"2010","unstructured":"Trepiccione F, Christensen BM (2010) Lithium-induced nephrogenic diabetes insipidus: new clinical and experimental findings. J Nephrol 23(Suppl 16):S43\u2013S48","journal-title":"J Nephrol"},{"key":"2543_CR41","doi-asserted-by":"publisher","unstructured":"Ueda-Wakagi M, Nagayasu H, Yamashita Y, Ashida AH (2019) Green Tea Ameliorates Hyperglycemia by Promoting the Translocation of Glucose Transporter 4 in the Skeletal Muscle of Diabetic Rodents. Int J Mol Sci 20. https:\/\/doi.org\/10.3390\/ijms20102436","DOI":"10.3390\/ijms20102436"},{"key":"2543_CR42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1469-7793.2001.00295.x","volume":"536","author":"LJ van Loon","year":"2001","unstructured":"van Loon LJ, Greenhaff PL, Constantin-Teodosiu D, Saris WH, Wagenmakers AJ (2001) The effects of increasing exercise intensity on muscle fuel utilisation in humans. J Physiol 536:295\u2013304. https:\/\/doi.org\/10.1111\/j.1469-7793.2001.00295.x","journal-title":"J Physiol"},{"key":"2543_CR43","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.lfs.2017.08.023","volume":"191","author":"N Wang","year":"2017","unstructured":"Wang N, Liu Y, Ma Y, Wen D (2017) High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice. Life Sci 191:122\u2013131. https:\/\/doi.org\/10.1016\/j.lfs.2017.08.023","journal-title":"Life Sci"},{"key":"2543_CR44","doi-asserted-by":"publisher","first-page":"19988","DOI":"10.1074\/jbc.RA119.010821","volume":"294","author":"S Wang","year":"2019","unstructured":"Wang S, Crisman L, Miller J, Datta I, Gulbranson DR, Tian Y, Yin Q, Yu H, Shen J (2019) Inducible Exoc7\/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis. J Biol Chem 294:19988\u201319996. https:\/\/doi.org\/10.1074\/jbc.RA119.010821","journal-title":"J Biol Chem"},{"key":"2543_CR45","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/0016-5085(84)90714-5","volume":"87","author":"RK Wong","year":"1984","unstructured":"Wong RK, Boedeker B, Hickey TM, Wilkinson DS, Johnson LF (1984) Lithium chloride: protective and antisecretory properties in rats. Gastroenterology 87:362\u2013371","journal-title":"Gastroenterology"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-021-02543-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-021-02543-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-021-02543-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T15:25:28Z","timestamp":1618500328000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-021-02543-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["2543"],"URL":"https:\/\/doi.org\/10.1007\/s00424-021-02543-0","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"assertion":[{"value":"26 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study design was approved by the Animal Experiment Ethics Committee of Daegu Technopark BioHealth Convergence Center (BHCC-IACUC-2018-01).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflicts of interest, financial or otherwise, are declared by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}