{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:57:15Z","timestamp":1790996235474,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00424-021-02550-1","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T06:49:21Z","timestamp":1618469361000},"page":"859-872","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A5 noradrenergic neurons and breathing control in neonate rats"],"prefix":"10.1007","volume":"473","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-420X","authenticated-orcid":false,"given":"Camila L.","family":"Taxini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuzia A.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-1132","authenticated-orcid":false,"given":"K\u00eania C.","family":"B\u00edcego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4097-5286","authenticated-orcid":false,"given":"Luciane H.","family":"Gargaglioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"2550_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.siny.2003.09.003","volume":"9","author":"JM Abu-Shaweesh","year":"2004","unstructured":"Abu-Shaweesh JM (2004) Maturation of respiratory reflex responses in the fetus and neonate. Semin Neonatol 9:169\u2013180. https:\/\/doi.org\/10.1016\/j.siny.2003.09.003","journal-title":"Semin Neonatol"},{"key":"2550_CR2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0006-8993(82)90502-9","volume":"242","author":"R Andrade","year":"1982","unstructured":"Andrade R, Aghajanian GK (1982) Single cell activity in the noradrenergic A-5 region: responses to drugs and peripheral manipulations of blood pressure. Brain Res 242:125\u2013135. https:\/\/doi.org\/10.1016\/0006-8993(82)90502-9","journal-title":"Brain Res"},{"key":"2550_CR3","doi-asserted-by":"publisher","unstructured":"Benchetrit G (2000) Breathing pattern in humans: diversity and individuality. Respir Physiol 122(2\u20133):123\u2013129. https:\/\/doi.org\/10.1016\/s0034-5687(00)00154-7","DOI":"10.1016\/s0034-5687(00)00154-7"},{"key":"2550_CR4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1113\/jphysiol.1984.sp015229","volume":"351","author":"CE Blanco","year":"1984","unstructured":"Blanco CE, Dawes GS, Hanson MA, McCooke HB (1984) The response to hypoxia of arterial chemoreceptors in fetal sheep and new-born lambs. J Physiol 351:25\u201337","journal-title":"J Physiol"},{"key":"2550_CR5","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1109\/10.959330","volume":"48","author":"M Brennan","year":"2001","unstructured":"Brennan M, Palaniswami M, Kamen P (2001) Do existing measures of Poincar\u00e9 plot geometry reflect nonlinear features of heart rate variability? IEEE Trans Biomed Eng 48:1342\u20131347. https:\/\/doi.org\/10.1109\/10.959330","journal-title":"IEEE Trans Biomed Eng"},{"key":"2550_CR6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0006-8993(84)90206-3","volume":"303","author":"CE Byrum","year":"1984","unstructured":"Byrum CE, Stornetta R, Guyenet PG (1984) Electrophysiological properties of spinally-projecting A5 noradrenergic neurons. Brain Res 303:15\u201329. https:\/\/doi.org\/10.1016\/0006-8993(84)90206-3","journal-title":"Brain Res"},{"key":"2550_CR7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/978-1-4615-2966-8_54","volume":"337","author":"JL Carroll","year":"1993","unstructured":"Carroll JL, Fitzgerald RS (1993) Carotid chemoreceptor responses to hypoxia and hypercapnia in developing kittens. AdvExp Med Biol 337:387\u2013391. https:\/\/doi.org\/10.1007\/978-1-4615-2966-8_54","journal-title":"Adv Exp Med Biol"},{"key":"2550_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41583-018-0003-6","volume":"19","author":"CA Del Negro","year":"2018","unstructured":"Del Negro CA, Funk GD, Feldman JL (2018) Breathing matters. Nat Rev Neurosci 19:351\u2013367. https:\/\/doi.org\/10.1038\/s41583-018-0003-6","journal-title":"Nat Rev Neurosci"},{"key":"2550_CR9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1113\/jphysiol.1994.sp020067","volume":"475","author":"DF Donnelly","year":"1994","unstructured":"Donnelly DF, Doyle TP (1994) Developmental changes in hypoxia-induced catecholamine release from rat carotid body, in vitro. J Physiol 475:267\u2013275. https:\/\/doi.org\/10.1113\/jphysiol.1994.sp020067","journal-title":"J Physiol"},{"key":"2550_CR10","doi-asserted-by":"publisher","first-page":"103313","DOI":"10.1016\/j.resp.2019.103313","volume":"272","author":"YA Dzal","year":"2020","unstructured":"Dzal YA, Sprenger RJ, Milsom WK (2020) Postnatal changes in O2 and CO2 sensitivity in rodents. Respir Physiol Neurobiol 272:103313","journal-title":"Respir Physiol Neurobiol"},{"key":"2550_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1113\/jphysiol.1987.sp016765","volume":"392","author":"GJ Eden","year":"1987","unstructured":"Eden GJ, Hanson MA (1987) Maturation of the respiratory response to acute hypoxia in the newborn rat. J Physiol 392:1\u20139. https:\/\/doi.org\/10.1113\/jphysiol.1987.sp016765","journal-title":"J Physiol"},{"key":"2550_CR12","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/cne.903480202","volume":"348","author":"JT Erickson","year":"1994","unstructured":"Erickson JT, Millhorn DE (1994) Hypoxia and electrical stimulation of the carotid sinus nerve induce fos-like immunoreactivity within catecholaminergic and serotoninergic neurons of the rat brainstem. J Comp Neurol 348:161\u2013182. https:\/\/doi.org\/10.1002\/cne.903480202","journal-title":"J Comp Neurol"},{"key":"2550_CR13","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1113\/jphysiol.1990.sp018269","volume":"429","author":"S Errchidi","year":"1990","unstructured":"Errchidi S, Hilaire G, Monteau R (1990) Permanent release of noradrenaline modulates respiratory frequency in the newborn rat: an in vitro study. J Physiol 429:497\u2013510. https:\/\/doi.org\/10.1113\/jphysiol.1990.sp018269","journal-title":"J Physiol"},{"key":"2550_CR14","doi-asserted-by":"publisher","first-page":"R1035","DOI":"10.1152\/ajpregu.1993.264.6.R1035","volume":"264","author":"PG Guyenet","year":"1993","unstructured":"Guyenet PG, Koshiya N, Huangfu D, Verberne AJ, Riley TA (1993) Central respiratory control of A5 and A6 pontine noradrenergic neurons. Am J Physiol Integr Comp Physiol 264:R1035\u2013R1044. https:\/\/doi.org\/10.1152\/ajpregu.1993.264.6.R1035","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"2550_CR15","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/cne.902930404","volume":"293","author":"H Herbert","year":"1990","unstructured":"Herbert H, Moga MM, Saper CB (1990) Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 293:540\u2013580. https:\/\/doi.org\/10.1002\/cne.902930404","journal-title":"J Comp Neurol"},{"key":"2550_CR16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.expneurol.2004.03.027","volume":"190","author":"E Herlenius","year":"2004","unstructured":"Herlenius E, Lagercrantz H (2004) Development of neurotransmitter systems during critical periods. Exp Neurol 190:8","journal-title":"Exp Neurol"},{"key":"2550_CR17","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1111\/j.1471-4159.1990.tb04559.x","volume":"55","author":"P Herregodts","year":"1990","unstructured":"Herregodts P, Velkeniers B, Ebinger G, Michotte Y, Vanhaelst L, Hooghe-Peters E (1990) Development of monoaminergic neurotransmitters in fetal and postnatal rat brain: analysis by HPLC with electrochemical detection. J Neurochem 55:774\u2013779. https:\/\/doi.org\/10.1111\/j.1471-4159.1990.tb04559.x","journal-title":"J Neurochem"},{"key":"2550_CR18","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1113\/jphysiol.1990.sp018099","volume":"425","author":"T Hertzberg","year":"1990","unstructured":"Hertzberg T, Hellstr\u00f6m S, Lagercrantz H, Pequignot JM (1990) Development of the arterial chemoreflex and turnover of carotid body catecholamines in the newborn rat. J Physiol 425:211\u2013225","journal-title":"J Physiol"},{"key":"2550_CR19","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0006-8993(89)90577-5","volume":"485","author":"G Hilaire","year":"1989","unstructured":"Hilaire G, Monteau R, Errchidi S (1989) Possible modulation of the medullary respiratory rhythm generator by the noradrenergic A5 area: an in vitro study in the newborn rat. Brain Res 485:325\u2013332","journal-title":"Brain Res"},{"key":"2550_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/J.RESP.2004.04.016","volume":"143","author":"G Hilaire","year":"2004","unstructured":"Hilaire G, Viemari J-C, Coulon P, Simonneau M, B\u00e9vengut M (2004) Modulation of the respiratory rhythm generator by the pontine noradrenergic A5 and A6 groups in rodents. Respir Physiol Neurobiol 143:187\u2013197. https:\/\/doi.org\/10.1016\/J.RESP.2004.04.016","journal-title":"Respir Physiol Neurobiol"},{"key":"2550_CR21","doi-asserted-by":"publisher","first-page":"H2280","DOI":"10.1152\/ajpheart.1997.273.5.h2280","volume":"273","author":"D Huangfu","year":"1997","unstructured":"Huangfu D, Guyenet PG (1997) Autoactivity of A5 neurons: role of subthreshold oscillations and persistent Na+ current. Am J Physiol - Hear Circ Physiol 273:H2280-9. https:\/\/doi.org\/10.1152\/ajpheart.1997.273.5.h2280","journal-title":"Am J Physiol - Hear Circ Physiol"},{"key":"2550_CR22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0006-8993(01)03256-5","volume":"925","author":"Y Ito","year":"2002","unstructured":"Ito Y, Oyamada Y, Hakuno H, Yamaguchi K (2002) Morphological analysis of developmental changes in pontine noradrenergic neuronal groups in the neonatal rat. Brain Res 925:107\u2013109. https:\/\/doi.org\/10.1016\/S0006-8993(01)03256-5","journal-title":"Brain Res"},{"key":"2550_CR23","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1164\/ajrccm.156.4.97-01080","volume":"156","author":"A Jubran","year":"1997","unstructured":"Jubran A, Grant BJB, Tobin MJ (1997) Effect of hyperoxic hypercapnia on variational activity of breathing. Am J Respir Crit Care Med 156:1129\u20131139. https:\/\/doi.org\/10.1164\/ajrccm.156.4.97-01080","journal-title":"Am J Respir Crit Care Med"},{"key":"2550_CR24","doi-asserted-by":"publisher","first-page":"R1356","DOI":"10.1152\/ajpregu.00884.2007","volume":"294","author":"C Julien","year":"2008","unstructured":"Julien C, Bairam A, Joseph V (2008) Chronic intermittent hypoxia reduces ventilatory long-term facilitation and enhances apnea frequency in newborn rats. Am J Physiol Integr Comp Physiol 294:R1356\u2013R1366. https:\/\/doi.org\/10.1152\/ajpregu.00884.2007","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"2550_CR25","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1113\/jphysiol.2010.198374","volume":"589","author":"R Kanbar","year":"2011","unstructured":"Kanbar R, Depuy SD, West GH, Stornetta RL, Guyenet PG (2011) Regulation of visceral sympathetic tone by A5 noradrenergic neurons in rodents. J Physiol 589:903\u2013917. https:\/\/doi.org\/10.1113\/jphysiol.2010.198374","journal-title":"J Physiol"},{"key":"2550_CR26","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1113\/jphysiol.1992.sp019239","volume":"453","author":"D Kholwadwala","year":"1992","unstructured":"Kholwadwala D, Donnelly DF (1992) Maturation of carotid chemoreceptor sensitivity to hypoxia: in vitro studies in the newborn rat. J Physiol 453:461\u2013473","journal-title":"J Physiol"},{"key":"2550_CR27","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000480612","volume":"18","author":"H Lagercrantz","year":"1992","unstructured":"Lagercrantz H, Holgert H, Pequignot J-M, Srinivasan M (1992) Expression and release of neuroregulators during development: monoamines and neuropeptides. Dev Pharmacol Ther 18:136\u2013138. https:\/\/doi.org\/10.1159\/000480612","journal-title":"Dev Pharmacol Ther"},{"key":"2550_CR28","doi-asserted-by":"publisher","unstructured":"Laouafa S, Ribon-Demars A, Marcouiller F, Roussel D, Bairam A, Pialoux V, Joseph V, Joseph V (2017) Estradiol protects against cardiorespiratory dysfunctions and oxidative stress in intermittent hypoxia. Sleep 40. https:\/\/doi.org\/10.1093\/sleep\/zsx104","DOI":"10.1093\/sleep\/zsx104"},{"key":"2550_CR29","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1113\/jphysiol.2005.099325","volume":"570","author":"A Li","year":"2006","unstructured":"Li A, Nattie E (2006) Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. J Physiol 570:385\u2013396. https:\/\/doi.org\/10.1113\/jphysiol.2005.099325","journal-title":"J Physiol"},{"key":"2550_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2017.03.031","volume":"351","author":"MR Malheiros-Lima","year":"2017","unstructured":"Malheiros-Lima MR, Takakura AC, Moreira TS (2017) Depletion of rostral ventrolateral medullary catecholaminergic neurons impairs the hypoxic ventilatory response in conscious rats. Neuroscience 351:1\u201314. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.03.031","journal-title":"Neuroscience"},{"key":"2550_CR31","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0034-5687(92)90079-C","volume":"90","author":"F Marchal","year":"1992","unstructured":"Marchal F, Bairam A, Haouzi P, Hascoet JM, Crance JP, Vert P, Lahiri S (1992) Dual responses of carotid chemosensory afferents to dopamine in the newborn kitten. Respir Physiol 90:173\u2013183. https:\/\/doi.org\/10.1016\/0034-5687(92)90079-C","journal-title":"Respir Physiol"},{"key":"2550_CR32","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1152\/jappl.1990.69.2.630","volume":"69","author":"M Modarreszadeh","year":"1990","unstructured":"Modarreszadeh M, Bruce EN, Gothe B (1990) Nonrandom variability in respiratory cycle parameters of humans during stage 2 sleep. J Appl Physiol 69:630\u2013639. https:\/\/doi.org\/10.1152\/jappl.1990.69.2.630","journal-title":"J Appl Physiol"},{"key":"2550_CR33","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0006-8993(94)91834-1","volume":"641","author":"A Monji","year":"1994","unstructured":"Monji A, Morimoto N, Okuyama I, Umeno K, Nagatsu I, Ibata Y, Tashiro N (1994) The number of noradrenergic and adrenergic neurons in the brain stem does not change with age in male Sprague-Dawley rats. Brain Res 641:171\u2013175. https:\/\/doi.org\/10.1016\/0006-8993(94)91834-1","journal-title":"Brain Res"},{"key":"2550_CR34","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1152\/jappl.1984.56.6.1533","volume":"56","author":"JP Mortola","year":"1984","unstructured":"Mortola JP (1984) Breathing pattern in newborns. J Appl Physiol 56:1533\u20131540. https:\/\/doi.org\/10.1152\/jappl.1984.56.6.1533","journal-title":"J Appl Physiol"},{"key":"2550_CR35","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.resp.2013.02.001","volume":"186","author":"JP Mortola","year":"2013","unstructured":"Mortola JP, Frappell PB (2013) Measurements of air ventilation in small vertebrates. Respir Physiol Neurobiol 186:197\u2013205. https:\/\/doi.org\/10.1016\/j.resp.2013.02.001","journal-title":"Respir Physiol Neurobiol"},{"key":"2550_CR36","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/BF00519099","volume":"137","author":"L Olson","year":"1972","unstructured":"Olson L, Seiger \u00c5 (1972) Early prenatal ontogeny of central monoamine neurons in the rat: fluorescence histochemical observations. Z Anat Entwicklungsgesch 137:301\u2013316. https:\/\/doi.org\/10.1007\/BF00519099","journal-title":"Z Anat Entwicklungsgesch"},{"issue":"Pt 2","key":"2550_CR37","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1469-7793.1998.381bb.x","volume":"513","author":"Y Oyamada","year":"1998","unstructured":"Oyamada Y, Ballantyne D, M\u00fcckenhoff K, Scheid P (1998) Respiration-modulated membrane potential and chemosensitivity of locus coeruleusneurones in the in vitro brainstem-spinal cord of the neonatal rat. J Physiol 513(Pt 2):381\u2013398","journal-title":"J Physiol"},{"key":"2550_CR38","doi-asserted-by":"publisher","first-page":"146508","DOI":"10.1016\/j.brainres.2019.146508","volume":"1726","author":"LGA Patrone","year":"2020","unstructured":"Patrone LGA, Capalbo AC, Marques DA, B\u00edcego KC, Gargaglioni LH (2020) An age- and sex-dependent role of catecholaminergic neurons in the control of breathing and hypoxic chemoreflex during postnatal development. Brain Res 1726:146508. https:\/\/doi.org\/10.1016\/j.brainres.2019.146508","journal-title":"Brain Res"},{"key":"2550_CR39","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1113\/JP275731","volume":"596","author":"LGALGA Patrone","year":"2018","unstructured":"Patrone LGALGA, Biancardi V, Marques DADA, B\u00edcego KCKC, Gargaglioni LHLH (2018) Brainstem catecholaminergicneurones and breathing control during postnatal development in male and female rats. J Physiol 596:3299\u20133325. https:\/\/doi.org\/10.1113\/JP275731","journal-title":"J Physiol"},{"key":"2550_CR40","volume-title":"The Rat Brain: In Stereotaxic Coordinates\u2014The New Coronal Set","author":"G Paxinos","year":"2004","unstructured":"Paxinos G, Watson C (2004) The Rat Brain: In Stereotaxic Coordinates\u2014The New Coronal Set. Elsevier Academic Press, Burlington"},{"key":"2550_CR41","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1152\/physiol.00035.2013","volume":"29","author":"DW Richter","year":"2014","unstructured":"Richter DW, Smith JC (2014) Respiratory rhythm generation in vivo. Physiology 29:58\u201371. https:\/\/doi.org\/10.1152\/physiol.00035.2013","journal-title":"Physiology"},{"key":"2550_CR42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00702-002-0767-7","volume":"110","author":"JC Roux","year":"2003","unstructured":"Roux JC, Mamet J, Perrin D, Peyronnet J, Royer C, Cottet-Emard JM, Pequignot JM, Dalmaz Y (2003) Neurochemical development of the brainstem catecholaminergic cell groups in rat. J Neural Transm 110:51\u201365. https:\/\/doi.org\/10.1007\/s00702-002-0767-7","journal-title":"J Neural Transm"},{"key":"2550_CR43","doi-asserted-by":"publisher","first-page":"R729","DOI":"10.1152\/ajpregu.2000.279.2.r729","volume":"279","author":"AM Schreihofer","year":"2000","unstructured":"Schreihofer AM, Guyenet PG (2000) Sympathetic reflexes after depletion of bulbospinalcatecholaminergic neurons with anti-D\u03b2H-saporin. Am J Physiol - Regul Integr Comp Physiol 279:R729-42. https:\/\/doi.org\/10.1152\/ajpregu.2000.279.2.r729","journal-title":"Am J Physiol - Regul Integr Comp Physiol"},{"key":"2550_CR44","doi-asserted-by":"publisher","first-page":"e91456","DOI":"10.1172\/jci.insight.91456","volume":"2","author":"G Song","year":"2017","unstructured":"Song G, Poon C-S (2017) \u03b12-Adrenergic blockade rescues hypoglossal motor defense against obstructive sleep apnea. JCI Insight 2:e91456. https:\/\/doi.org\/10.1172\/jci.insight.91456","journal-title":"JCI Insight"},{"key":"2550_CR45","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0034-5687(01)00242-0","volume":"127","author":"CE Stunden","year":"2001","unstructured":"Stunden CE, Filosa JA, Garcia AJ, Dean JB, Putnam RW (2001) Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats. Respir Physiol 127:135\u2013155. https:\/\/doi.org\/10.1016\/S0034-5687(01)00242-0","journal-title":"Respir Physiol"},{"key":"2550_CR46","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.neuroscience.2017.04.033","volume":"354","author":"CL Taxini","year":"2017","unstructured":"Taxini CL, Moreira TS, Takakura AC, B\u00edcego KC, Gargaglioni LH, Zoccal DB (2017) Role of A5 noradrenergic neurons in the chemoreflex control of respiratory and sympathetic activities in unanesthetized conditions. Neuroscience 354:146\u2013157. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.04.033","journal-title":"Neuroscience"},{"key":"2550_CR47","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.neuroscience.2011.09.068","volume":"199","author":"CL Taxini","year":"2011","unstructured":"Taxini CL, Takakura AC, Gargaglioni LH, Moreira TS (2011) Control of the central chemoreflex by A5 noradrenergic neurons in rats. Neuroscience 199:177\u2013186. https:\/\/doi.org\/10.1016\/j.neuroscience.2011.09.068","journal-title":"Neuroscience"},{"key":"2550_CR48","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1152\/jappl.1988.65.1.309","volume":"65","author":"MJ Tobin","year":"1988","unstructured":"Tobin MJ, Mador MJ, Guenther SM, Lodato RF, Sackner MA (1988) Variability of resting respiratory drive and timing in healthy subjects. J ApplPhysiol 65:309\u2013317. https:\/\/doi.org\/10.1152\/jappl.1988.65.1.309","journal-title":"J ApplPhysiol"},{"key":"2550_CR49","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1046\/j.1460-9568.2003.02561.x","volume":"17","author":"J-C Viemari","year":"2003","unstructured":"Viemari J-C, Burnet H, B\u00e9vengut M, Hilaire G (2003) Perinatal maturation of the mouse respiratory rhythm-generator: in vivo and in vitro studies. Eur J Neurosci 17:1233\u20131244","journal-title":"Eur J Neurosci"},{"key":"2550_CR50","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1523\/JNEUROSCI.3065-03.2004","volume":"24","author":"JC Viemari","year":"2004","unstructured":"Viemari JC, B\u00e9vengut M, Burnet H, Coulon P, Pequignot JM, Tiveron MC, Hilaire G (2004) Phox2a gene, A6 neurons, and noradrenaline are essential for development of normal respiratory rhythm in mice. J Neurosci 24:928\u2013937. https:\/\/doi.org\/10.1523\/JNEUROSCI.3065-03.2004","journal-title":"J Neurosci"},{"key":"2550_CR51","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1111\/j.1460-9568.2005.04441.x","volume":"22","author":"JC Viemari","year":"2005","unstructured":"Viemari JC, Maussion G, B\u00e9vengut M, Burnet H, Pequignot JM, N\u00e9pote V, Pachnis V, Simonneau M, Hilaire G (2005) Ret deficiency in mice impairs the development of A5 and A6 neurons and the functional maturation of the respiratory rhythm. Eur J Neurosci 22:2403\u20132412. https:\/\/doi.org\/10.1111\/j.1460-9568.2005.04441.x","journal-title":"Eur J Neurosci"},{"key":"2550_CR52","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.resp.2012.05.026","volume":"185","author":"MTT Wong-Riley","year":"2013","unstructured":"Wong-Riley MTT, Liu Q, Gao X (2013) Peripheral\u2013central chemoreceptor interaction and the significance of a critical period in the development of respiratory control. Respir Physiol Neurobiol 185:156\u2013169. https:\/\/doi.org\/10.1016\/j.resp.2012.05.026","journal-title":"Respir Physiol Neurobiol"},{"key":"2550_CR53","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1097\/01.CCM.0000227175.83575.E9","volume":"34","author":"M Wysocki","year":"2006","unstructured":"Wysocki M, Cracco C, Teixeira A, Mercat A, Diehl JL, Lefort Y, Derenne JP, Similowski T (2006) Reduced breathing variability as a predictor of unsuccessful patient separation from mechanical ventilation. Crit Care Med 34:2076\u20132083. https:\/\/doi.org\/10.1097\/01.CCM.0000227175.83575.E9","journal-title":"Crit Care Med"},{"key":"2550_CR54","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/374640a0","volume":"374","author":"QY Zhou","year":"1995","unstructured":"Zhou QY, Quaife CJ, Palmiter RD (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374:640\u2013643. https:\/\/doi.org\/10.1038\/374640a0","journal-title":"Nature"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-021-02550-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-021-02550-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-021-02550-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T09:34:33Z","timestamp":1625564073000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-021-02550-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2550"],"URL":"https:\/\/doi.org\/10.1007\/s00424-021-02550-1","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]},"assertion":[{"value":"27 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. This article does not contain any studies with human participants performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}